Cov txiaj ntsig zoo thiab tsis zoo rau kev noj qab haus huv ntawm cannabis, Kev sib raug zoo ntawm Cannabis Thiab Ntau Yam Kab Mob Part 1

Thov hu rauoscar.xiao@wecistanche.comyog xav paub ntxiv

Abstract:Hemp (Cannabis sativa L.) yog ib tsob nroj herbaceous-anemophilous uas belongs rau tsev neeg Cannabis-Linaceae. Cov noob cannabis (hemp) tau ntev tau siv los ua khoom noj thiab yog qhov tseem ceeb ua lag luam raws li cov roj noj tau. Hauv qhov kev tshuaj xyuas no, qhov txiaj ntsig zoo thiab tsis zoo rau kev noj qab haus huv ntawm cannabis, kev sib raug zoo ntawm cannabis thiab ntau yam kab mob, thiab kev siv cov cannabis hauv ntau yam khoom noj tau sib tham. Tsis tas li ntawd, cov ntaub ntawv tshawb fawb txog kev siv cov cannabis thiab nws cov derivatives raws li kev noj haus ntxiv rau kev tiv thaiv thiab kho cov kab mob inflammatory thiab mob ntev degenerative hauv cov tsiaj thiab tib neeg tau raug tshuaj xyuas. Cannabis tau tsim los ua cov khoom tseem ceeb hauv ntau yam khoom noj, suav nrog bakery, confectionery, dej haus, mis nyuj, txiv hmab txiv ntoo, zaub, thiab nqaij. Cov noob hemp muaj cov protein uas yooj yim digestible, lipids, polyunsaturated fatty acids (PUFA), insoluble fiber, carbs, thiab txaus siab omega -6 PUFA acid rau omega -3 PUFA ratio thiab muaj cov khoom noj muaj txiaj ntsig zoo. Cov tshuaj antioxidants ntawm cannabis, xws li polyphenols, pab nrog kev ntxhov siab, oxidative kev nyuaj siab, thiab kev pheej hmoo ntawm cov kab mob ntev, nrog rau mob qog noj ntshav, kab mob hauv lub paj hlwb, teeb meem digestive, thiab kab mob ntawm daim tawv nqaij. Cannabis tau pom tias muaj kev cuam tshuam rau kev noj qab haus huv tsis zoo ntawm lub ntsws, kev tsav tsheb, kev ua haujlwm ntawm psychomotor, thiab lub cev xeeb tub. Zuag qhia tag nrho, lub hom phiaj ntawm qhov kev tshawb fawb no yog txhawm rau txhawb kev tshawb fawb ntau ntxiv ntawm cannabis kev hloov mus rau ntau yam zaub mov thiab kev kho mob ntev.

Ntsiab lus:cannabis; hemp; tetrahydrocannabinol;lub neej extension cistanche; cannabidiol; cannabis-infused khoom noj;maca ginseng cistanche seahorseCov khoom lag luam cannabis

Thov nias ntawm no kom paub ntxiv

1. Taw qhia

Cannabis sativa L., feem ntau hu ua hemp (cannabis noob) lossis cannabis, yog cov nroj tsuag herbaceous anemophilous hauv tsev neeg Cannabaceae. Cannabis yog ib lo lus dav dav uas hais txog tag nrho cov nroj tsuag uas koom nrog Cannabis genus. Cov kws tshawb fawb feem ntau tau pom tias cov nroj tsuag no tuaj hauv Asia thiab raug thauj mus rau Tebchaws Europe raws li kev cog qoob loo thiab cog qoob loo thaum lub hnub nyoog Bronze (22nd mus rau xyoo pua 16 BC), raws li tau pom los ntawm kev tshuaj ntsuam molecular, kev tshawb fawb polygenetic, thiab DNA rho tawm los ntawm niaj hnub no. thiab archaeobotanical qauv. Txawm hais tias nws nyob qhov twg los xij, C. Sativa tau loj hlob thiab cog qoob loo tsis yog hauv tebchaws Esxias nkaus xwb tab sis kuj nyob hauv Africa, Canada, Europe, thiab Tebchaws Meskas [1].

