Cov txiaj ntsig ntawm Cov Kev Txwv Tsis Pub Mus Los Ntawm Kev Tswj Kev Sib Txuas Ntawm Tus Kab Mob Khaus Viv -19 hauv Kev Tiv Thaiv Cov Pej Xeem Ntu 2

3. Txoj kev

Peb faib peb cov txheej txheem rau hauv peb kauj ruam: Kev Ntsuas Txhua Hnub, Kev Sib Raug Zoo thiab Cov Pej Xeem Resistance Range, thiab Delta Variant Estimates. Tag nrho cov cai tau sau los ntawm kos siv Python.

Kev sib raug zoo ntawm Delta kev hloov pauv thiab kev tiv thaiv kab mob yog qhov nyuaj heev vim tias Delta kev hloov pauv yog tus kabmob tshiab hloov pauv, uas txawv ntawm kev hloov pauv tus kabmob coronavirus yav dhau los. Raws li kev tshawb fawb tam sim no, Delta variant muaj kev sib kis ntau dua thiab muaj zog pathogenicity, uas txhais tau hais tias nws yuav muaj qee yam cuam tshuam rau kev tiv thaiv kab mob. Txoj kev tshawb nrhiav pom tias Delta hloov pauv ntawm tus kabmob tshiab tuaj yeem ua rau tsis muaj zog tiv thaiv cov tshuaj tiv thaiv. Raws li kev tshawb fawb tsis ntev los no, kev tiv thaiv kev tiv thaiv ntawm kev txhaj tshuaj tiv thaiv Delta variant yog me ntsis txo. Qhov no yuav cuam tshuam nrog kev hloov pauv tseem ceeb hauv Delta variant, ua rau nws yooj yim dua rau tus kab mob kom tsis txhob muaj kev tiv thaiv kab mob. Tsis tas li ntawd, qee qhov kev tshawb fawb tau pom tias Delta variant tuaj yeem kis rau cov neeg uas twb tau kis tus kab mob no, ua rau lawv lub cev tsis muaj zog.

Txawm li cas los xij, txawm hais tias kev hloov pauv ntawm Delta tuaj yeem muaj qee yam tsis zoo rau kev tiv thaiv kab mob, cov tshuaj tiv thaiv tseem yog ib qho tseem ceeb hauv kev tiv thaiv thiab tswj kev kis tus kabmob tshiab. Thaum cov tshuaj tiv thaiv yuav tsum tau hloov kho kom zoo dua nrog kev tshwm sim ntawm Delta variant thiab lwm yam txawv, cov tshuaj tiv thaiv tseem muaj txiaj ntsig zoo los tiv thaiv tib neeg los ntawm kev mob hnyav thiab mus pw hauv tsev kho mob. Tsis tas li ntawd, nws yog ib qho tseem ceeb heev uas yuav tsum tsom mus rau kev nyiam huv tus kheej kom zoo dua thiab kev nyob sib nrug deb ntawm kev sib raug zoo los txo kev kis tus kabmob tshiab. Los ntawm qhov kev xav no, peb yuav tsum xyuam xim rau kev txhim kho peb txoj kev tiv thaiv kab mob. Cistanche tuaj yeem txhim kho kev tiv thaiv kab mob, thiab cov polysaccharides hauv cov nqaij tuaj yeem tswj lub cev tiv thaiv kab mob ntawm tib neeg lub cev, txhim kho kev ntxhov siab ntawm lub cev tiv thaiv kab mob, thiab ntxiv dag zog rau lub cev tiv thaiv kab mob. bactericidal nyhuv.

Nyem cistanche tubulosa extract hmoov

3.1. Kev ntsuas txhua hnub

Hauv seem no, peb lub hom phiaj tseem ceeb yog suav cov kev hloov pauv niaj hnub hauv qab no: kev txav mus los (rau txhua tus ntawm tsib POIs), kev loj hlob tus nqi (GRt j) ntawm cov neeg mob, thiab feem pua ​​​​ntawm cov pej xeem nrog kev tawm tsam (FR), raws li qhia hauv Daim duab 3. Rau tus nqi txav mus los, peb muab cov nqi ncaj qha los ntawm Google Mobility dataset. Lwm qhov sib txawv tau suav nrog hauv qab no.

