Pw Tsaug Zog Thiab Kev Tiv Thaiv Kev Sib Txuas Nrog Inflammatory Response Part 2

Cov kev hloov zoo sib xws tau pom txawm nyob hauv cov menyuam yaus, tsis hais poj niam txiv neej. Txawm li cas los xij, qhov cuam tshuam ntawm kev txo qis ntawm kev pw tsaug zog ntawm telomere ntev yuav yog qhov tsis ncaj, vim tias cov cytokines tuaj yeem ua rau lawv tus kheej muaj qhov cuam tshuam no.

Proinflammatory cytokines yog cov protein molecules uas ua rau cov lus teb inflammatory thiab ua lub luag haujlwm tseem ceeb hauv tib neeg lub cev tiv thaiv kab mob. Txawm hais tias proinflammatory cytokines tuaj yeem pib cov lus teb inflammatory, cov lus teb inflammatory kuj yog ib feem ntawm cov lus teb ib txwm ntawm lub cev.

Thaum lub cev muaj kab mob los yog raug mob, lub cev tiv thaiv kab mob tso tawm proinflammatory cytokines los ua kom cov lus teb inflammatory los tiv thaiv lub cev los ntawm kev puas tsuaj ntxiv thiab kev puas tsuaj. Tsis tas li ntawd, proinflammatory cytokines tseem tuaj yeem pab tswj hwm ntau lwm yam kev tiv thaiv kab mob, nrog rau kev txhim kho lub zog ntawm lub cev tiv thaiv kab mob thiab ua kom lawv muaj peev xwm tiv thaiv kab mob.

Txawm li cas los xij, yog tias proinflammatory cytokines raug tsim ntau dhau los yog ntev dhau lawm, nws yuav ua rau cov lus teb ntau dhau, uas yuav ua rau tib neeg noj qab haus huv. Piv txwv li, cov lus teb inflammatory ntau dhau yuav ua rau mob caj dab, lupus erythematosus, thiab lwm yam kab mob autoimmune, thiab tej zaum yuav ua rau muaj kab mob txaus ntshai xws li mob qog noj ntshav.

Yog li ntawd, nws tseem ceeb heev uas yuav tsum ua kom lub cev tiv thaiv kab mob sib npaug. Peb yuav tsum xyuam xim rau cov cwj pwm zoo xws li kev noj zaub mov, so ua haujlwm tsis tu ncua, thiab ua kom lub siab zoo siab los txhim kho peb txoj kev tiv thaiv thiab tiv thaiv cov lus teb ntau dhau los ntawm kev tsis zoo rau peb txoj kev noj qab haus huv. Tsis tas li ntawd, rau qee cov kab mob uas yuav tsum tau tswj lub cev tiv thaiv kab mob, xws li mob caj dab rheumatoid thiab lupus erythematosus, cov tshuaj kho tshwj xeeb tuaj yeem siv los tswj cov khoom tsim tawm ntawm cov cytokines. Nws tuaj yeem pom tias peb yuav tsum txhim kho kev nco, thiab Cistanche tuaj yeem txhim kho kev nco zoo vim tias nws muaj cov tshuaj tua kab mob antioxidant, tiv thaiv kab mob, thiab tiv thaiv kev laus, uas tuaj yeem pab txo qis oxidation thiab cov tshuaj tiv thaiv kab mob hauv lub hlwb, yog li tiv thaiv kev noj qab haus huv. paj hlwb. Tsis tas li ntawd, Cistanche tseem tuaj yeem txhawb kev loj hlob thiab kho cov paj hlwb, yog li txhim kho kev sib txuas thiab kev ua haujlwm ntawm neural networks. Cov teebmeem no tuaj yeem pab txhim kho kev nco, kev kawm muaj peev xwm, thiab kev xav nrawm, thiab tseem tuaj yeem tiv thaiv qhov tshwm sim ntawm kev paub tsis meej thiab cov kab mob neurodegenerative.

Nyem tam sim no kom nce lub zog nco

Muaj kev sib raug zoo ntawm kev ntsuas ntawm kev humoral thiab cellular tiv thaiv ntawm ib sab thiab pw tsaug zog ntawm lwm tus hauv cov pej xeem.

Kev txo qis hauv lub sijhawm pw tsaug zog li niaj zaus yog nrog los ntawm kev nce hauv cov ntsiab lus ntawm proinflammatory cytokines thiab CRP, uas ua rau muaj kev pheej hmoo ntawm kev tsim cov kab mob plawv thiab kev tuag. Lub sijhawm pw tsaug zog txaus tuaj yeem txiav txim siab rau cov kab mob sib kis.

Cov kev tshawb fawb qhia los ntawm Patel et al. [14] qhia tias luv (<5 h) nocturnal sleep was associated with an elevated (1.7-fold) risk of pneumonia in the next two years or the next few months. 