Cannabis muaj ntau dua 100 yam tshuaj nquag hu ua cannabinoids[2]Cov nroj tsuag muaj ntau tus lej ntawm cannabinoids, feem ntau psychoactive ntawm uas yog delta -9-tetrahydrocannabinol (THC).THC kuj muaj qab los noj mov, tiv thaiv kab mob, analgesic. , thiab anti-emetic zoo, ua rau nws yog ib qho kev cog lus zoo heev rau kev siv tshuaj [3]. Cannabis yog siv rau textile thiab zaub mov siv vim nws siab hauv cannabidiol (CBD) los yog cov tshuaj zoo sib xws thiab xyaum tsis muaj delta -9-THC[4]. Hauv cov nroj tsuag tshuaj, feem ntau cannabinoids yog delta -9-tetrahydrocannabinol acid (THCA) thiab THC, whereas fiber-hom nroj tsuag paub tias muaj feem ntau cannabinoid acids, xws li cannabigerol acid (CBGA) thiab cannabidiol acid (CBDA. ), ua raws li lawv cov ntaub ntawv decarboxylated, uas yog cannabigerol (CBG) cannabidiol (CBD) [5].

Cistanche tuaj yeem txhim kho kev tiv thaiv

Muaj peb hom loj ntawm cannabis uas tau txheeb xyuas (Sativa, Indica, thiab ruderalis). Lub zog ntawm ob lub ntsiab active tshuaj nyob rau hauv cannabis, THC, thiab CBD, sib txawv ntawm hom, nrog Sativa nqa THC feem ntau thiab tsawg tshaj CBD [6]. Cov teebmeem euphoric thiab psychotropic ntawm cannabis yog vim THC. Synthetic versions ntawm THC, xws li dronabinol thiab nabilone, yog siv los txo qhov xeev siab thiab txhim kho qab los noj mov, ntxiv rau lawv cov teebmeem kev ua si. CBD, uas tsis yog-psychoactive tivthaiv, tuaj yeem cuam tshuam cov teebmeem no. Tsis tas li ntawd, Lub Chaw Tswj Xyuas Khoom Noj thiab Tshuaj tsis ntev los no tau pom zoo rau kev daws qhov ncauj CBD rau kev kho mob ntawm ob yam tsis tshua muaj neeg mob qaug dab peg raws li "cov tshuaj menyuam ntsuag." Nws tau pom zoo siv rau kev siv mob ntev thiab mob vim nws cov tshuaj tiv thaiv kab mob [ 7].

