Cov nyhuv Neuroprotective ntawm Cistanche Deserticola - Cytological Thiab Pharmacological teebmeem
Jul 22, 2024
Lub paj hlwb yog lub ntsiab kev tswj hwm ntawm lub cev, uas koom ua ke thiab tswj cov kev ua ub no ntawm lub cev ntawm ntau lub cev kom hloov mus rau ib puag ncig kev hloov pauv thiab kev xav tau ntawm lub cev kev ua ub no. Nws yog ib qho tseem ceeb rau kev ua kom lub cev ua haujlwm ntawm lub neej ua haujlwm, thiab rau tib neeg, nws yog cov khoom siv rau kev hais lus, kev xav, kev nco qab, thiab kev ua siab zoo. Qhov tshwm sim thiab ntau yam tshwm sim ntawm neurosis yog ze ze rau lub paj hlwb.
Suab puam nyob cistanche- Txhim kho kev nco
Raws li txoj cai, lub paj hlwb muaj xws li lub hauv nruab nrab lub paj hlwb thiab lub paj hlwb peripheral. Lub hauv paus paj hlwb muaj lub hlwb thiab qaum qaum, uas muaj ntau cov neurons (xws li paj hlwb). Lub hlwb muaj xws li telencephalon, diencephalon, midbrain, hindbrain, thiab medulla oblongata. Lub telencephalon tsim rau sab laug thiab sab xis cerebral hemispheres, ua ke nrog lub diencephalon tsim lub hlwb. Qhov normality ntawm kev puas siab puas ntsws feem ntau yog nyob ntawm seb cov qauv thiab kev ua haujlwm ntawm lub hlwb puas zoo li qub, thiab tseem muaj feem cuam tshuam rau lwm qhov ntawm lub hauv paus paj hlwb.
Lub paj hlwb peripheral suav nrog cov paj hlwb, cov paj hlwb txha caj qaum, cov hlab ntsha tsis muaj zog, thiab cov leeg hlwb uas muaj cov neurons uas txuas nrog hauv nruab nrab neurons. Dav dav faib nyob rau hauv ntau yam ntaub so ntswg thiab kabmob thoob plaws lub cev. Lub paj hlwb yog tsim los ntawm lub hauv nruab nrab lub paj hlwb thiab lub paj hlwb peripheral uas muab faib thoob plaws hauv lub cev, uas ua haujlwm ua ke los ua ke, tswj hwm, thiab ua haujlwm hauv lub cev.
Cov txiaj ntsig ntawm cistanche tubulosa-Txhim kho kev nco
Cov haujlwm thiab cov txheej txheem physiological ntawm ntau yam kabmob thiab cov kab ke hauv tib neeg lub cev tsis tau ua nyob rau hauv kev sib cais tab sis muaj kev sib cuam tshuam, cuam tshuam, thiab sib koom ua ke zoo raws li kev tswj hwm ncaj qha lossis tsis ncaj thiab kev tswj hwm ntawm lub paj hlwb, ua rau tib neeg lub cev ua tiav thiab sib koom ua ke. kab mob, ua tiav thiab tswj kev ua neej ib txwm muaj. Nyob rau tib lub sijhawm, tib neeg lub cev nyob hauv ib puag ncig hloov pauv tas li, uas cuam tshuam rau ntau yam haujlwm hauv lub cev txhua lub sijhawm. Qhov no kuj yuav tsum tau lub paj hlwb kom hloov kho thiab ua tiav ntau yam kev ua haujlwm hauv lub cev, kom tib neeg lub cev tuaj yeem hloov mus rau kev hloov pauv hauv ib puag ncig sab hauv thiab sab nraud.
Suav cistanchetshuaj ntsuab-Txhim kho kev nco
Nyem qhov no mus saib Cistanche Txhim Kho Kev Nco thiab Tiv Thaiv Alzheimer's Disease cov khoom
【Nug ntxiv】 Email: cindy.xue@wecistanche.com / Whats App: 0086 18599088692 / Wechat: 18599088692
Yog li ntawd, lub paj hlwb yog qhov tseem ceeb ntawm kev tswj hwm hauv lub cev, thiab Cistanche deserticola, uas muaj kev tiv thaiv tseem ceeb ntawm cov paj hlwb, yog li ntawd cov neeg nyiam heev.
