Daim ntawv thov ntawm cov khoom siv tshuaj pleev ib ce tau tseem ceeb heev rau lub sijhawm ntev

Thov hu rauoscar.xiao@wecistanche.comyog xav paub ntxiv

Abstract:Cov lipids feem ntau yog roj, rog, waxes, thiab phospholipids yog qhov tseem ceeb hauv kev txhim kho thiab ua haujlwm ntawm cov khoom kom zoo nkauj. Cov lipid nanoparticles-raws li cov khoom siv tshuaj pleev ib ce muaj peev xwm tiv thaiv daim tawv nqaij tiv thaiv kev puas tsuaj hluav taws xob thiab siv los kho kev laus. Ib txwm muab tau cov tshuaj antioxidants xws li carotenoids, retinoids, thiab tocopherols tuaj yeem ua haujlwm rau lawv cov khoom antioxidant raws li kev kho mob thiab kev tu tawv nqaij muaj zog moieties hauv cov khoom kom zoo nkauj. Xws li lipid nanoparticles-raws li cov tshuaj pleev ib ce uas muaj cov tshuaj tua kab mob antioxidant zoo heev tiv thaiv tawv nqaij thiab khaus khaus thiab zoo heev rau kev kho cov tawv nqaij mob xws li atopic dermatitis thiab psoriasis. Yog li, qhov kev tshuaj xyuas tam sim no muab kev nkag siab rau lipid nanoparticle-based tshuaj pleev ib ce thiab cov cuab yeej ntawm lawv cov percutaneous absorption.txo cov roj cholesterolKev sib tham hauv phau ntawv qhia txog lub luag haujlwm ntawm lipid nanoparticles-raws li tshuaj pleev ib ce / cosmeceuticals siv cov khoom xyaw nquag ntawm cov khoom siv hluavtaws thiab cov hauv paus chiv keeb hauv kev txo cov kab mob dermatological thiab txhim kho daim tawv nqaij noj qab haus huv thiab rov hais dua. Tsis tas li ntawd, cov ntawv sau kuj hloov kho cov kev tshawb fawb niaj hnub no ua los ntawm lub tswv yim ntawm lipid nanoparticles-based formulation tsim ntawm kev npaj kom zoo nkauj thiab cov txiaj ntsig tseem ceeb rau kev txo cov tawv nqaij.

Thov nias ntawm no kom paub ntxiv

Ntsiab lus:lipid nanoparticles; tshuaj pleev ib ce; cosmeceuticals; percutaneous nqus; antioxidants; tawv nqaij mob

1. Taw qhia

Kev siv cov khoom siv tshuaj pleev ib ce yog qhov tseem ceeb rau lub sijhawm ntev. Txawm li cas los xij, tam sim no, qhov tseem ceeb ntawm cov khoom siv tshuaj pleev ib ce tau hloov kho nws tus kheej mus rau kev kho mob nrog rau cov khoom noj khoom haus uas txuas mus rau cov tawv nqaij noj qab haus huv thiab ntxiv kev kho mob ntawm cov kab mob dermatological. Cov khoom siv tshuaj pleev ib ce nrog lub peev xwm tiv thaiv kab mob ua lub luag haujlwm tseem ceeb hauv kev txhim kho kev loj hlob txhua xyoo ntawm cov khoom siv tshuaj pleev ib ce hauv khw. Cov kws tshuaj noj zaub mov, kws muag tshuaj, thiab kws kho mob tau siv zog ntau heev hauv kev tsim cov khoom kom zoo nkauj uas muaj peev xwm kho tau lossis noj zaub mov kom txaus siab rau qhov kev xav tau thiab cov kev xav tau ntawm cov neeg siv khoom [1-3].

Cov khoom siv tshuaj pleev ib ce tshiab tau tsim tawm ntawm qhov nrawm nrawm hauv kev lag luam tshuaj pleev ib ce uas muaj zog heev uas tuaj yeem raug ntaus nqi los ntawm kev qhia txog qhov tshiab lipid-based nanoparticulate system. Lipid nanoparticles encapsulated nyob rau hauv active ingredient-raws li tshuaj pleev ib ce muaj mounting zoo ntawm enhanced daim tawv nqaij nkag mus rau hauv lub sib sib zog nqus strata ntawm daim tawv nqaij khaubncaws sab nraud povtseg, txhawb thiab tsom tso tawm cov khoom xyaw nquag mus rau cellular thiab subcellular cheeb tsam, thiab txhim kho tag nrho functionality ntawm cov khoom zaum kawg nrog lub peev xwm cosmetic cum kho. effect [4,5].cistanche deserticola phivKev xa tawm ntawm cov khoom xyaw nquag loaded lipid nanoparticles raws li cov tshuaj pleev ib ce muab lub ntsiab lus tshiab rau cov tshuaj pleev ib ce uas yog txoj kev ntau tshaj li cov khoom txhawb kev zoo nkauj xwb. Cov khoom siv tshuaj pleev ib ce uas muaj txiaj ntsig zoo hauv kev kho cov kab mob dermatological nrog rau kev muab lub ntsej muag ci rau ntawm daim tawv nqaij yog qhov xav tau tam sim no [4,5]. Lub ntsiab lus ntawm cov khoom siv tshuaj pleev ib ce tau hloov pauv nrog lub hom phiaj tam sim no tau hloov mus rau kev nkag mus rau cov tshuaj pleev ib ce zoo nkauj uas suav tias yog "chemotherapy".

Cistanche tuaj yeem tiv thaiv kev laus

Lub sij hawm "cosmeceutical", coined los ntawm Kligman, yog amalgamation ntawm cov tshuaj pleev ib ce thiab tshuaj uas yog txhais raws li cov khoom constituting cov khoom xyaw npaj rau tus kheej thiab / los yog kev kho mob siv 6]. Cov cosmeceuticals suav nrog ntau cov khoom lag luam uas suav nrog cov tshuaj pleev, tshuaj pleev, tshuaj pleev, thiab cov khoom noj zoo nkauj uas tuaj yeem ua kua, tshuaj, thiab khoom noj khoom haus. Cov khoom siv tshuaj pleev ib ce tshwj xeeb no muaj cov khoom xyaw lossis cov khoom noj muaj peev xwm los txhawb kev noj qab haus huv ntawm daim tawv nqaij, plaub hau, thiab rau tes thiab tej zaum yuav muaj cov vitamins, minerals, cov nroj tsuag extracts, thiab antioxidants [7-9]. Txawm li cas los xij, hauv cov ntawv sau tam sim no, cov tshuaj pleev ib ce uas tshwj xeeb siv rau ntawm daim tawv nqaij los kho cov tawv nqaij mob thiab pab tswj kev noj qab haus huv ntawm daim tawv nqaij yog tham txog kom meej.cistanche noj redditQhov no cosmo-kho kho txoj kev yog txawv ntawm cosmeceuticals vim nws tsis npog cov khoom noj khoom haus zoo nkauj thiab cov khoom muaj cov as-ham. Lub hom phiaj tseem ceeb yog kev tiv thaiv thiab kho cov kab mob dermatological xws li pob txuv, dermatitis, thiab psoriasis nrog rau kev ua kom zoo nkauj ntawm daim tawv nqaij. Cov ntawv sau tam sim no txhawb kev siv cov khoom xyaw ntuj los kho cov kab mob dermatological txawm li cas los xij, nws kuj suav nrog kev kho tshuaj khomob nrog cov tshuaj siv tshuaj.

