Kev tshawb fawb los ntawm Xinjiang Medical University pom tias Cistanche muaj Neuroprotective Functions

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Cerebral ischemiayog ib yam kab mob hauv chaw kho mob, thiab nws qhov xwm txheej feem ntau cuam tshuam nrog oxygen dawb radicals, excitatory amino acids, thiab calcium ions. Kev tshawb fawb los ntawm Department of Pharmacology ntawm Xinjiang Medical University pom tias tag nrho glycosides ntawmCistanche(GCs) tautswj kev tsim khoom thiab tshem tawm cov pa oxygen dawb radicals, thiab muaj aneuroprotective nyhuv ntawm focal cerebral ischemia raug mob hauv nas.

Cistanche muaj cov teebmeem neuroprotective

Nyem rau Cistanche rau DHT neuroprotection

Cov kws tshawb fawb tau siv txoj kev suture los thaiv qhov nruab nrab cerebral artery (MCAO) hauv cov nas los tsim cov qauv nas ntawm focal cerebral ischemia thiab saib xyuas cov teebmeem loj thiab me ntawm GGs ntawm focal ischemia hauv nas. NBT staining yog siv los txiav txim seb qhov twg ntawm lub paj hlwb infarction, thiab feem pua ​​​​ntawm cov ntaub so ntswg infarct nyob rau hauv qhov loj ntawm lub hlwb contralateral raug xam los ntawm "qhov hnyav cheeb tsam txoj kev" raws li kev txiav txim ntawm infarct loj. Tus cwj pwm Performance index tau qhab nia siv ib qho 11-point scoring system, thiab cov tshuaj tiv thaiv oxidation ntawm ischemic paj hlwb raug ntsuas. Cov ntsiab lus enzyme thiab malondialdehyde (MDA). Cov txiaj ntsig tau pom tias GCs125,250 mg / kg tuaj yeem txo qhov cuam tshuam ntawm cerebral infarction, txhim kho cov tsos mob ntawm lub paj hlwb, thiab nce kev ua ub no ntawm lub paj hlwb superoxide dismutase (SOD) thiab glutathione peroxidase (GSH-Px). Cov ntsiab lus MDA poob qis heev. Nws qhia tau hais tias GCs muaj cov nyhuv neuroprotective ntawm focal cerebral ischemia raug mob hauv cov nas, thiab cov nyhuv no yuav cuam tshuam rau kev nce qib ntawm SOD thiab GSH-Px kev ua haujlwm.

Raws li cov kws tshawb fawb, cerebral ischemia feem ntau tshwm sim hauv cov neeg mob stroke thiab qhov chaw tshaj plaws ntawm tib neeg ischemic stroke nyob rau hauv nruab nrab cerebral hlab ntsha thiab nws cov ceg. Ischemic raug mob qauv, los kawm txog cov txiaj ntsig ntawm GCs ntawm kev raug mob ntawm lub paj hlwb. Cov txiaj ntsig tau pom tias txhua tus nas muaj cov tsos mob ntawm lub paj hlwb ntawm 12 thiab 24 teev tom qab kev ua haujlwm, thiab pom tseeb infarcts tshwm sim hauv lub hlwb. Cov ischemia tshwj xeeb yog pom tseeb ntawm 24 teev, qhia tias tus qauv tau npaj tiav.

Oxygen-dawb radicals ua lub luag haujlwm tseem ceeb hauv kev raug mob cerebral ischemia. Kev tsim thiab tshem tawm cov pa oxygen dawb radicals hauv lub cev ib txwm muaj nyob rau hauv qhov sib npaug dynamic. Thaum cerebral ischemia, kev tiv thaiv kab mob raug puas tsuaj, tsim cov pa dawb radicals nce thiab cov kab mob lom raug tawm tsam, lipid peroxidation tshwm sim, polyvalent unsaturated fatty acids raug rhuav tshem, thiab cov khoom lag luam lom nruab nrab raug tsim. (xws li lipid hydroperoxide) thiab cov khoom kawg malondialdehyde. Malondialdehyde tuaj yeem cuam tshuam cov amino pawg ntawm cov proteins thiab phospholipids, txo cov kua dej ntawm daim nyias nyias, ua rau cov cell deformation thiab ua haujlwm tsis zoo.

Tag nrho glycosides ntawm Cistanche GCs tau lees paub tias muaj cov teebmeem antioxidant, suav nrog kev tiv thaiv lipid peroxidation, tshem tawm superoxide anions, inhibiting thiab tshem tawm hydroxyl dawb radicals.Qhov kev sim no ntsuas qhov kev hloov pauv ntawm SOD thiab GSH-Px kev ua haujlwm hauv nas nrog cerebral ischemia. Cov txiaj ntsig tau pom tias nyob rau 24 teev ntawm cerebral ischemia, kev ua haujlwm ntawm SOD hauv cov ntaub so ntswg hauv hlwb tau txo qis, GSH-Px tsis hloov ntau, thiab cov ntsiab lus ntawm MDA tau nce ntau. Thiab GCs tuaj yeem txhim kho cov tsos mob ntawm lub paj hlwb ntawm nas, txo qhov cuam tshuam ntawm cerebral infarction, nce cov haujlwm ntawm SOD, GSH-Px, thiab txo cov ntsiab lus ntawm MDA. Nws qhia tias cov nyhuv neuroprotective ntawmCistanche glycosides GCstuaj yeem ua tiav los ntawm kev nce cov haujlwm ntawm lub hlwb cov ntaub so ntswg antioxidant enzymes, inhibiting lipid peroxidation, yog li tiv thaiv cov hlwb ntawm ischemic puas. Cov nyhuv antioxidant ntawm Cistanche glycosides GCs tuaj yeem cuam tshuam nrog phenolic hydroxyl pawg uas muaj nyob hauv cov qauv, thiab cov txheej txheem tshwj xeeb yuav tsum tau kawm ntxiv.

Cistanche tuaj yeem txhim kho kev kawm thiab kev nco