Txhawm rau kwv yees qhov kev loj hlob ntawm tus neeg mob, peb siv Formula (2) los ntawm [21] nrog rau 11-hnub lag ntawm kev ntsuas kev txav mus los thiab cov txiaj ntsig ntawm lub cev tam sim no ntawm tus lej ntawm cov xwm txheej raws li qhov pom zoo lag luam pom hauv [35] :

Kev loj hlob tus nqi ntawm cov neeg mob (GRt j) rau ib lub teb chaws tshwj xeeb j thiab ib hnub muab t yog xam raws li tus lej logarithmic ntawm kev hloov pauv rau cov xwm txheej tshiab peb hnub dhau los ntsig txog tus lej logarithmic ntawm cov neeg mob tshiab nyob rau lub lim tiam dhau los. Ntawm no c t j yog cov neeg mob tshiab hauv lub tebchaws j hnub t.

Txhawm rau kwv yees cov feem ntawm cov pej xeem uas muaj kev tawm tsam rau ib lub tebchaws nyob rau ib hnub, peb muab cov feem ntawm cov neeg uas muaj kev tiv thaiv kab mob (piv txwv li, cov uas twb tau cog lus COVID-19 thiab rov zoo) nrog cov feem ntawm cov neeg txhaj tshuaj :

qhov twg tag nrho cov feem ntawm cov neeg uas muaj qee hom kev tiv thaiv (FRT) nyob ntawm qhov feem ntawm cov neeg mob (FRc) rau hnub tim, uas yog kwv yees los ntawm kev ntsuas tag nrho cov ntaub ntawv qhia (CTot) los ntawm qhov sib npaug (m) rau txhua lub tebchaws, raws li qhia nyob rau hauv Table 2. Cov multipliers m, uas suav nrog kev tshaj tawm tsis txaus, raug coj los ntawm ntau cov kev tshawb fawb hauv cov ntaub ntawv. Txoj hauv kev no xav tias kev tiv thaiv ntuj tsis tau ploj mus, uas tej zaum yuav yog qhov kev xav tau thaum lub sijhawm pib ntawm tus kabmob kis. Yog tias qhov kev tshuaj xyuas no yuav tsum tau rov ua dua, peb xav kom txwv tsis pub lub qhov rais ntawm cov xwm txheej uas ua rau muaj kev tiv thaiv ntuj rau qhov tseeb tias (a) tus kabmob kis tau zoo yuav ua rau lub sijhawm ntev ntawm kev tiv thaiv, raws li pom los ntawm cov lej loj ntawm kev rov ua dua tshiab tau pom. nyob rau hauv lub xyoo dhau los, thiab (b) nws tshwm sim hais tias cov Omicron variants yog tshwj xeeb yog zoo ntawm evading peb tiv thaiv thiab reinfection yuav tshwm sim nyob rau hauv lub sij hawm luv luv. Qhov feem cuam tshuam nrog ntuj tsis kam (FRc) yog ntxiv rau feem ntawm cov pejxeem uas tau txhaj tshuaj tiv thaiv (FRv), uas yog kwv yees hauv Equation (5). Txhawm rau zam kom tsis txhob suav ob tus neeg uas ob leeg tau cog lus COVID-19 thiab tau txhaj tshuaj tiv thaiv, FRv yog ntsuas los ntawm (1−FRc).