Nano-based thev naus laus zis tau ntxiv rau kev txhim kho cov khoom siv tshuaj pleev ib ce. Piv txwv li, nanosized sunscreens uas muaj ZnO lossis TiO, nanoparticles muaj kev ua tau zoo dua li cov micron loj [10]. Qhov kev tshuaj xyuas tam sim no muab kev nkag siab rau lipid nanoparticle-based tshuaj pleev ib ce thiab cov txheej txheem ntawm lawv cov percutaneous nqus. Kev tshuaj xyuas qhia txog lub luag haujlwm ntawm lipid nanoparticle-raws li kev npaj tshuaj pleev ib ce hauv alleviating dermatological kab mob. Tsis tas li ntawd, cov ntawv sau kuj tseem hloov kho cov kev tshawb fawb niaj hnub ua los ntawm lub tswv yim ntawm cosmo-kho kho kom zoo nkauj txhawm rau tsim cov lipid nanoparticles-raws li kev npaj tshuaj pleev ib ce.

2. Lipid Nanoparticles siv nyob rau hauv Formulation Design of Nanocosmetics

Qhov tseem ceeb fatty acids thiab triglycerides uas muaj unsaturated fatty acids yog lub hauv paus ntawm cov khoom kom zoo nkauj 'muaj pes tsawg leeg thiab kev loj hlob [11,12]. Cov roj uas muaj linoleic thiab -linolenic acid hauv cov ntsiab lus siab yog qhov tseem ceeb hauv kev tiv thaiv eczemas lossis atopic dermatitis. Xws li cov fatty acids tseem ceeb ua ke nyob rau hauv cov cell membranes thiab rov ua kom puas lipid barrier ntawm lub epidermis thiab tiv thaiv dej poob. Cov unsaturated fatty acids pab txhawb kev kho mob ntawm daim tawv nqaij mob thiab feem ntau yog siv los ua ib qho tseem ceeb ntawm kev npaj tshuaj pleev ib ce [11,12]. Cov lipid nanoparticles-raws li cov khoom siv tshuaj pleev ib ce muaj cov tshuaj lom neeg ruaj khov, thiab cov tawv nqaij zoo sib xws thiab tiv thaiv tawv nqaij tiv thaiv hluav taws xob thiab kev laus [11].

Lipid nanoparticle-based tshuaj pleev ib ce tau txais kev saib xyuas ntau nyob rau hauv ob peb lub xyoo dhau los vim lawv cov biocompatibility, kev nyab xeeb, thiab kev ua haujlwm zoo dua qub. Cov lipidic nanocargos ua rau muaj txiaj ntsig zoo rau kev npaj tshuaj pleev ib ce tsom rau kev tiv thaiv kab mob dermal vim tias lawv cov khoom siv ntau dua thiab cov khoom siv sib xyaw ua ke tso tawm kom raug. Lawv qhov me me me me yog nyob ntawm 1-100 nm thiab qhov siab tshwj xeeb ntawm thaj chaw los ntawm qhov ntim uas ntau dua 60 m2 / cm³ ua rau lawv cov neeg sib tw zoo tshaj plaws rau kev tsim cov khoom xyaw hauv cov khoom kom zoo nkauj[13-15]. Cov khoom xyaw nquag-loaded lipid nanoparticle-based cosmetic / cosmeceutical tau ua haujlwm tshwj xeeb hauv kev kho cov kab mob dermatological vim muaj kev txhim kho kev nkag mus, hloov tshuaj tso tawm, lub hom phiaj hauv zos, thiab tsawg kawg toxicity. Lub luag haujlwm ntawm lipid nanoparticles-raws li tshuaj pleev ib ce / cosmeceuticals hauv kev kho cov kab mob dermatological tau tham hauv cov ncauj lus kom ntxaws hauv cov ntu tom ntej. Qhov me me, kev thauj khoom siab, thiab muaj peev xwm ua kom ntev ntev ntawm kev tso tawm ntawm cov khoom muaj txiaj ntsig, cov kev sib txawv hauv kev sib txawv, kev xaiv, lub hom phiaj hauv zos, biocompatibility, thiab kev nyab xeeb yog cov cwj pwm txawv ntawm lipid nanoparticle-based tshuaj pleev ib ce uas tau ua rau lawv sawv siab nyob rau hauv plethora. ntawm lwm yam nanopticulate formulations uas yuav siv tau nyob rau hauv cov tshuaj pleev ib ce npaj [15].

Muaj cov chav kawm sib txawv ntawm lipid-based nanoparticulate systems uas tau siv rau hauv cov khoom siv tshuaj pleev ib ce xws li khoom lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), liposomes, thiab nanoemulsions. Nanoemulsions uas yog colloidal dispersion ntawm nanoscale droplets ntawm ib tug kua nyob rau hauv lwm cov kua yog siv dav hauv cov khoom tu tawv nqaij, deodorants, tshuaj pleev thaiv hnub, thiab cov khoom tu plaub hau. Lawv cov yam ntxwv tseem ceeb ntawm kev nkag mus sai, assimilating textures, thiab hydration muaj peev xwm tso cai rau lawv cov khoom siv suav nrog hauv cov tawv nqaij xa khoom ntawm cov tshuaj pleev ib ce [16-18].

