Kev ua tau zoo ntawm Cistanche Deserticola ntawm Kev Loj Hlob

Ntsiab lus: Herba Cistanche; kev yug me nyuam; pharmacological kev txiav txim; tshuaj xyuas

Cistanche deserticolaNws yog scaly, qhuav, fleshy qia ntawm genus Cistanche, uas muaj keeb kwm ntev tshuaj. Cistanche deserticola yog tsim nyob rau hauv Inner Mongolia, Xinjiang, Gansu, Qinghai, Ningxia, thiab lwm qhov chaw hauv Suav teb. Nws yog ib qho khoom siv tshwj xeeb thiab muaj kev phom sij nyob rau hauv thaj chaw arid ntawm sab qaum teb sab hnub poob Tuam Tshoj, hu ua "desert ginseng". Txhawm rau kom paub meej cov tshuaj hauv paus ntawm Cistanche deserticola, cov kws tshawb fawb hauv tsev thiab txawv teb chaws tau ua qhov tob thiab kev tshuaj xyuas thiab kev tshawb fawb txog cov khoom siv zoo ntawm Cistanche deserticola. Tam sim no,Ntau yam tshuaj muaj txiaj ntsig zoo tau raug cais thiab txheeb xyuas, feem ntau suav nrog phenylethanoid glycosides, iridoids, thiab lignans, ntxiv rau ntau tshaj kaum amino acids, qab zib, vitamins, thiab ntau yam kab kawm..

Cistanche deserticola, me ntsis sov, qab zib, thiab qab ntsev hauv saj, nkag mus rau hauv lub raum meridian thiab txoj hnyuv loj meridian, thiab muaj qhov ua kom sov thiab tonifying raum yang, tonifying ntshav essence, moistening dryness, thiab relieving cem quav. Nws yog siv los kho deficiency ntawm lub raum yang, tsis muaj ntshav essence, mob khaub thuas ntawm lub duav thiab lub hauv caug, ejaculation, ejaculation ntxov ntxov, uterine txias band, infertility, cem quav, thiab lwm yam. 

Superman tshuaj ntsuab cistanche-Improv kev ua haujlwm deev

Raws li Kev Tshawb Fawb Txog Tshuaj Kho Mob,Cistanche deserticola pab cov pob txha, ci xim, ua kom lub neej ntev, kho cov poj niam cov ntshav avalanche, txhawb kev loj hlob, thiab muaj txiaj ntsig zoo rau lub cev.Raws li Classic ntawm Materia Medica, Cistanche deserticola, uas yog qhov sov sov hauv qhov xwm txheej, yog cov tshuaj tseem ceeb rau kev txhawb nqa lub raum thiab ua kom cov ntshav ntxiv. Nws tuaj yeem kho qhov qhuav ntawm cov neeg laus thiab kaw lub pob. Nws muaj cov txiaj ntsig zoo rau lub siab thiab lub raum thiab ntxiv cov ntshav cov ntsiab lus tom qab noj nws ntev [1]. Cistanche deserticola yog ib qho ntawm cov tshuaj nquag siv nyob rau hauv cov tshuaj ntawm tonifying lub raum, ntxiv dag zog rau yang, thiab ntxiv dag zog rau lub zog.Ntau cov kev kho mob thiab kev tshawb fawb tau ua pov thawj tias Cistanche deserticola muaj cov txiaj ntsig zoo kawg thiab yog cov khoom muaj nqis ntawm kev noj zaub mov hauv Suav. Nyob rau hauv xyoo tas los no, kev tshawb fawb, kev loj hlob, thiab kev siv ntawm Cistanche deserticola tau nyiam cov neeg tshawb fawb ntawm cov tshuaj suav tshuaj thiab tau dhau los ua ib qho kev tshawb fawb hotspots hauv thaj chaw ntawm cov tshuaj suav tshuaj.. Nyob rau hauv daim ntawv no, cov teebmeem ntawm Cistanche deserticola thiab nws cov active Cheebtsam ntawm lub cev xeeb tub nyob rau hauv lub xyoo tsis ntev los no raug tshuaj xyuas rau siv.

