Kev Tshawb Fawb Thiab Kev Txhim Kho: Kev Tshawb Fawb Txog Kev Tshawb Fawb Ntawm Cov Tshuaj Hauv Suav Teb Hauv Kev Tiv Thaiv Thiab Kho Mob Alzheimer's
Mar 29, 2022
Alzheimer's disease (AD) yog ib qho kab mob degenerative ntawm lub hauv paus paj hlwb nrog kev paub tsis meej thiab kev coj tus cwj pwm tsis zoo raws li cov kev kho mob tseem ceeb thiab yog ib hom ntawmsenile dementia. Tam sim no, thoob ntiaj teb lees paub pathogenesis ntawm AD suav nrog amyloid-beta cascade txoj kev xav, txawv txav phosphorylation txoj kev xav ntawm Tau protein, dawb radical puas txoj kev xav, noob hloov txoj kev xav, o, lub cev tsis muaj zog txoj kev xav, cholinergic neuron hypothesis, insulin hypothesis, thiab lwm yam. Cov tshuaj Western tsis muaj txiaj ntsig zoo rau kev kho AD. Nyob rau hauv xyoo tas los no, kev tshawb fawb txog kev tiv thaiv thiab kev kho mob ntawm AD los ntawm cov tshuaj suav tshuaj niaj hnub tau nyiam cov neeg mob thoob plaws ntiaj teb, uas xav tias yuav coj kev cia siab tshiab rau cov neeg mob.
Hu rau:joanna.jia@wecistanche.com/ WhatsApp: 008618081934791
Cistanche raws li kev noj haus ntxivmuajtiv thaiv Alzheimer's disease
1. Tswj AD cholinergic system
Cov kab mob cholinergic yog ze ze rau tib neeg lub hlwb kev kawm thiab kev nco. Cov cholinergic neurons nyob rau hauv lub hlwb ntawmADCov neeg mob raug kev puas tsuaj loj heev, thiab kev ua haujlwm ntawm choline acetyltransferase (ChaT) hauv cov ntaub so ntswg ntawm lub hlwb ntawm cov neeg mob tau txo qis, thaum cov haujlwm ntawm acetylcholinesterase (AchE) txo qis. Kev txhim kho tseem ceeb, yog li cov ntsiab lus ntawm acetylcholine tau txo qis, uas nws thiaj li ua rau cov tsos mob tshwm sim los ntawm kev kawm thiab kev nco tsis zoo thiab kev paub tsis meej, ua rau cov tsos mob dementia. Yog li ntawd, kev txhim kho kev ua haujlwm ntawm lub paj hlwb cholinergic tau dhau los ua ib txoj hauv kev tseem ceeb rau kev tiv thaiv thiab kho AD. Cov kev sim cuam tshuam tau pom tias Xiaoyao Powder (muaj cov tshuaj suav tshuaj suav tshuaj xws li Bupleurum, Angelica, Baishao, Mint, Poria, Atractylodes) tuaj yeem ua rau kom muaj kev sib tham ntawm choline hydrobromide-induced.ADqauv nas, txo cov haujlwm AchE, thiab txhim kho AD. Cholinergic muaj nuj nqi hauv cov qauv nas. Jin Siwei (suav nrog cov tshuaj suav tshuaj xws li ginseng, Cistanche, Polygala Radix, Curcuma Radix thiab Rhizoma) tuaj yeem ua rau cov ntsiab lus Ach hauv lub cortex thiab hippocampus ntawm AD qauv nas tshwm sim los ntawm choline, thiab txo cov kev ua ntawm AchE hauv cortex thiab hippocampus, yog li kev txhim kho AD induced los ntawm choline kev kawm thiab kev nco muaj peev xwm ntawm cov qauv nas.
herba cistanchesrau AD
2. Antagonize beta-amyloid thiab hyperphosphorylated Tau protein nyob rau hauv AD
Cov kev tshawb fawb tau pom tias neuronal plaques (SP) nrog A raws li cov khoom tseem ceeb thiab neuronal fibrillary tangles (NFT) tshwm sim los ntawm hyperphosphorylated Tau protein yog lub ntsiab pathological tshwm sim ntawm AD, yog li kev cuam tshuam ntawm A aggregation thiab Tau protein hyperphosphorylation Metabolism yog ib qho ntawm cov cov kev ntsuas tseem ceeb los tiv thaivAD. Cov kev tshawb fawb tau pom tias Jiajiajingyijing decoction tuaj yeem txo cov qib phosphorylation ntawm Tau cov protein ntsig txog qhov chaw los ntawm kev txo qis cov lus qhia nquag ntawm GSK-3, tiv thaiv morphology thiab kev ua haujlwm ntawm paj hlwb hauv hippocampus, thiab tiv thaiv kev txhim kho ntawmAlzheimer tus kab mob. Erzhi Pills (muaj li ntawm Ligustrum lucidum thiab Eclipta Chinensis) tuaj yeem kho AD los ntawm kev ncua sijhawm ntawm A thiab oxidative puas hlwb ntawm paj hlwb. Fuzheng Quxie Recipe (muaj li ntawm ginseng, Coptis Chinensis, thiab Chuanxiong) tuaj yeem txhim kho cov haujlwm ntawmADqauv hlwb los ntawm kev txo cov kev qhia ntawm A protein.