Nyob rau hauv thaum ntxov 90s, Muller thiab Gasco qhia ib tug lipid-raws li nanoparticulate system uas yog tsis tu ncua hloov nrog ib tug ntau tshaj thiab ntse tiam ntawm lipid nanoparticles [19]. Los ntawm qhov kev xav ntawm cov khoom siv tshuaj pleev ib ce, lipid-based nano xa tshuab tuaj yeem faib dav dav li liposomes thiab ntse tiam lipid nanoparticles (xws li tshwj xeeb SLN thiab NLC) [20]. Liposomes tuaj yeem txhais tau tias yog cov kab mob me me uas muaj cov tub ntxhais aqueous ncig los ntawm ib lossis ntau dua phospholipid bilayer daim nyias nyias. Feem ntau siv phospholipids yog phosphatidylcholine thiab phosphatidylethanolamine. Liposomes yog cov tseem ceeb lipid-raws li nano xa cov tshuab uas siv hauv kev kho mob kom xa cov neeg ua haujlwm kho mob [21,22]. Thawj cov khoom lag luam tsim kho kom zoo nkauj raws li liposomes li nanocosmetics yog cov tshuaj tiv thaiv kev laus hu ua 'Capture' (los ntawm Dior hauv 1986) [21,22]. Cov khoom xyaw tseem ceeb ntawm liposomes yog phosphatidylcholine uas muaj cov yam ntxwv ntawm daim tawv nqaij softening thiab yog li, muaj kev siv tsis tau zoo hauv cov khoom siv tawv nqaij thiab tawv nqaij [21. Cov liposome tuaj yeem siv tau zoo los txhawm rau ob qho tib si hydrophilic thiab lipophilic cov khoom xyaw nquag npaj rau kev kho mob lossis kho kom zoo nkauj. Tsis tas li ntawd, qhov kev nyiam loj ntawm liposomal mediated xa hauv cov kws khomob yog lawv cov biocompatibility, biodegradability, tsawg toxicity, thiab qhov chaw tshwj xeeb cov khoom xyaw. Txawm li cas los xij, liposomes raug kev txom nyem vim lawv cov solubility tsawg thiab luv ib nrab-lub neej [22-24].

Cov qeb tom ntej ntawm lipid-based nano xa khoom muaj cov txheej txheem qib siab thiab ntse dua lipidic nanocargos uas yog SLN thiab NLC raws li tau piav qhia hauv daim duab 1. SLN thiab NLC yog pawg tshwj xeeb ntawm lipid nanoparticles vim lawv cov cim matrix tshwj xeeb.SLN yog qhov tseem ceeb ntawm cov khoom. lipids tshwj xeeb yog fatty acids, waxes, glycerides, thiab triglycerides whereas NLC matrix yog ib qho tsis zoo tag nrho ntawm cov lipids thiab kua lipids [13,14,20,25,26]. Tam sim no ob qho tib si SLN thiab NLC tab tom tshawb nrhiav pom tseeb hauv kev kho tshuaj khomob. Cov txheej txheem tshiab no tshwj xeeb muaj txiaj ntsig zoo ntawm daim tawv nqaij adhesion, txhim kho hydration, nkag mus rau ntau yam, improvised thiab tswj kev tso tawm ntawm cov khoom xyaw nquag, zam kev siv lub cev, thiab txhim kho percutaneous absorption 25-27I. Qhov tsis zoo nyob hauv NLC matrix qauv ua rau muaj peev xwm muaj peev xwm thauj khoom ntau dua thiab txo kev tshem tawm thaum lub sijhawm khaws cia hauv qhov sib piv rau SLN [13,26]. Cov qauv sib piv ntawm SLN thiab epidermal lipid hauv daim tawv nqaij ua rau SLN yog ib qho zoo tshaj plaws nanoparticle rau transdermal xa ntawm cov khoom xyaw nquag hauv kev kho mob. Txawm li cas los xij, vim muaj cov khoom lipid hauv SLN, cov lipid particles zoo li tsim cov muaju uas ua rau recrystallization.cistanche extract cov txiaj ntsigQhov no yog ib qho ntawm cov teeb meem loj ntawm SLN ua rau txo qis lub peev xwm ntawm cov khoom xyaw nquag [14,25,26].

Cov liposomes, SLN, thiab NLC muaj qhov zoo tshaj plaws adhesion zog thaum lawv tuaj rau ntawm daim tawv nqaij nto [26]. Nws tau raug tsim los ntawm ntau yam kev tshawb fawb uas lipid nanoparticles ntawm 200 nm qhov loj me tuaj yeem ua tau zoo tsim hydrophobic monolayers thaum siv rau hauv qhov chaw ruaj khov ntawm daim tawv nqaij [21,25,26]. Cov hydrophobic monolayers tiv thaiv kev poob dej los ntawm kev tsim cov dej noo npog ntawm daim tawv nqaij. Cov cuab yeej no ntawm lipid nanoparticles system yog siv tshwj xeeb los daws cov teeb meem occlusion thiab hydration nyob rau hauv cov khoom kom zoo nkauj.

Cov tiam tom ntej lipid nanoparticles-SLN thiab NLC tau pom muaj peev xwm loj heev hauv kev xa cov khoom xyaw nquag thiab kho cov kab mob dermatological nrog rau cov cwj pwm zoo ntawm kev tu tawv nqaij. Cov qauv no tau ua haujlwm zoo los ntawm cov kws tshawb fawb thoob ntiaj teb kom tuaj nrog cov khoom zoo nkauj zoo nkauj uas muaj peev xwm kho tau zoo heev rau cov tawv nqaij tsis zoo nrog cov yam ntxwv ntawm daim tawv nqaij-beautifying. Cov npe ntawm cov khoom lag luam muaj lipid nanoparticles-raws li cov khoom siv tshuaj pleev ib ce yog nthuav tawm hauv Table 1.

