Kev Tshawb Fawb Kev Txhim Kho Ntawm Cov Nroj Tsuag Extracts Tawm Tsam Novel Coronavirus
May 17, 2023
Nroj tsuag rho tawm yog cov khoom ntuj tsim los ntawm kev tau txais ib lossis ntau cov khoom xyaw hauv cov nroj tsuag los ntawm kev siv lub cev thiab tshuaj. Nws daim ntawv thov teb yog dav heev, suav nrog zaub mov, tshuaj, pub, tshuaj pleev ib ce, thiab lwm yam.
Nyem rau cistanche tubulosa Australia rau kev tiv thaiv
Txij li cov nroj tsuag ntuj extracts muaj zog lom, xws li kev tiv thaiv kab mob, tiv thaiv kab mob, txhim kho cov antioxidant muaj peev xwm, tiv thaiv kab mob, thiab lwm yam. [1], kev tshawb fawb ntawm lawv cov nqi tshuaj kuj tau nyiam cov neeg tshawb fawb. Txij li thaum muaj tus kab mob tshiab coronavirus tshiab xyoo 2019, tseem muaj ob peb txoj kev kho mob zoo thiab paub zoo. Cov txiaj ntsig zoo kawg nkaus tau ua tiav hauv tsev thiab txawv teb chaws hauv kev tshawb fawb txog kev tiv thaiv thiab kev kho mob ntawm cov kab mob tshiab nrog cov nroj tsuag rho tawm. Cov hauv qab no yog kev tshawb fawb txog kev nce qib ntawm ntau cov nroj tsuag khaws cia los ntawm Absin ntawm cov txiaj ntsig ntawm inhibiting Covid-19
Stephaniacine tau siv rau kev sim tshuaj hauv kev kho mob me me mus rau nruab nrab tus kab mob tshiab coronavirus
Stephalin yog ib qho alkaloid ntawm Stephania vine thiab ib tug tswv cuab ntawm bisbenzylisoquinoline alkaloid tsev neeg. Ntau qhov kev tshawb fawb tau pom tias Stepherin tuaj yeem cuam tshuam kev kis tus kabmob tshiab [2]. Nws txoj haujlwm tiv thaiv tus kabmob coronavirus tau pom thawj zaug los ntawm Fan Huahao li al. [3], thiab tau ua tiav daim ntawv thov patent rau Lub Ob Hlis 16, 2020 "Siv Stephalin rau Kev Npaj Tshuaj Kho Mob Novel Coronavirus Infectious Diseases" [4]. Tom qab ntawd, ntau pab pawg tshawb fawb hauv tsev thiab txawv teb chaws tau tshawb pom thiab paub tseeb tias muaj txiaj ntsig zoo los tiv thaiv tus kabmob coronavirus ntawm Stephen. Piv txwv li, Ohashi et al. [5-6] hauv Nyij Pooj pom tias Stephaniacine muaj peev xwm tiv thaiv tus kabmob tshiab tau zoo dua li Remdesivir. Kev tshawb fawb los ntawm Mark Andrew White thiab al. [7] los ntawm University of Texas School of Medicine hauv Tebchaws Meskas tau qhia tias Stephen yog tus muaj peev xwm inhibitor ntawm SARS-CoV-2 Nsp13. Huang Ailong et al. [8] los ntawm Chongqing Medical University pom tias Stephanie tuaj yeem cuam tshuam S protein / ACE2-kev sib haum xeeb membrane fusion los ntawm kev tsom tus tswv tsev calcium ion channel, yog li thaiv kev nkag ntawm tus kabmob tshiab no rau hauv hlwb. Tsab ntawv luam tawm hauv Science los ntawm Nir Drayman li al. [9] los ntawm University of Chicago tau qhia tias kev ua haujlwm hauv vitro tiv thaiv tus kabmob coronavirus ntawm Stephalin yog ntau dua li ntawm cov khoom lag luam uas twb tau ua lag luam los tiv thaiv tus kabmob coronavirus thiab cov mosaic hauv qhov tsom mus rau hauv tsab xov xwm. Ni (Masitinib). Cov txiaj ntsig kev tshawb fawb ntawm pab pawg ntawm Tsinghua University thiab Peking Union Medical College tau qhia tias Stephanie tuaj yeem siv cov tshuaj tiv thaiv tus kabmob tshiab tshiab ntawm qhov qis dua, thiab muaj peev xwm kho tau tus nqi hauv kev tswj tus kabmob tshiab [10]. Tsis tas li ntawd, lub tuam txhab tshuaj Canadian PharmaDrug tau thov rau kev sim tshuaj ntsuam xyuas ntawm Stephanie hauv kev kho mob me me mus rau nruab nrab tus kab mob tshiab.