Cannabis muaj cov khoom noj muaj txiaj ntsig zoo, uas yog vim li cas txhua qhov chaw ntawm cov nroj tsuag, suav nrog cov qia, cov noob, cov hauv paus hniav, thiab paj, tau siv los ua zaub mov, pub, thiab kho mob rau lub sijhawm ntev. Cov noob hemp tau siv los ua zaub mov txij li lub sijhawm thaum ub, tshwj xeeb tshaj yog nyob rau hauv Asian civilizations, thiab yog cov lag luam tseem ceeb raws li qhov chaw ntawm cov roj noj [1]. Nws muaj 30 feem pua ​​​​cov roj thiab 25 feem pua ​​​​ntawm cov protein, ob qho tib si uas muaj txiaj ntsig zoo, nrog rau 10-15 feem pua ​​​​inssoluble fiber. Cov noob tuaj yeem siv rau hauv tshuaj pleev ib ce, khoom noj khoom haus sib txawv, thiab tsiaj pub [8]. Noob yog raug rau ib tug txias nias kom rho tawm cov roj zoo. Polyunsaturated fatty acids (PUFA) muaj nyob rau hauv cov roj, nrog rau kev xaiv piv ntawm -linolenic acid (w-6) rau linoleic acid (w-3) ​​rau kev noj haus science (2.5-3: 1). Cov roj yog siab nyob rau hauv linoleic acid, oleic acid, stearidonic acid, thiab a-linolenic acid, nrog rau cov fatty acids saturated tsuas yog kwv yees li 10 feem pua ​​​​ntawm tag nrho [9]. Hemp noob muaj cov tshuaj antioxidants muaj zog, xws li polyphenols, uas tuaj yeem pab kho ntau yam kab mob, xws li kev ntxhov siab, oxidant kev nyuaj siab, thiab kev pheej hmoo ntawm cov kab mob ntev, nrog rau mob qog noj ntshav, kab mob hauv lub paj hlwb, teeb meem digestive, thiab kab mob ntawm daim tawv nqaij, piv rau lwm hom paj. , lub hauv paus system ntawm hemp yog zoo tsim, uas ua rau nws zoo tagnrho rau lub phytoremediation ntawm hnyav hlau-contaminated av [10]. Fiber residue yog sau los ntawm qia ntawm cannabis. Hemp fiber yog ib qho tseem ceeb heev raw cov ntaub ntawv rau zus tau tej cov textiles ntev ntev thiab cov ntaub ntawv tshwj xeeb [1]. Hemp yog tsim los ntawm cov tshuaj sib txuas, xws li linoleic acid, alpha-Linolenic acid, tocopherol, cannabidiol cannabis hauv A, thiab caffeoyltyramine (Daim duab 1)[11-14]. ALA (alpha-linolenic acid) yog ib qho n-3(-3) fatty acid feem ntau pom nyob rau hauv cov zaub mov xws li flaxseed, walnuts, thiab zaub roj xws li canola thiab soybean roj. Kev sim tshuaj ntsuam xyuas tau pom tias hloov cov roj saturated nrog linoleic acid txo qis tag nrho thiab LDL cov roj cholesterol, qhia tias ALA muaj cov nyhuv cardioprotective [12].micronized purified flavonoid feem ntsiav tshuaj siv.Cannabidiol, uas tsis yog-psychoactive cannabinoid mole, yog ib qho kev cog lus kho mob rau ob qho kev mob. Cannabinoids koom nrog hauv pathophysiology ntawm ob qho tib si puas siab puas ntsws thiab tshuaj yeeb-tshuaj (SUDs) [13]. Caffeoyltyramine thiab nws cov phenolic amides, suav nrog cis-N-caffeoyltyramine thiab trans-N-caffeoyltyramine, paub tias muaj cov tshuaj tiv thaiv kab mob thiab antioxidant [14].

2. Cov txiaj ntsig kev noj qab haus huv muaj peev xwm ntawm Cannabis

Hemp noob yog txuam nrog ntau yam kev noj qab haus huv thiab kev kho mob tau. Cov noob hemp muaj cov tshuaj antioxidants siab, uas tuaj yeem pab tiv thaiv cov kab mob ntev xws li mob qog noj ntshav, kab mob hauv lub paj hlwb, cov teebmeem immunomodulatory, kab mob plab, lipid metabolism, kab mob dermatological, thiab kev noj qab haus huv ntawm lub plawv [15]. 2.1.Cardiovascular Health Kab mob plawv yog hais txog txhua yam mob uas cuam tshuam rau lub plawv lossis cov hlab ntsha. Nws feem ntau txuas mus rau qhov tso tawm ntawm cov rog nyob rau hauv cov hlab ntsha (atherosclerosis) thiab muaj feem ntau ntawm thrombosis. Cov kab mob plawv (CVDs) yog qhov ua rau muaj kev tuag thoob plaws ntiaj teb.oteflavonoidLos ntawm 2030, kab mob plawv tau kwv yees tias yuav tua 25 lab tus tib neeg thoob ntiaj teb [16].

THC tau tshawb pom los ua cov khoom xyaw tseem ceeb hauv cannabis, uas ua rau pom qhov tshwj xeeb THC receptors hauv tib neeg lub cev, hu ua cannabinoid receptors type1(CB-1) thiab type2(CB-2)( CB-2).CB-1 receptors muaj nyob rau hauv daim siab, rog, nqaij, thiab hlwb, whereas CB-2 receptors muaj nyob rau hauv ntau ntau nyob rau hauv lub cev tiv thaiv kab mob, tus po, thiab peripheral lub cev, txawm tias qis dua [17] Cov kev tshawb pom no ua rau muaj kev tshawb fawb nthwv dej uas thaum kawg ua rau kev txhim kho endocannabinoids (ECS). ECS tau kuaj pom nyob rau hauv cov ntaub so ntswg, thiab kev tshawb fawb tshiab qhia tias nws cuam tshuam rau cov ntshav siab thiab lub plawv dhia (HR) kev tswj hwm, nrog rau lwm yam kab mob. Nyob rau hauv lub xub ntiag ntawm cov xwm txheej mob, kev sim kev tshawb fawb tau pom tias redundancy nyob rau hauv endocannabinoid signaling thiab endocannabinoid substrates, nrog dual kev koom tes ntawm CB-1 thiab CB-2 receptors [18].