Daim tawv nqaij ua raws li thawj kab ntawm kev tiv thaiv tawm tsam lwm yam stimuli thiab kuj yog qhov loj tshaj plaws ntawm lub cev nyob rau hauv tib neeg lub cev. Yog li ntawd, dermal absorption yog qhov tseem ceeb tshaj plaws thiab yuav tsum tau saib xyuas tshwj xeeb. Permeation ntawm lipid nanoparticles los ntawm daim tawv nqaij nyob ntawm lawv cov khoom xws li nto morphology, nqi, thiab particle loj (Daim duab 3). Feem ntau qhov tsis zoo ntawm tus nqi lossis zeta muaj peev xwm thiab qhov me me particle loj nyiam trans-dermal nkag. Lub microenvironment nyob ib ncig ntawm lipid nanoparticles muaj qhov cuam tshuam loj heev hauv kev cuam tshuam rau kev tso tawm cov khoom xyaw nquag ua piv txwv. Lub xub ntiag ntawm noo noo los yog lipids yuav pab hydration / dissolution thiab yog li permeation ntawm lipid nanoparticles. Qhov tseem ceeb, txoj hauv kev nkag mus rau hauv kev tswj hwm kev tso tawm cov khoom xyaw nquag los ntawm lipid nanoparticles. Tsis tas li ntawd, qhov sib npaug hydrophilic-lipophilic (HLB) ntawm cov khoom siv surfactant nyob rau hauv lipid nanoparticles tuaj yeem siv los ua kev nkag mus rau kev txhim kho lub tswv yim los txhim kho kev tso tawm ntawm cov khoom muaj zog-loaded lipid nanoparticles.cistanche genghis khanIntercellular, transcellular / trans appendageal txoj kev raug suav hais tias yog txoj hauv kev ua tau rau kev xa tshuaj dermal los ntawm nanoparticles raws li cov ntaub ntawv muaj uas tuaj yeem ua raws li hla cov txheej txheem epidermal thiab dermis thiab tom qab ntawd mus rau cov hlab ntsha [21].

3.1. Tso tawm cov khoom xyaw nquag / Bioactive los ntawm Lipid Nanoparticles Raws li cov khoom siv tshuaj pleev ib ce

Novel lipid nanoparticles-based tshuaj xa khoom yog kev siv zog kom ua tiav cov tshuaj tso tawm ntev nrog cov teebmeem tsawg. Kev tswj kev tso tawm, nyob ib sab ntawm lub hom phiaj ntawm lub cev mus rau ib hom xovtooj ntawm tes ntawm cov tshuab no, kuj tuaj yeem ua tiav los ntawm kev ua haujlwm hauv zos los ntawm kev siv cov cab kuj [30].

Ib qho kev tshawb fawb sib piv ntawm cov qauv sib txawv ntawm cov tshuaj tso tawm los ntawm tus neeg nqa khoom yuav tsum tau ua kom nkag siab txog lawv cov tshuaj tso tawm profile. Ntau yam cuam tshuam rau lawv cov teebmeem ntawm cov khoom muaj txiaj ntsig tus qauv ntawm kev tso tawm los ntawm lipid nanoparticles xws li concentration ntawm cov khoom muaj nyob rau hauv lipid matrix, particle loj, hom surfactant, lipid matrix, thiab cov yam ntxwv ntawm active moiety. Yuav tsum muaj nyob rau hauv vitro hauv vivo kev sib raug zoo ntawm cov tshuaj tso tawm thiab ib puag ncig ntawm qhov chaw tso tawm. Cov muaj pes tsawg leeg ntawm nanoparticles thiab lawv cov enzymatic degradation kuj muaj feem xyuam rau qee qhov [31].

Liposomes tuaj yeem muab kev tso tawm tas mus li thiab ncua ntev ntawm cov khoom muaj txiaj ntsig rau lub hom phiaj ntawm daim tawv nqaij kom ntseeg tau tias qhov ua tau zoo ntawm cosmo-therapy [32]. Peb tus qauv txhais cov tshuaj tso tawm los ntawm SLN's viz. lipid core nrog active tivthaiv supplemented plhaub, lipid plhaub nrog active tivthaiv supplemented core, thiab homogenous matrix [33]. Qee yam uas cuam tshuam rau cov tshuaj tso tawm los ntawm NLCs suav nrog kev tsim khoom kub, qhov feem ntawm cov roj hauv matrix ntawm lipid, thiab surfactant muaj pes tsawg leeg [34]. Rau cov khoom xyaw nquag tso tawm, muaj ob hom kev coj cwj pwm uas xav tau los ntawm NLCs viz, tawg tawm los ntawm sab nrauv ntawm lub plhaub nanoparticles impregnated nrog active moiety thiab tas li tso tawm ntawm cov khoom nquag los ntawm cov augmented cores. Ntev-tso tawm ntawm cov khoom xyaw nquag los ntawm NLCs tuaj yeem raug ntaus nqi los ntawm kev faib tawm ntawm cov active moiety ntawm cov dej thiab lipophilic matrix thiab lub luag hauj lwm ntawm lub interfacial membrane uas ua raws li ib tug barricade rau kev nkag mus ntawm lub active ingredient [35,36].

3.2.Mechanism of Absorption of Lipid Nanoparticles Based Cosmetic Products thoob cov tawv nqaij txheej

Cov txheej txheej saum toj kawg nkaus ntawm daim tawv nqaij SC ua lub luag haujlwm tseem ceeb hauv kev tswj cov tawv nqaij zoo thiab ua haujlwm uas tshwj xeeb suav nrog kev tiv thaiv dej ntau dhau thiab tiv thaiv kev nkag mus ntawm xenobiotics hla cov txheej txheem dermal. Corneocytes thiab intercellular lipids, uas yog nyob rau hauv ib tug npog ntawm heev crosslinked proteins (loricrin, filaggrin), yog cov tseem ceeb Cheebtsam ntawm SC. Corneocytes thiab lipids yog lub luag haujlwm rau khaws cov dej zoo gradients uas ua kom SC dej txaus [37]. Cov lipids tam sim no nyob rau hauv cov khoom siv tshuaj pleev ib ce xws li phosphatidylcholine pab txhawb kev txhim kho ntawm daim tawv nqaij thiab cov khoom emollient. Muaj tseeb tiag, phosphatidyl lecithins muaj nyob rau hauv cov tshuaj pleev, tshuaj pleev, thiab tshuaj zawv plaub hau ua lub luag haujlwm tseem ceeb hauv kev ua kom cov tawv nqaij softening. Ntxiv mus, cov surfactants thiab polar lipids tam sim no nyob rau hauv lipid nanoparticles-raws li tshuaj pleev ib ce kuj yog ib tug tseem ceeb Cheebtsam nyob rau hauv kev tswj ntawm daim tawv nqaij functionality thiab noj qab haus huv thiab tseem ceeb tshaj tiv thaiv daim tawv nqaij los ntawm ntau yam kab mob [38].