3.2. Kev sib raug zoo thiab cov pej xeem kuj muaj ntau yam

Tom qab kwv yees qhov hloov pauv txhua hnub, peb muab lub sijhawm sib txuas ntawm lub teb chaws mus rau ntau yam raws li FRT. Qhov no ua rau lub sijhawm sib txawv rau txhua lub tebchaws uas feem pua ​​​​ntawm cov pejxeem muaj kev tawm tsam zoo sib xws. Txhawm rau ua tiav qhov no, peb tau ua raws li cov txheej txheem hauv daim duab 4, qhov twg peb thawj zaug tau txiav txim siab txhua lub tebchaws thiab faib lub sijhawm ua haujlwm rau lub sijhawm raws li tag nrho cov feem ntawm kev tawm tsam FRT: peb xaiv thawj lub hauv paus ntawm FRT los dag ntawm {{1} }–10 feem pua, qhov thib ob ntawm 10–20 feem pua, thiab li ntawd mus txog 60–70 feem pua ​​. Tom qab ntawd rau txhua lub sijhawm, peb suav qhov sib txheeb ntawm lub sijhawm ua haujlwm Google cov qhab nia thiab qhov kev loj hlob ntawm cov neeg mob (GRt j) rau txhua qhov ntawm POIs. Peb siv Pearson correlation, qhov twg 1 qhia tias muaj kev sib raug zoo zoo, 0 tsis muaj kev sib raug zoo, thiab −1 yog qhov sib raug zoo tsis zoo.

3.3. Delta Variant kwv yees

Txhawm rau txiav txim siab seb qhov tshwm sim ntawm Delta variant cuam tshuam li cas rau cov kev sib raug zoo no, peb suav cov feem ntawm Delta rau txhua lub sijhawm ntawm FRT thiab txheeb xyuas lub sijhawm uas muaj feem ntau ntawm Delta thiab cov feem tsawg ntawm Delta (<10%) (Figure 5). This was accomplished by first filtering the COVID-19 variants dataset based on country and variant. The start and end dates for each FRT period were identified, and 14 days of lag were added to each (since the sequenced samples were only collected every two weeks). Then the nearest dates from the COVID-19 variants dataset were selected to represent the relevant period. The following formula was used to estimate the fraction of the Delta variant (F∆):

qhov twg (F∆) sib npaug ntawm cov qauv sib txuas ntawm Delta variant (n∆) muab faib los ntawm tag nrho cov qauv ua ntu zus thaum lub sijhawm ntawd (tsis yog).

Thaum kawg, peb tau sau cov coefficients sib raug zoo rau txhua lub tebchaws thiab txhua lub sijhawm POIs thiab FRT; peb xav txog ob txoj kev sib kis, ib qho uas tsuas yog suav nrog cov ntaub ntawv uas Delta <10 feem pua ​​(Pre-Delta) thiab lwm qhov uas suav nrog tag nrho cov ntaub ntawv (tom qab Delta).

4. Cov txiaj ntsig

4.1. Kev sib txheeb ntawm Mobility thiab COVID-19 Cases

Cov histogram ntawm kev ntsuas kev sib raug zoo ntawm qhov kev loj hlob ntawm cov neeg mob thiab kev mus los ntawm tag nrho 14 lub teb chaws thiab rau tag nrho cov POIs yog qhia nyob rau hauv daim duab 6. Qhov sib txheeb ntawm −0.67 mus rau 0.66, nrog rau feem ntau ntawm cov ntaub ntawv hauv qhov ntau [−0.29, 0.28]. Ntawm qhov granularity no, cov ntaub ntawv qhia tias tsis muaj kev sib raug zoo ntawm kev txav mus los thiab kev loj hlob, piv txwv li, qhov nruab nrab, hloov cov qauv kev txav mus los tsis cuam tshuam rau cov neeg mob. Txawm li cas los xij, txoj hauv kev ntxhib no ua rau lub ntsej muag ntawm cov pej xeem tsis kam, uas yuav raug nthuav tawm hauv cov ntu hauv qab no.

