Txoj Kev Ua Tau Zoo Thiab Noj Txoj Kev Cistanche uas Koj Tsis Paub

Roucongrong yog ib qho ntawm cov tshuaj ntsuab muaj txiaj ntsig suav nrog ntau yam kev siv. Nws tau siv los ua tshuaj ntsuab muaj zog thiab noj qab haus huv txij thaum ub. Nws muaj keeb kwm ntau dua 1, 000 xyoo. Nws muaj lub koob npe nrov ntawm "desert ginseng". Nws yog sov tab sis tsis kub, nourishing tab sis tsis hnyav, sov tab sis tsis venting, yog li nws yog hu ua nyob ntsiag to." Rou Congrong tau teev raws li qib siab tshaj plaws los ntawm "Shen Nong's Materia Medica", uas tau hais tias nws yog siv rau "tsib tsib. kev ua haujlwm thiab xya qhov kev raug mob, txhawb nqa nruab nrab, tshem tawm qhov mob khaub thuas thiab kub hauv lub cev, nourishing tsib lub hauv nruab nrog cev, ntxiv dag zog rau yin, muaj txiaj ntsig zoo, thiab kho cov poj niam cov tsos mob. , Cov khaub ncaws yav tsaus ntuj ua rau lub teeb ci ntawm ib tus neeg lub neej "Nws yog ib qho tshuaj nquag siv rau kev ua kom lub raum muaj zog thiab ntxiv dag zog rau yang. Nws muaj cov txiaj ntsig zoo thiab tsis tshua muaj txiaj ntsig, thiab ib txwm tau suav tias yog khoom muaj nqis hauv tshuaj. "Bielu ntawm Cov Kws Kho Mob Ntog" hais tias nws muaj peev xwm tshem tawm "pob zais zis dab phem, lumbago, thiab nres dementia." "Zhen Quan Medicinal Materia Medica" muaj cov ntaub ntawv hais txog "kev pab cov pob txha, plam xim, kho los ntshav ntawm cov poj niam, ntxiv dag zog rau yang ntawm cov txiv neej, muaj txiaj ntsig zoo, Nws tau sau tseg hauv xyoo 2000 ntawm "Lub Pharmacopoeia ntawm Cov Neeg Koom Tes ntawm Tuam Tshoj" uas Roucongrong "invigorates raum yang, nourishes essence, thiab ntshav, moisturizes thiab relieves cem quav.

Nyem rau cistanche tubulosa extract

Tus nqi tshuaj tshwj xeeb thiab kev kho mob kho mob ntawm Roucongrong ib txwm yog kev tshawb fawb ntawm ntau tus neeg ua haujlwm kho mob. Tshwj xeeb tshaj yog nyob rau hauv kev tshawb fawb ntawm pharmacology, qee qhov kev ua tiav tau txais. Nws tau ua lub luag haujlwm kho mob thiab kho mob hauv ntau yam ntawm tib neeg lub cev. Cov kev tshawb fawb tau pom tias cov nqaij, ntsev, nqaij nyoos, thiab cov nqaij Guanhua tuaj yeem ua rau cov nas hnyav nce ntxiv, thiab ua rau lub sijhawm ua luam dej tsis tu ncua. Nws tuaj yeem pom tau tias tag nrho peb tuaj yeem txhawb kev loj hlob ntawm cov nas thiab ua rau kom muaj zog tiv thaiv. Txhim kho lub peev xwm ntawm nas kom zam tau qhov hypoxia. Cov tshuaj aqueous ntawm Roucongrong tuaj yeem ua rau muaj kev cuam tshuam ntawm cov hnyuv me ntawm cov nas, ua rau lub sijhawm tshem tawm ntawm nas, thiab tseem muaj qhov cuam tshuam tseem ceeb ntawm kev nqus dej ntawm txoj hnyuv loj, qhia tias Roucongrong muaj cov nyhuv laxative. Cov nyhuv ntawm Xinjiang Roucongrong ntawm daim siab thiab lub paj hlwb ntawm cov kev sim nas aging qauv tau pom los ntawm xov tooj cua induction. Cov txiaj ntsig tau pom tias Roucongrong muaj kev saib xyuas kev noj qab haus huv zoo thiab kev kho mob rau lub siab ntawm cov qauv kev laus.

