Kev Tshawb Fawb Txog Kev Tshawb Fawb Hauv Kev Tshawb Fawb Ntawm Cov Tshuaj Suav Tshuaj Ntsuab Tshuaj Extracts Regulating Ferroptosis Yog li txhim kho Cov tsos mob ntawm Alzheimer's Disease Ⅲ

6 Cov ntsiab lus thiab Outlook

Qee cov ferroptosis tshwj xeeb inhibitors tau pom tias muaj txiaj ntsig zoo hauv kev sim tshuaj, txhua tus tau txhim kho AD mus rau qhov sib txawv.Cov neeg sawv cev hlau ion chelators, zoo liDeferoxamine (DFO)[79], tuaj yeem txhim kho kev kawm thiab kev nco muaj peev xwm ntawm AD tsiaj qauv los ntawm kev tswj hwm intranasal. Nws txoj kev ua haujlwm yuav ua tiav los ntawm kev ncaj qha hlau chelation, ua kom HIF-1 , lossis inactivation ntawm GSK-3 los ntawm phosphorylation. Lwm tus neeg sawv cev ferroptosis inhibitor, xws li ferrostatin-1 (Fer-1), tuaj yeem tiv thaiv kev tsim cov cytoplasmic thiab lipid ROS thiab inhibit oxidative toxicity los tiv thaiv HT-22 hlwb. Txawm hais tias tam sim no cov tshuaj no muaj qee yam kev kho mob hauv kev kho mob ntawm AD, raws li cov tshuaj hluavtaws tshiab, lawv cov kev ua tau zoo mus ntev thiab kev ruaj ntseg pharmacodynamic tseem tsis paub meej. Lawv lub hom phiaj tshwj xeeb thiab cov txheej txheem koom nrog hauv AD ferroptosis tseem yuav tsum tau txhim kho. Tsis tas li ntawd, kev soj ntsuam mus sij hawm ntev yog xav tau los txiav txim seb lawv puas yuav rhuav tshem cov hlau tseem ceeb ntawm lub cev muaj zog hauv cov hlwb thiab seb lawv puas tseem yuav muaj kev nyab xeeb thiab ua haujlwm tau zoo nyob rau hauv rooj plaub ntawm AD nrog rau lwm yam kab mob.

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Tsis tas li ntawd, kev siv qee cov tshuaj suav tshuaj suav tshuaj tau koom nrog kev tswj hwm ferroptosis thiab txhim kho AD cov tsos mob.Icariin-astragaloside-puerarin (YHG)mix [80], uazoo monomers ntawm epimediumastragalus thiab pueraria,tuaj yeem txhim kho kev kawm thiab kev nco muaj peev xwm ntawm APP / PS1 nas, txo cov deposition ntawm senile plaques nyob rau hauv lub hlwb, thiab txo cov neuronal ferroptosis los ntawm kev txhim kho ferroptosis amino acid metabolism txoj kev thiab txhim kho antioxidant muaj peev xwm. Suanzaoren decoction [81] tautxo ferroptosisthiabtxhim kho kev paub tsis meej hauv ADcov nas los ntawm kev ua kom DJ-1/Nrf2 taw qhia txoj hauv kev thiab txo qis A deposition, neuronal poob thiab synaptic puas hauv AD nas. Piv nrog rau ib qho tshuaj suav tshuaj suav tshuaj ib txwm muaj, kev siv tshuaj kho mob ntawm cov tshuaj sib xyaw ua haujlwm nyuaj los xyuas kom meej cov txiaj ntsig ntawm cov tshuaj concentration thiab kev yooj yim ntawm kev tswj hwm. Tam sim no, feem ntau cov kev tshawb fawb soj ntsuam tsom rau cov txheej txheem ntawm kev ua ntawm ib qho tshuaj ntsuab thiab lawv cov khoom xyaw tseem ceeb hauv AD, thiab tsis muaj kev tshawb fawb me me ntawm cov ntawv sau tshuaj, xws li cov khoom siv hauv paus ntawm kev ua tau zoo, kev tshuaj xyuas cov tshuaj metabolic thiab qhov tob. kev tshawb nrhiav mechanism hauv AD. Kev tshawb fawb soj ntsuam tam sim no tsom mus rau kev soj ntsuam kev ua tau zoo ntawm ib tus kab mob neurological, nrog kev tshawb fawb tsawg dua ntawm cov txheej txheem sib sib zog nqus thiab tsis muaj qhov loj, ntau qhov chaw, qhov zoo tshaj plaws randomized tswj kev sim.