Quercetin tuaj yeem muaj lub luag haujlwm tseem ceeb tshaj plaws hauv kev tawm tsam tus kabmob tshiab
Nws paub zoo tias Lianhua Qingwen muaj cov txiaj ntsig kho mob rau cov mob ntsws tshiab. Forsythia, honeysuckle, ephedra (steamed), iab almond (kib), gypsum, Isatis cag, Mianma Guanzhong, Houttuynia cordata, patchouli, rhubarb, liab Muaj 13 tshuaj ntsuab suav nrog sedum, menthol, thiab licorice. Lub Peb Hlis 2020, Wang Lin [11] et al. soj ntsuam 22 cov ntsiab lus tseem ceeb raws li "degree" raws li "active ingredient-common target-pathway diagram". Sab saum toj 9 feem ntau suav nrog quercetin, luteolin, kaempferol phenol, sitosterol, naringenin, locust nyob rau hauv, aloe-emodin, wogonin, thiab genkwain, ntawm cov quercetin muaj cov qib siab tshaj plaws thiab cov hom phiaj loj tshaj plaws, qhia tias nws cov nyhuv yuav yog tseem ceeb tshaj plaws. Quercetin muaj cov tshuaj siv tshuaj xws li tshuaj tiv thaiv kab mob, tshuaj tiv thaiv kab mob, thiab kev tiv thaiv kab mob [12], thiab nws tseem yog cov khoom tseem ceeb ntawm Forsythia thiab Honeysuckle hauv Lianhua Qingwen.
Siav rhubarb tau siv nyob rau hauv cov tsoos suav tshuaj npaj rau kev kho mob tshiab coronary pneumonia
Thaum Lub Plaub Hlis 2021, Gu Shiping [13] tau luam tawm cov ntaub ntawv "Qhov cuam tshuam ntawm cov khoom lag luam sib txawv ntawm Rhubarb hauv Kev Kho Mob Tshiab Coronavirus Pneumonia", los ntawm kev txheeb xyuas qhov cuam tshuam ntawm cov khoom sib txawv ntawm rhubarb thiab lawv cov teebmeem ntawm ntau hom kab mob ntsws tshiab. , Lub luag haujlwm ntawm ntau theem ntawm kev kho mob, siv cov tshuaj suav tshuaj suav tshuaj los piav qhia lub luag haujlwm ntawm rhubarb feem ntau los ntawm kev tshem tawm, txhawb cov ntshav ncig thiab tshem tawm cov ntshav stasis kom ua tiav lub ntsws ncig, tswj tag nrho lub cev qi, thiab pab qi, ntshav thiab lub cev kua dej. kom faib thoob plaws hauv lub cev, tshem tawm cov dab phem thiab tawm mus, tswj kev ncaj ncees, kom tus kab mob yuav loj hlob mus rau kev coj rov qab. Tsis tas li ntawd, "Sancai Granule" (siav rhubarb) siv rau cov neeg mob nyob rau lub sijhawm rov qab los ntawm tus kabmob tshiab mob ntsws tau raug thov los ntawm pab pawg xibfwb Ba Yuanming ntawm Hubei Provincial Tsev Kho Mob ntawm Cov Tshuaj Suav Tshuaj nyob rau hauv kev taw qhia ntawm xibfwb Mei Guoqiang, a tus tswv ntawm cov tshuaj suav tshuaj suav tshuaj, dhau los ntawm kev sib tham hauv chaw kho mob thiab ntau xyoo ntawm kev kho mob. , ib qho tshuaj suav tshuaj npaj rau lub sijhawm rov qab los ntawm cov kab mob ntsws tshiab, thiab tau txais daim ntawv pov thawj Suav tshuaj thaum muaj xwm txheej ceev uas tau tso cai los ntawm Hubei Provincial Drug Administration rau lub sijhawm rov qab los ntawm tus kabmob tshiab kis mob ntsws rau lub Plaub Hlis 30, 2020 (Hubei Tshuaj Npaj. lo lus Z20200011).