Suab puam Nyob Cistanche-Impov thawj kev ua haujlwm ntawm kev sib deev

Nyem qhov no mus saib Cistanche deserticola Txhim kho cov khoom ua haujlwm kev sib deev

【Nug ntxiv】 Email: cindy.xue@wecistanche.com / Whats App: 0086 18599088692 / Wechat: 18599088692

1. cuam tshuam rau kev sib deev hormone

Ntau cov kev tshawb fawb tau pom tias Cistanche deserticola tuaj yeem txhawb kev tso tawm ntawm cov tshuaj hormones poj niam txiv neej lossis pom cov nyhuv ntawm cov tshuaj hormones poj niam txiv neej.. Cov txheej txheem transgenic poov xab tau siv los kuaj Cistanche deserticola, thiab nws tau pom tias Cistanche deserticola muaj cov tshuaj estrogen siab [2]. Zhao Piwen et al. [3] tshawb xyuas cov tshuaj estrogen zoo li Cistanche deserticola los ntawm kev kawm txog cov txiaj ntsig ntawm Cistanche deserticola ntawm nas txoj kev loj hlob ntawm lub tsev menyuam. Cov txiaj ntsig tau pom tias Cistanche deserticola tuaj yeem nce cov ntsiab lus ntawm cov ntshav estradiol (E2) thiab luteinizing hormone (LH) thiab txo cov ntsiab lus ntawm follicle-stimulating hormone (FSH) hauv cov nas. Cistanche deserticola tuaj yeem nce qib ntawm cov tshuaj estrogen hauv cov nas. Cov txheej txheem ntawm nws qhov kev ua yuav yog tias qee cov tshuaj nquag ntawm Cistanche deserticola tuaj yeem ua rau kom muaj kev zais ntawm LH. Txoj kev tshwj xeeb ntawm nws qhov kev txiav txim tseem tsis meej. Tsis tas li ntawd, qhov tso tawm ntawm FSH tsis nce. Nws tau kwv yees tias nrog lub sijhawm ntev ntawm qhov kev sim, qhov nce qib ntawm cov tshuaj estrogen ntawm cov nas tuaj yeem tawm tswv yim inhibit qhov tso tawm ntawm LH, ua rau qhov kawg ntawm LH secretion theem.

Wang Lin et al. [4] siv cov luciferase reporter plasmid txoj kev thiab cov tshuaj estrogen receptor kev sib tw khi kev sim los ntsuas cov tshuaj estrogen zoo li cov nyhuv ntawm cov khoom tseem ceeb ntawmCistanche deserticola, suav nrogEchinacosidethiabActeoside. Cov txiaj ntsig tau pom tias ob qho tib siEchinacosidethiabActeosidetuaj yeem khi cov tshuaj estrogen receptor ER , EＲ , Up-regulate lub luciferase kev ua ntawm cov tshuaj estrogen teb (ERE), ua lub luag haujlwm ntawm estrogen, thiab tso saib SERMs kev ua;EchinacosidethiabActeosidetseem tuaj yeem sib tw khi rau cov tshuaj estrogen receptor nrog estradiol, yog li tiv thaiv kev tswj hwm ntawm estradiol ntawm ERE luciferase kev ua. Nws tuaj yeem pom tau tias Echinacoside thiab Acteoside muaj feem xyuam rau cov tshuaj estrogen receptor ER, Er Combine los ua lub luag haujlwm ntawm estrogen [4].

Superman tshuaj ntsuab cistanche-Improv kev ua haujlwm deev

【Nug ntxiv】 Email: cindy.xue@wecistanche.com / Whats App: 0086 18599088692 / Wechat: 18599088692

