Pw Tsaug Zog Thiab Kev Tiv Thaiv Kev Sib Txuas Nrog Inflammatory Response Part 3

Ib txoj hauv kev thib peb los kho cov teeb meem pw tsaug zog hauv insomnia yog siv cov tshuaj melatonin receptor antagonists. Thepineal hormone melatonin muaj qhov tsis muaj zog GABAergic nkaus xwb, pom tsuas yog hauv kev sim ntawm knockout (tsis muaj qhov tshwj xeeb) tsiaj.

Nyem tam sim no txhawm rau txhim kho lub hlwb ua haujlwm

Insomnia yog hais txog cov tsos mob ntawm kev tsis tuaj yeem tsaug zog lossis tswj kev pw tsaug zog txaus. Nws tsis tsuas yog cuam tshuam rau peb lub siab thiab kev ua haujlwm tab sis kuj tuaj yeem ua rau lub cev tsis muaj zog. Yog li ntawd, peb yuav tsum coj txoj hauv kev zoo rau insomnia thiab siv cov kev tshawb fawb los txhawb kev pw tsaug zog zoo thiab txhim kho kev tiv thaiv.

Peb paub tias kev pw tsaug zog tseem ceeb heev rau lub cev. Nws tsis tsuas yog txhawb kev kho thiab rov ua haujlwm ntawm lub cev tab sis kuj txhim kho kev ua haujlwm ntawm lub cev. Qhov no yog vim tias thaum peb tsaug zog, peb lub cev zais qee cov tshuaj hormones tseem ceeb xws li cytokines los txhim kho kev ua haujlwm ntawm lub cev tiv thaiv kab mob. Nyob rau tib lub sijhawm, kev pw tsaug zog kuj tseem tuaj yeem pab lub cev tiv thaiv kev cuam tshuam ntawm cov kab mob hauv qhov chaw sab nraud thiab txhawb kev noj qab haus huv ntawm lub cev.

Txawm li cas los xij, thaum peb raug kev txom nyem los ntawm insomnia, qhov zoo thiab lub sij hawm ntawm kev pw tsaug zog yuav cuam tshuam. Qhov no tuaj yeem ua rau lub cev tsis muaj zog, ua rau peb muaj kev cuam tshuam ntau yam kab mob. Yog li ntawd, peb yuav tsum tau siv qee yam kev ntsuas los txhawb kev pw tsaug zog thiab txhim kho kev tiv thaiv.

Ua ntej, peb yuav tsum tswj kom muaj kev noj qab nyob zoo, xws li kev ua haujlwm tsis tu ncua thiab so, tswj lub sijhawm pw tsaug zog txaus thiab zoo, thiab tsis txhob coj tus cwj pwm phem xws li pw tsaug zog ntev ntev, kom lub cev tau so txaus thiab rov zoo.

Qhov thib ob, peb tuaj yeem siv qee txoj hauv kev los daws kev pw tsaug zog, xws li kev so so, ua pa tob tob, thiab lwm yam, los pab lub cev so thiab nkag mus rau hauv lub xeev ntsiag to, ua rau nws yooj yim dua tsaug zog.

Thaum kawg, yog tias insomnia hnyav dua, peb kuj tuaj yeem nrhiav kev pab kho mob, xws li sab laj nrog kws kho mob lossis noj tshuaj, pab peb daws teeb meem pw tsaug zog thiab txhim kho kev tiv thaiv.

Nyob rau hauv luv luv, insomnia pw tsaug zog mob yog ze ze rau kev tiv thaiv. Los ntawm kev siv txoj kev tshawb fawb thiab ua tau zoo, peb tuaj yeem tiv thaiv thiab kho insomnia, yog li txhim kho lub cev tiv thaiv kab mob thiab tswj lub neej noj qab haus huv thiab qab ntxiag. Nws tuaj yeem pom tau tias peb yuav tsum txhim kho kev nco, thiab Cistanche tuaj yeem txhim kho kev nco zoo vim Cistanche tuaj yeem tswj hwm qhov sib npaug ntawm cov neurotransmitters, xws li nce qib ntawm acetylcholine thiab kev loj hlob yam, uas tseem ceeb heev rau kev nco thiab kev kawm. Tsis tas li ntawd, Cistanche tseem tuaj yeem txhim kho cov ntshav khiav thiab txhawb nqa cov pa oxygen, uas tuaj yeem ua kom lub hlwb tau txais cov khoom noj txaus thiab lub zog, yog li txhim kho lub hlwb tseem ceeb thiab kev ua siab ntev.

Nws cov txiaj ntsig tseem ceeb yog hloov lub moos sab hauv los ntawm kev ua haujlwm ntawm cov receptors tshwj xeeb (MT1 thiab MT2) hauv suprachiasmatic nuclei ntawm hypothalamus. Ib qho melatonin formulation tam sim no muaj nyob rau hauv Russia yog Sonnovan (CanonpharmaProduction).

Cov teebmeem ntawm melatonin ntawm lub sijhawm pw tsaug zog, lub sijhawm pw tsaug zog, thiab kev pw tsaug zog zoo yog ntau dua li cov placebo thiab feem ntau pom tau tias yog cov neeg muaj hnub nyoog laus dua [30, 31].

Yog li, cov lus qhia thoob ntiaj teb rau kev kho mob insomnia ntev siv ntau txoj haujlwm ntawm qhov no. Cov lus qhia Asmeskas thiab European tsis suav nrog cov tshuaj melatonin rau kev kho mob insomnia [27, 28].

