LUB SIJ HAWM MICROBIOME HAUJ LWM HAUJ LWM HAUJ LWM HAUV BARIATRIC SurgeRY: A SYSTEMATIC REVIEW Ⅰ
Dec 08, 2023
Tib neeg txoj hnyuv microbiota (IM) yog tsim los ntawm yug mus rau 2 xyoos ntawm lub hnub nyoog vim yog endogenousand exogenous yam, xws li ib puag ncig, kev noj haus, kev sib cuag nrog lwm tus neeg, kab mob, thiab kev siv tshuaj. Yog li, lub plab harbors ntau haiv neeg microbialcommunities, nrog rau phyla Bacteroidetes thiab Firmicutesprevailing. Txawm li cas los xij, cov kab mob, cov kab mob bacteriophages, cov poov xab, thiab cov fungi tsim kom muaj kev sib haum xeeb nrog tus tswv tsev, xws li generaClostridium, Lactobacillus, Escherichia, thiab Bifidobacterium.
Cov zej zog zoo li no muaj kev ua haujlwm dav dav ntawm kev ua haujlwm biochemical, thiab qhov kev nplua nuj ntawm cov noob microbial no tseem ceeb rau kev tswj cov txheej txheem metabolic thiab lwm yam kev cai ntawm lub cev14,16. Feem ntau, IM tseem nyob ruaj khov hauv lub neej. Txawm li cas los xij, microbiome, nkag siab zoo li microbiota, nws cov metagenome, thiab cov kab mob abiotic ib puag ncig tuaj yeem hloov kho cov txheej txheem.
Dysbiosis ntawm plab hnyuv microbiome, uas yog, kev hloov pauv ntawm qhov sib npaug ntawm microbialcommunity muaj pes tsawg leeg, cuam tshuam nrog kev rog, ntshav qab zib, thiab kev hloov pauv tom qab phais, nrog rau lwm yam 14.Nyob rau hauv cov ntsiab lus no, dysbiosis ntawm plab microbiota feem ntau pom muaj nyob rau hauv cov mob rog thiab lwm yam. Cov kab mob metabolic, xws li hom 2 mob ntshav qab zib mellitus (DM2). Tam sim no, cov kev tshawb fawb qhia tias qhov tshwj xeeb microbiota profile tuaj yeem ua rau muaj kev rog dhau ntawm cov tib neeg ib txwm muaj thiab cov kev rog uas twb tau teeb tsa lawm tuaj yeem ua rau muaj txiaj ntsig zoo ntawm cov microbiota uas twb muaj lawm.
Cov kev tshawb fawb kuj tau taw qhia tias kev rog rog muaj feem cuam tshuam nrog qis microbiota ntau haiv neeg thiab microbial gene richness (MGR), nrog rau qhov txo qis hauv Firmicutes-Bacteroidetes ratio.Cov microbiota muaj pes tsawg leeg hauv cov neeg mob ntshav qab zib zoo ib yam li cov neeg rog rog. Nws kuj tseem raug ntaus nqi rau qhov phenotype ntawm IM qhov kev ua tau zoo ntawm kev siv zog hauv cov hnyuv loj ntawm cov neeg rog rog, kev saib xyuas ntawm lub cev muaj zog, thiab kev tiv thaiv ntau dua rau insulin1,13.
Tam sim no, tau muaj kev nce qib hauv kev ua haujlwm ntawm kev phais bariatric thoob ntiaj teb raws li txoj hauv kev kho mob rog thiab ua rau txo qis kev pheej hmoo ntawm cov hlab plawv thiab ntshav qab zib, ua cov txheej txheem no "kev phais mob metabolic." Cov txheej txheem kev cai lij choj suav nrog lub tes tsho ntsug gastrectomy (SG), Roux-en-Y bypass (RYGB), thiab biliopancreatic diversion / duodenalswitch (BPD). RYGB thiab BPD yog cov txheej txheem txwv tsis pub noj thiab tsis haum, txwv tsis pub noj zaub mov thiab txo cov hnyuv hauv plab.