Steffens thiab Pacher [19] tau tshuaj xyuas cov ntaub ntawv tsis ntev los no ntawm cannabinoid receptor CB-2nyob rau hauv cov kab mob plawv thiab tau hais tias CB-2 receptor qhia nyob rau hauv cov kab mob plawv, nrog rau kev sim nkag mus rau lub cev tiv thaiv kab mob, xws li leukocytes thiab macrophages, tau pom meej koom nrog hauv kev sim tswj qhov hnyav ntawm cov ntaub so ntswg o thiab raug mob tshwm sim hauv cov kab mob plawv sib txawv, txhais tau hais tias tag nrho cov receptors tuaj yeem ua lub luag haujlwm hauv kev tswj hwm qhov mob hnyav ntawm cov ntaub so ntswg thiab kev puas tsuaj tshwm sim hauv cov kab mob plawv sib txawv. Kev siv CB-2 receptor agonists thiab antagonists los tswj CB-2 receptors zoo li yog qhov kev xaiv kho mob rau cov mob, xws li mob stroke, plawv tsis ua hauj lwm, atherosclerosis, thiab restenosis. Kev txheeb xyuas cov molecules nrog cov kev kho mob zoo ib yam li cannabis thiab cannabinoids tab sis nrog tsawg dua cov teebmeem yuav xav tau kev nkag siab zoo ntawm tib neeg endocannabinoid receptor system.

Raws li kev tshawb fawb nas tsis ntev los no uas tau tshuaj xyuas peb txoj kev tswj hwm THC, kev kho mob ua ntej nrog kev noj tshuaj tsawg tsawg ntawm THC tau muab kev tiv thaiv kev tiv thaiv ntawm cov cellular puas rau lub plawv, raws li pom los ntawm kev txo qis infarct loj thiab qis troponin qib [20]. Raws li qhov tshwm sim, muaj cov ntaub ntawv qhia tias kev siv cannabis cuam tshuam nrog kev pheej hmoo ntawm cov teeb meem mob plawv hauv ob qho tib si cov neeg mob atrial fibrillation thiab cov uas tsis muaj ntau yam kev pheej hmoo atherosclerotic. Txawm li cas los xij, qee cov kws tshawb fawb xav tias kev siv cannabis tsuas yog txuas nrog tsawg thiab muaj kev pheej hmoo ib ntus ntawm cov xwm txheej hauv plawv, muab qhov tsis tshua muaj ntawm cov ntaub ntawv ntawm kev tuag ntawm cov neeg siv tshuaj kho mob cannabis vim cov tshuaj [21]. Qee qhov kev tshawb fawb txog kev txhawb nqa cannabis cuam tshuam txog kev mob qog noj ntshav tau qhia hauv Table 1.

2.2. Cancer

Mob qog noj ntshav yog qhov thib ob loj tshaj plaws ntawm kev tuag thoob ntiaj teb, suav txog kwv yees li 8.8 lab tus neeg tuag hauv 2015 (GHO 2018 kwv yees); mob qog noj ntshav muaj ze li ib ntawm txhua rau rau tus neeg tuag. Mob qog noj ntshav yog ib hom kab mob ntau yam uas pib nrog kev tsim cov kab mob paraneoplastic (cov txheej txheem pib) thiab txhim kho mus rau hauv cov qog nqaij hlav hauv lub sijhawm. Mob qog noj ntshav tshwm sim thaum lub cellular reproduction mechanism ua uncontrolled. Nws yog ib qho mob uas cim los ntawm kev tswj tsis tau, tsis muaj teeb meem, thiab tsis xav tau ntawm tes faib. Cov qog nqaij hlav cancer, tsis zoo li cov hlwb ib txwm, txuas ntxiv faib thiab txhim kho thoob plaws hauv lawv lub neej, yog li tsim cov hlwb tsis zoo [11].