Artesunate nquag tawm tsam tus kabmob tshiab no lossis tuaj yeem tiv taus qee yam kabmob sib kis
Ib tsab xov xwm hu ua "In vitro kev ua tau zoo ntawm artemisinin-raws li kev kho mob tawm tsam SARS-CoV-2" luam tawm nyob rau hauv Nature sub-journal Scientific Reports nyob rau lub Xya hli ntuj 21, 2021, qhia cov extracts ntawm Artemisia annua thiab artemisin-raws li kev kho mob hauv vitro inhibitory effects of succinate and artemether against SARS-CoV-2 [14]. Cov kev tshawb fawb tau pom tias tag nrho cov kev tshawb fawb extracts thiab cov tebchaw muaj peev xwm inhibit tus kab mob ntawm SARS-CoV-2 VeroE6 hlwb, tib neeg lub siab mob qog noj ntshav Huh7.5 hlwb, thiab tib neeg mob ntsws cancer A549-hACE2 hlwb, thiab lub cell. hom tsis muaj qhov cuam tshuam loj rau cov nyhuv antiviral. Ntawm lawv, artesunate muaj qhov zoo tshaj plaws inhibitory nyhuv, ua raws li artemether thiab artemisinin. Cov kws tshawb fawb tau hais tias yuav tsum muaj kev tshawb fawb soj ntsuam ntxiv txhawm rau ntsuas cov khoom sib xyaw ua ke rau kev kho mob rau COVID-19.
Cov tshuaj tsuag uas muaj tannic acid thiab tooj liab ions (Cu2 ntxiv) tuaj yeem tua tus kabmob tshiab
Thaum Lub Ob Hlis 8, 2022, Guo Junling pab neeg los ntawm Sichuan University, Zhang Xingcai pab neeg los ntawm Harvard University, thiab Cai Kun pab neeg los ntawm Hubei Center for Disease Control and Prevention tau luam tawm ib daim ntawv hu ua "Kev muab rov siv tau thiab SARS-CoV-2 inhibition zog rau tus qauv" nyob rau hauv phau ntawv Journal of Hazardous Materials, cov ntawv xov xwm saum toj kawg nkaus hauv thaj chaw ib puag ncig los ntawm cov hlau-organic nanocoatings" [15], lawv tau siv cov nyhuv synergistic ntawm tannic acid thiab tooj liab ions (Cu2 ntxiv) los tsim cov tshuaj tsuag uas tuaj yeem tua tau. Cov tshuaj tsuag no tuaj yeem ua kom tsis muaj menyuam thiab tua kab mob los ntawm tsuas yog txau ntawm lub elevator nyees khawm, qhov rooj tuav, rooj, faucets, thiab lwm qhov chaw pej xeem, thiab nws yuav tsis ua rau muaj tshuaj lom lossis muaj kev phiv rau tib neeg lub cev. Lub npog ntsej muag tuaj yeem tsim Nano-txheej, uas tuaj yeem ua rau lub ntsej muag muaj kuab paug thiab muaj peev xwm ua tau ib puag ncig kev ua kom muaj kuab paug. Qhov project tau txais kev txhawb nqa los ntawm National Natural Science Foundation ntawm Tuam Tshoj, National " Ob Chav First-Class" cov nyiaj siv rau kev qhuab qhia tseem ceeb, Lub Xeev Lub Chaw Haujlwm Tseem Ceeb ntawm Polymer Materials Engineering, National Postdoctoral Fund, thiab Sichuan Postdoctoral Research thiab Development Fund.