Lub SG, ntawm qhov tsis sib xws, yog kev txwv tsis pub dawb huv. Bariatricsurgery feem ntau yog tsom rau kev poob phaus ntev, tab sis nws kuj pom muaj nyob rau hauv cov ntaub ntawv ua rau txo qis kev tuag thiab kev txhim kho ntawm cov kab mob sib kis, xws li DM2. Lwm qhov txiaj ntsig ntawm kev phais mob bariatric, taw qhia los ntawm kev tshawb fawb, yog qhov ua tau zoo ntawm dysbiosis pom hauv cov neeg mob rog rog, uas yuav ua rau muaj kev sib txawv ntawm IM thiab kev nplua nuj ntawm cov kab mob microbial, ntxiv rau kev nce hauv cov kab mob tshwj xeeb ntawm cov kab mob.
Cov kev hloov pauv no ua rau poob phaus, txo cov kab mob hauv lub cev, nce insulin rhiab heev, thiab ntau yam kev txhim kho metabolic 17.Lub hom phiaj ntawm tsab xov xwm no yog, los ntawm kev siv lub systematicreview, los tshuaj xyuas qhov muaj peev xwm ntawm bariatric phais ntawm cov plab hnyuv microbiota thiab cov metabolicmodifications tshwm sim. nws nyob rau hauv cov neeg mob postbariatric.
Kab lus no yog kev tshuaj xyuas cov ntaub ntawv zoo nrog cov txheej txheem zoo uas nrhiav kev txheeb xyuas cov kev hloov pauv hauv IM ntawm cov neeg mob uas tau txais kev phais bariatric. Tsis tas li ntawd, tsab xov xwm no yog ib qho yooj yim thiab kev tshawb fawb ntawm cov ntaub ntawv sau los ntawmthawj cov kev tshawb fawb los yog cov ntaub ntawv tshuaj xyuas, kev nthuav qhia cov txiaj ntsig, thiab kev tawm tsam nrog cov ntaub ntawv tam sim no.
Ua ntej, kev tshawb nrhiav cov lus piav qhia txog cov ntsiab lus tau ua tiav, uas tau txheeb xyuas siv DeCS (HealthScience Descriptors). Yog li, cov ntsiab lus hauv qab no tau siv rau kev tshawb fawb: "kev rog," "plab plab dysbiosis," "kev phais bariatric," thiab "microbiota," uas ua rau kev tsim cov kev tshawb fawb, nrog THIAB lossis LOSSIS, xav txog kev siv cov ntsiab lus hauv titleor abstract ntawm cov ntaub ntawv. Tom qab ntawd, kev tshawb fawb tau ua nyob rau hauv PubMed, Google Scholar, thiab SciELO, thiab tag nrho ntawm 76 kab lus tau pom (Daim duab 1). Tom qab tshawb nrhiav cov ntawv uas ua tau raws li cov qauv tsim ua ntej, thawj kauj ruam yog los tshuaj xyuas cov npe thiab cov lus piav qhia, uas tau ua los ntawm ob tus kws tshawb fawb, thiab tom qab ntawd tsuas yog cov lus pom zoo los ntawm ob qho tib si raug xaiv.
Cov txheej txheem suav nrog yog raws li hauv qab no: cov ntawv hauv Lus Askiv lossis Portuguese uas tau hais txog lub ntsiab lus ntawm kev tshuaj xyuas, uas yog, kev tsom xam ntawm plab hnyuv dysbiosis hauv cov neeg mob postbariatric, thiab cov ntawv tsis ntev los no los ntawm 2009 txog 2022. Tsis tas li ntawd, peb siv cov ntawv uas tsis muaj kev nyeem ntawv raws li kev cais tawm. , as wellas cov khoom uas tsis tau raws li qhov kev tshawb fawb lub hom phiaj, nrog rau lub ntsiab tsom rau lwm yam, xws li ib tug yooj yim citation ntawm lub postbariatric IM, hom kev phais bariatric, thiab lwm yam uas tsis tau soj ntsuam qhov kev hloov nyob rau hauv microbiota tom qab thereduction phais. Thaum kawg, 28 kab lus raug xaiv, uas tau kawm thiab tshuaj xyuas, los piav qhia qhov tshwm sim ntawm cov ntsiab lus. Cov kev tshawb fawb tsis xav tau kev pom zoo los ntawm Lub Tsev Haujlwm Saib Xyuas Kev Ncaj Ncees Kev Ncaj Ncees.