Lwm qhov kev sim nrog cov neeg ua haujlwm noj qab haus huv tau soj ntsuam qhov tshwm sim ntawm kev kis tus kab mob ua pa nyuaj (ARVD), nyob ntawm lub sijhawm pw tsaug zog.

Cov hluas tsaug zog<7 h (assessed subjectively) fell ill 2.9 times more frequently than those sleeping ≥8 h [15]. This experiment was subsequently repeated using actigraphy as a method for objective assessment of sleep duration. 

Qhov no tau txais txiaj ntsig tsawg dua - txawm tias cov neeg tsaug zog<5 h fell ill 4.2 times more frequently than those sleeping >7 h, pw tsaug zog nyob rau hauv thaj tsam ntawm 6-7 h tsis tau nrog ib qho kev nce ntxiv hauv kev pheej hmoo ntawm kev mob [16].

Kev sib raug zoo ntawm qhov tshwm sim ntawm cov kab mob sib kis (ARVD, mob npaws, mob plab) thiab lub sijhawm pw tsaug zog kuj pom nyob rau hauv cov tub ntxhais hluas. Ib qho qauv rau kev tshawb fawb txog cov teebmeem ntawm kev pw tsaug zog ntawm kev ntsuas kev tiv thaiv kev tiv thaiv kab mob tuaj yeem muab los ntawm kev sim tshuaj tiv thaiv ntawm cov neeg ua haujlwm noj qab haus huv uas muaj sijhawm pw tsaug zog sib txawv.

Thawj txoj kev tshawb fawb ntawm hom no tau hais txog qhov cuam tshuam ntawm kev pw tsaug zog ntawm kev tsim cov tshuaj tiv thaiv tshwj xeeb rau tus kab mob khaub thuas H1N1. Spiegel et al. [17] pom tias cov neeg mob uas ib txwm muaj (7-8 teev) pw tsaug zog muaj cov tshuaj tiv thaiv titers 2.5 npaug ntau dua li cov neeg tuaj yeem pw tau 4 teev rau rau hmo.

Cov kev tshawb fawb ntxiv tau pom tias txawm tias ib hmos ntawm kev pw tsaug zog ua rau txo qis hauv titers ntawm cov tshuaj tiv thaiv kab mob siab A thiab B thiab swine flu raws li [1].

Qhov zoo ntawm kev pw tsaug zog ntawm kev tsim ntawm kev tiv thaiv kev tiv thaiv yog txuas nrog cov kev cuam tshuam ntawm kev nce hauv proinflammatory cytokine thiab / lossis effector cell pejxeem tau tham saum toj no. Nyob rau hauv lub sij hawm ntev thiab loj contingents ntawm cov neeg mob, nce nyob rau hauv pw tsaug zog ntev kuj yog ib tug yeej muaj tswv yim nyob rau hauv ua kom cov kev ua tau zoo ntawm kev txhaj tshuaj.

Yog li, ib qho kev tshawb fawb qhia los ntawm Prathner li al. [18] nyob rau hauv ib pawg ntawm cov neeg mob uas tau txhaj peb koob tshuaj tiv thaiv kab mob siab B pom muaj kev sib raug zoo ntawm kev txhaj tshuaj tiv thaiv kab mob thiab lub sijhawm pw tsaug zog li niaj zaus.

The proportion of people attaining adequate protection as a result of vaccination (defined as a level of anti-HBs IgG ≥ 10 mIU/ml) was 3.5 times higher in the group of people sleeping >7 h dua cov pw tsaug zog<6 h. Researchers have explained better immunization associated with sleep primarily in terms of the anabolic effects of prolactin and somatotropic hormones. 

Tsis tas li ntawd, lub luag haujlwm tseem ceeb hauv kev txhawb nqa cov lus teb zoo dua yog ua los ntawm "mob txaus ntshai" kho ntawm cytokinesystem thaum pw tsaug zog. Besedovsky et al. [1] coj qhov kev xav tias muaj coob tus ntawm cov antigen-presentingcells thiab T-hlwb nyob rau hauv cov lymphoid lwm yam kabmob thaum lub sij hawm pw tsaug zog yuav muab ib tug zoo pauv ntawm cov ntaub ntawv nyob rau hauv lub tuaj antigen.

Qhov no suav nrog cov txheej txheem zoo sib xws rau kev nco txog kev sib koom ua ke hauv lub hlwb - uas ua haujlwm zoo dua hauv kev pw tsaug zog vim tias cov xwm txheej zoo rau nws raug tsim (detachmentfrom sab nraud stimuli thiab hom tshwj xeeb ntawm neuronal hluav taws xob ua haujlwm nyob rau hauv daim ntawv ntawm qeeb-yoj oscillations).