2. Cov nyhuv ntawm spermatogenic muaj nuj nqi

Cov kev tshawb fawb tau ua pov thawj tiasCistanche deserticola mamuajmuaj kev tiv thaiv zoo ntawm spermatogenic muaj nuj nqi thiab phev zoo. Cistanche Singicicola Decoction tuaj yeem nce phev ceev, thiab phev zog, ceev phev txav, thiab txo cov phev fareormity nyob rau hauv nas; Txhim kho lub morphology ntawm nas testis, ua rau cov duab ntawm seminiferous tubules tsis tu ncua, kev npaj ntawm spermatogenic hlwb nyob rau hauv tag nrho cov theem yog nruj thiab zoo, tus naj npawb ntawm testicular interstitial hlwb yog ho nce, cov hlab ntsha yog nplua nuj, spermatogenic muaj nuj nqi ntawm lub testis. yog kho kom zoo, microenvironment ntawm epididymis yog ho txhim kho, thiab cov ntsiab lus fructose yog nce; Ob leeg succinate dehydrogenase (SDH) thiab non-specific lipase (NSE) hauv testis thiab epididymis tau pom muaj cov tshuaj tiv thaiv zoo. [5].

Tripterygium wilfordii polyglycolide tuaj yeem ua rau kom cov phev deformity ntawm nas, txo qhov cev xeeb tub ntawm cov poj niam nas, txo cov qog nqaij hlav hauv nruab nrog cev, txo cov theem ntawm 17-hydroxy cortisol (17-OHCS) thiab testosterone ( T) nyob rau hauv cov zis, nce qib ntawm HCG hauv cov zis, txo qis kev qhia theem ntawm cov noob Dzip1 ntsig txog microdeletion ntawm nas Y chromosome, nce qib ntawm cov gene Fas thiab proto-oncogene c-jun ntsig txog kab mob cell apoptosis. , thiab nce qib kev qhia ntawm cov noob Wnt4 ntsig txog cov teeb liab transduction;Tom qab kev cuam tshuam ntawm Cistanche deserticola, qhov kev qhia ntawm ntau yam ntsuas thiab cov noob muaj feem xyuam tau zoo tuaj mus rau qhov sib txawv, iKev qhia tias Cistanche deserticola tuaj yeem tiv thaiv kev ua haujlwm ntawm kev ua me nyuam ntawm cov txiv neej nas los ntawm Tripterygium wilfordii polyglycolide., thiab muaj kev tiv thaiv zoo rau kev ua me nyuam toxicity ntawm Tripterygium wilfordii [6-8].

Qhov tseem ceeb ua haujlwm ntawm cistanchoid ntawm cistanchoid ntawm cisticular tus nqi ntawm nas nrog cyclophosphalamide-inductspordamide unorder.Raws li qib nce, cov txheej txheem ntawm cov qog nqaij hlav qog nqaij hlav spermatogenic epithelial nce, cov khaubncaws sab nraud povtseg yog qhov tseeb, thiab cov spermatogenic hlwb ntawm txhua qib yog nyob ze thiab zoo zoo. Qhov kev sim ua pov thawj tias phenylethanoid ntawm Cistanche deserticola tuaj yeem tiv thaiv cov kab mob spermatogenic ntawm nas los ntawm cyclophosphamide, thiab nws cov txheej txheem yuav cuam tshuam rau Cistanche deserticola nce qib ntawm testosterone [9].

Cistanche txiv neej cov txiaj ntsig - Improv kev ua haujlwm deev

Oxidative puas tuaj yeem cuam tshuam cov phev ua haujlwm los ntawm kev rhuav tshem cov phev cell membrane cov qauv thiab ua rau cov phev DNA puas. Ib tug loj tus naj npawb ntawm cov kev tshawb fawb sim tau ua pov thawj tiasCistanche extract hmoovthiab nws cov active Cheebtsammuaj zog antioxidant puas.Nws muaj qee qhov kev tshem tawm ntawm superoxide anion radicals thiab hydroxyl radicals [10-13]. Li Gang et al. [14] siv txoj kev ntawm FeSO4 / H2O2 los tsim cov pa oxygen reactive (ROS) ua rau nas phev oxidative kev puas tsuaj qauv thiab kawm txog antagonistic nyhuv ntawmCistanche deserticola extractntawm phev membrane qauv thiab muaj nuj nqi oxidative puas.Cov txiaj ntsig tau pom tias ROS tuaj yeem ua rau puas tsuaj rau cov qauv thiab kev ua haujlwm ntawm nas phev daim nyias nyias, txo cov kev ua ntawm T-SOD hauv kev tshem tawm cov phev, nce cov ntsiab lus ntawm MDA, thiab txo cov phev o thiab cov phev ciaj sia.Cistanche deserticola extract tuaj yeem txhim kho T-SOD kev ua haujlwm ntawm cov phev ncua, txo cov ntsiab lus ntawm MDA, muaj ntau theem ntawm antagonistic cuam tshuam rau oxidative kev nyuaj siab puas tsuaj ntawm cov phev daim nyias nyias los ntawm ROS, zoo txo ​​cov lipid peroxidation ntawm cov phev membrane, ua lub luag haujlwm zoo antioxidant. , thiab muaj qee yam kev tiv thaiv ntawm cov qauv thiab kev ua haujlwm ntawm cov phev membrane[14].