3. Inhibit oxidative stress thiab scavenge dawb radicals hauv AD
Cov kws tshawb fawb feem ntau ntseeg hais tias nyob rau hauv cov txheej txheem ntawm lub hlwb degeneration, unsaturated fatty acids ntawm neuron cell membranes tau yooj yim oxidized los tsim ib tug loj tus naj npawb ntawm dawb radicals, uas ua rau ib tug loj tus naj npawb ntawm lipid peroxides (LPO), thiab malondialdehyde (MDA) yog feem ntau. tshuaj lom metabolite. Nws muaj zog, zoo heev cuam tshuam cov cell metabolism thiab ua haujlwm ib txwm ua rau apoptosis ntawm paj hlwb ua haujlwm, thiab induces tsim ntawmAD. Tab sis muaj ntau yam dawb radical scavenging systems nyob rau hauv lub cev, xws li superoxide dismutase (SOD) thiab glutathione peroxidase (GSH-Px), thiab lwm yam antagonistic oxidation systems. Yog li ntawd, antagonizing oxidative kev nyuaj siab tau dhau los ua ib qho ntawm cov kev ntsuas tseem ceeb los tiv thaiv thiab kho AD.
Jiawei Buwangsan (sib xyaw ntawm Zhiyuanzhi, Shichangpu, Ginseng, Poria, Angelica, Atractylodes, Coptidis, thiab Fusion) tuaj yeem txhim kho kev sib tham hauv SD nas nrog kev paub tsis meej tshwm sim los ntawm overexpression ntawm microRNA-30e hauv hippocampus. Liuwei Dihuang ntsiav tshuaj uas muaj cov ntshav tuaj yeem ua rau qeeb ntawm LDH thiab cov ntsiab lus ntawm MDA hauv PC12 hlwb puas los ntawm H2O2, txhim khu kev ua haujlwm ntawm SOD, txhim kho lub peev xwm antioxidant ntawm cov hlwb, thiab ncua kev puas tsuaj oxidative ntawm cov hlwb. Tus kheej tsim Qingxin Yizhi Decoction (muaj li ntawm raw astragalus, kib jujube kernel, Dilong, hemp noob, liab peony cag, Yizhi siab zoo, angelica, txiv duaj kernel, cinnamon twig, thiab Zhigancao) tuaj yeem txhim kho qhov tseem ceeb ntawm SOD thiab txo MDA hauvADcov neeg mob cov ntsiab lus, yog li txhim kho lub neej zoo thiab kev txawj ntse theem ntawmADcov neeg mob.
Noj Cistanche Supplementslos tiv thaiv Alzheimer's Disease
4. Antagonize lub apoptosis ntawm AD neurons
Ntau qhov kev tshawb fawb tau lees paub tias qhov poob ntawm cov paj hlwb hauv lub hlwb yog ib qho ntawm cov kab mob tseem ceeb ntawm AD. Lub neuronal apoptosis mechanism ntawm AD yog ze ze rau A overexpression, oxidative kev nyuaj siab, caspase activation, kev cai txawv txav ntawm ntau yam hauv lub voj voog ntawm tes, thiab lub zog metabolism. Bcl -2 gene tsev neeg yog ib pawg ntawm cov noob muaj feem rauneuronal txouas tau kawm dav, thiab nws cov kev cai thiab kev qhia yog ib qho tseem ceeb ntawm kev cuam tshuam rau neuronal apoptosis. Yog li ntawd, inhibition ntawm neuronal apoptosis tau dhau los ua cov ntsiab lus tseem ceeb hauv kev tiv thaiv thiab kho AD.