3.3. Permeation ntawm Lipid Nanoparticles los ntawm Follicular Routes

Cov hauv paus plaub hau raws li tuaj yeem pom hauv daim duab 2c sawv cev rau lwm txoj hauv kev thiab muaj peev xwm nkag mus rau lipid nanoparticles tshwj xeeb SLN thiab NLC. Cov plaub hau follicle feem ntau yog ntawm sebum milieu uas yog tsim los ntawm lipid, waxes, thiab squalene. Qhov sib piv ntawm lipids hauv sebum thiab SLN thiab NLC pab txhawb kev nkag mus tob dua thiab zoo kawg li ntawm cov lipid nanoparticles thoob plaws ntawm daim tawv nqaij. Tom qab tso tawm ntawm cov khoom xyaw nquag yog ntaus nqi los ntawm kev yaig lossis kev tawg ntawm lipid matrix hauv sebum. Yog li ntawd, cov hauv paus plaub hau ua piv txwv txoj kev nkag mus rau qhov tob tob ntawm lipid nanoparticles piv rau SC. Hauv SC cov khaubncaws sab nraud povtseg cov lipid nanoparticles feem ntau yog sau rau ntawm qhov chaw thaum, los ntawm txoj kev follicular, kev sib cuam tshuam ntawm lipid matrix ntawm SLN thiab NLC dispersion thiab sebum expedites tob percutaneous absorption [39].

4. Qhov tseem ceeb ntawm Lipid Nanoparticles Raws li cov tshuaj pleev ib ce siv rau hauv cov phiaj xwm Cutaneous Inflammations

Cov lipid nanoparticles xws li liposomes, SLNs, thiab NLCs feem ntau yog ua haujlwm ua cov khoom siv tshuaj lom neeg xws li vitamin E txhawm rau tiv thaiv cov tshuaj degradation ntawm cov khoom sib xyaw ua ke [40]. Tsis tas li ntawd, lipid nanoparticles kuj tseem muaj txiaj ntsig zoo hauv kev xa khoom sib txawv ntawm cov khoom xyaw nquag ua haujlwm zoo rau kev kho mob ntawm daim tawv nqaij. Lub peev xwm ntawm lipid nanoparticles tau muab tso rau hauv aqueous dispersions ua kom lawv lub cev ruaj khov thiab tom qab sib xyaw nrog cov tshuaj dermal xws li qab zib los ua cov nplaum nplaum nrog cov nyhuv occlusive yog qhov tseem ceeb heev. Xws li occlusive cawv accelerates qhov nkag mus ntawm cov tshuaj pleev ib ce rau hauv daim tawv nqaij uas ua rau muaj kev kho kom zoo dua qub [37,38]. Hauv seem no, lub peev xwm ntawm lipid nanoparticles-raws li tshuaj pleev ib ce / cosmeceuticals hauv alleviating dermatological disorders yog highlighted.

4.1.Lipid Nanoparticles Raws li Tshuaj pleev ib ce/Cosmeceuticals thiab pob txuv

Pob txuv yog ib qho ntawm cov kab mob dermatological ntau tshaj plaws hauv cov hluas. Muaj ntau ntau cov tshuaj pleev ib ce muaj nyob rau hauv kev ua lag luam uas hais tias kho pob txuv. Txawm li cas los xij, lawv cov kev mob tshwm sim cuam tshuam overshadows lawv cov txiaj ntsig zoo thiab kho mob. Kev taw qhia ntawm lipid nanoparticles hauv cov tshuaj pleev ib ce tau ua tiav cov kev txhawj xeeb toxicity cuam tshuam nrog cov khoom siv tshuaj pleev ib ce los tiv thaiv pob txuv los ntawm kev txhim kho dermal localization ntawm cov tshuaj tiv thaiv pob txuv [41]. Hauv kev tshawb fawb los ntawm Munster thiab cov neeg koom tes, SLN tau siv los ua cov neeg nqa khoom ntawm nonsteroidal antiandrogen prodrug RU 58841 myristate (RUM) npaj rau follicular targeting [42]. Cov kev tshawb fawb tshawb pom tau pom tias RUM-loaded SLN tau txais txiaj ntsig zoo los ntawm cov hauv paus hniav thiab tom qab ntawd cov txheej txheem npaj tau nyob hauv cheeb tsam thiab nyob hauv cov txheej txheem sab saud ntawm daim tawv nqaij. Cov txiaj ntsig ntawm txoj kev tshawb fawb tau lees paub qhov kev kho pob txuv tau zoo heev vim yog los ntawm SLN ua kom yooj yim hauv zos depot tsim uas kho kom haum rau kev tso tawm cov tshuaj tiv thaiv kab mob ntxiv rau kev cuam tshuam nws txoj kev nqus.

4.2.Lipid Nanoparticles Raws li Tshuaj pleev ib ce/Cosmeceuticals thiab daim tawv nqaij mucoses

Cov kab mob fungal ntawm daim tawv nqaij yog qhov tshwm sim heev thiab ua rau cov kab mob ntawm daim tawv nqaij. Txhawm rau kho cov kab mob saum toj no, cov khoom siv tshuaj pleev ib ce uas muaj cov tshuaj tua kab mob tau siv tshuaj pleev ib ce [43]. Cov txheej txheem qib siab lipid nanoparticles SLN thiab NLC tau tshawb xyuas los ntawm cov kws tshawb fawb sib txawv thoob ntiaj teb kom lees paub lawv lub peev xwm los txhim kho cov tshuaj tiv thaiv kab mob ntawm cov khoom kom zoo nkauj. Cov tshuaj tua kab mob, tshwj xeeb tshaj yog clotrimazole thiab ketoconazole, feem ntau siv los kho cov tawv nqaij mycoses. Cov tshuaj tiv thaiv kab mob no tau encapsulated hauv SLN thiab NLC-raws li kev npaj tshuaj pleev ib ce los tshawb xyuas lawv cov kev kho mob. Souto thiab cov neeg ua hauj lwm tau tsim clotrimazole-encapsulated lipid nanoparticles (ob leeg SLN thiab NLC) thiab tau soj ntsuam ncua sij hawm thiab txhawb nqa cov tshuaj tiv thaiv kab mob nrog SLN thaum tam sim thiab ceev kho cov teebmeem nrog NLC. Qhov sib txawv ntawm cov nyhuv kho tau yog vim qhov kev tso tawm ntev ntawm clotrimazole los ntawm cov khoom lipid integrated SLNin nyob rau hauv sib piv rau qhov ceev tso tawm tus nqi los ntawm hybrid lipid matrix los ntawm NLC. Kev kho mob ntev ntev raws li pom nrog SLN yog qhov xav tau los txhim kho cov txiaj ntsig ntawm kev kho kom zoo nkauj los kho cov tawv nqaij mob xws li mycoses [44,45].

