Cov teebmeem ntawm Echinacoside rau tib neeg lub cev

Tau txais cov ntaub ntawv ntxiv. tiv taujtina.xiang@wecistanche.com 

Dab tsi yogechinacoside cov tshuaj? Ntau tus neeg tsis paub ntau txog echinacoside. Qhov tseeb, echinacoside yog ib qho extract, dawb crystalline hmoov muab rho tawm los ntawm cistanche pipiensis. Nws cov khoom tseem ceeb yog cistanche deserticola, Suav lub npe: echinacoside, molecular mis: C35H46O20 ntom: 1.66g / cm3 boiling point: 1062.7 degree ntawm 760 mmHg, flash point: 327.8 degree, vapor siab ntawm 20 mm. purity: siab dua 99 feem pua, nrhiav kom tau txoj kev: HPLC. Yog li dab tsi yog qhov ua tau zoo thiab cov teebmeem ntawm echinacoside? cia peb suav daws ua ke.

Kev ua tau zoo thiab kev ua haujlwm ntawm echinacoside

Echinacosideyog qhov zoo tshaj plaws ntawm cistanche rau tonifying lubraumthiab ntxiv dag zog rau yang, yog li nws kuj tau siv dav hauv kev tsim tshuaj hauv kev kho mob. Muaj ntau hom cistanche, thiab txhua hom cistanche muaj qhov sib txawv. Cov phooj ywg uas tau noj cistanche tau hais tias lawv tau noj cistanche tau ntev, tab sis qhov cuam tshuam rau lawv tus kheej tsis pom tseeb. Tom qab ntawd qhov no yog ncaj qha ntsig txog lub cistanche xaiv.

Echinacosidemuaj ntau yam haujlwm thiab cov teebmeem. Ntxiv nrog rau kev siv los ntxiv dag zog rau yang thiab txhawb lub raum, nws kuj tseem zoo heev hauv kev kho txiv neej impotence thiab emission nocturnal. Thiab nws muaj txiaj ntsig zoo rau cov poj niam cov kab mob, xws li kev coj khaub ncaws tsis xwm yeem, uterine txias infertility, thiab cov tsos mob ntawm cov hnyuv loj thiab cov quav qhuav, uas tuaj yeem kho nrog echinacoside. Nrog rau kev ntxhov siab ntau ntxiv rau tib neeg lub neej, ntau tus neeg lub cev kuj tseem qhia txog cov teeb meem kev noj qab haus huv sib txawv. Piv txwv li, ntau tus txiv neej raug kev txom nyem los ntawm lub raum tsis txaus qi, thiab cov poj niam feem ntau raug kev txom nyem los ntawm uterine txias, yog li ntawd lub hav zoov ntawm cov tsos mob no yuav kho tau los ntawm kev so. txiv hmab txiv ntoo chrysanthemum glycosides rau kev kho mob.

Cov nyhuv ntawm echinacoside yog txhawm rau txhim kho lub cevtiv thaiv kab mob, lub luag hauj lwm yog los txo qhov o thiab ntshav stasis, nrog rau kev tawm tsam, tshem tawm cov cua sov, thiab detoxifying. Hauv kev kho mob, echinacoside feem ntau tuaj yeem siv los kho cov kab mob. Qhov ntau tshaj plaws yog lub xeev kev noj qab haus huv. echinacoside tuaj yeem txhim kho lub cev tiv thaiv kab mob thiab tshem tawm cov teeb meem muaj feem cuam tshuam. echinacoside tseem tuaj yeem tua cov qog, txhim kho cov tshuaj tiv thaiv toxicity ntawm cov hlwb, inhibit lub hom phiaj ntawm kev mob qog noj ntshav, tsim kom muaj ntau tus neeg tua neeg lub cev, tuaj yeem cuam tshuam thiab tua cov qog hlwb, thiab muaj txiaj ntsig zoo rau cov neeg mob qog noj ntshav. Nyob rau tib lub sijhawm, echinacoside tuaj yeem tiv taus oxidation thiab dawb radicals, uas tuaj yeem yuam kom ncua kev laus.

1 Antioxidant nyhuv

Sib piv cov teebmeem inhibitory ntawm alkylamides, polysaccharides, thiab caffeic acid derivatives hauv ECH ntawm tib neeg tsawg-density lipoprotein oxidation hauv vitro, nws tau pom tias kev sib xyaw ntawm ECH thiab alkylamides lossis macromolecular polysaccharides muaj kev sib koom ua ke antioxidant, uas yog, cov nyhuv lom neeg. ntawm ECH. Kev ua yog tsim synergistically los ntawm ntau yam Cheebtsam nyob rau hauv nws formulation. ECH ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv DNA ntawm kev puas tsuaj. Hauv kev xaus, ntau cov kev tshawb fawb tau pom tias ECH yog cov tshuaj antioxidant zoo.