Txog tam sim no, ze li ntawm 70 lub tebchaw tau raug cais tawm ntawm cov nroj tsuag ntawm Cistanche genus, feem ntau suav nrog phenylethanoid glycosides, cyclohexene ether terpenes thiab lawv cov glycosides, lignans thiab lawv glycosides, nrog rau alkaloids thiab qab zib thiab lwm yam khoom. Ntawm lawv, muaj 6 monomers tau tshaj tawm tias muaj cov teebmeem neuroprotective meej, xws li ergot glycoside, campneoside II, verbascoside, pineal chrysanthemum glycoside, yeeb nkab paj glycoside B, thiab ziwei xin glycoside. Yog li ntawd, cov khoom uas tsis yog-monomeric uas muaj cov monomers uas tau hais los saum toj no, xws li tag nrho glycosides ntawm Cistanche deserticola, phenylethanoid glycosides, thiab polysaccharides, kuj muaj cov teebmeem neuroprotective.
Cov tshuaj tseem ceeb ntawm Cistanche deserticola
Campneoside II, verbascoside, guanosine B, thiab pineal glycoside, uas yog phenylethanolic glycosides, feem ntau muaj kev tiv thaiv ntawm MPP +, H2O2 (hydrogen peroxide), lossis THF - - induced apoptosis ntawm nas cerebellar granule hlwb, SH-SYuroma ) cell puas, thiab PC12 (pheochromocytoma) neuronal apoptosis; Pinecone glycoside tuaj yeem txo MPTP (neurotoxin) cuam tshuam kev coj tus cwj pwm hauv nas, nce qib ntawm striated dopamine (DA) thiab DA metabolites, txo cov cell tuag, thiab txhim kho tyrosine hydroxylase qhia; Verbascoside tuaj yeem txhim kho MPTP induced tus cwj pwm kev ua tau zoo hauv C57 nas, nce cov ntsiab lus ntawm dopamine neurotransmitters hauv lub hlwb, tus naj npawb ntawm dopamine neurons, thiab qib ntawm - synuclein protein nyob rau hauv substantia nigra striatum; Guanhua glycoside B zoo txo qhov tshwm sim ntawm H2O2 induced cell apoptosis, inhibits tiam ntawm reactive oxygen hom thiab nce ntawm caspase{11}} (cysteine aspartate protease-3) kev ua hauv hlwb, thiab tswj lub zog siab. lub xeev ntawm mitochondrial membrane muaj peev xwm. Cov kev sib txuas no muaj kev cuam tshuam, sib koom ua ke inhibiting cell apoptosis thiab ua tiav cov teebmeem neuroprotective. Cov phenylethanoid glycoside tivthaiv ntawm ntsev-loj Cistanche deserticola tuaj yeem tiv thaiv apoptosis ntawm nas pheochromocytoma PC12 hlwb induced los ntawm p amyloid protein 25-35 los ntawm kev nce cell ciaj sia taus thiab txo lactate dehydrogenase kev ua. Tag nrho glycosides ntawm Cistanche deserticola (GCs) tuaj yeem ua tiav cov haujlwm tiv thaiv neuroprotective los ntawm kev txo cov ntsiab lus ntawm malondialdehyde hauv cov ntaub so ntswg thiab ua kom cov haujlwm ntawm superoxide dismutase, uas yog, txhim kho cov haujlwm ntawm cov dawb radical scavenging enzymes. Cistanche polysaccharides tuaj yeem tiv thaiv cov paj hlwb los ntawm kev txhim kho kev qhia ntawm Bel -2 thiab inhibiting kev qhia ntawm Caspase-3, yog li suppressing neuronal apoptosis.
Suav cistanchetshuaj ntsuab-Txhim kho kev nco
Kev puas tsuaj thiab kev tuag ntawm cov paj hlwb hauv lub paj hlwb yog cov txheej txheem pathological hauv ntau cov kab mob hauv lub cev thiab tseem nyuaj thiab cov ntsiab lus tseem ceeb hauv kev tiv thaiv thiab kho cov kab mob neurological. Yog li ntawd, kev sib sib zog nqus ntxiv thiab txhim kho cov txheej txheem ntawm kev ua haujlwm ntawm cov khoom noj qab haus huv nrog cov teebmeem neuroprotective yog lub luag haujlwm tseem ceeb rau cov neeg ua haujlwm kho mob kom tau txais txiaj ntsig zoo rau pej xeem.