Hauv kev tshawb fawb, Sanna thiab cov neeg koom tes tau tsim cov econazole nitrate-loaded SLN thiab pom cov kev tswj xyuas nruj heev thiab ua kom muaj kev sib txawv ntawm cov tshuaj tiv thaiv kab mob sib piv rau cov khoom lag luam. Lawv xaus qhov kev txhim kho thiab tswj xyuas permeation ntawm cov tshuaj tiv thaiv kab mob los ntawm SLN feem ntau yog los ntawm cov ntsiab lus lipid thiab particle loj [46,47]. Ntxiv mus, Bhalekar thiab cov neeg koom tes tau tshawb xyuas cov tshuaj miconazole nitrate-loaded SLN formulation rau nws cov cawv ntawm permeation profile ntawm cov tshuaj los ntawm daim tawv nqaij [48]. Cov txiaj ntsig ntawm kev tshawb fawb tau nthuav tawm ntau ntxiv permeation ntawm miconazole los ntawm SLN hauv kev sib piv rau cov khoom lag luam gel. Txawm li cas los xij, hauv kev tshawb fawb los ntawm Jain thiab cov neeg ua haujlwm ua haujlwm, miconazole nitrate-loaded SLN tau nthuav tawm cov tshuaj ntev ntev tso tawm rau ntau tshaj 24-h nrog concomitant 10-folds ntau dua tuav hauv kev sib piv nrog cov khoom siv [49].

4.3.Lipid Nanoparticles Raws li Tshuaj pleev ib ce/Cosmeceuticals thiab Psoriasis

Qee cov kab mob ntawm daim tawv nqaij ua rau muaj kev hem thawj rau lub neej zoo ntawm cov neeg mob. Ib qho teeb meem zoo li no yog psoriasis uas yog ib qho kev mob ntawm daim tawv nqaij mob uas tshwm sim los ntawm qhov liab liab, thiab khaus khaus, feem ntau ntawm lub hauv caug, lub luj tshib, pob tw, thiab tawv taub hau. Txawm hais tias muaj ntau cov tshuaj pleev, tshuaj pleev, thiab gels muaj nyob rau hauv kev ua lag luam los kho cov tsos mob ntawm psoriasis, qee qhov teeb meem feem ntau yog cov tshuaj lom neeg ua rau txo qis lawv txoj kev siv hauv kev kho mob. Txawm li cas los xij, lipid nanoparticles xws li SLNand NLC muaj peev xwm los txhim kho kev ua tau zoo thiab kev nyab xeeb ntawm cov khoom siv tshuaj pleev ib ce. Hauv kev tshawb fawb los ntawm Lin thiab cov neeg koom tes, kev sib xyaw ntawm calcipotriol thiab methotrexate tau thauj khoom hauv NLC los kawm txog nws cov txiaj ntsig hauv kev kho mob psoriasis [50]. Lub permeation profile ntawm txhua yam tshuaj ib leeg los yog nyob rau hauv lub koom haum tau soj ntsuam los ntawm kev siv cov tawv nqaij hyperproliferative raws li ib tug permeation barrier. Cov txiaj ntsig ntawm txoj kev tshawb fawb tau pom tias qhov permeation ntawm calcipotriol los ntawm NLC tau nce me ntsis hauv kev sib piv rau hydro-alcoholic gel siv los ua cov qauv siv, thaum tus nqi ntawm methotrexate permeated thoob plaws ntawm daim tawv nqaij yog ntau dua li piv rau kev tswj kev tsim.

4.4.Lipid Nanoparticles Raws li Tshuaj pleev ib ce/Cosmeceuticals thiab Atopic Dermatitis

Lwm qhov kev xav tsis zoo ntawm daim tawv nqaij uas ntev ntev thiab nyuaj rau kev kho yog atopic dermatitis uas yog ib qho mob rov qab los ntawm eczema yam ntxwv ntawm daim tawv nqaij mob [51. Rau kev kho mob atopic dermatitis, tacrolimus yog cov tshuaj tiv thaiv kab mob ntawm kev xaiv. Txawm li cas los xij, kev xa khoom hauv zos ntawm tacrolimus mus rau qhov chaw muaj tus kab mob nrog qhov tsawg kawg nkaus cov kev mob tshwm sim yog qhov nyuaj. Encapsulating tacrolimus nyob rau hauv lipid nanoparticles tuaj yeem ua pov thawj cog lus hauv kev kho qhov kev txiav txim nrog kev txo cov tshuaj lom ntau. Nyob rau hauv ib txoj kev tshawb fawb los ntawm Pople thiab cov neeg ua hauj lwm tacrolimus-loaded lipid nanoparticles tau tsim thiab soj ntsuam rau lub hom phiaj thiab localized xa cov tshuaj nyob rau hauv txawv daim tawv nqaij lavers [52]. Cov txiaj ntsig ntawm kev tshawb fawb hauv vitro pom tau tias muaj kev tso tshuaj ntau ntxiv, kev nkag mus rau ntawm daim tawv nqaij, thiab daim tawv nqaij txuam nrog piv nrog cov khoom lag luam. Txoj kev tshawb no yog pov thawj ntawm kev ncav cuag ntawm tacrolimus mus rau qhov tob ntawm daim tawv nqaij qhov twg cov hlwb tshwj xeeb, lav ris rau lub immunopathogenesis ntawm atopic dermatitis, feem ntau nyob ntawm lipid nanoparticles.

4.5.Lwm cov kev siv tshwj xeeb ntawm Lipid

Nanoparticles Raws li Tshuaj pleev ib ce/Cosmeceuticals Tam sim no, kev kho cov plaub hau poob tau txais kev saib xyuas loj thiab tau muab thaj chaw tshawb fawb rau cov kws tshawb fawb ua haujlwm. Lipid nanoparticles tau sim los ntawm ntau tus kws tshawb fawb kom tau txais txiaj ntsig zoo. Nws yog qhov tsim nyog tias minoxidil, uas yog ib qho tshuaj tiv thaiv kab mob ua rau muaj txiaj ntsig zoo rau cov plaub hau kev loj hlob. Txawm li cas los xij, qhov kev txwv loj nrog minoxidil yog qhov liab lossis khaus hauv thaj chaw kho. Tsis tas li ntawd, cov dej cawv muaj nyob rau hauv cov tshuaj pleev ib ce ua rau kom qhuav ntawm tawv taub hau thiab dandruff. Txhawm rau daws qhov teeb meem no Silva thiab cov neeg ua haujlwm ua haujlwm tau tsim cov minoxidil-encapsulated NLC kom txo qis cov tshuaj pleev ib ce ntawm cov dej cawv[53]. Cov qauv tsim tau ua pov thawj tias muaj kev nyab xeeb thiab muaj txiaj ntsig zoo rau kev daws cov tshuaj cawv. Tsis ntev los no Padois thiab cov neeg koom tes tau tsim minoxidil-encapsulated SLN thiab xaus lus tias qhov kev tshem tawm SLN tau tsim muaj kev nkag mus tau zoo dua thiab tsis yog corrosive hauv qhov sib piv rau cov khoom lag luam [54].