2 Cov teebmeem Neuroprotective

ECH muaj kev tiv thaiv tseem ceeb ntawm cov qog nqaij hlav necrosis (TNF- )-induced neuronal cell SHSY5Y apoptosis, thiab nws cov txheej txheem yog tswj hwm mitochondrial muaj nuj nqi los ntawm cov teebmeem antioxidant, txo cov qib ntawm intracellular reactive oxygen hom, thiab inhibit qhov kev ua ntawm caspase{{ 3}} ib. thiab tuav lub zog siab ntawm mitochondrial membrane muaj peev xwm. Txij li ECH muaj zog tiv thaiv apoptotic kev ua si, nws muaj peev xwm siv tau rau hauv kev kho mob ntawm neurodegenerative thiab neurological kab mob xws li neuronal apoptosis.

3 Txhim kho kev kawm thiab kev nco

ECH muaj cov nyhuv los tiv thaiv kev laus, thiab nws cov txheej txheem yog tias nws tuaj yeem cuam tshuam cov dawb radicals xws li O2−•, OH•, thiab tib lub sijhawm, nws tuaj yeem ua kom cov haujlwm ntawm GSH-Px thiab SOD, thiab txo cov ntsiab lus. ntawm MDA. Txhim kho kev nco hauv nas vim inhibition ntawm MAO kev ua haujlwm. Cov txiaj ntsig ntawm txoj kev tshawb no qhia tias cov tshuaj tiv thaiv lipid peroxidation thiab tiv thaiv kev laus ntawm ECH muaj feem cuam tshuam rau nws cov haujlwm antioxidant. ECH tuaj yeem txhim kho kev kawm thiab kev nco muaj peev xwm ntawm SAM-P/8 nas los ntawm kev txhim kho kev ua haujlwm ntawm lub hauv paus cholinergic system, txhim kho tag nrhoantioxidantmuaj peev xwm, txhawb nqa cov protein thiab nucleic acid synthesis, thiab tswj kev tiv thaiv kab mob.

4 Anti-inflammatory teebmeem

Kab mob plab hnyuv loj yog tshwm sim los ntawm lub cev tsis zoo lossis kev tiv thaiv kab mob ntau dhau rau cov kab mob, uas TGF- 1 yog ib qho tseem ceeb cuam tshuam. Tej zaum nws yuav yog TGF- 1 inhibits inflammatory teb los ntawm Smad signaling txoj kev. Nyob rau hauv ib tug npua qauv ntawm unilateral lub suab qaum raug mob, echinacoside nce lub suab pib lub siab thiab vocalization zoo ntawm cov qauv npua los tiv thaiv hyaluronidase, yog li txhawb kev kho ntawm qhov chaw raug mob.

5 Anti-tumor nyhuv

Cov qog hlwb tuaj yeem tsim cov khoom lag luam ntau ntawm ROS, thiab tso siab rau ntau yam ntawm cov txiaj ntsig zoo ROS cuam tshuam txog DNA kev tiv thaiv kev tiv thaiv kom muaj sia nyob. Cov qog hlwb tau txais txiaj ntsig los ntawm lub cev ROS tshem tawm thiab muaj peev xwm antioxidant ntau dua li cov hlwb qub. Ntxiv mus, echinacoside tuaj yeem tiv thaiv cov paj hlwb hauv neuroblastoma; echinacoside tuaj yeem ua rau cov nyhuv antitumor los ntawm kev ua haujlwm catalytic ntawm Mut T homologous enzyme 1.

6 Kev tiv thaiv daim siab

Verbasin, isaveraside, 2′-acetyl verbascoside, thiab ECH tau los ntawm cistanche deserticola muaj cov haujlwm hepatoprotective tseem ceeb. Cov nyhuv hepatoprotective ntawm echinacoside yog ua tiav los ntawm kev tiv thaiv oxidative puas tsuaj, txhawb kev loj hlob ntawm hepatocytes, thiab txhim kho microenvironment ntawm hepatocytes. Raws li ib txwm muaj, oxidative kev nyuaj siab yog koom nrog hauv daim siab raug mob, thiab cov nyhuv antioxidant ntawm echinacoside tuaj yeem tiv thaiv daim siab. Hauv txoj kev tshawb no, echinacoside tuaj yeem txhim kho qhov ciaj sia ntawm cov nas thiab txo qis kev hloov pauv ntawm alanine hauv tus qauv nas ntawm lub siab raug mob vim D-galactosamine (GalN) thiab lipopolysaccharide (LPS). Enzyme (ALT) qib thiab txhim kho daim siab histological morphology, qhia tau zoo los tiv thaiv apoptotic thiab tiv thaiv kev mob. Thiab nyob rau hauv cov pa roj carbon tetrachloride-induced nas lub siab raug mob qauv, tom qab kev cuam tshuam ntawm echinacoside, cov tshuaj ALT, AST, MDA, thiab ROS cov khoom raug txo qis, thiab cov tshuaj antioxidant SOD thiab GSH cov ntsiab lus tau nce ntxiv, qhia tias echinacoside muaj qhov zoo. tiv thaiv thiab kho cov teebmeem ntawm daim siab raug mob los ntawm oxidative kev nyuaj siab.

7 Immunomodulatory teebmeem

Phenyl ethanol glycosides muaj cov nyhuv regulating rau tib neegtiv thaiv kab mobthiab kev ua haujlwm immunosuppressive. Phenyl ethanol glycosides tuaj yeem txhim kho tus nqi ntawm hemolysin thiab fibrinogen thiab muaj kev txhim kho ntawm lub cev tsis muaj zog tiv thaiv kab mob.