Kev Tshawb Fawb Kev Kawm ntawm Suav Tshuaj Tiv Thaiv Hauv Mesenchymal Qia Cell Kev Laus

Lo lus tseem ceebmesenchymal qia hlwb;kev laus; Tsoos suav tshuajMesenchymal Qia hlwb (MSC) yog pluripotent qia hlwb derived los ntawm mesoderm uas tuaj yeem sib txawv rau ntau yam kev tsim nyog los hloov cov hlwb uas cov neeg puas. Cov ntaub so ntswg thiab cov hlwb muaj kev ua haujlwm ib txwm muaj thiab hompostasis ntawm lub cev. Txawm li cas los xij, MSCS lawv tus kheej kuj tau nyob rau hauv sencual. Wagner li al. [1] systematically tshaj tawm covKev laus tshwm sim ntawm MSCSThawj thawj zaug, taw qhia tias MSCS yuav dhau los ua Senpication, uas yog qhov muaj peev xwm nthuav dav thiab kev tsiv teb chaws, thiab -galactolipids. Nce glycosidase kev ua si, thiab lwm yam.

Cov tshuaj suav hauv Suav teb tshiab cistance ntsuab pab txhawb nqa

MSC Kev Laustsis yogtseem ceeb cuam tshuam rau lawv tus kheej cov kev ua haujlwm regenerative, tab sis kuj tseem ua rau txo qis hauv qia cell cov peev nyiaj, yog li txo lub cev muaj peev xwm kho cov ntaub so ntswg puas thiab ua kom nrawm duaTib neeg kev laus.Yog li ntawd, hauv kev tshawb fawb hauv qhov tob ntawm kev laus mechanism ntawm MSC yog qhov tseem ceeb hauv tsev kho mob.

Kev Tshawb Nrhiav Tam Sim No [2] qhia tau tias MSC kev laus me nyuam cuam tshuam nrog ntau txoj kev teeb tsa txoj hauv kev. Tsoos suav tshuaj muaj cov yam ntxwv ntawm ntau hom thiab ntau hom phiaj, antioxidant, anti-anti-antiamently msc laus [3]. nyob rau tam sim no
Feem ntau ntawm cov kev tshawb fawb txog cov khoom xyaw nquag ntawm cov tshuaj uas yog lub raum-toning los ntawm kev txhim kho cell ua haujlwm, anti-inflammatory, anti-inflammatory thiab lwm yam cuam tshuam thiab tswj cov kev qhia txog txoj moo zoo. Kab lus no ua kom lub ntsiab lus ntawm cov mechanism ntawm cov tshuaj tsoos Suav cuam tshuam nrog MSC kev laus kom muab lub hauv paus rau kev txhim kho kev siv dag zog tshiab.

1 MSC kev laus me nyuam yaus thiab koom nrog cov phiajcim txoj hauv kev

Cov kev tshawb fawb tam sim no [2] qhia tau tias MSC Aching Mechanism cuam tshuam nrog Telomeral tsis zoo, kev ntxhov siab ntawm oxidatas, thiab cov ensient illing distorders. Raws li tus naj npawb ntawm kev sib cais nce, MSC Telomeres yuav ua rau ntev tshaj plaws rau qhov tseem ceeb ntev, tabking DNA replication thiab ntxias kev laus DNA thiab ntxias. Nyob rau tib lub sijhawm, lub sij hawm ntev proliferating MSCS yuav poob lub peev xwm los paub thiab kho DNA kev puas tsuaj, exacerbating cov txheej txheem kev laus [4].
Kev rov kho dua tshiab, xws li kev txhim kho kev txhim kho, cov methylation, cov chromatin reaciemization, thiab txhawb nqa cov cuab yeej ntawm tes [5]. Senterescent cells senitrete sences-cuam tshuam cov lus zais, thiab matrix Metaloprores, thiab ua rau lub xov tooj ntawm lub cev loj hlob, thiab ua kom nrawm dua MSC Aging [6]. Refeattive oxygen hom (ros) tsim los ntawm oxidative kev puas tsuaj yuav ua rau DNA kev puas tsuaj thiab mitochondrial kawg, ncaj qha rau lossis ua kom nrawm rau kev laus [7]. Protein Annasterers tsis zoo, tshwj xeeb yog autophagy thiab ubiquittinction ua le kuj ua rau MSC kev laus ({}]. Hyperglycemia thiab cov roj ua kom muaj zog nrawm nrawm nrog MSC kev laus los ntawm kev paub txog kev ua kom zoo nkauj [{{}]. Cov txheej txheem no cuam tshuam thiab sib koom ua ke txhawb cov txheej txheem kev laus ntawm MSC.