Cannabinoids tau pom tias txo cov qog cell proliferation thaum sparing ib txwm cov ntaub so ntswg. Glioma hlwb raug rau cannabis, piv txwv li, tuag los ntawm ceramide-induced cell tuag, tab sis astrocytes raug tiv thaiv los ntawm oxidative kev nyuaj siab tib yam [27]. Cannabidiol txhim kho THC qhov kev tiv thaiv qog nqaij hlav ntawm glioma hlwb [28]. Thaum kawg, hauv qee yam mob qog noj ntshav, kev qhia ntawm CBT thiab / lossis CB2 receptors tau txuas rau kev kwv yees. Kev nthuav qhia ntau ntxiv ntawm CBT thiab CB2 receptors tau cuam tshuam nrog kev txhim kho kev mob qog nqaij hlav hauv hepatocellular carcinomas, thaum kev qhia ntau dua ntawm CB2 receptors tau txuas rau cov qog qog ntau dua hauv gliomas [29]. Glioblastoma multiform, prostate, mis thyroid, nyuv, nyuv, pancreatic, leukemia, thiab lymphoma qauv tau pom tag nrho cov qog loj hlob inhibition hauv vitro thiab hauv vivo. Kev txo qis ntawm kev loj hlob ntawm tes taw qhia txoj hauv kev, thaiv ntawm cell migration thiab angiogenesis, kev txhawb nqa ntawm apoptosis, thiab / lossis kev tswj hwm ntawm autophagy tuaj yeem ua rau tag nrho cov txiaj ntsig los tiv thaiv qog nqaij hlav [30].

THC qhov kev nyab xeeb thiab kev ua tau zoo hauv cov neeg mob uas muaj refractory glioblastoma multiform tau tshawb xyuas hauv kev tshawb fawb. Cuaj tus neeg mob tau mob qog nqaij hlav ua haujlwm tom qab los ntawm kev tso ib qho infusion catheter mus rau hauv qhov chaw phais. THC tau txhaj rau hauv cov kab noj hniav txhua hnub rau {{0}} hnub ntawm koob tshuaj xws li 0.80 txog 3.29mg tag nrho. Cov tshuaj no ua rau muaj kev puas siab puas ntsws me ntsis rau ib tus neeg mob, tab sis nws tau txais txiaj ntsig zoo. THC inhibited qog loj hlob ntawm MRI, nrog rau qog ki-67 immunostaining thiab angiogenesis hauv cov ntaub so ntswg noj tom qab kho [31]. Txhawm rau txheeb xyuas cannabis lub peev xwm zoo li tshuaj tiv thaiv kab mob qog noj ntshav, xav tau kev tshawb fawb ntau dua thiab kho mob.

2.3.Kev mob ntawm Central Nervous System

Central nervous system (CNS) mob yog ib lo lus dav rau ib pawg kab mob uas ua rau lub hlwb tsis zoo txwv tsis pub muaj kev noj qab haus huv thiab muaj peev xwm ua haujlwm. Txhua xyoo, kwv yees li 6.8 lab tus tib neeg thaum kawg tuag los ntawm kev puas hlwb [32]. Qee cov tsos mob txuas nrog cov kab mob neurological, xws li ntau yam sclerosis (MS) thiab mob ntev, tau pom tias yuav txo tau los ntawm cannabis. MS yog ib qho kab mob autoimmune neurodegenerative tus cwj pwm los ntawm demyelinating CNS pathology. Cov tsos mob ntawm tus mob no muaj xws li spasticity, tremors, mob ntev, mob pob qij txha, thiab vesicle thiab plab hnyuv dysfunctions, tag nrho cov uas xav tias yog tshwm sim los ntawm tus txheej txheem demyelinating. Hauv cov tib neeg uas muaj MS thiab mob hauv nruab nrab, cov tshuaj cannabis-raws li txo qis kev ntsuas ntawm MS cov tsos mob thiab txhim kho qab los noj mov [3].

Kev qaug dab peg yog ib yam kab mob ntawm lub paj hlwb uas nquag ua rau qaug dab peg, uas yog cov hluav taws xob tawm ntawm cov hlwb hlwb uas ua rau cov leeg tsis muaj zog thiab tuaj yeem ua rau tuag taus. Kev qaug dab peg cuam tshuam txog 50 lab tus tib neeg thoob ntiaj teb, raws li World Health Organization; Lub Tsev Haujlwm Saib Xyuas Kabmob thiab Tiv Thaiv Kabmob tau tshaj tawm txog kev qaug dab peg cuam tshuam txog 3.4 lab tus tib neeg hauv Tebchaws Meskas [34].

