Kev tshawb fawb nce qib hauv Daim Ntawv Thov Cistanche hauv Tshuaj pleev ib ce

Yog xav paub ntxiv:ali.ma@wecistanche.com

Hao Shanshan 1, Chen Sumei 2, Yan Donghai 1, Chen Mingxia 1, Han Yahui 1, Yi Bin1, 2

(1. Beijing Silian Pharmaceutical Co., Ltd., Beijing 102600; 2. Jianchangbang Pharmaceutical Co., Ltd., Fuzhou 344099, Jiangxi)

Abstract:Daim ntawv thov kev tshawb fawb nce qib ntawmCistanchehauv tshuaj pleev ib ce yog tshuaj xyuas. Cov khoom xyaw tseem ceeb ntawm Cistanche tau qhia, suav nrog phenethyl cawv glycosides, polysaccharides, thiab lwm yam.

Thiab los ntawm kev tshuaj xyuas ntawm cov khoom xyaw tseem ceeb ntawm Cistanche nyob rau hauv ntau hom, sib txawv ntau lawm cheeb tsam, sib txawv lub sij hawm sau qoob, thiab sib txawv hosts, qhov sib txawv ntawm cov khoom xyaw tseem ceeb ntawmCistancheraws li cov xwm txheej sib txawv tau qhia meej. Kev tsom mus rau kev zoo nkauj thiab kev tu tawv nqaij mechanism ntawm Cistanche thiab kev ua haujlwm ntawmCistanche hauv tshuaj pleev ib ce, suav nrog kev ntxuav hniav dawb, tiv thaiv kev laus, tiv thaiv tshav ntuj, tiv thaiv kab mob, thiab moisturizing. Daim ntawv thov xwm txheej ntawmCistanche hauv tshuaj pleev ib ceraw cov ntaub ntawv thiab tshuaj pleev ib ce nyob rau hauv xyoo tas los no tau piav qhia, thiab kev loj hlob tsis xws luag thiab kev tsis zoo nyob rau hauv daim ntawv thov ntawm Cistanche li cosmetic raw cov ntaub ntawv rau tshuaj pleev ib ce tau soj ntsuam. Thaum kawg, kev tshawb fawb yav tom ntej ntawm Cistanche hauv kev lag luam tshuaj pleev ib ce yog taw qhia.

Ntsiab lus: tshuaj pleev ib ce; Cistanche; daim ntawv thov

Suav Tsev Qiv Ntawv Tus lej: TQ658 Cov Ntaub Ntawv Qhia Tus Kheej Code: Ib Tshooj Naj Npawb: 1006-7264 (2021) 09-036-06

DOI: 10.3969/j.issn.1006-7264.2021.09.009

Cistanchetau siv nyob rau hauv kuv lub teb chaws rau ntau tshaj ob txhiab xyoo. Nws tau luam tawm thawj zaug hauv "Shen Nong's Materia Medica" thiab tau teev npe raws li qib siab tshaj plaws. Nws saj yog qab zib, salty, thiab sov. Nws yog lub npe hu ua "suab puam ginseng" thiab "Suav fairy nyom" [1]. Cistanche yog nplua nuj nyob rau hauv ntau yam khoom xyaw nquag thiab muaj kev noj qab haus huv thiab kev zoo nkauj. Cov ntaub ntawv qub ntawm Cistanche ntawm kev saib xyuas kev noj qab haus huv thiab kev zoo nkauj muaj xws li: "Kev ua haujlwm ntev ntev", "moisturizing tsib lub hauv nruab nrog cev, cov nqaij ntshiv loj", "kev pab rau cov pob txha, cov xim zoo nkauj, ua kom lub neej ntev", "replenishing the essence of lub cev, lub ntsej muag dub, straining" thiab lwm yam. Nyob rau hauv xyoo tas los no, txoj kev loj hlob thiab kev siv ntawm Cistanche nyob rau hauv cov tshuaj pleev ib ce tau maj mam ua. Cov kev tshawb fawb ntsig txog kev tshawb fawb tau pom tias nws muaj cov txiaj ntsig zoo hauv kev ntxuav hniav dawb, tiv thaiv kev laus, tiv thaiv tshav ntuj, tiv thaiv kab mob, tiv thaiv kab mob, moisturizing, thiab tiv thaiv hluav taws xob. Kab lus no tshuaj xyuas cov khoom xyaw tseem ceeb ntawm Cistanche, nws txoj kev zoo nkauj thiab kev tu tawv nqaij, nws txoj kev ua tau zoo hauv cov tshuaj pleev ib ce, thiab nws daim ntawv thov raws li txoj cai, thiab muab lub hauv paus rau kev siv ntxiv ntawm Cistanche hauv tshuaj pleev ib ce.