Liang Hualun et al. [15] tsim cov phev oxidative kev puas tsuaj qauv hauv vitro, thiab tiv thaiv nws nrog phenylethanol glycosides ntawmCistanche deserticola. Cov kev hloov ntawm DNA nyob rau hauv lub nucleus ntawm cov phev puas los ntawm oxidative puas tau kuaj pom los ntawm Raman spectroscopy, thiab cov antagonistic nyhuv ntawm phenylethanol glycosides ntawm Cistanche deserticola ntawm phev oxidative puas tsuaj tau kawm. Cov txiaj ntsig tau pom tias Raman spectral siv thiab spectral ncov hloov pauv ntawm cov phev nuclei hauv cov qauv ntawm oxidative puas phev hloov pauv loj, thiab cov kev hloov pauv tau cuam tshuam loj heev tom qab kev tiv thaiv phenylethanol glycosides ntawm Cistanche deserticola.Qhov kev sim ua pov thawj tias phenylethanol glycosides ntawm Cistanche deserticola tuaj yeem tiv thaiv oxidative kev puas tsuaj ntawm cov oxidants muaj zog ntawm tib neeg phev DNA rau qee yam.

Tag nrho glycosides ntawm Cistanche deserticolarhiab heev rau 60 Co Lub ultrastructural puas ntawm nas testis cov ntaub so ntswg tom qab irradiationmuaj qee yam kev tiv thaiv. Cov txheej txheem tiv thaiv yuav yog tag nrho glycosides ntawmCistanche deserticola txhim kho SOD kev ua haujlwm, txo qhov kev puas tsuaj ntawm lipid peroxidation rau nas testis cov ntaub so ntswg, los yog txhawb kev rov qab los ntawm testicular ultrastructure thiab kev ua haujlwm los ntawm kev txhawb nqa cov synthesis ntawm DNA, RNA thiab protein [16].

3. cuam tshuam rau "Lub raum Yang Deficiency"Model

Cov txiaj ntsig ntawm cistanche deserticola ntawm lub raum kuj yog qhov tseeb heev. Ma Jingjing et al. siv hydrocortisone los tsim cov qauv ntawm lub raum yang deficiency hauv nas thiab kawm txog cov nyhuv ntawm Cistanche deserticola ntawm lub raum thiab yang. Cov txiaj ntsig tau pom tias cimetidine tuaj yeem txo lub sijhawm latent ntawm noov erection,nce cov phev, nce coefficient ntawm kev sib deev hauv nruab nrog cev, thiab txhim kho cov qauv histological ntawm lub testis.. Nws qhia tau hais tias cov txiaj ntsig zoo ntawm Cistanche tubulosa muaj qhov pom tseeb ntawm tonifying lub raum thiab ntxiv dag zog rau yang [17]. Cov cawv extract ntawm Cistanche deserticola tuaj yeem txo qhov atrophy ntawm adrenal cortex thiab o ntawm lub raum tubular epithelial hlwb tshwm sim los ntawm cov tshuaj hormones, thiab muaj kev tiv thaiv ntawm lub raum ua haujlwm [18]. Ntau cov kev tshawb fawb tau pom tias Cistanche deserticola muaj cov nyhuv estrogen, thiab Cistanche deserticola extract tuaj yeem ua lub luag haujlwm ntawm tonifying lub raum thiab txhawb cov yang los ntawm kev txo cov ntsiab lus ntawm estradiol thiab nce qib ntawm gonadotropin thiab testosterone [19]. Nws lub tshuab xav tau kev tshawb fawb ntxiv.