Ntuj Herbal Tshuaj Rau Relieving cem quav-Cistanche
Cistanche yog ib tug genus ntawm parasitic nroj tsuag uas belongs rau tsev neeg Orobanchaceae. Cov nroj tsuag no paub txog lawv cov khoom siv tshuaj thiab tau siv hauv Cov Tshuaj Suav Tshuaj (TCM) rau ntau pua xyoo. Cov hom Cistanche feem ntau pom muaj nyob hauv thaj av qhuav thiab suab puam ntawm Tuam Tshoj, Mongolia, thiab lwm qhov chaw ntawm Central Asia. Cistanche nroj tsuag yog tus cwj pwm los ntawm lawv cov nqaij tawv, yellowish stems thiab muaj nuj nqis heev rau lawv cov txiaj ntsig kev noj qab haus huv. Hauv TCM, Cistanche ntseeg tau tias muaj cov khoom siv tonic thiab feem ntau yog siv los kho lub raum, txhim kho qhov tseem ceeb, thiab txhawb kev ua haujlwm ntawm kev sib deev. Nws kuj yog siv los daws cov teeb meem ntsig txog kev laus, qaug zog, thiab kev noj qab haus huv tag nrho. Thaum Cistanche muaj keeb kwm ntev ntawm kev siv tshuaj ib txwm siv, kev tshawb fawb tshawb fawb txog nws txoj kev ua tau zoo thiab kev nyab xeeb yog tsis tu ncua thiab txwv. Txawm li cas los xij, nws paub tias muaj ntau yam bioactive tebchaw xws li phenylethanoid glycosides, iridoids, lignans, thiab polysaccharides, uas tuaj yeem ua rau nws cov teebmeem tshuaj.
Wecistanche covcistanche hmoov, cistanche ntsiav tshuaj, cistanche capsules, thiab lwm yam khoom tsim los sivsuab puamcistancheraws li cov khoom siv raw, txhua yam muaj txiaj ntsig zoo rau kev tshem tawm cem quav. Cov txheej txheem tshwj xeeb yog raws li hauv qab no: Cistanche ntseeg tau tias muaj cov txiaj ntsig zoo rau kev tshem tawm cem quav raws li nws cov kev siv ib txwm siv thiab qee cov tshuaj uas nws muaj. Txawm hais tias kev tshawb fawb tshawb fawb tshwj xeeb ntawm Cistanche qhov cuam tshuam rau cem quav yog txwv, nws tau xav tias muaj ntau lub tswv yim uas yuav ua rau nws muaj peev xwm txo tau cem quav. Laxative nyhuv: Cistanche tau ntev tau siv nyob rau hauv Tsoos Suav Tshuaj raws li ib tug tshuaj rau cem quav. Nws ntseeg tau tias muaj cov nyhuv laxative me me, uas tuaj yeem pab txhawb kev zom zaub mov thiab ua rau cem quav. Cov nyhuv no tej zaum yuav raug ntaus nqi rau ntau cov tebchaw nyob hauvCistanche, xws li phenylethanoid glycosides thiab polysaccharides. Moistening cov hnyuv: Raws li kev siv ib txwm siv, Cistanche suav hais tias muaj cov khoom siv moisturizing, tshwj xeeb yog tsom rau cov hnyuv. Txhawb nqa dej thiab lubrication ntawm cov hnyuv yuav pab tau cov cuab yeej soften thiab yooj yim dua, yog li no relieving cem quav. Anti-inflammatory Effect: cem quav tej zaum yuav txuam nrog o nyob rau hauv lub plab zom mov. Cistanche muaj qee qhov sib txuas, suav nrog phenylethanoid glycosides thiab lignans, uas ntseeg tau tias muaj cov tshuaj tiv thaiv kab mob. Los ntawm kev txo cov kab mob hauv cov hnyuv, nws tuaj yeem pab txhim kho kev zom zaub mov tsis tu ncua thiab txo qhov cem quav.