4.2. Qhov cuam tshuam ntawm Population Resistance ntawm COVID-19 Kev sib kis

Raws li kev kis tus kabmob kis mus ntxiv, cov feem ntawm cov pejxeem uas tiv thaiv tus kabmob no nce ntxiv los ntawm kev txhaj tshuaj lossis los ntawm kev cog lus COVID-19 thiab rov zoo. Txhawm rau kom tau txais kev nkag siab ntawm qhov cuam tshuam ntawm kev tawm tsam ntawm kev sib raug zoo ntawm kev loj hlob nrog kev txav mus los, xav txog ob qhov xwm txheej hnyav hauv qab no. Hauv cov neeg tsis paub lus uas tsis muaj leej twg tiv thaiv tus kab mob no, txhua qhov kev sib cuag sawv cev rau tus kab mob tshiab; nyob rau hauv qhov xwm txheej no, kev siv sijhawm nyob rau hauv POIs uas ua rau muaj kev sib cuag hauv cov pej xeem (xws li, chaw nres tsheb thauj mus los) yuav ua rau muaj neeg coob coob. Yog li ntawd, nyob rau hauv ib tug neeg tsis paub qab hau, peb cia siab tias kev txav mus los hauv kev sib cuag POIs yuav tsum muaj kev cuam tshuam nrog kev loj hlob ntawm cov neeg mob. Ntawm qhov tsis sib xws, yog tias feem ntau ntawm cov pej xeem tiv taus tus kab mob, feem ntau ntawm cov neeg sib cuag hauv POI tsis zoo li yuav ua rau kis tau tus mob. Qhov no qhia tau hais tias nyob rau hauv cov pej xeem muaj zog tiv taus, kev txav mus los hauv kev sib cuag POIs yuav tsuas yog tsis muaj zog cuam tshuam nrog kev loj hlob, yog tias tag nrho.

Txhawm rau kuaj qhov no, peb tau khi cov ntaub ntawv los ntawm feem pua ​​​​ntawm cov pej xeem nrog kev tiv thaiv, FRT (uas yog kwv yees los ntawm kev txhaj tshuaj tiv thaiv kab mob thiab kab mob yav dhau los raws li tau piav qhia saum toj no). Cov txiaj ntsig ntawm qhov kev tawm dag zog no rau kev ua si thiab khw muag khoom POIs tau pom nyob rau hauv daim duab 7. Txhua qhov taw qhia sawv cev rau qhov nruab nrab ntawm kev sib raug zoo coefficient (nruab nrab thoob plaws txhua lub tebchaws nyob rau lub sijhawm cuam tshuam) nruab nrab ntawm qhov kev loj hlob ntawm COVID-19 mob thiab kev txav mus los. Cov tuav tuav 75 feem pua ​​​​ntawm cov ntaub ntawv; outliers tau raug tshem tawm kom declutter qhov kev pom thiab qhia txog cov tiam sis. Tus qauv yuam kev hauv qhov txhais tau tias yog 0.056, raws li pom los ntawm thaj av grey hauv cov phiaj xwm. Raws li kev cia siab, thaum tsuas yog ib feem me me ntawm cov pej xeem tuaj yeem tiv taus (kwv yees li 0-25 feem pua, raws li qhia los ntawm cov ntsiab lus txiv kab ntxwv hauv qhov piv txwv no), muaj kev sib raug zoo ntawm kev txav mus los thiab kev loj hlob ntawm cov xwm txheej, qhia tias txwv tsis pub nkag mus. kev ua si thiab khw muag khoom lag luam thaum ntxov ntawm kev sib kis yuav muaj txiaj ntsig zoo hauv kev txo qis kev sib kis. Txawm li cas los xij, raws li kev tiv thaiv hauv cov pej xeem loj hlob tuaj, kev sib raug zoo ntawm kev txav mus los thiab kev loj hlob ntawm cov neeg mob tau ua tiav tsis muaj zog.