5. Kev tshawb fawb niaj hnub qhia txog lub luag haujlwm ntawm Lipid Nanoparticles Raws li kev tsim kho cov khoom siv tshuaj pleev ib ce/Cosmeceutical

Txoj hauv kev zoo rau kev kho cov tawv nqaij mob xws li pob txuv, psoriasis, thiab atopic dermatitis yog tsim los ntawm cov tshuaj tua kab mob lossis cov tshuaj steroids thauj khoom ua tus neeg sawv cev kho mob hauv cov khoom kom zoo nkauj. Muaj tseeb tiag, cov tshuaj hluavtaws hauv cov khoom siv tshuaj pleev ib ce yog nrog los ntawm cov kev mob tshwm sim hnyav thiab txwv tsis pub tus neeg mob ua raws. Niaj hnub no tshwj xeeb yog tau txais kev saib xyuas tshwj xeeb rau kev siv cov tshuaj kho tus neeg sawv cev hauv lipid nanoparticles-based cosmetic khoom [55]. Txoj hauv kev ntawm kev kho mob ntawm daim tawv nqaij thiab txhim kho daim tawv nqaij noj qab haus huv thiab rov hais dua siv tshuaj ntsuab los yog ib txwm muab cov khoom xyaw hauv lipid nanoparticles-based cosmetic khoom tuaj yeem hu ua bio-cosmo-therapy. Kev mob siab rau yog ua los ntawm cov kws tshawb fawb thoob ntiaj teb los tsim cov khoom lag luam kom zoo nkauj raws li bio-cosmo-therapy.

Vero tsis ntev los no Arsenie thiab cov neeg ua haujlwm sib koom ua ke tsim NLCformulation nrog kev ua tau zoo

thauj khoom ntawm peb bio-actives, azelaic acid, dawb willow bark extract, thiab panthenol los txhim kho daim tawv nqaij hydration thiab antioxidant kev ua. Cov qauv tsim NLC tau txhim kho kev tsim kho ntawm cov hlwb epidermal thiab txo qis hemolysis. Kev sib koom ua ke ntawm tsim NLC rau hauv Carbopol gel stemmed los ntawm kev tsim kho kom zoo nkauj zoo nkauj nrog cov nyhuv dej ntau heev. Kev tshawb fawb ua haujlwm tau los nrog cov tshiab bio-cosmo-therapy-based NLC cov tshuaj pleev ib ce rau ob daim ntawv thov hauv pob txuv thiab atopic dermatitis [55].

Hauv kev kho pob txuv, retinol thiab retinoids ua lub luag haujlwm tseem ceeb, txawm li cas los xij, ua kom lawv cov duab tsis zoo hauv kev npaj kom zoo nkauj yog qhov nyuaj. Hauv kev tshawb fawb, Tretinoin-loaded SLN-raws li gels tau tsim los ntawm Mandawgade thiab cov neeg ua haujlwm nrog cov purified qib stearine tau los ntawm cov txiv hmab txiv ntoo kernel rog [56]. Lawv tau tsim ib qho qauv uas nthuav tawm txo cov tawv nqaij khaus, zoo ntawm daim tawv nqaij sib xws, txhim kho occlusive nyhuv, thiab tso tawm cov khoom xyaw nquag thiab yog li ua pov thawj zoo dua cov tshuaj pleev ib ce rau kev kho pob txuv hauv kev sib piv rau cov khoom lag luam [57]. Tsis tas li ntawd, tag nrho-trans retinoic acid (ATRA)-loaded SLN tsim los ntawm Castro thiab cov koom haum siv glyceryl behenate li cov lipids tau pom tias muaj cov txiaj ntsig comedolytic piv rau cov khoom lag luam muaj. Txawm li cas los xij, qhov kev tshawb pom tseem ceeb ntawm txoj kev tshawb fawb yog tias cov qauv tsim tau tuaj yeem txo qis ATRA-induced tawv nqaij khaus uas yog qhov teeb meem loj ntawm cov khoom lag luam muag.

Psoralen yog ib txwm tshwm sim furocoumarin hauv cov noob ntawm Psoralea corylifolia thiab feem ntau siv los kho Psoriasis. Hauv kev tshawb fawb, Fang thiab cov neeg koom tes tau tshawb xyuas qhov kev nqus ntawm percutaneous ntawm psoralen derivatives los ntawm SLN thiab NLC los ntawm kev siv cov tawv nqaij nas ua ib daim nyias nyias [58]. Txoj kev tshawb nrhiav pom tau pom tias muaj kev txhim kho permeation thiab tswj kev tso tawm psoralen xa los ntawm NLC. Tsis tas li ntawd, acitretin yog lwm cov tshuaj ntsuab siv dav hauv kev kho mob hnyav ntawm psoriasis. Agrawal thiab cov neeg ua haujlwm ua haujlwm tau npaj cov acitretin-loaded NLC uas yog ntxiv rau hauv gel puag [59]. Cov txiaj ntsig ntawm txoj kev tshawb fawb tau pom tias muaj kev tso tawm ntau ntawm acitretin hauv tib neeg cov tawv nqaij cadaver los ntawm acitretin-NLC gel hauv kev sib piv rau cov ntaub ntawv siv gel. Txoj kev tshawb fawb soj ntsuam tau lees paub qhov kev txhim kho zoo kawg nkaus hauv kev kho cov lus teb nrog rau kev txo qis hauv cov tshuaj lom los ntawm acitretin-NLC-gel.

Hauv kev kawm nthuav dav los ntawm Lacatusu thiab cov koom tes, NLC-based hydrogel tau tsim los ntawm phytochemicals- zaub ntug hauv paus extract thiab marigold extract muaj txiaj ntsig zoo rau kev noj qab haus huv [60]. Cov txiaj ntsig ntawm txoj kev tshawb fawb tau tsim kom muaj txiaj ntsig zoo kho tau zoo vim yog cov tshuaj tiv thaiv kab mob antioxidant, tiv thaiv kab mob, thiab tiv thaiv pob txuv, nrog rau qhov tsis muaj qhov tshwm sim tsis zoo. Tsis tas li ntawd, cov qib ntawm daim tawv nqaij hydration thiab elasticity tau txhim kho zoo los ntawm kev siv cov phytochemical-loaded NLC hydrogel.