Cov lus qhia ntawm BritishAssociation for Psychopharmacology pom zoo melatonin rau kev pw tsaug zog tsis zoo rau cov neeg muaj hnub nyoog 55 xyoo [29].

Lub melatonin receptor agonist ramelteon muaj nyob rau hauv American cov lus qhia rau kev kho mob insomnia, txawm hais tias nws tsis suav nrog European cov lus qhia rau tib yam li suvorexant.

Kev siv melatonin receptor agonists rau kev kho mob insomnia ntev yog nrog los ntawm kev txo qis hauv CRP. Qhov no tau pom nyob rau hauv kev tshawb fawb txog kev ua tau zoo ntawm ramelteon qhia los ntawm Shimizu li al. [32].

Cov kws sau ntawv no tau piav qhia txog cov txiaj ntsig zoo ntawm ramelteon ntawm cov kab mob biomarkers tsis yog li ntawm kev txhim kho cov neeg mob pw tsaug zog zoo li immunomodulatory, tiv thaiv kev mob ntsws, thiab cov teebmeem antioxidant tshwm sim los ntawm kev txhawb nqa ntawm melatonin receptors.

Cov kev cuam tshuam ntawm melatonin yog kho feem ntau ntawm cov molecular (txoj kev uptake offree radicals - kev tshawb fawb pom tias ib qho melatonin molecule tuaj yeem txeeb tau txog 10 hom dawb radicals) thiab cellularlevels.

Melatonin muaj lub luag haujlwm hauv inhibiting zus tau tej cov proinflammatory cytokines thiab inflammatory prostaglandins thiab synthesis ntawm adhesion molecules, nrog rau kev txo qis cyclooxygenase -2 qhia hauv macrophages.

Melatonin tau pom tias muaj lub luag haujlwm hauv T-lymphocyteproliferation. Cov ntaub ntawv los ntawm kev tshuaj ntsuam meta los ntawm Zarezadeh li al.[33] qhia tias kev siv melatonin ua cov khoom noj ntxiv ntawm koob tshuaj 3-25 mg rau ob peb lub hlis yog nrog los ntawm kev txo qis hauv cov qib proinflammatory cytokines TNF- thiab IL-6 thiab qee zaum CRP. Cov kws sau ntawv ntawm qhov kev tshuaj ntsuam meta no tau xaus lus tias melatonin muaj txiaj ntsig zoo rau kev txo qis qhov mob qis qis.

Cov ntaub ntawv melatoninformulations feem ntau siv hauv kev kho mob feem ntau muaj 3 mg ntawm cov khoom xyaw nquag.

Kev mob siab rau cov cuab yeej tiv thaiv kab mob ntawm melatonin tau ua kom pom tseeb hauv keeb kwm yav dhau los ntawm COVID-19 kis mob - mob tshwm sim los ntawm tus mob coronavirus SARS-CoV-2.

Ib qho teeb meem loj thiab muaj peev xwm ua rau tuag taus ntawm COVID-19 yog kev txhim kho ntawm "cytokine cua daj cua dub" - cov tshuaj tiv thaiv ntawm innateimmunity system nyob rau hauv daim ntawv ntawm kev tswj tsis tau thiab tshaj tawm ntawm proinflammatory cytokines, tshwj xeeb tshaj yog TNF- thiab interferon-.

Qhov tshwm sim ntawm "cytokine cua daj cua dub" thiab oxidative kev nyuaj siab piav qhia txog kev txhim kho ntawm delirium hauv COVID-19 cov neeg mob, uas tshwm sim thaum kho mob hnyav. Cov txiaj ntsig tau los ntawm kev ntsuas ntawm Suav kev paub dhau los hauv kev tswj hwm cov neeg mob no qhia los ntawm Shang et al. [34] qhia txog kev siv cov tshuaj melatonin los tiv thaiv delirium.

Melatonin formulation Sonnovan muaj 3 mg ntawm melatonin. Indications rau tshuaj yog pw tsaug zog impairment thiab desynchronosis. Sonnovan kuj tseem siv los ua ib qho adaptogen rau kev hloov pauv hauv lub sijhawm. Cov tshuaj yog muab raws li ib ntsiav tshuaj 30–40 min ua ntej yuav mus pw.1 Xaus.

Yog li, tam sim no muaj pov thawj txaus hais tias lub xeev ntawm kev pw tsaug zog nws tus kheej, ntawm nws tus kheej ntawm kev ua haujlwm ntawm lub cev lub moos, txhawb kev txhim kho hauv kev ntsuas kev tiv thaiv kab mob.

Ib txwm pw tsaug zog tsis txaus yog nrog los ntawm kev hloov pauv hauv kev tiv thaiv kab mob, pom meej asincreases hauv proinflammatory cytokine qib. Cov txheej txheem no cuam tshuam nrog kev nce hauv morbidity thiab kev tuag.

Kev them nyiaj rau kev pw tsaug zog tsis txaus yog nrog los ntawm kev cuam tshuam nrog kev txhim kho hauv kev ntsuas ntawm lub cev tiv thaiv kab mob.

Kev kho ntawm kev pw tsaug zog tsis zoo hauv insomniausing nonpharmacological thiab pharmacological txoj kev yog nrog los ntawm kev txo qis hauv kev hloov pauv.

Kev siv cov tshuaj melatonin hauv kev pw tsaug zog tsis zoo nyob rau hauv cov ntsiab lus ntawm kev tiv thaiv kab mob muaj peev xwm cuam tshuam nrog kev txhim kho antioxidant thiab immunomodulatory teebmeem. Kab lus no tau npaj nrog kev txhawb nqa los ntawm Canonpharma Production.

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