Cov phiaj xwm zoo sib xws uas qhia txog qhov cuam tshuam ntawm cov pej xeem tsis kam ntawm plaub lwm POIs - chaw nres tsheb, chaw ua haujlwm, khoom noj khoom haus thiab chaw muag tshuaj, thiab chaw ua si - muaj nyob rau hauv daim duab 8. Tag nrho cov POIs qhia cov qauv zoo sib xws nrog kev sib raug zoo ntawm kev txav mus los thiab kev loj hlob ntawm cov neeg mob thaum feem ntau ntawm cov pej xeem uas tsis kam yog tsawg; Raws li kev tiv thaiv nce, cov kev sib raug zoo tsis tu ncua, ua tsis zoo ntawm qhov sib txawv tseem ceeb ntawm FRT.

Transit stations reveal a similar trajectory to retail and recreation, as shown at the top of Figure 8, where for FRT between 0–25%, there is a significant mean correlation (>0.056) nruab nrab ntawm kev txav mus los thiab kev loj hlob. Tom qab ntawd, raws li FRT nce siab tshaj 25 feem pua, qhov kev sib raug zoo tsis tu ncua; chaw ua hauj lwm qhia ib yam zoo sib xws thiab. Rau cov khw muag khoom noj thiab chaw muag tshuaj thiab chaw ua si, kev sib raug zoo tsis muaj zog xws li chaw nres tsheb thauj mus los, khw muag khoom, chaw ua si, lossis chaw ua haujlwm. Raws li pom hauv daim duab 8, muaj kev sib raug zoo thaum FRT <10 feem pua. Tom qab ntawd, kev sib raug zoo txhais tau tias hover zero, tawm tswv yim tias kev txwv tsis pub txav mus los yuav pab tau qee qhov thiab tsis nyob hauv lwm tus; seb puas yog qhov no yuav yog nyob ntawm lwm yam kev txo qis uas nyob hauv qhov chaw.

The mean correlation thresholds used to distinguish between correlated (orange), uncorrelated (light blue), and slight negative correlation (dark blue) in this analysis, along with their restriction recommendations, are shown in Table 3. Here we have taken a conservative approach in which any correlation mean greater than the standard error in the mean, >0.056, yog cim tias muaj kev sib raug zoo (txiv kab ntxwv), yog li kev txwv kev txav mus los hauv lub sijhawm ntawd yuav pab tau. Ntawm qhov tod tes, kev sib raug zoo txhais tau tias yog<−0.056 are negatively correlated and are marked as dark blue. The correlation means between −0.056 and 0.056 represent a regime in which no significant correlation was measured; hence, within the sensitivity of the measurement, mobility restrictions are unlikely to have a significant impact on the growth rate of cases; these points are indicated with light blue markers in Figure 8.

5. Kev sib tham

5.1. Qhov cuam tshuam rau Txoj Cai Mobility-Restricting

Tag nrho peb cov ntaub ntawv qhia txog qhov pom tseeb thiab zoo ib yam: nyob rau hauv cov neeg tsis paub lus, kev txav mus los yog cuam tshuam nrog kev loj hlob ntawm cov xwm txheej; Raws li cov pej xeem tau txais kev tiv thaiv, qhov kev sib raug zoo no poob mus rau xoom thaum FRT nce mus txog qhov tseem ceeb. Thaum tus nqi tseem ceeb ntawm FRT tau txais thiab tsis muaj kev sib raug zoo ntawm kev txav mus los thiab kev loj hlob (raws li qhov xwm txheej ntawm cov ntsiab lus xiav hauv daim duab 7 thiab 8), txo qis kev txav mus los ntawm kev kaw POI tuaj yeem cuam tshuam me ntsis ntawm tus nqi sib kis. Nws tau tsim tau zoo tias kev kaw POIs tuaj yeem ua rau muaj kev cuam tshuam loj nyiaj txiag thiab kev sib raug zoo. Yog li nws yog ib qho tseem ceeb rau kev txiav txim siab seb qhov kev lag luam tawm puas tsim nyog nws. Tag nrho cov ntaub ntawv qhia hauv daim duab 7 thiab 8 qhia tias kev txwv tsis pub txav mus los yuav ua tau zoo thaum ntxov ntawm kev sib kis tab sis maj mam poob lawv lub zog vim cov pej xeem tau txais kev tiv thaiv los ntawm kev txhaj tshuaj tiv thaiv lossis rov qab los thiab, yog li ntawd, kev sib txuas ntawm kev txav mus los thiab kev sib kis tsis muaj zog. Ntawm no peb tau hais txog qhov tseem ceeb ntawm FRT (hauv txiv kab ntxwv) rau cov cai uas txwv tsis pub txav mus los yuav muaj kev cuam tshuam zoo rau kev ua kom qeeb ntawm COVID-19. Ib yam li ntawd, lub ntsiab lus xiav qhia txog qhov tseem ceeb ntawm FRT rau qhov kev txwv kev txav mus los tsis zoo li yuav muaj kev cuam tshuam loj rau kev sib kis.