Nyem rauCistanche rau cov khoom tu tawv nqaij thiab cistanche tubulosa ntau npaum

1 Cov khoom xyaw tseem ceeb ntawm Cistanche

Cov khoom xyaw nquag ntawm covCistanchesuab puam muaj ob qho tib si volatile Cheebtsam thiab ntau tshaj 100 yam uas tsis yog-volatile Cheebtsam uas tau raug rho tawm, xws li phenethyl glycosides, polysaccharides, oligosaccharides, lignans, iridoids, flavonoids, alkaloids, Amino acids, kab kawm, thiab lwm yam. Phenycharaccharides mainly glycosides yog polysaccharides. Cov khoom xyaw uas tau kawm hauv qhov tob thiab muaj qhov tseem ceeb hauv kev tiv thaiv neuroprotection, kev tiv thaiv kab mob, tiv thaiv oxidation, thiab lwm yam tshuaj muaj txiaj ntsig [1]. Tam sim no, 70 phenylethanoid tag nrho glycosides tau raug cais tawm ntawm Cistanche, cov uasechinacoside thiab verbascosideyog cov tseem ceeb phenethanol glycoside tebchaw los ntsuas tus qauv zoo ntawm Cistanche [2]. Cov qauv qauv ntawmechinacoside thiab verbascosidemuaj nyob hauv daim duab 1. Cov polysaccharides cais tawm ntawm Cistanche suav nrog cistan A, CDA-1A, CDA-3B, CDP-4, ACDP-2, SPA, thiab lwm yam, Feem ntau muaj cov piam thaj, galactose, rhamnose, arabinose, fructose, thiab lwm yam monosaccharides [3]. Cov kev tshawb fawb tau pom tias yam xws li cov tsiaj sib txawv thiab cov keeb kwm sib txawv yuav cuam tshuam cov ntsiab lus ntawm cov khoom xyaw nquag xws li phenethyl cawv glycosides thiab polysaccharides hauv Cistanche deserticola.

Fig.1 Cov qauv ntawm echinacoside thiab acteoside

1.1 Qhov sib txawv ntawm cov khoom xyaw tsis muaj zog ntawm ntau hom Cistanche

Muaj txog 20 hom ntawm Cistanche. Muaj 4 hom thiab 1 ntau yam hauv kuv lub tebchaws, uas yog Cistanche deserticola YC Ma,Cistanche deserticolaYC Ma, C. tubulosa (Schenk) R. Wight, and C. salsa, CA Mey.) G. Beck), C. sinensis G. Beck thiab C. salsa var. albiflora PF Tu et ZC Lou [4]. Tu Pengfei et al. [5] Zoo soj ntsuam cov phenethyl cawv glycosides muaj nyob rau hauv 5 hom Cistanche hauv kuv lub teb chaws thiab quantitatively analyzed echinacoside thiab verbascoside. Cov txiaj ntsig ntawm kev soj ntsuam zoo tau pom tias phenethyl cawv glycosides muaj nyob hauv suab puam Cistanche, Cistanche tubulosa, Cistanche salsa, thiab Cistanche salsa zoo ib yam, tab sis qhov sib txawv ntawm Cistanche salsa yog qhov sib txawv heev. Cov txiaj ntsig ntawm kev txheeb xyuas ntau pom tau tias cov ntsiab lus ntawm echinacoside thiab verbascoside hauv 5 hom Cistanche yog qhov sib txawv, cov uas cov cistanche ntsev muaj cov ntsiab lus siab tshaj plaws thiab cov salsa muaj cov ntsiab lus qis tshaj.

1.2 Qhov sib txawv ntawm cov khoom xyaw uas tsis muaj zog ntawm Cistanche nyob rau hauv txawv keeb kwm

Cov tshuaj suav tshuaj yog "cov qhabnias", thiab muaj qee qhov sib txawv ntawm cov khoom xyaw nquag ntawm cov tshuaj suav los ntawm ntau qhov chaw ntawm keeb kwm. Liu Xiong et al. [6] txiav txim siab cov ntsiab lus echinacoside hauv Cistanche hauv plaub qhov chaw tsim khoom ntawm Zhangye, Gansu, Jingyuan, Xinjiang, thiab Inner Mongolia, thiab pom tias qhov loj ntawm covechinacoside cov tshuajnyob rau hauv plaub qhov chaw tsim khoom ntawmCistancheyog nruab nrab ntawm 0.42 feem pua ​​thiab 1.52 feem pua ​​. Ntawm lawv, Zhangye muaj cov ntsiab lus siab tshaj plaws thiab Jingyuan muaj cov ntsiab lus qis tshaj. Wang Guoping [7] pom tias cov ntsiab lus ntawm echinacoside hauv Cistanche los ntawm ntau lub hauv paus chiv keeb nyob rau yav qab teb Xinjiang yog qhov sib txawv loj, nrog rau feem ntau ntawm 2.78 feem pua ​​​​rau 11.93 feem pua, thiab kuj tseem muaj qhov sib txawv ntawm echinacoside cov ntsiab lus ntawm cultivated thiab qus Cistanche nyob rau hauv lub tib qhov chaw tsim khoom. Xue Dejun et al. [8] muab piv thiab txheeb xyuas cov ntsiab lus polysaccharide ntawm Cistanche deserticola los ntawm cov chaw tsim khoom sib txawv thiab pom tias cov ntsiab lus polysaccharide ntawm Cistanche deserticola los ntawm cov chaw tsim khoom sib txawv, thiab cov khoom siv monosaccharide ntawm polysaccharides kuj txawv.