Nyob rau hauv rooj plaub no, cov xwm txheej muaj feem cuam tshuam nrog kev sib raug zoo nrog cov kab mob immunocompetent hauv cov lymphoidorgans theem nrab, cov kab mob proinflammatory cytokine, thiab cov txiaj ntsig zoo (anabolic) hormonal keeb kwm yav dhau.

Cov txiaj ntsig zoo ntawm qhov tshwj xeeb hormonal-neuronal "tuning" ntawm lub cev thaum pw tsaug zog tau txais kev txhawb nqa los ntawm cov ntaub ntawv qhia los ntawm Besedovsky li al.[19] los ntawm cov kev tshawb fawb uas tsim ib qho kev nce ntxiv hauv kev ua haujlwm qeeb qeeb hauv lub sijhawm qeeb-yoj pw tsaug zog, uas txo qis hauv cov cortisol concentration thiab txo qis ntawm cov lymphocytes (tshwj xeeb los ntawm cov kws sau ntawv vim lawv txoj kev tsiv teb tsaws mus rau cov lymphoidorgans theem nrab) yog pom.

Lwm txoj hauv kev rau kev siv pw tsaug zog ua ib qho immunomodulator suav nrog kev sim tshuaj xyuas qhov cuam tshuam ntawm kev pw tsaug zog thaum tsaus ntuj hauv tib neeg ntawm kev ntsuas ntawm cellular thiab humoral tiv thaiv, thiab tseem kawm txog qhov cuam tshuam ntawm kev pw tsaug zog ntev ntev ntawm cov kev ntsuas no.

Hauv kev tshawb fawb qhia los ntawm Chennaoui li al. [20], sijhawm pw tsaug zog hauv cov tub ntxhais hluas noj qab haus huv tau nce los ntawm 1.5 teev rau rau hmo, lees paub los ntawm cov ntaub ntawv polysomnography. Txawm li cas los xij, tsis muaj qhov hloov pauv tsis tseem ceeb ntawm cov ntshav peripheral lymphocytes, monocytes, thiab neutrophils thaum nruab hnub pw tsaug zog.

Ib txoj kev tshawb fawb qhia los ntawm Haack et al. [21] nyob rau hauv uas pw tsaug zog tau soj ntsuam los ntawm actigraphy, qhov twg qhov nce pib txo qis (mus rau 6 h ib hmo) pw tsaug zog ntev ua rau muaj kev txo qis hauv lymphocyte suav, CRP, thiab IL-6.

Cov txiaj ntsig tau txhawb nqa ntau dua tau txais los ntawm kev ntsuam xyuas ntawm ib hnub luv luv pw tsaug zog ntawm kev ntsuas kev tiv thaiv. Populationstudies tau pom tias qhov tshwm sim ntawm cov hnub luv luv (kev tshaj tawm tus kheej) tau cuam tshuam nrog nce CRP thiabIL-6 qib, piv txwv li, cov tshuaj proinflammatory [1]. Txawm li cas los xij, cov xwm txheej sim tsis tau tso cai rau kev ntsuam xyuas ntawm qhov kev coj ua ntawm kev ua txhaum.

Nws yog qhov tseeb tias qhov muaj nyob ntawm lub xeev kev noj qab haus huv nrog rau kev nce qib ntawm cov tshuaj no txhawb kev xav tau kev pw tsaug zog, vim tias kev tswj hwm ntawm IL-6 inexperimental qauv hauv cov tsiaj ua rau nce ntxiv hauv lub sijhawm qeeb- pw tsaug zog [1].

Kev pw tsaug zog nruab hnub hauv kev tswj xyuas tau pom tias muaj kev cuam tshuam zoo ntawm kev ntsuas kev tiv thaiv thaum pib txo qis ntawm keeb kwm ntawm kev pw tsaug zog. Forexample, kev tshawb fawb qhia los ntawm Vgontzas li al. [22] pom tias 2-h postprandial pw tsaug zog ua rau txo qis hauv IL-6 thiab cortisol concentrations.

Hauv ob qhov kev tshawb fawb ntxiv, kev ua haujlwm nruab hnub tom qab tseem ceeb (txog 2 h) kev cog lus ntawm lub sijhawm nocturnalsleep nrog kev txo qis hauv IL-6 qib thiab cov neutrophil suav [1].Pw tsaug zog thiab tiv thaiv kab mob.

Qhov tshwm sim ntawm kev pw tsaug zog tsis zoo yog nrog tsis yog los ntawm kev txo qis kev pw tsaug zog tab sis kuj los ntawm kev puas tsuaj ntawm nws qhov tsis zoo. Kev tshawb fawb qhia los ntawm Donners et al. [23] hauv Dutch cov tub ntxhais kawm siv daim ntawv nug txog kev pw tsaug zog pw tsaug zog -50 thiab kev ntsuas tus kheej.