Txhim khu kev tiv thaiv kab mob

Cov nyhuv ntawm tag nrho glycosides ntawm Cistanche ntawm kev ua haujlwm ntawm T lymphocytes hauv nas raug mob los ntawm Co irradiation pom tias tag nrho glycosides ntawm Cistanche (GCs) cuam tshuam rau kev ua haujlwm ntawm T lymphocytes hauv nas raug mob los ntawm Co hluav taws xob. Tag nrho lub cev ntawm NIH nas tau irradiated nrog 1Gy ntawm Co ib zaug, thiab ncua sij hawm-hom hypersensitivity cov tshuaj tiv thaiv, thymus index, T lymphocyte proliferation teb, thiab IL-2 kev ua ntawm cov nas tau kuaj pom. Cov txiaj ntsig tau pom tias tom qab Co irradiation, ncua sij hawm-hom hypersensitivity cov tshuaj tiv thaiv ntawm nas tuaj yeem cuam tshuam loj heev, thymus Performance index raug txo, qhov muaj peev xwm loj hlob ntawm T lymphocytes thiab kev ua ntawm IL-2 tau txo qis, thiab GCs tuaj yeem ua tau. txhim kho qhov ncua sij hawm-hom hypersensitivity cov tshuaj tiv thaiv ntawm irradiated nas, Nce thymus Performance index, txhim khu T lymphocyte proliferation teb thiab IL-2 kev ua. Cistanche tag nrho glycosides muaj kev tiv thaiv zoo rau kev ua haujlwm ntawm T lymphocytes hauv cov nas uas raug hluav taws xob. Kev npaj tsis zoo ntawm Cistanche deserticola tuaj yeem txhim kho kev tiv thaiv kab mob, tiv thaiv cov ntshav los ntawm kev puas tsuaj, thiab tuaj yeem tswj hwm kev tiv thaiv kab mob humoral, kev tiv thaiv kab mob ntawm tes, thiab tsis muaj kev tiv thaiv kab mob ntawm cov nas tawg mus rau ntau qib.

Tonify lub raum thiab ntxiv dag zog rau yang

Cistanche deserticola yog ib qho khoom muaj txiaj ntsig zoo, uas muaj lub luag haujlwm ntawm tonifying lub raum, ntxiv dag zog rau yang, ntxiv dag zog rau daim siab thiab lub raum, thiab ntxiv cov ntsiab lus thiab qi. Cov kev tshawb fawb tau pom tias cov khoom xyaw nquag hauv Cistanche tonify lub raum thiab ntxiv dag zog rau yang yog phenylethanoid glycosides, xws li echinacoside thiab eugenol glycosides. Nws ua haujlwm feem ntau hauv ob txoj kev; ua ntej, nws txhim khu kev ua haujlwm ntawm hypothalamus-pituitary-adrenal caj pas, txhawb kev tso tawm ntawm cov khoom sib txuas thiab cov tshuaj hormones hauv lub cev, thiab txhim kho libido; thib ob, nws fights qaug zog thiab txhim kho lub cev ua haujlwm. Lub raum-tonifying muaj nuj nqi ntawm Cistanche desertic yog txawv ntawm cov tshuaj rau lub raum-tonifying tshuaj xws li Epimedium thiab Morinda officinalis. Nws tsis ua tiav, yog li nws muaj lub npe nyob ntsiag to", uas txhais tau hais tias lub raum ua kom lub siab thiab ua kom lub raum. Cistanche yog tsim rau cov txiv neej thiab poj niam, yog li nws tuaj yeem kho impotence ntawm cov txiv neej thiab infertility ntawm cov poj niam. , nws tau dhau los ua ib qho tshuaj tonic uas siv ntau tshaj plaws hauv cov ntawv tshuaj ntawm cov kws kho mob yav dhau los dynasties. Cov txiaj ntsig tau pom tias ntxiv cov cawv extract ntawm Cistanche deserticola, ib txwm suav tshuaj rau invigorating raum thiab yang, rau cov tsiaj thaum siv. Cov tshuaj corticosteroids ntev ntev tuaj yeem tiv thaiv adrenal cortex atrophy tshwm sim los ntawm cov tshuaj hormones ib leeg, cawv extract ntawm Cistanche deserticola muaj qee yam kev tiv thaiv rau lub raum ua haujlwm.

Lub cev qia ib feem ntawm cov nroj tsuag yog lub raum muaj nuj nqis-tonifying tshuaj suav tshuaj. Vim yog tus cwj pwm loj hlob ntawm Cistanche deserticola thiab nws cov txiaj ntsig zoo tshuaj, nws tau raug hu ua "desert ginseng" los ntawm cov kws kho mob ntawm tag nrho cov dynasties.