1.3 Qhov sib txawv ntawm cov khoom xyaw uas tsis muaj zog ntawm Cistanche nyob rau lub sijhawm sib txawv

Xyoo 2020 tsab ntawm Suav Pharmacopoeia tau teev tseg tias Cistanche yuav tsum tau khawb thaum cov yub tsuas yog unearthed nyob rau lub caij nplooj ntoos hlav los yog ua ntej cov av khov nyob rau lub caij nplooj zeeg [9], tab sis qhov zoo ntawm cistanche harvested nyob rau hauv caij nplooj ntoos hlav thiab lub caij nplooj zeeg muaj qee qhov sib txawv. Qian Hao et al. [10] piv cov ntsiab lus ntawm 4 phenylethanoid tag nrho glycosides, echinacoside, cistanche glycoside A, verbascoside, thiab 2'-acetyl verbascoside hauv Cistanche tau sau rau lub caij nplooj ntoos hlav thiab lub caij nplooj zeeg. Cov txiaj ntsig tau pom tias muaj qhov sib txawv tseem ceeb hauv cov ntsiab lus ntawm plaub yam khoom hauv Cistanche tau sau rau ntau lub caij. Ntawm lawv, cov ntsiab lus ntawmechinacoside cov tshuajthiabcistancheglycoside A yog siab dua nyob rau hauv cistanche sau nyob rau hauv lub caij nplooj zeeg, thiab 2'-acetyl verbascoside thiab ntoo thuv tau pom nyob rau hauv cistanche harvested nyob rau hauv caij nplooj ntoos hlav. Cov ntsiab lus ntawm txiv hmab txiv ntoo chrysanthemum glycosides yog qhov siab. Wang Xu Yuan et al. [11] tshawb xyuas cov ntsiab lus ntawm cov khoom xyaw nquag xws li echinacoside, verbascoside, thiab polysaccharides hauv Cistancheharvested thaum caij nplooj ntoos hlav thiab caij nplooj zeeg. Cov txiaj ntsig tau pom tias tag nrho cov nyiaj ntawmechinacoside thiab verbascoside hauv Cistanchesau nyob rau hauv lub caij nplooj ntoos hlav yog ntau tshaj peb zaug nyob rau hauv lub caij nplooj zeeg, mus txog 12.21 mg / g, thaum lub sij hawm tus naj npawb ntawm polysaccharides nyob rau hauv cistanche sau nyob rau hauv lub caij nplooj zeeg yog ho ntau dua li nyob rau hauv caij nplooj ntoos hlav.

1.4 Qhov sib txawv ntawm cov khoom nquag ntawm Cistanche hauv cov tswv tsev sib txawv

CistancheNws yog perennial, hauv paus kab mob tshuaj ntsuab, parasitizing ntawm cov hauv paus hniav ntawm cov nroj tsuag xws li Haloxylon ammodendron thiab ntsev claw claws. Cistanche yog ze ze rau nws tus tswv tsev, thiab tus tswv tsev cog khoom thauj khoom noj thiab dej rau Cistanche. Zhang Xuan et al. [12] txiav txim siab cov ntsiab lus ntawmechinacoside thiab verbascosidenyob rau hauv 3 ntau yam sib txawv, 5 natural hosts, thiab 2 cultivated hosts ntawm Cistanche, thiab pom tias tib ntau yam ntawm txawv hosts ntawmCistanchemuaj tib tus nqi ntawmechinacoside thiab verbascoside. Cov ntsiab lus yog txawv heev. Rau Cistanche salsa, qhov kev txiav txim raws liechinacoside cov tshuajcontent is: sugar beet>pipa chai>Suaeda phytocarpa (cultivation)>Salt claw; the order based on verbascar glycoside content is Suaeda physalis (cultivation)> Beet> Pipa Chai>Salt Claw Claw.

Cistanche muaj cov txiaj ntsig zoo ntawm kev tu tawv nqaij thiab cov khoom kom zoo nkauj

2 Kev zoo nkauj thiab kev tu tawv nqaij mechanism thiab kev ua tau zoo ntawm Cistanche

Cov kev tshawb fawb tau ua pov thawj tiasCistancheTsis tsuas yog muaj ntau yam ntawm cov tshuaj pharmacological tab sis kujmuaj txiaj ntsig zoo rau kev txhim kho daim tawv nqaij thiab kev zoo nkauj.