Hlau yog cov hlau ntau tshaj plaws nyob rau hauv tib neeg lub hlwb thiab cov khoom tseem ceeb rau kev tswj cov metabolism hauv tib neeg thiab kev ua neej nyob. Nws cov tsub zuj zuj ntau hauv lub hlwb tuaj yeem ua rau ferroptosis ntxiv. Ferroptosis nyob rau hauv lub hlwb ntawm cov neeg mob AD tau ua kom pom tseeb ntawm cov kws tshawb fawb hauv xyoo tas los no. Hauv cov hlwb uas muaj ferroptosis, ROS thiab lipids hauv cytoplasm nce ntxiv, nrog rau kev txo qis hauv mitochondrial ntim thiab nce hauv cell membrane ntom. Nws tsis yooj yim los nrhiav los ntawm cov kev tshawb fawb yav dhau los uas ferroptosis tuaj yeem ua lub luag haujlwm tseem ceeb hauv qhov tshwm sim thiab kev loj hlob ntawm AD. Txij li thaum cov kev tshawb fawb ntsig txog uas twb muaj lawm tseem nyob rau hauv nws cov me nyuam mos, yuav ua li cas txo ferroptosis tsis cuam tshuam nrog kev ua haujlwm ntawm lub cev ntawm cov hlau homeostasis yuav tsum tau tshawb nrhiav ntxiv ntawm qhov zoo tshaj plaws anti-ferroptosis lub hom phiaj nrog neuroprotection yav tom ntej. Yav dhau los, kev txhim kho tshuaj nrog A raws li lub hom phiaj kho tsis tau ua tiav hauv theem kev sim tshuaj. Ferroptosis, raws li lub hom phiaj tshiab, tau qhib kev taw qhia rau kev txhim kho tom ntej ntawm cov tshuaj kho mob AD tshiab. Tam sim no, txawm hais tias thawj kab kev kho mob ntawm cov tshuaj Western tuaj yeem txhim kho cov tsos mob ntawm AD mus rau qee qhov, qhov kev kho mob txawv ntawm ib tus neeg mus rau lwm tus, thiab nws tsis tuaj yeem txo thiab tiv thaiv kev puas tsuaj los ntawm AD, thiab tsis tuaj yeem thim rov qab. ntawm tus kab mob.

Tsis tas li ntawd, muaj teeb meem ntawm kev phiv tshuaj thiab tshuaj tiv thaiv, thiab kev kho mob tsis txaus siab. Nyob rau hauv cov ntsiab lus no, tsab xov xwm systematically qhia ib tug series ntawm Suav tshuaj uas kho AD los ntawm lub hom phiaj ferroptosis, xws li Rhodiola rosea, Polygala tenuifolia, Ginkgo biloba, Poria cocos, thiab lwm yam, uas qhia pom tseeb qhov zoo xws li kev ua tau zoo thiab kev tsis zoo me me thaum lub sij hawm. txoj kev kho mob. Nyob rau hauv lub neej yav tom ntej, cov kws tshawb fawb txog kev noj qab haus huv yuav tsum tau kawm txuas ntxiv mus ntxiv thiab txhim kho cov txheej txheem tseeb ntawm ferroptosis hauv pathogenesis ntawm AD, txhawb nqa cov kev soj ntsuam kuaj xyuas, thiab ua tiav cov kev tshawb fawb ntxiv txog kev cuam tshuam ntawm Suav cov tshuaj hauv kev tiv thaiv ferroptosis thiab kev kho mob. AD. Tsis tas li ntawd, feem ntau ntawm cov kev tshawb fawb ntawm anti-AD mechanism ntawm Suav tshuaj yog tseem nyob rau hauv vitro thiab tsiaj sim theem. Nyob rau hauv lub neej yav tom ntej, nws yog ib qho tsim nyog los tshawb nrhiav cov qauv kev sim ntawm TCM syndrome sib txawv thiab kev kho mob kom zoo dua cov yam ntxwv ntawm TCM.

Cov neeg sau kev koom tes: Pei Jinying tau tshaj tawm cov ntsiab lus tshawb fawb, xeeb thiab sau tsab xov xwm; Song Jinzhou thiab Ma Daofeng tau tshawb nrhiav thiab sau cov ntaub ntawv; Luo Xiaoting, Dong Xiaohong, thiab Cong Shuyuan tau kho daim ntawv; Liu Bin yog lub luag haujlwm rau kev tswj hwm thiab tshuaj xyuas ntawm tsab xov xwm, thiab yog lub luag haujlwm rau tsab xov xwm tag nrho.

Kev siv

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