Hauv xyoo 2015, American Academy of Neurology tau nthuav tawm txoj kev tshawb fawb soj ntsuam peb lub hlis uas muaj 137 tus menyuam yaus thiab cov neeg laus hluas uas muaj ntau yam mob vwm uas tau kho nrog CBD tshuaj Epidiolex. Dravet syndrome (16 feem pua), Lennox-Gastaut syndrome (16 feem pua), thiab kaum hom kab mob vwm ntxiv rau cov tib neeg (ib txhia ntawm lawv yog cov mob tsawg heev). Ze li ib nrab ntawm cov tib neeg nyob rau hauv qhov kev sim no tau qhia txog qhov txo qis ntawm kev qaug dab peg. Kev qaug zog, raws plab, thiab tsis qab los noj mov tag nrho tau tshaj tawm tias muaj kev phiv los ntawm 21 feem pua, 17 feem pua, thiab 16 feem pua, raws li. Cov kev mob tshwm sim hnyav tau raug tshaj tawm hauv ob peb kis, tab sis nws tsis meej: yog tias cov no tshwm sim los ntawm Epidiolex. Muaj kaum qhov xwm txheej ntawm tus mob epilepticus, peb kis mob raws plab, ob kis ntawm qhov hnyav, thiab ib qho mob siab [35].

Bergamaschi et al. [36] tau piav qhia txog kev tshawb fawb mus sij hawm ntev uas cov tub ntxhais hluas uas muaj cov tshuaj tiv thaiv kab mob tseem ceeb tau muab rau 1500 mg ntawm CBD ib hnub rau plaub lub lis piam. Nws cov tsos mob zoo dua, thiab tsis muaj kev phiv. Bergamaschi et al. tau tshaj tawm cov txiaj ntsig zoo sib xws hauv lwm qhov kev sim, uas peb tus neeg mob tau pib koob tshuaj CBD ntawm 40 mg, uas tau maj mam nce mus rau 1280mg / hnub rau plaub lub lis piam.

Lorenzetti thiab nws cov neeg koom tes piv cov neuroanatomical correlates ntawm ib txwm siv cannabis rau tsis siv hauv kev tshuaj ntsuam meta [37]. Kev siv Cannabis tau txuas nrog lub hlwb me me hauv thaj chaw koom nrog hauv kev kawm, khoom plig, thiab kev quav tshuaj (piv txwv li, hippocampus thiab orbitofrontal cortex). Neuroscientific theories ntawm kev quav yeeb quav tshuaj tau txheeb xyuas txoj hauv kev no, thiab lawv cov kev hloov kho tau pom nyob rau hauv kev siv tshuaj yeeb yam tsis zoo li cannabis. Kev tshawb fawb ntxiv yog xav tau los txiav txim seb leej twg feem ntau cuam tshuam rau cov kev hloov pauv ntawm lub hlwb, lub luag haujlwm ntawm cov yam ntxwv tsis zoo (xws li hnub nyoog thiab poj niam txiv neej, cannabis kev vam khom thiab muaj zog, thiab kev noj qab haus huv thiab kev siv yeeb tshuaj), thiab yuav ua li cas lub hlwb hloov pauv mus rau cannabis cuam tshuam. tsis meej pem.

2.4.Rheumatoid mob caj dab

Rheumatoid mob caj dab (RA) yog ib qho mob autoimmune mus ntev uas ua rau mob pob qij txha thiab cov ntaub so ntswg ib puag ncig. RA feem ntau cuam tshuam rau cov pob qij txha, uas feem ntau tawm tsam tib lub sijhawm. Hauv xyoo 2007-2009, kwv yees li 50million (22.2 feem pua) cov neeg Asmeskas cov neeg laus muaj hnub nyoog 18 xyoo tau kuaj pom tias muaj mob caj dab, feem ntau yog osteoarthritis thiab kab mob autoimmune rheumatoid mob caj dab. Los ntawm 2030, qhov pib xav tias yuav loj hlob mus rau 67 lab tus tib neeg [38].