2.1 Dawb

Muaj ib lo lus hais nyob rau hauv peb lub teb chaws, "Ib tug dawb nkaum ib puas ugliness." Cov tawv nqaij dawb, du, thiab muag heev yeej ib txwm yog lub hom phiaj nrhiav los ntawm cov poj niam oriental. Yog li ntawd, kev tshawb fawb thiab kev tsim cov tshuaj ntxuav hniav dawb ib txwm yog qhov teeb meem tseem ceeb hauv kev lag luam. Tam sim no, kev tshawb fawb thiab kev txhim kho ntawm cov tshuaj ntxuav hniav dawb feem ntau yog ua raws li inhibition ntawm tyrosinase kev ua haujlwm [13]. Cov tshuaj uas muaj benzene nplhaib lossis phenolic hydroxyl qauv muaj peev xwm ua kom dawb huv. Piv txwv li, arbutin, uas feem ntau siv cov tshuaj ntxuav hniav dawb, tuaj yeem ua kom cov nyhuv whitening los ntawm inhibiting cov haujlwm ntawm tyrosinase.

Phenylethanoid glycosides, lub ntsiab active ingredient ntawm Cistanche, yog ib chav kawm ntawm natural glycoside tebchaw, uas yog tsim los ntawm kev sib txuas ntawm niam txiv ribose pawg, phenylacetic acid, thiab ib feem ntawm phenylethanoid los ntawm ester bonds thiab glycosidic bonds. Yang Jianhua et al. [14] pom tias tag nrho cov phenylethanoid glycosides nrog purity ntawm 48.2 feem pua ​​tuaj yeem cuam tshuam cov haujlwm ntawm tyrosinase, thiab cov nyhuv ntawm tyrosinase qhia tau hais tias muaj kev sib tw thim rov qab. Tom qab ntawd, Jianhua Yang pab neeg [15] tau tshawb xyuas cov nyhuv inhibitory ntawm tag nrho cov phenylethanoid glycosides nrog purity ntawm 87.6 feem pua ​​ntawm tyrosinase kev ua thiab melanin ntau lawm hauv tib neeg epidermal melanocytes. Cov txiaj ntsig tau pom tias cov nyhuv inhibitory ntawm tag nrho phenylethanoid glycosides ntawm tyrosinase zoo dua li ntawm arbutin, nrog IC50 ntawm 716.51 µg / mL. Kev tshawb fawb ntxiv pom tias 400 µg / mL ntawm tag nrho cov phenethyl cawv glycosides tuaj yeem cuam tshuam kev tsim cov melanin, nrog rau qhov inhibition ntawm 31.43 feem pua, uas yog sib npaug rau arbutin. Nyob rau tib lub sijhawm, los ntawm kev sib piv cov teebmeem inhibitory ntawm 10 phenylethanoid glycoside tebchaw ntawm melanin ntau lawm, nws tau pom tias lawv cov peev xwm inhibitory cuam tshuam nrog cov phenolic hydroxyl pawg thiab aglycones, txoj haujlwm ntawm phenolic hydroxyl pawg, steric hindrance, thiab Cov tshuaj hloov pauv ntawm niam txiv ribosyl uronic pawg. ntsig txog. Thiab Yang Jianhua pab neeg tau siv cov tshuab microemulsion [16] thiab hloov lub cev tshuab [17] los daws qhov teeb meem ntawm kev solubility tsis zoo thiab transdermal absorption ntawm phenethyl glycosides, thiab coj cov ntawv thov ntawm phenethyl glycosides hauv cov tshuaj pleev ib ce. YANG et al. [18] kuj pom tiasCistanche extractmuaj zog inhibitory nyhuv ntawm tyrosinase kev ua, thiab tus nqi inhibition ntawmCistanche extractntawm 10 mg / mL ntawm kev ua tyrosinase yog siab li 78.5 feem pua.

2.2 Anti-aging

Kev laus yog ib txoj cai tseem ceeb tshaj plaws hauv ntiaj teb lom neeg. Nws yog cov txheej txheem maj mam uas txhua tus neeg yuav ntsib kev ua haujlwm thiab lub cev poob qis thaum lub sijhawm. Cov tawv nqaij laus tsim ib txhij nrog lub cev laus. Raws li tib neeg txoj kev nkag siab ntawm daim tawv nqaij aging mechanism txuas ntxiv mus, tam sim no muaj ntau tshaj 30 txoj kev xav ntawm cov txheej txheem ntawm daim tawv nqaij laus [19]. Cov nyhuv ntawm cov tshuaj suav tshuaj hauv kev ncua kev laus ntawm daim tawv nqaij yog qhov tseem ceeb hauv kev tshem tawm cov dawb radicals thiab kho collagen.

YANG et al. [18] pom tiasCistanche deserticola extracttuaj yeem tshem tawm DPPH dawb radicals thiab muaj peev xwm antioxidant. Tib lub sijhawm,Cistanche extractNws tuaj yeem txo qhov kev qhia ntawm collagenase thiab elastase mRNA, inhibit qhov kev ua ntawm collagenase, elastase, thiab hyaluronidase, thiab muaj cov nyhuv ntawm ncua kev laus ntawm daim tawv nqaij. Cov kev tshawb fawb tau pom tias cov khoom xyaw nquag ntawmCistanche, phenylethanoid tag nrho glycosides thiab polysaccharides, muaj qee yam cuam tshuam rau ncua kev laus ntawm daim tawv nqaij. Table 1 qhia txog cov txheej txheem kev laus ntawm cov khoom xyaw sib txawv ntawm Cistanche.