Cov pab pawg xiav thiab txiv kab ntxwv no tau sau tseg hauv Table 3. Cov ntaub ntawv qhia tias cov chaw muag khoom thiab chaw ua si, chaw nres tsheb thauj mus los, thiab chaw ua haujlwm yog POIs uas tau txais txiaj ntsig zoo tshaj plaws los ntawm kev txwv tsis pub txav mus los thiab muaj feem yuav tau txais txiaj ntsig zoo dua li thawj theem. ntawm tus kab mob sib kis (xws li kom txog thaum FR loj hlob siab dua 25–30 feem pua ​​​​raws li qhia hauv Table 4). Peb xav tias qhov no yuav tshwm sim vim tias cov POIs no muaj cov yam ntxwv hauv qab uas pab txhawb kev sib kis (xws li, sab hauv tsev, neeg coob coob, thiab lub sijhawm nyob ntev).

Pab pawg thib ob ntawm POIs uas tuaj yeem tau txais txiaj ntsig los ntawm kev txwv tsis pub txav mus los thaum ntxov ntawm kev sib kis thoob ntiaj teb (tab sis cov khoom xa rov qab tuaj yeem raug tshaj tawm tsawg dua li thawj theem) yog cov khoom noj khoom haus thiab chaw muag tshuaj. Qhov no rov qhia tau meej meej tias nyob rau hauv cov neeg tsis paub qab hau (txog li 10 feem pua ​​​​tiv taus) kev txav mus los thiab kev loj hlob ntawm cov neeg mob muaj feem cuam tshuam; yog li kev txwv tsis pub nkag los yog tswj kev ceev yuav tau txais txiaj ntsig. Peb kwv yees tias cov khoom noj khoom haus thiab cov khw muag tshuaj yuav zoo dua li cov khw muag khoom thiab chaw ua si thiab chaw ua haujlwm vim tias qee qhov chaw ntawm cov neeg saib xyuas "xaiv thiab mus" txo lub sijhawm nyob.

Txawm li cas los xij, nws tseem ceeb heev uas yuav tsum nco ntsoov tias cov txiaj ntsig tseem ceeb no - rau txhua qhov chaw sib tham saum toj no - yog qhov nruab nrab, thiab qhov tseem ceeb ntawm FRT ntawm ib qho chaw yuav nyob ntawm POI qhov loj me, cov tswv yim txo qis hauv zos, thiab lwm yam. Thaum txoj kev tshawb no muab qee qhov "txoj cai ntawm tus ntiv tes xoo", ib yam li txhua txoj cai, nws yog ib qho tseem ceeb uas yuav tsum tau ua kom tob tob kom nkag siab txog cov teeb meem hauv zos los txiav txim siab seb POIs yuav qhib thiab qhov twg los txwv.