Hauv kev tshawb fawb tsis ntev los no los ntawm Masiero thiab cov neeg koom tes, nws tau pom tias lipid nanoparticles uas muaj cov roj zaub muaj txiaj ntsig zoo dua piv rau kev kho kev lag luam, uas qhia txog lawv txoj kev cog lus siv cov khoom pleev xim rau kev kho mob ntawm daim tawv nqaij nrog kev nyab xeeb thiab zoo dua [61] .cistanche genghis khanCov kev tshawb fawb zoo li no txhawb kev lag luam tshuaj pleev ib ce los tsim cov lipid nanoparticles tshiab raws li bio-cosmo kho cov khoom uas tau txais txiaj ntsig zoo rau kev noj qab haus huv nrog rau kev kho mob sib xyaw (antioxidant, anti-inflammatory, thiab anti-pob txuv ua) thiab daim tawv nqaij rov hais dua (hydration thiab elasticity. ) kev cia siab. Qhov tseem ceeb tshaj plaws ntawm cov khoom zoo li no yuav ua kom tau txais kev kho kom zoo dua qub thiab rov hais dua ntawm daim tawv nqaij raws li kev nyab xeeb tag nrho.

6. Lub Sijhawm thiab Kev Sib Tw ntawm Lipid Nanoparticles Raws Li Cov Khoom Siv Tshuaj pleev ib ce Lub khw muag tshuaj pleev ib ce hu rau cov kev tshawb pom tshiab uas ua kom muaj kev nyab xeeb thiab ua tau zoo ntawm cov khoom tsim.

Cov lipid nanoparticles tsim cov khoom siv tshuaj pleev ib ce vehad lub luag haujlwm tseem ceeb rau kev nyab xeeb thiab txhim kho kev ua haujlwm. Cov txiaj ntsig tseem ceeb tshaj plaws cuam tshuam nrog lipid nanoparticles yog lub peev xwm los txhawb kev nkag mus ntawm cov khoom xyaw nquag rau hauv daim tawv nqaij augmenting kev kho mob. Lipid nanoparticles lub hom phiaj tseem ceeb ntawm cov kab mob epidermis thiab cov txheej txheem tob ntawm daim tawv nqaij los ntawm kev txwv kom tsis txhob muaj kev nqus ntawm lub cev thiab ua rau txo qis qhov cuam tshuam tsis zoo ntawm cov khoom xyaw lossis kev kho mob. Kev ua tiav biodegradation ntawm lipid nanoparticles tau khaws lawv qhov chaw tshwj xeeb thiab kev ntseeg siab nyob rau hauv plethora ntawm lwm cov txheej txheem nanoparticulate ntawm cov hlau los yog inorganic keeb kwm. Tsis tas li ntawd, lub peev xwm ntawm lipid nanoparticles nqa thiab tso tawm cov khoom xyaw hauv cov txheej txheem tob ntawm daim tawv nqaij tau ua rau muaj kev cia siab rau cov khoom siv tshuaj pleev ib ce / tshuaj pleev ib ce tshaj li tsuas yog adorning daim tawv nqaij.

Kev sib tw yav tom ntej ntawm lipid nanoparticles tsim cov tshuaj pleev ib ce tuaj yeem txhim kho kev noj qab haus huv ntawm daim tawv nqaij los ntawm kev daws teeb meem tseem ceeb ua haujlwm kom tau raws li qhov xav tau ntawm cov neeg siv khoom. Novel herbal raw khoom thiab excipients yuav tsum tau tshawb nrhiav kom tau raws li kev lag luam loj hlob. Nws yog ib qho tsim nyog yuav tau tshawb nrhiav qhov muaj peev xwm ntawm kev siv cov lipid matrices tshiab thiab surfactants uas tuaj yeem zam tau zoo dua. Kev xaiv dav dua ntawm cov khoom siv lipid tuaj yeem ntxiv dag zog rau kev tshawb fawb hauv cheeb tsam no. Kev teeb tsa ntawm cov txheej txheem tseem ceeb hauv kev lag luam yuav tsum tau ua kom yooj yim xws li cov tshuaj tsuag kom qhuav uas tsis siv los txog niaj hnub no thiab yuav tsum tau tshawb xyuas rau nws cov peev txheej tsis tau siv [20,21].

7. Cov lus xaus

Qhov xwm txheej tam sim no hu rau cov khoom lag luam kom zoo nkauj nyab xeeb, suav nrog cov khoom xyaw nquag thiab cov khoom siv ntxiv, thiab muaj cov kev kho mob cum beautifying daim ntaub ntawv. SLN, NLC, thiab liposomes yog cov muaj peev xwm lipid-based nanocarriers, lossis peb tuaj yeem hais cov cuab yeej, uas ua lub luag haujlwm tseem ceeb hauv kev txhim kho cov haujlwm ntawm bioactive thiab embellishing thov ntawm cov khoom kom zoo nkauj. Tsis tas li ntawd, kev siv cov khoom xyaw bioactive lossis kev kho mob ntawm cov hauv paus chiv keeb hauv kev npaj tshuaj pleev ib ce multiplies lub lag luam thiab kho tus nqi ntawm cov khoom kom zoo nkauj. Lub luag hauj lwm ntawm lipid nanoparticles-raws li tshuaj pleev ib ce / cosmeceuticals rau daim tawv nqaij daim ntawv thov siv cov khoom xyaw bioactive thiab cov nquag moiety ntawm hluavtaws / tshuaj ntsuab keeb kwm rau alleviating daim tawv nqaij mob yuav yog ib qho tseem ceeb rau cov neeg soj ntsuam ua hauj lwm nyob rau hauv cheeb tsam no. Cov kev nkag siab zoo li no rau lub peev xwm ntawm lipid nanoparticles-raws li tshuaj pleev ib ce / cosmeceuticals tsim nyog yuav tsum tau coj los ntawm cov chaw tshawb fawb me me mus rau theem kev lag luam loj tom qab kev soj ntsuam ntxiv rau nws txoj kev nyab xeeb thiab kev ua tau zoo.

Kab lus no yog muab rho tawm los ntawm Cosmetics 2021, 8, 84. https://doi.org/10.3390/cosmetics8030084 https://www.mdpi.com/journal/cosmetics