Phenylethanoids glycosides:

①Scavenge hydroxyl dawb radicals thiab superoxide anion dawb radicals, txo cov tsub zuj zuj ntawm reactive oxygen dawb radicals (RO S), thiab txo RO S puas [20,21];

② Ua kom cov glutathione peroxidase (GS HP x), cov dej num ntawm superoxide dismutase (SOD) thiab catalase (CAT), txo cov ntsiab lus ntawm malondialdehyde (M DA), thiab txo qhov tsim thiab tsub zuj zuj ntawm lipid peroxide (LPO) [21,22] ;

③ nce Hydroxyproline cov ntsiab lus, txhawb collagen ntau lawm [2 2];

④ tswj cov kab mob loj heev xws li phages, T hlwb, thiab NK hlwb cuam tshuam rau interleukins

-2 (IL-2), interleukin-6 (IL-6), qog necrosis factor- (TNF-) thiab lwm yam cytokines tsim tawm thiab tso tawm, txhim kho lub cev tiv thaiv kab mob, thiab ncua cell senescence[23,24]

⑤Los ntawm kev tswj hwm cov haujlwm ntawm NR F2 thiab RAC H1 cov ntaub ntawv hloov pauv, nws ua rau cov noob qhia ntawm heme oxidase 1 (HM OX1) hauv keratinocytes, txhawb nqa cov txheej txheem tiv thaiv endogenous, txhim kho kev tiv thaiv ntawm tes, thiab txo cov tawv nqaij laus thiab oxidative kev nyuaj siab Excitation puas tsuaj [25] .

Polysaccharides:

① Antioxidant nyhuv, tshem tawm DPPH dawb radicals, hydroxyl dawb radicals, thiab A BTS dawb radicals [26], txhawb kev ua haujlwm ntawm SOD, CAT, GSH-Px hauv daim tawv nqaij, txo cov ntsiab lus ntawm M DA thiab lipofuscin, thiab txo cov tawv nqaij oxidative. kev puas tsuaj [27]];

② Ua kom daim tawv nqaij hydroxyproline cov ntsiab lus thiab txhim kho daim tawv nqaij elasticity [28];

③ inhibit non-enzymatic saccharification cov tshuaj tiv thaiv thiab txo cov khoom lag luam qib siab glycation kawg (AGEs) [29];

④ Txhawb kev loj hlob ntawm lymphocytes, txhim khu kev ua haujlwm ntawm macrophages, thiab txhim kho lub cev tiv thaiv kab mob [30].

Lwm tus:

D-Mannitol tuaj yeem ua kom cov tawv nqaij hydroxyproline cov ntsiab lus thiab thim rov qab LPO / SO D cov haujlwm ntawm cov nas qub rau cov nas laus ib txwm muaj[28]; flavonoids thiab phenolic tshuaj muaj

Qhov tseem ceeb antioxidant nyhuv [31].

2.3 Kev tiv thaiv tshav ntuj

Raws li kev tshawb fawb txog kev puas tsuaj ntawm daim tawv nqaij los ntawm lub teeb txuas ntxiv zuj zus, tib neeg kev paub txog kev tiv thaiv lub hnub tseem nce ntxiv. Txawm li cas los xij, cov tshuaj pleev thaiv hnub hauv cov tshuaj pleev thaiv hnub tshuaj pleev ib ce tam sim no nyob rau hauv kev ua lag luam, suav nrog cov tshuaj pleev thaiv hnub lub cev thiab tshuaj pleev thaiv hnub, muaj qee yam teeb meem thiab nyuaj rau cov neeg xav tau. Broad-spectrum, nyab xeeb thiab ntuj tshuaj pleev thaiv hnub tau dhau los ua qhov chaw kub hauv kev tshawb fawb tam sim no.