Tom qab ua hauj lwm Freund's adjuvant los ua kom mob caj dab hauv nas, ntau qhov koob tshuaj CBD (0.6,3.1,6.2, lossis 62.3 mg / hnub) tau muab txhua hnub hauv gel rau kev tswj hwm transdermal rau plaub hnub. CBD tau pom tias txo qis kev sib koom tes o thiab tiv thaiv kab mob hauv lub cev. Tom qab plaub hnub ntawm kev tswj hwm CBD, lub synovial membrane thickened thiab nociceptive rhiab heev / qhov mob tshwm sim tau nce nyob rau hauv ib hnub npaum li cas. Hauv cov hauv paus dorsal ganglia (TNF alpha) thiab qaum qaum, cov cim qhia txog kev mob tshwm sim tau zoo sib xws hauv cov koob tshuaj (CGRP, OX42). Tsis muaj kev phiv, thiab kev tshawb nrhiav tus cwj pwm tsis muaj kev cuam tshuam (tsis zoo li 9-THC, uas ua rau lub cev muaj zog) [38]. Ib txoj kev tshawb fawb txog kev txhawb nqa cannabis cuam tshuam txog kev mob caj dab yog qhia hauv Table 1.

2.5.Dermatitis thiab tawv nqaij mob

Dermatitis yog ib lo lus hais txog ib pawg ntawm cov tawv nqaij uas ua rau mob. Cov kab mob ntawm daim tawv nqaij no muaj xws li atopic dermatitis (eczema), seborrheic dermatitis (dandruff), thiab hu rau dermatitis. Cov pob liab liab, tawv nqaij qhuav, thiab khaus khaus yog qee cov tsos mob ntawm cov kab mob no. Eczema (atopic dermatitis) yog kab mob ntawm daim tawv nqaij uas ua rau liab thiab khaus khaus. Nws muaj ntau tshaj plaws ntawm cov menyuam yaus, txawm hais tias nws tuaj yeem cuam tshuam rau leej twg ntawm txhua lub hnub nyoog. Atopic dermatitis yog ib qho mob ntev (ntev) uas tshwm sim los ntawm lub sijhawm. Nws yog qhov ua tau tias nws yuav txuas nrog mob hawb pob lossis kev ua xua raws caij nyoog. Eczema yog kab mob ntawm daim tawv nqaij uas cuam tshuam txog li 10 feem pua ​​​​rau 20 feem pua ​​​​ntawm cov neeg hauv ntiaj teb [39].

Hempseed roj yog qhov zoo ntawm w-6 thiab w-3 PUFAs. Hauv 20-lub lim tiam tswj hwm, ib leeg dig muag randomized sim nrog cov neeg mob atopic, noj cov roj hempseed thiab roj txiv roj tau muab piv. Hauv qhov kev tshawb fawb no, fatty acid profile hauv plasma triglycerides, roj cholesterol, thiab phospholipid Cheebtsam tau tshawb xyuas. Cov ntaub ntawv ntxiv txog cov tawv nqaij qhuav, khaus khaus, thiab siv cov tshuaj dermatological tau txais los ntawm kev soj ntsuam tus neeg mob. TEWL (Trans Epidermal Water Loss) kuj tau txheeb xyuas ntawm daim tawv nqaij. Ob qho tib si tseem ceeb fatty acids (EFAs), ALA (18: 3n3), thiab linoleic acid (18: 2n6), nrog rau gamma-linolenic acid (GLA; 18: 3n6), tau txhim kho nyob rau hauv tag nrho cov lipid Cheebtsam tom qab hempseed roj, tab sis Tsis yog arachidonic acid (20:4n6). Tom qab kev kho cov roj hempseed, intra-group TEWL qhov tseem ceeb txo qis (p50.074), daim tawv nqaij roughness thiab khaus khaus (p50.027), thiab kev siv tshuaj pleev ib ce txo (p50.024). Kev siv roj hempseed ua rau muaj kev hloov pauv tseem ceeb hauv plasma lipid cov ntsiab lus, nrog rau kev txo qis hauv cov tsos mob ntawm dermatitis.cov txiaj ntsig polyphenols, Cov txiaj ntsig zoo no tau xav tias yog vim li cas cov roj hempseed muaj qhov sib npaug thiab muaj txiaj ntsig zoo ntawm PUFAs [26]. Ib txoj kev tshawb fawb txog kev txhawb nqa cannabis ntsig txog cov kab mob ntawm daim tawv nqaij tau qhia hauv Table 1. 2.6.Sleep Disorders thiab Mental Health