Txhim khu lub cev tiv thaiv kev laus muaj peev xwm

(a) Cov teebmeem ntawm Cistanche deserticola polysaccharides ntawm lub hlwb neurons ntawm cov nas laus

Los ntawm txoj kev tshawb fawb ntawm Cistanche deserticola polysaccharides ntawm morphology ntawm cov laus nas hlwb neurons, nws tau pom tias Cistanche deserticola polysaccharides cuam tshuam ozone-induced aging nas cerebral cortex neurons. Ozone ua rau muaj zog monoamine oxidase, lactate dehydrogenase, thiab lipofuscin hauv cov neurons hauv cerebral cortex ntawm nas, thiab thickened vascular hauv qab daim nyias nyias. Hauv pawg tswj hwm, MAO-B, LDH, thiab lipofuscin nyob rau hauv cov neurons ntawm lub paj hlwb cortex ntawm nas tau txo qis, thiab Nissl lub cev thiab lysosomes tau nce. Cov kev sim tau ua pov thawj los ntawm qib cellular tias Cistanche muaj kev puas tsuaj los tiv thaiv neuron thiab tiv thaiv kev laus ntawm cov nas laus, thiab tuaj yeem txhim kho lub cev nqaij daim tawv thiab biochemical ntsuas ntawm cov nas laus uas tshwm sim los ntawm ozone.

(b) Cov teebmeem ntawm Cistanche deserticola polysaccharide ntawm lub ntsws nitric oxide thiab apoptosis hauv cov nas laus

Cov nyhuv thiab cov txheej txheem ntawm Cistanche deserticola polysaccharide (CDP) ntawm cell apoptosis, nitric oxide (NO) cov ntsiab lus, thiab superoxide dismutase (SOD) kev ua hauv lub ntsws aging qauv tau kawm, thiab nws tau pom tias kev laus tuaj yeem ua rau txo qis ntawm cov ntshav thiab cov ntaub so ntswg. Kev ua haujlwm SOD, nce NO cov ntsiab lus tuaj yeem ua rau lub ntsws ntawm tes apoptosis. CDP tuaj yeem ua rau muaj kev ua haujlwm SOD ntawm lub cev cov ntshav thiab lub ntsws, txo cov concentration ntawm NO, cuam tshuam cov apoptosis ntawm lub ntsws cov hlwb, txo cov hlwb, thiab txo cov feem pua ​​​​ntawm apoptosis (APO). Cov txiaj ntsig tau ua pov thawj tias CDP tuaj yeem txhim kho lossis ncua kev hloov pauv ntawm lub ntsws cov hlwb hauv cov nas laus. Cov kev tshawb fawb Apoptosis tau lees paub tias Cistanche muaj kev tiv thaiv oxidation, tiv thaiv qaug zog, thiab tiv thaiv kev laus.

Tiv thaiv lub siab

Txoj kev tshawb fawb txog kev tiv thaiv ntawm Cistanche deserticola ntawm daim siab oxidative puas tsuaj rau cov nas laus tau pom tias thaum lub sij hawm laus, kev ua ntawm SOD hauv hlwb, tshwj xeeb tshaj yog mitochondria, txo qis, thiab cov ntsiab lus ntawm MDA nce. Cov pa oxygen nquag (antioxidant muaj peev xwm) hauv daim siab cov ntaub so ntswg ntawm cov nas hnub nyoog qis dua li cov nas hluas, thiab cov ntsiab lus ntawm malondialdehyde (MDA) hauv daim siab mitochondria tau nce ntau. Kev sim tau pom tias qhov poob ntawm Ca-ATPase kev ua haujlwm hauv daim siab cov ntaub so ntswg ntawm cov nas laus kuj yog qhov tshwm sim ntawm kev puas tsuaj rau cov cell membranes los ntawm oxygen dawb radicals los ntawm mitochondria. Dysregulation ntawm intracellular calcium homeostasis thiab txo cellular calcium kev cai tshwm sim thaum laus. Kev ua haujlwm ntawm calcium twj tso kua mis hauv cov cell membrane txo qis nrog lub hnub nyoog, thiab lub peev xwm ntawm efflux Ca txo qis, ua rau cov calcium uas tsis muaj nyob hauv lub cev thiab qhov tsis txaus ntawm calcium homeostasis. Kev sim tau lees paub tias kev ua haujlwm ntawm Ca-ATPase hauv daim siab cov ntaub so ntswg ntawm cov nas laus txo qis thiab kev ua haujlwm ntawm PLA2 hauv daim siab mitochondria nce, qhia tias qhov txo qis hauv Ca-ATPase kev ua haujlwm tuaj yeem ua rau nce qhov concentration ntawm Ca hauv cytoplasm, uas ua rau muaj kev ua haujlwm ntawm Ca-ATPase. nce kev ua haujlwm ntawm PLA2 hauv mitochondria. PLA2 yog ib qho enzyme tseem ceeb hauv ntau cov txheej txheem biochemical. Nws muaj peev xwm hydrolyze nws cov phospholipids, ua rau kom lub fragility ntawm mitochondrial membrane skeleton, thiab ua rau kom tso tawm arachidonic acid; Nyob rau tib lub sijhawm, ntau cov dawb radicals raug tsim tawm, ua rau muaj qhov permeability ntawm daim nyias nyias, muaj ntau cov calcium ions, thiab ntxiv rau PLA2 los ntawm calcium ions, yog li ua rau lub voj voog vicious.