Lub ntsiab active tivthaiv ntawm Cistanche muaj ntau benzene rings thiab conjugated lug nyob rau hauv nws molecule. Cov kev tshawb fawb tau pom [32] tias phenethyl glycosides muaj zog nqus ntawm 280-380 nm thiab tuaj yeem siv los ua cov tshuaj pleev thaiv hnub ntuj los daws cov teebmeem ntawm ultraviolet rays ntawm daim tawv nqaij. s kev puas tsuaj. Cov tshuaj pleev thaiv hnub nrog 1 feem pua ​​​​lossis 2 feem pua ​​​​ntawm phenethyl glycosides tsis muaj qhov cuam tshuam tsis zoo thiab muaj kev ruaj ntseg zoo thiab tiv thaiv lub teeb. FACING et al. [33] pom tias echinacoside tuaj yeem tiv thaiv daim tawv nqaij los ntawm UVA / UVB-induced oxidative stress puas, tshem tawm cov dawb radicals, thiab tiv thaiv collagen degradation. ZHANG et al. [34] siv UVB irradiation nas ntawm daim tawv nqaij puas qauv thiab tib neeg immortalized epidermal cell (HaCaT) kev puas tsuaj qauv los kawm ntxiv txog cov nyhuv photoprotective thiab muaj peev xwm mechanism ntawm echinacoside ntawm UVB-induced tawv nqaij puas. Kev sim cov nas pom tau tias cov tshuaj pleev echinacoside tuaj yeem txhim kho cov tawv nqaij ntawm cov nas los ntawm UVB, suav nrog edema, roughness, erythema, ulceration, wrinkles, thickening ntawm epidermis, teeb meem ntawm dermal ntaub so ntswg, thiab lwm yam. Nws muaj kev cuam tshuam zoo nrog cov ntsiab lus ntawm echinacoside. Cov txiaj ntsig ntawm HaCaT cell thwmsim qhia tias echinacoside muaj kev tiv thaiv tseem ceeb ntawm UVB-induced DNA puas thiab cell apoptosis. Echinacoside tuaj yeem ua kom cov haujlwm ntawm SOD, CAT, GSH-Px hauv hlwb, txo cov ntsiab lus ntawm MDA thiab ROS, ua kom muaj cov nyhuv antioxidant, txo cov oxidative puas hlwb, tiv thaiv DNA fragmentation, thiab inhibit cell apoptosis; Tsis tas li ntawd, ntoo thuv cones Chrysanthemum glycosides tuaj yeem txo qis- tswj kev qhia ntawm ATM / Rad3-txog protein (ATR), Chk1, p53, caspase-3, thiab polyadenosine diphosphate ribose polymerase (PARP) hauv hlwb, txo cell apoptosis, thiab Up- tswj kev qhia ntawm XPA protein thiab txhawb kev kho DNA. AVILA et al. [35] tau kawm txog cov nyhuv photoprotective ntawm Verbascum glycosides thiab pom tias qhov kev tiv thaiv ntawm Verbascum glycosides ntawm UVB-induced apoptosis zoo dua li cov tshuaj pleev thaiv hnub Ethylhexyl methoxycinnamate, thiab tus nqi SPF ntsuas los ntawm tus qauv npua guinea yog 4 npaug ntau dua. Ethylhexyl methoxycinnamate. Hauv kev xaus, phenethyl glycosides ntawmCistanchetuaj yeem tsis tsuas yog nqus tau ultraviolet lub teeb, tab sis kuj muaj qhov cuam tshuam ntawm kev tiv thaiv oxidation, kho DNA puas, thiab txo cov cell apoptosis, thiab muaj peev xwm siv cov nqi hauv cov tshuaj pleev thaiv hnub tiv thaiv.

2.4 Antibacterial

Tshuaj pleev ib ce muaj nplua nuj nyob rau hauv cov as-ham xws li roj, dej, thiab protein, uas yog haum rau kev loj hlob thiab kev loj hlob ntawm cov kab mob. Yog li ntawd, ib co preservatives yuav tsum tau ntxiv rau cov tshuaj pleev ib ce kom tiv thaiv kom txhob lwj. Piv nrog rau cov khoom siv tshuaj hluavtaws uas nquag siv, cov tshuaj suav tshuaj suav tshuaj muaj ntau yam zoo xws li tsis muaj tshuaj lom, muaj kev nyab xeeb siab, thiab lub hauv paus chiv keeb, thiab nyiam cov neeg siv khoom.

Cistanche muaj cov nyhuv antibacterial zoo. Wang Xiaoqin et al. [36] pom tias polysaccharides ntawm Cistanche muaj qee yam cuam tshuam rau kev loj hlob ntawm Tetraassus, Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae, thiab Penicillium citrinum. Du Rui et al. [37] pom tias Cistanche Decoction kuj muaj qhov cuam tshuam tseem ceeb ntawm Staphylococcus aureus. NAJEEB et al. [38] kawm txog cov tshuaj tua kab mob ntawm methanol extract, dej extract, ethyl acetate extract, chloroform extract, n-hexane extract, thiab butanol extract ntawm Cistanche (Salmonella typhi, Staphylococcus aureus, Streptococcus pneumonia, Klebsiella pneumonia, Proteus mirabilis, coli) thiab tshuaj tua kab mob (Aspergillus fumigatus, Aspergillus niger thiab Aspergillus flavus). Nws tau pom tias txawv extracts ntawmCistanche tubulosamuaj cov tshuaj tua kab mob sib txawv. Cov nyhuv yuav muaj feem xyuam rau cov khoom xyaw sib txawv uas muaj nyob rau hauv txawv extracts.

2.5 Moisturizing

Moisturizing yog qhov tseem ceeb ntawm kev tu tawv nqaij, thiab nws kuj yog ib qho tseem ceeb rau kev noj qab haus huv ntawm daim tawv nqaij thiab ncua kev laus. Thaum cov dej ntsiab lus ntawm stratum corneum ntawm daim tawv nqaij yog khaws cia ntawm 10 feem pua ​​-20 feem pua, daim tawv nqaij yog nyob rau hauv lub zoo tagnrho physiological lub xeev, mos, plump, ci, thiab elastic; Thaum nws tsawg dua 10 feem pua, cov tawv nqaij mob zuj zus tuaj, qhuav, ntxhib, thiab ntev ntev ntawm daim tawv nqaij dull, wrinkles tshwm. Sab nrauv moisturizing tshuaj pleev ib ce tuaj yeem ua kom cov dej ntawm cov stratum corneum, txo cov dej tsis zoo, thiab tswj cov kev ua haujlwm ntawm daim tawv nqaij.