Tripterygium liposomes tej zaum yuav ua tau zoo hauv kev kho mob hnyav COVID-19 mob ua pa
Thaum Lub Kaum Ob Hlis 24, 2022, Wei Xiawei pab pawg los ntawm Sichuan University tau luam tawm ib daim ntawv "Tripterin liposome relieves mob hnyav ua pa ua pa uas muaj peev xwm tiv thaiv COVID-19 kev kho mob" ntawm Kev Hloov Pauv thiab Kev Kho Mob (IF=38). Nws yog ib qho tshuaj zoo rau kev kho mob ntawm COVID-19 thiab tuaj yeem txo qhov mob ua pa nyuaj [16]. Lawv tau siv tib neeg ACE2 transgenic (hACE2) nas, ob tus qauv hnyav ntawm tus kabmob tshiab mob ntsws, los tshuaj xyuas cov txiaj ntsig ntawm tripterine lipid ntawm lub ntsws tiv thaiv kab mob. Cov txiaj ntsig tau pom tias tripterine liposomes inhibited SARS-CoV-2 replication thiab ntau dhau inflammatory teb nyob rau hauv cov kab mob thiab cov nas, qhia tias tripterine liposomes yog cov neeg sib tw rau kev kho mob ntawm SARS-CoV{11}}induced ARDS tshuaj.
Kawm txog cov yam ntxwv hauv vitro thiab hauv vivo ntawm tripterine (TP) liposomes (daim duab qhov chaw: Teeb liab Transduction thiab Targeted Therapy)
Los ntawm cov ntaub ntawv tshawb fawb saum toj no, nws tuaj yeem pom tias cov nroj tsuag rho tawm muaj peev xwm zoo hauv kev tshawb fawb ntawm cov tshuaj tshiab tus mob coronavirus. Nyob rau lub sijhawm muaj kev kis tus kabmob tshiab sai sai, kev hloov pauv tshiab thiab kev tiv thaiv lub sijhawm luv luv tawm tsam qhov ua tau zoo ntawm cov tshuaj tiv thaiv, yog li kev nrhiav tshuaj tiv thaiv kab mob thiab tshuaj tiv thaiv kab mob tseem ceeb heev. Peb lub teb chaws thiab pab pawg tshawb fawb tau ua haujlwm tsis tu ncua los yeej kev tawm tsam kev sib kis, thiab peb cov neeg ua haujlwm kho mob kuj tseem tawm tsam hnub thiab hmo ntuj ntawm qhov ua ntej ntawm kev tawm tsam kev sib kis. Ua ntej cov tshuaj tshwj xeeb rau tus kabmob tshiab no muaj nyob rau hauv kev ua lag luam, peb yuav tsum muaj cov khoom noj muaj txiaj ntsig zoo, txhim kho peb cov kev tiv thaiv, thiab tiv thaiv tus kheej zoo, ntseeg ruaj khov tias qhov kaj ntug ntawm kev yeej yuav los txog thaum kawg.
Cistanche txhim kho kev tiv thaiv li cas?
Cistanche yog ib hom tshuaj suav tshuaj uas tau siv ntau pua xyoo los txhim kho kev tiv thaiv kab mob. Nws muaj ntau yam sib xyaw ua ke, suav nrog echinacoside, acteoside, thiab phenylethanoid glycosides, uas tau pom los txhim kho lub cev tiv thaiv kab mob. Cistanche ua haujlwm los ntawm kev txhawb kev tsim cov qe ntshav dawb, uas yog lub luag haujlwm rau kev tawm tsam cov kab mob thiab cov neeg txawv teb chaws invaders hauv lub cev. Nws kuj tseem pab ua kom lub cev tiv thaiv kab mob, xws li macrophages thiab T-cells, uas ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kab mob. Ntxiv mus, Cistanche muaj cov tshuaj antioxidant uas tiv thaiv lub cev tiv thaiv kab mob los ntawm kev puas tsuaj los ntawm cov dawb radicals. Nws kuj muaj cov tshuaj tiv thaiv kab mob uas pab txo qhov mob thiab ntxiv dag zog rau lub cev tiv thaiv kab mob. Zuag qhia tag nrho, Cistanche yog cov tshuaj ntsuab muaj zog uas tuaj yeem txhim kho kev tiv thaiv kab mob los ntawm kev txhawb nqa kev tsim khoom thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob, tiv thaiv oxidative kev nyuaj siab, thiab txo qhov mob.