Cov ntsiab lus saum toj no tau hais los ntawm kev sib txuam nrog kev sib txuam nrog ntau txoj kev teeb tsa. Daim Ntawv Qhia Txog P53 / P26 thiab P16 txoj kev nyob rau hauv kev ua si ntawm cov kev ua voj voog ntawm tes-teev ntawv, yog li thaiv lub voj voog ntawm tes. Ob qho tib si feem ntau siv raws li kev ntsuas kev laus ntawm kev laus. Lub sirtuin 1 (SIDD1) Cov kab txuas ntxiv inhibits lub P53 / P26 txoj hauv kev, nce kev puas tsuaj rau DNA, yog li ncua MSC Kev Laus [12]. Lwm tus neeg hauv tsev neeg, tus thawj coj ntawm tsev neeg, koom nrog Epigenetic cov kev cai los ntawm Deacetylation, tswj hwm cov kev ruaj khov ruaj khov, thiab tiv thaiv MSC poob [13]. Lub hom phiaj Mammalian ntawm RapamyCin (MTOR) txoj kev yog tswj hwm los ntawm cov protutsream factin Kinase B (AKT). Kev cuam tshuam ntawm Pi3k / AKT / MTOR Av tuaj yeem ua haujlwm rau lub neej kawm thiab txhim kho cov kev laus ntawm tes [8]. Ib puag ncig cov piam thaj zoo tuaj yeem ua kom lub mtor txoj hauv kev thiab cov lus tsis txaus ntseeg Cellenesc [10]. AMP-ua cov protein kinase (AMPK) tsis yog tswj hwm MTORDIVE

Silencing lub Ligand Ihh hauv Streethog kos npe rau txoj kev Basway tuaj yeem txo qhov kev zais cia ntawm MSCS thiab inhibit aging [16]. Lub insulin / insulin-xws li kev loj hlob kev loj hlob ntawm cov pob txha thiab txhawb nqa cov tshuaj insulin thiab cov tshuaj insulin - xws li nws tus receptor (iGFr) signaling [17]. Inhibition ntawm wnt / -catenin txoj kev tuaj yeem txo cov penotype [18], thaum overactivation txhawb nqa tiam thiab nrawm MSC Aging [19]. Tsis tas li ntawd, kev poob ntawm Wnt txoj hauv kev feem ntau nrog cov chromatin remerfeling thiab kev hloov kho qhov txawv txav, uas nyob rau hauv cov kev ua haujlwm ntawm MSCS [13]. Txo cov kev sib txuas lus ntawm Nuclear Erythroid {}}}}}}}}}} Kev ua kom muaj kev ua kom tau ntawm NRF2 txoj kev tuaj yeem thim kev laus thiab rov ua haujlwm ntawm tes kom muaj [7]. P38Mapk hauv mitogen-activated protein kinase (maptonin) txoj kev tuaj yeem tiv thaiv P53 / P38 MSCE MSBK GATWAY thiab RACC Aging [20]. Ua kom muaj kev cuam tshuam no nuclear Txawm li cas los xij, qee qhov kev tshawb fawb [21] tau pom tias nws txoj kev ua kom muaj peev xwm txhim kho cov kev qhia ntawm teloere-cuam tshuam txog noob caj dab tinf2 thiab ncua kev laus MSC. Lub Janus Kinase 2 / Kos npe ntawm cov kev sib sau ua ke 3 (Jak2 / Stat3) Txoj kev tuaj yeem tiv thaiv MSCONENT, thiab txhim kho kev tiv thaiv kev laus ntawm cov hlwb [23]. Qhov kev qhia ntawm yog-cuam tshuam cov protein (yap) thiab cov ntawv sib txuas nrog pdz khi motif (Taz) hauv Hippo txoj hauv kev txo qis hauv MSCS. Txhim kho yap kev ua haujlwm pab kho DNA kev puas tsuaj thiab qeeb hauv tes ntawm cov laus kev laus; Hloov siab, inhibiting yap qhia restores mitochondction thiab txhim kho MSC Aging [24]. MSC Aging Mechanism thiab kev teeb tsa txoj kev koom tes nrog muaj nyob hauv daim duab 1.