Cov kev tshawb fawb tau pom [39] tias Cistanche extract muaj peev xwm tuav dej zoo heev. Tom qab 30 feem pua ​​​​ntawm Cistanche cawv extract yog siv rau ntawm daim tawv nqaij, evaporation ntawm dej yuav txo tau, thiab nws yuav siv tau nyob rau hauv moisturizing tshuaj pleev ib ce. Fan Qianwen et al. [40] tau tsim lub Cistanche noob extract uas muaj cov sib xyaw ntawm oligosaccharides thiab pom cov qib ntawm cov hlwb epidermal qhia hauv vitro protein, aquaporin (AQP-3), thiab hyaluronic acid receptor CD44 protein los ntawm fluorescent labeling. Thiab tom qab ntawd txiav txim qhov dej-xauv kev ua haujlwm ntawm cov extract. Cov txiaj ntsig tau pom tias Cistanche noob extract tuaj yeem nce qib kev qhia ntawm peb cov proteins hauv keratinocytes, txhim kho lub zog ntawm tus kheej ntawm cov epidermis, thiab ua rau lub sijhawm ntev moisturizing. Nyob rau tib lub sijhawm, mannitol, betaine, thiab allantoin muaj nyob rau hauv Cistanche yog tag nrho cov khoom xyaw moisturizing classic, uas kuj qhia tiasCistanchemuaj cov nyhuv moisturizing.

2.6 Kev tiv thaiv hluav taws xob

Tag nrho cov khoom nyob rau hauv qhov xwm txheej, tsuav yog qhov kub siab tshaj xoom, nyob rau hauv daim ntawv ntawm electromagnetic tsis, tas li hloov tshav kub mus rau sab nraud. Txoj kev hloov hluav taws xob no hu ua hluav taws xob. Cov hluav taws xob puas tsuaj rau daim tawv nqaij, lub cev tsis muaj zog, lub paj hlwb, hematopoietic system, thiab lwm yam, thiab tseem ua rau mob qog noj ntshav thiab tuag. Natural anti-radiation active cov khoom xyaw tau dhau los ua qhov kev tshawb fawb hotspot tam sim no.

Cov kev tshawb fawb tau pom [41] qhov ntawdCistanchemuaj kev tiv thaiv zoo tiv thaiv 60Co -ray hluav taws xob puas tsuaj, thiab tuaj yeem txhim kho kev tiv thaiv kab mob ntawm cov nas uas raug hluav taws xob puas. Cov txheej txheem tuaj yeem yog los ntawm kev ncaj qha lossis tsis ncaj ntawm kev tshem tawm cov dawb radicals thiab txo qhov tsim cov lipid peroxides. Nws muaj feem xyuam rau kev tiv thaiv kab mob hauv lub cev, cov hlwb, thiab cov molecules. YANG et al. [42] pom tias Verbascum glycosides tuaj yeem tshem tawm ROS, txo qhov piv ntawm Bax/Bcl-2, down-regulate cov haujlwm ntawm procaspase-3, tswj MAPK signaling pathway, tiv thaiv daim tawv nqaij fibroblasts los ntawm X-ray. kev puas tsuaj, thiab inhibit fibroblasts los ntawm kev poob qis. Tuag.

Cistanche muaj cov txiaj ntsig zoo ntawm kev tu tawv nqaij thiab cov khoom kom zoo nkauj