Cov tub ntxhais kawm uas ntsuas lawv tus kheej li "frequentlyill" muaj qhov kev ntsuas tus kheej ntawm kev pw tsaug zog thiab cov qhab nia siab dua cov lus nug uas hais txog kev pw tsaug zog xws li insomnia, obstructive pw tsaug zog apnea syndrome, thiab circadianrhythm pw tsaug zog tsis meej.

Insomnia yog ib qho kev pw tsaug zog ntau, uas nyob rau hauv nws daim ntawv muaj feem xyuam rau tsawg kawg yog 6% ntawm cov pej xeem.Qhov tshwm sim txhua xyoo ntawm cov mob (lub sij hawm luv) ntawm insomnia yog 20% ​​[24].

Cov qauv ntawm insomnia suav nrog ntau yam kev puas tsuaj rau cov txheej txheem ntawm kev pw tsaug zog lossis nws txoj kev xav (yooj yim mus pw tom qab mus pw thaum yav tsaus ntuj los yog tom qab pw tsaug zog, nquag pw tsaug zog, pw tsaug zog, sawv ntxov sawv ntxov, pw tsis txaus).

Kev xav txog lub luag haujlwm ntawm kev pw tsaug zog hauv kev ua kom lub cev ua haujlwm ntawm lub cev tiv thaiv kab mob ua rau cov lus nug ntawm seb cov neeg mob insomnia puas muaj qhov txawv txav hauv lub cev lossis kev tiv thaiv kab mob.

Sib nrug los ntawm Dutch txoj kev tshawb fawb [23] tau sau tseg saum toj no, uas tau muab kev ntsuam xyuas ncaj qha ntawm lub cev tiv thaiv kab mob ua haujlwm, peb pom ib qho kev tshawb fawb ntsuas lub luag haujlwm ntawm kev pw tsaug zog hauv kev tsim kev tiv thaiv tshwj xeeb ntawm kev txhaj tshuaj tiv thaiv kab mob khaub thuas nrog cov tshuaj tiv thaiv trivalent.

Kev txhaj tshuaj tiv thaiv cov menyuam kawm ntawv uas muaj kev pw tsaug zog tau qis dua tom qab txhaj tshuaj tiv thaiv kab mob titers dua li cov uas tsis muaj kev pw tsaug zog [25]. Kev kho mob ntawm kev xaiv rau insomnia yog kev paub txog tus cwj pwm kev coj cwj pwm (CBT-I).

Qhov no yog ib qho kev qhia ntau yam qhia rau cov neeg mob txog cov ntsiab lus tseem ceeb ntawm cov txheej txheem ntawm lawv txoj kev pw tsaug zog thiab ua rau nws qhov kev puas tsuaj thiab tom qab ntawd ua cov kev sim coj cwj pwm raws li qhov kev paub dhau los.

Thaum kawg, qhov no zam kev ntseeg tsis zoo thiab txhim kho kev pw tsaug zog zoo. Standard CBT-I cov kev pab cuam muaj 6–8 lub rooj sib tham txhua lub lim tiam nrog tus kws tshaj lij tsim nyog. Cov kev tshawb fawb qhia los ntawm Irwin et al. [26] suav nrog CBT-I thiab ntsuas kev hloov pauv hauv IL-6, TNF- , thiab CRP qib.

Kev kho ntawm kev pw tsaug zog tsis zoo siv txoj kev no tau nrog los ntawm kev txo qis hauv txhua qhov kev mob tshwm sim nyob rau lub sijhawm ua raws ob lub hlis, qhov kev txhim kho tsuas yog txuas ntxiv mus rau 16 lub hlis ua CRP.

Cov kev tshawb fawb sau tseg tau pom tias txo qis hauv kev nthuav tawm cov noob rau cov tshuaj tiv thaiv kab mob humorals thaum kho, thaum qhov kev qhia ntawm genesin koom nrog tsim cov tshuaj interferons thiab cov tshuaj tiv thaiv tau nce.

Hauv lwm txoj kev tshawb fawb, CBT-I hauv cov poj niam uas muaj qog mis yog nrog los ntawm kev nce hauv lipopolysaccharide-inducedIL-1 thiab interferon ntau lawm. Hauv ob qhov kev soj ntsuam, kev txhim kho hauv kev pw tsaug zog thaum CBT-Kuv tau nrog los ntawm kev txo qis hauv kev ncig IL-1, CRP, thiab IL-18 (ib qho pro-inflammatory cytokine ntawm IL-1 tsev neeg) qib [1].

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