Pw tsaug zog yog ib qho tseem ceeb physiological kev ua ub no uas pab txhawb kev kho cov txheej txheem uas tsim nyog rau kev ua haujlwm txhua hnub [40]. Kev noj qab nyob zoo pw tsaug zog yog cuam tshuam los ntawm ntau yam, suav nrog lub sijhawm, sijhawm, kev ua haujlwm, thiab kev paub txog kev pw tsaug zog uas ua rau tus neeg ceeb toom thiab ua haujlwm tau zoo thoob plaws hnub [41]. Kev pw tsaug zog tsis txaus yog qhia los ntawm 30-35 feem pua ​​​​ntawm cov pej xeem [42].

Cannabinoids (nabilone) tau kuaj tshwj xeeb rau kev kho mob ntawm kev pw tsaug zog nyuaj hauv ob txoj kev tshawb fawb (5 tsab ntawv ceeb toom; 54 tus neeg koom). Thawj yog qhov kev pheej hmoo siab-ntawm-kev tsis ncaj ncees thaum sib luag-pab pawg sim. Txoj kev tshawb no pom tias nabilone muaj txiaj ntsig ntau dua ntawm kev pw tsaug zog apnea / hyponea Performance index dua li cov placebo (txhais tau qhov sib txawv ntawm lub hauv paus, 19.64; p tus nqi=0.02). Lwm qhov yog qhov kev sim me me hauv cov neeg mob fibromyalgia uas piv nabilone rau amitriptyline. Qhov no qhia tau hais tias nabilone tau txuas rau txo qis insomnia (txhais tau qhov sib txawv ntawm lub hauv paus, 3.25 feem pua ​​​​CI, 5.26 txog 1.24) thiab nce pw tsaug zog (txhais tau qhov txawv ntawm qhov pib, 0.48(95 feem pua ​​CI,0 . , ib tug saib ntawm dronabinol, ob tug saib ntawm THC / CBD capsules, thiab ob tug saib ntawm haus luam yeeb THC (ib qho ntawm ntau koob). Muaj qee qhov qhia tias cannabinoids tuaj yeem pab cov neeg mob pw tsaug zog zoo dua. Cannabinoids (feem ntau yog nabiximols) tau txuas rau qhov nruab nrab ntawm kev pw tsaug zog ntau dua (WMD,{{30}}.58,95 feem pua ​​CI, 0.87 rau 0.29; 8 kev sim) thiab pw tsaug zog tsis zoo (WMD, 0.26, 95 feem pua ​​CI, 0.52 txog 0.00; 3 kev sim). THC/CBD tau sim hauv o tsis muaj kev sim, thaum nabiximols tau sim hauv lwm tus; Cov txiaj ntsig tau muab piv rau ob qho tib si cannabinoids [33].

Hoch thiab cov npoj yaig tau saib ntawm qhov kev sim tshuaj ntsuam xyuas uas tau saib xyuas qhov ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj cannabis hauv kev kho mob hlwb. Nyob rau hauv dementia, cannabis thiab opioid dependence, schizophrenia, kev ntxhov siab nyob rau hauv kev sib raug zoo, post-traumatic stress disorder, anorexia nervosa, tsis txaus siab/hyperactivity disorder, thiab Tourette qhov teeb meem, lawv systematic tshuaj xyuas pom ib co pov thawj uas THCor CBD muab raws li kev kho mob rau lwm yam pharmacotherapies. thiab kev kho puas siab puas ntsws txhim kho cov tsos mob tshwj xeeb ntawm qee qhov mob (piv txwv li, hauv dementia, schizophrenia, cannabis thiab opioid dependence, kev ntxhov siab hauv zej zog, anorexia nervosa, post-traumatic stress disorder, thiab Tourette's disorder). Muaj qee qhov tsis zoo hais txog, tab sis lawv tsis tshua muaj mob hnyav [43].

Kab lus no yog muab rho tawm los ntawm Molecules 2021, 26, 7699