3 Daim ntawv thov xwm txheej hauv tshuaj pleev ib ce

Nrog rau kev paub ntau ntxiv ntawm Suav tshuaj suav tshuaj kab lis kev cai hauv ntiaj teb, "Suav cov tshuaj pleev ib ce" uas yog hu ua "natural, nyab xeeb thiab siv tau" tau dhau los ua qhov tseem ceeb ntawm kev saib xyuas hauv kev lag luam thiab nyiam los ntawm cov neeg siv khoom.Cistanchemuaj ntau yam kev ua haujlwm xws li ntxuav hniav dawb, tiv thaiv kev laus, tiv thaiv tshav ntuj, thiab moisturizing, thiab tau siv hauv tshuaj pleev ib ce rau qee yam. Zhao Yi et al. [43] nthuav tawm cov tshuaj pleev xim dawb thiab tiv thaiv kev laus uas muaj Cistanche tubulosa extract thiab nws txoj kev npaj. Cov tshuaj pleev ib ce uas muaj Cistanche tubulosa extract tuaj yeem txhim kho daim tawv nqaij elasticity, txo cov tawv nqaij melanin cov ntsiab lus, thiab txhim kho daim tawv nqaij brightness. Ntau cov khoom xyaw ua haujlwm tsim los ntawm Dongfang Miaosen tag nrho muaj Cistanche extract. Piv txwv li, patented moisturizing khoom "Jiao Bei Hu" [44], los ntawm "tsawg kub thiab lub sij hawm tas li" tshuab extraction, extract natural macromolecular polysaccharides ntawm txiv duaj gum, Dendrobium officinale, Tremella, thiab Cistanche, tsim ib tug spatial network qauv ntawm cog polysaccharide tiv thaiv Lub membrane tuaj yeem ua rau cov tawv nqaij mos thiab du. Lwm qhov piv txwv yog Nutri-Boost, cov khoom siv los tiv thaiv kev laus "Cordyceps Huiqing Extract". Los ntawm lub hauv paus ntsiab lus ntawm "Monarch thiab Advocate", plaub Suav tshuaj ntawm Cordyceps, Matsutake, Dendrobium officinale, thiab Cistanche yog kev sib raug zoo, uas tuaj yeem tshem tawm cov dawb radicals thiab tiv thaiv cov tawv nqaij oxidative puas tsuaj. . Nutri-Boost tau siv rau hauv DR PLANT Cordyceps rejuvenating thiab nourishing thawj cov kua, uas tuaj yeem ntxiv ntau cov as-ham rau ntawm daim tawv nqaij thiab ua kom tawv nqaij. Herborist thiab Gaofu cov npe ntawm Shanghai Jahwa United Co., Ltd. kuj tau ntxiv cistanche extract rau ntau yam khoom, xws li cov khoom muaj patented "Hengyan Sancuifang" [45] ua los ntawm cistanche, astragalus, thiab snow lotus 3 Cov tshuaj suav tshuaj zoo tuaj yeem tiv thaiv. tawv nqaij laus, tshwj xeeb tshaj yog cov duab-aging; Gough's Moisturizing Multi-effect Moisturizing Mask yog ntxiv nrog lub hnub qub moisturizing cov khoom "Silk Road" uas yog kev sib xyaw ntawm plaub suav tshuaj: cistanche, astragalus, snow lotus, thiab Ophiopogon japonicus Dej qhov chaw ". Los ntawm daim ntawv thov txheej xwm ntawm Cistanche hauv tshuaj pleev ib ce. , Nws tuaj yeem pom tias Cistanche muaj ntau yam ntawm daim ntawv thov tus nqi hauv cov tshuaj pleev ib ce raws li nws cov txiaj ntsig zoo hauv Suav tshuaj.

4 Kev xaus

Cistanche, raws li cov tshuaj suav muaj txiaj ntsig rau kev ua neej ntev, ua kom zoo nkauj, thiab ua kom zoo nkauj ntawm daim tawv nqaij, muaj ntau yam haujlwm xws li ntxuav hniav dawb, tiv thaiv kev laus, tiv thaiv tshav ntuj, tiv thaiv kab mob, moisturizing, thiab tiv thaiv hluav taws xob, thiab tau siv hauv tshuaj pleev ib ce. Txawm hais tias Cistanche muaj qee daim ntawv thov hauv tshuaj pleev ib ce, tseem muaj kev tshawb fawb tsis txaus ntawm cov khoom xyaw nquag thiab cov txheej txheem ntawmCistanche. Nyob rau hauv lub neej yav tom ntej, kev tshawb fawb kev taw qhia ntawm Cistanche raws li ib tug raw khoom rau tsoos suav tshuaj tshuaj pleev ib ce tuaj yeem pib los ntawm cov nram qab no: ① Cov khoom xyaw tseem ceeb ntawm Cistanche yog nyob ntawm hom, keeb kwm, thiab lwm yam. Cov yam ntxwv muaj kev cuam tshuam ntau dua. Txoj kev loj hlob ntawm cov khoom siv tshuaj pleev ib ce yuav tsum tau ua tib zoo saib xyuas nws cov qauv zoo thiab cov ntawv thov kev lag luam; ② Cistanche muaj ntau yam kev tu tawv nqaij, tab sis feem ntau ntawm cov ntaub ntawv tshawb fawb tau los ntawm kev sim hauv vitro, thiab tib neeg cov ntaub ntawv yuav tsum tau ntxiv; ③ Cov ntawv thov tam sim no ntawm Cistanche feem ntau yog tsom rau kev tiv thaiv kev laus thiab moisturizing, thiab feem ntau yog ua los ntawm cov khoom siv raw uas muaj Cistanche, nrog tsawg daim ntawv thov rau whitening, tshuaj pleev thaiv hnub, thiab lwm yam teebmeem. Kev taw qhia los ntawm cov tshuaj suav tshuaj suav tshuaj, suav nrog kev tshawb fawb thiab thev naus laus zis niaj hnub, kev siv ib leeg thiab kev sib xyaw ntawm Cistanche yog qhov tsim nyog ntawm kev tshawb fawb tob thiab kev tshawb fawb. Hauv cov ntsiab lus, Cistanche muaj ntau yam kev tu tawv nqaij, thiab nws tsim nyog rau kev tshawb fawb ntxiv los ntawm cov kws tshawb fawb los qhib lub ntiaj teb dav dav rau nws daim ntawv thov hauv tshuaj pleev ib ce.

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