Superman tshuaj ntsuab cistanche-Improv kev ua haujlwm deev

4. cuam tshuam rau kev loj hlob ntawm embryonic.

Kev sib ntxiv ntawm Suav tshuaj nyob rau hauv thaum ntxov embryo kab lis kev cai nyob rau hauv vitro yuav txhawb embryo txoj kev loj hlob nyob rau hauv vitro.Tag nrho glycosides thiab polysaccharides ntawmCistanche deserticolamuaj zog antioxidant teebmeem,uas tuaj yeem tiv taus cov pa oxygen dawb radicals tsim thaum lub sij hawm embryonic txoj kev loj hlob thiab txhawb nqa

Nyob rau hauv kev loj hlob ntawm embryos thaum ntxov. Li Yufang et al. Kawm txog cov txiaj ntsig ntawm Cistanche deserticola ntawm kev loj hlob ntawm embryos thaum ntxov los ntawm kev siv cov embryos ntawm porcine hauv vitro fertilization.Qhov kev sim qhia tau hais tias qhov sib ntxiv ntawm Cistanche deserticola rau cov kab lis kev cai kua tuaj yeem txhim kho tus nqi blastocyst.[20-21]. Xie An et al. xaiv cov nas embryos thaum ntxov los kawm txog cov txiaj ntsig ntawm Cistanche deserticola ntawm kev loj hlob ntawm nas ntxov embryos hauv vitro. Cov txiaj ntsig tau pom tias tus nqi ntawm morula thiab blastocyst hauv cov pab pawg nrog Cistanche deserticola tau nce siab dua li ntawm pawg neeg dawb huv, qhia tias Cistanche deserticola tuaj yeem txhawb kev loj hlob ntawm embryos thaum ntxov hauv vitro. Nws cov txheej txheem yuav cuam tshuam txog qhov txo qis ntawm TSIS muaj siab thiab tshem tawm cov dawb radicals uas tsim thaum lub sijhawm loj hlob thiab faib cov embryos los ntawm Cistanche deserticola.Cistanche deserticola tuaj yeem tswj hwm microenvironment ntawm embryo txoj kev loj hlob,Yog li, qhov kev loj hlob hauv vitro ntawm embryos tuaj yeem txhim kho tau zoo [22], tab sis cov txheej txheem tshwj xeeb xav tau kev kawm ntxiv.

5. Cov ntsiab lus

Cistanche deserticola, raws li ib txwm siv tshuaj thiab muaj txiaj ntsig Suav,yog ib tug thawjzaj tshuaj ntsuab cistanchethiab muaj txiaj ntsig essence. Cov khoom xyaw nquag thiab cov tshuaj pharmacological ntawm Cistanche deserticola tau dhau los ua qhov tseem ceeb ntawm kev tshawb fawb los ntawm Suav cov kws kho mob, tshwj xeeb tshaj yog cov teebmeem tshuaj thiab cov txheej txheem ntawm nws cov kev loj hlob ntawm cov menyuam yaus tau ua tiav qee qhov txiaj ntsig. Cov txheej txheem ntawm Cistanche deserticola qhov cuam tshuam rau kev ua me nyuam yuav muaj ntau qhov txuas, thiab cov txheej txheem ntxaws tseem xav tau kev tshawb fawb ntxiv.Nrog rau qhov txuas ntxiv mus tob zuj zus ntawm kev tshawb fawb ntawm cov khoom siv tau zoo thiab cov tshuaj pharmacological ntawm Cistanche deserticola, nws xav tias yuav muab kev kho mob zoo rau kev ua me nyuam tsis ntev los no.

Cistanche txiv neej cov txiaj ntsig - Improv kev ua haujlwm deev