Thaum kawg, cov ntaub ntawv qhia me ntsis kev sib raug zoo ntawm kev txav mus los thiab kev loj hlob ntawm cov chaw ua si rau yuav luag txhua qhov txiaj ntsig ntawm FRT. Rau FRT > 5–10 feem pua, qhov kev sib raug zoo tsis txaus ntseeg, qhia tias rau COVID-19, ua kom cov chaw ua si qhib, uas muab qhov chaw sab nraum zoov rau tib neeg sib tham, tsis zoo li yuav ua rau muaj kev sib kis ntau ntxiv (thiab tej zaum yuav muaj txiaj ntsig yog tias lub xub ntiag ntawm qhov chaw muaj nyob sab nraum zoov txhawb kom cov neeg tsiv tawm ntawm qhov chaw sib kis ntau dua).

5.2. Qhov cuam tshuam ntawm Delta Variant ntawm COVID-19 Kev sib kis

Ib qho kev sib tw nrog peb txoj hauv kev yog qhov feem pua ​​​​ntawm cov pej xeem uas muaj kev tawm tsam tsis tshwm sim raws li tus qauv randomized nyob rau lub sijhawm: kev tiv thaiv nce ntxiv thaum muaj kev sib kis loj. Qhov no qhia txog qhov muaj peev xwm uas qhov kev sib raug zoo uas peb ntsuas tsis yog vim kev tawm tsam tab sis vim yog qhov sib txawv sib txawv uas hloov zuj zus raws li kev sib kis loj zuj zus. Thaum lub sij hawm, peb xav txog hauv txoj kev tshawb no, qhov sib txawv tseem ceeb yog thawj hom kab mob thiab Delta variant, uas tau ua pov thawj tias ob qho tib si kis tau zoo dua thiab muaj kev tuag ntau dua li thawj hom. Txhawm rau suav rau qhov tshwm sim ntawm Delta, peb tau ua tib yam kev tshuaj ntsuam tab sis tshem tawm tag nrho cov ntsiab lus uas Delta suav txog ntau dua 10 feem pua ​​​​ntawm cov teeb meem kuaj pom. Nyob rau hauv daim duab 7 thiab 8, cov kab khoom sib raug rau qhov kev tshuaj ntsuam no, piv txwv li, thawj hom kab mob tsis muaj Delta (<10% Delta), and the dashed line indicates correlations, including Delta variants. All of our analyses were performed before the emergence of the Omicron variants. The results suggest that the emergence of the Delta variant does not impact any of our conclusions.

6. Cov lus xaus

Hauv qhov kev tshawb fawb no, peb tau txheeb xyuas qhov cuam tshuam ntawm kev txwv kev txav mus los ntawm kev txwv kev txo qis ntawm cov pej xeem resistant uas peb tau txiav txim siab ob yam: ua ntej, cov txiaj ntsig ntawm kev tawm tsam rau cov ntsiab lus sib txawv (POIs), suav nrog chaw nres tsheb, khoom noj khoom haus thiab chaw muag tshuaj, khw muag khoom thiab chaw ua si, chaw ua haujlwm, thiab chaw ua si; thib ob, cov nyhuv ntawm kev tiv thaiv ua ntej thiab tom qab qhov tshwm sim ntawm Delta variant. Peb tau kawm ib pab pawg ntawm 14 lub teb chaws uas muaj kev ntseeg siab ntawm COVID-19 cov ntaub ntawv suav - uas peb tau muab cov ntaub ntawv los ntawm cov feem pua ​​​​ntawm cov pej xeem nrog kev tawm tsam thiab muaj qhov sib txawv ntawm Delta - siv Pearson kev sib raug zoo ntawm kev txav mus los thiab rooj plaub. Peb pom tias kev txwv tsis pub txav mus los ntawm cov khw muag khoom thiab chaw ua si, chaw nres tsheb thauj mus los, thiab chaw ua haujlwm feem ntau yuav muaj txiaj ntsig zoo los tswj kev kis tus kabmob, tshwj xeeb tshaj yog tias feem pua ​​​​ntawm cov pejxeem muaj kev tiv thaiv qis dua 25-30 feem pua. Qee qhov xwm txheej, cov khw muag khoom noj thiab cov khw muag tshuaj yuav tau txais txiaj ntsig los ntawm kev txwv kev txav mus los yog tias feem pua ​​​​ntawm cov pej xeem muaj kev tiv thaiv qis dua 10 feem pua. Txawm li cas los xij, hauv cov chaw ua si, muaj qhov zoo me me rau kev txwv kev txav mus los.