Tsis tas li ntawd, kev ua haujlwm siab PLA2 tuaj yeem hloov pauv qhov sib xyaw ntawm cov membrane phospholipids, cuam tshuam rau cov kua dej ntawm daim nyias nyias. Nyob rau tib lub sijhawm, cov khoom ntawm PLA2 degradation ntawm phospholipids tuaj yeem ua rau cov kab mob ua pa, cuam tshuam rau oxidative phosphorylation thiab ua rau muaj kev puas tsuaj rau mitochondria. PLA2 tseem tuaj yeem ua ncaj qha ua rau txo qis ntawm kev thauj mus los ntawm proton thoob plaws hauv mitochondrial membrane thiab txo qis ntawm H-ATPase kev ua haujlwm. PLA2 yuav ua rau poob ntawm mitochondrial kev ua haujlwm los ntawm ntau yam thiab cuam tshuam rau kev ua haujlwm ntawm lub cev. Kev sim tau pom tias cov dej extract ntawm Cistanche tuaj yeem txhim kho lub siab lub peev xwm antioxidant thiab Ca-ATPase kev ua haujlwm. Txo daim siab mitochondria MDA cov ntsiab lus, thiab PLA2 kev ua haujlwm. Qhov no tej zaum yuav yog vim muaj kev ua haujlwm antioxidant ntawm Cistanche, uas txo cov tiam ntawm cov dawb radicals, yog li txo qhov kev puas tsuaj ntawm dawb radicals rau daim siab nqaij thiab mitochondria, yog li txhim kho lub siab lub peev xwm antioxidant, txo lipid peroxidation, thiab tiv thaiv Ca-ATPase los ntawm kev puas tsuaj. , xyuas kom meej cov kev ua ntawm Ca-ATPase, tswj cov theem ib txwm ntawm calcium ion concentration nyob rau hauv thiab sab nraum lub siab hlwb, thiab zam qhov nce ntawm mitochondrial PLA2 kev ua si vim intracellular calcium overload. Cov kev sim tau pom tias cov dej extract ntawm Cistanche muaj kev tiv thaiv kev laus los ntawm kev txhim kho cov nyhuv antioxidant ntawm daim siab, txo cov lipid peroxidation cov khoom, thiab txo cov mitochondrial oxidative puas.

Anti-oxidize nyhuv

Cistanche deserticola extract txo cov ntsiab lus ntawm lipid peroxide (LPO) hauv tib neeg lub cev. Cistanche deserticola, Cistanche saline, Cistanche tubulosum, thiab Cistanche deserticola tag nrho cov muaj kev cuam tshuam tseem ceeb ntawm kev tsim LPO hauv cov ntshav luav thiab nas lub siab, ntawm cov Cistanche saline muaj qhov muaj zog tshaj plaws, ua raws li Cistanche tubulosum. Li Lin et al. tau kawm txog cov nyhuv antioxidant ntawm phenylethanol tag nrho glycosides ntawm Cistanche deserticola thiab pom tias nws tuaj yeem ua rau muaj txiaj ntsig zoo ntawm selenium glutathione peroxidase thiab SOD hauv nas plawv, siab, thiab paj hlwb, thiab nce cov haujlwm ntawm SOD hauv cov ntaub so ntswg. , thiab txo cov ntsiab lus ntawm LPO thiab lipofuscin hauv ntau cov ntaub so ntswg. Xiong Quanbo et al. qhia tias cuaj phenylethanol glycosides cais los ntawm Cistanche deserticola muaj qhov tseem ceeb ntawm cov dawb radical scavenging kev ua si thiab los tiv thaiv lipid peroxidation, thiab pom tias ntau phenolic hydroxyl pawg nyob rau hauv lub molecule, lub zog ua hauj lwm. Nws yog speculated tias phenylethanoid glycosides Lub compound yog lub ntsiab active ingredient ntawm Cistanche deserticola antioxidant.