Ib qho kev txwv ntawm txoj kev tshawb fawb no yog qhov tsis paub tseeb hauv kev sau cov ntaub ntawv thaum COVID-19. Txawm li cas los xij, peb tau siv zog los daws qhov teeb meem no los ntawm kev siv kev suav rau kev xaiv lub teb chaws tau piav qhia hauv Tshooj 2.4, uas peb tau xaiv 14 lub tebchaws uas ntseeg siab tshaj plaws rau txoj kev kawm. Ntawm qhov tod tes, txoj haujlwm no lub zog yog nws txoj kev xav thoob ntiaj teb thiab kev pom dav dav. Tsis tas li ntawd, raws li txoj cai cuam tshuam, cov kev nkag siab no tuaj yeem siv tau tom qab rau cov kab mob sib kis zoo ib yam li COVID-19, raws li tau tham hauv Tshooj 5.1. Paub txog qhov twg POIs txwv kom txwv ntau dua thaum xav txog qhov pib tiv thaiv tuaj yeem pab tiv thaiv kev kis tus kab mob thiab cawm neeg txoj sia los ntawm cov theem ua ntej.

Hauv kev ua haujlwm yav tom ntej, peb tsom mus kawm txog cov txiaj ntsig ntawm cov pej xeem tiv thaiv ntawm ob tus neeg tuag thiab cov neeg mob ICU. Tsis tas li ntawd, nws yuav nthuav kom sib piv cov txiaj ntsig ntawm ntau hom kev tiv thaiv (natural resistance tiv thaiv cov tshuaj tiv thaiv kev sib xyaw ua ke ntawm ob). Tsis tas li ntawd, raws li cov ntaub ntawv ntau ntxiv, kev tshuaj xyuas micro-scale tuaj yeem ua tau thaum ib qho suav nrog cov cheeb tsam sib txawv thiab cov chaw hauv nroog.

Tus sau kev koom tes:

Methodology, DA thiab AH; coding thiab tsom xam, DA; cov peev txheej, DA; cov ntaub ntawv curation, DA; kev sau ntawv—kev npaj ua ntej, DA thiab AH; kev sau ntawv— tshuaj xyuas thiab kho, DA, AH thiab MN; kev pom, DA thiab AH; kev saib xyuas, AH thiab MN Txhua tus kws sau ntawv tau nyeem thiab pom zoo rau cov ntawv luam tawm ntawm cov ntawv sau.

Nyiaj txiag:

Qhov kev tshawb fawb no tau nyiaj los ntawm King Abdulaziz City rau Kev Tshawb Fawb thiab Tshuab.

Institutional Review Board Statement:

Tsis siv tau.

Cov Lus Qhia Txog Kev Pom Zoo:

Tsis siv tau.

Cov ntaub ntawv muaj nyob:

Peb Lub Ntiaj Teb hauv Cov Ntaub Ntawv [31]—Google muab cov ntaub ntawv kev txav mus los rau pej xeem muaj feem cuam tshuam txog kev sib kis [32]—Peb Lub Ntiaj Teb hauv Cov Ntaub Ntawv tau qhia txog COVID-19 cov ntaub ntawv sib txawv [33].

Kev tsis sib haum xeeb ntawm kev txaus siab:

Cov kws sau ntawv tshaj tawm tsis muaj kev sib cav txog kev txaus siab.

Cov ntaub ntawv

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