Bunao Fushen Recipe (sau ntawm Bamboo ginseng, Gastrodia, Ginkgo) tuaj yeem cuam tshuam A 25-35-induced hlwb puas nyob rau hauv lub hippocampus ntawm AD qauv nas, nce tus naj npawb ntawm Nissl lub cev, txhawb lub synthesis ntawm neurotransmitters, thiab ua tiav kev tiv thaiv. lub hom phiaj ntawm lub hlwb cov ntaub so ntswg thiab neurons. Bushen Yizhi Recipe (sau Cnidium, Lycium barbarum, Ginseng, Polygonum multiflorum, Cortex Moutan, thiab Borneol) tuaj yeem kho qhov kev puas tsuaj thiab poob ntawm cov neurons hauv hippocampus, txhim kho kev kawm thiab kev nco muaj peev xwm ntawm nas nrog kev nco tsis zoo los ntawm A {{ 1}} txhaj tshuaj hauv hippocampus, thiab muaj AD muaj qee yamkho cov nyhuv.
5. Anti-AD inflammatory teb
Mob inflammatoryCov txheej txheem tau ntev tau suav hais tias yog ib qho ntawm cov txheej txheem tseem ceeb ntawm cov neuropathological pathogenesis ntawm AD. Nyob rau hauv tus txheej txheem ntawm AD inflammatory teb, kev puas tsuaj ntawm inflammatory cytokines, nuclear transcription factor (NF-κB), ua kom, thiab glial hlwb tau txais kev saib xyuas. Yog li ntawd, inhibiting qhov inflammatory teb tau dhau los ua ib txoj hauv kev tseem ceeb los tiv thaiv thiab kho AD.
Kev Yuav Huanwu Decoction cuam tshuam rau vascular endothelial o mob kho los ntawm ICAM-1 thiab VCAM-1 proteins los ntawm antagonizing NK-κBP65 txoj kev taw qhia, kho cov kev hloov morphological los ntawm A-induced cerebral microvascular endothelial cell puas, thiab tiv thaiv cerebral microvascular endothelial hlwb. nyhuv. Lub raum-tonifying mis (muaj xws li Rehmannia glutinosa, Cornus Officinalis, Suav yam, Poria cocos, Morinda Officinalis, Schisandra Chinensis, Cistanche deserticola, Lycium barbarum, Eucommia ulmoides, thiab tunicate) tuaj yeem ua los ntawm cov kab mob neuroinflammatory los kho AD. Modified Sanjia Powder (suav los ntawm Sunburned vaub kib, Sunburned vaub kib plhaub, Sunburned Turtleworm, Chidilong, Shichangpu, thiab Polygonum multiflorum) uas muaj cov tshuaj cerebrospinal kua yuav txo tau JNK phosphorylation, ncua kev tso tawm ntawm inflammatory mediators thiab cytokines, yog li activated B2V hlwb, yog li ua lub luag haujlwm hauv kev kho mob Alzheimer's disease.
6. Txhim kho AD synaptic plasticity
Lub pathogenesis ntawm AD muaj kev sib raug zoo nrog kev puas tsuaj ntawm synaptic plasticity. Kev puas tsuaj rau lub hlwb synaptic qauv thiab kev ua haujlwm ntawm plasticity yog qhov tseem ceeb hauv kev sib txuas hauv cov kab mob pathological ntawm AD, thiab nws kuj yog ib qho ntawm cov txheej txheem pathological ntawm kev poob qis ntawm AD kev kawm thiab kev nco muaj peev xwm. Yog li ntawd, kev txhim kho synaptic plasticity tau dhau los ua ib qho kev ntsuas tseem ceeb los tiv thaiv AD. Txoj kev tshawb nrhiav pom tias cov tshuaj suav tshuaj suav tshuaj Jin Siwei (suav nrog ginseng, Cistanche deserticola, calamus, thiab turmeric) tuaj yeem ua rau muaj cov synapses hauv cov neuropil ntawm AD qauv nas, thiab txhim kho cov neuron thiab synaptic qauv kom sib txawv. Toxin daim ntawv qhia (muaj xws li Codonopsis pilosula, Guizhi, Shichangpu, Polygala, keel, dawb peony, thiab licorice) tuaj yeem cuam tshuam cov qauv synaptic degeneration thiab tsawg dua cov synapses hauv APP / PS1 ob npaug ntawm transgenic AD nas, uas muaj kev cuam tshuam tsis zoo rau kev txawj ntse thiab kev txawj ntse muaj nuj nqi. Synapses yog kev tiv thaiv.
Tam sim no, txawm hais tias muaj ntau qhov kev tshawb fawb soj ntsuam tau lees paub qhov ua tau zoo ntawm cov tshuaj suav tshuaj hauv kev tiv thaiv thiab kho AD, tseem muaj ntau qhov tsis txaus hauv nws cov kev tshawb fawb. Piv txwv li, qee cov ntawv sau tshuaj muaj cov qauv me me, tsis tsim qauv tsim, thiab tsis muaj cov ntaub ntawv pov thawj raws li cov ntaub ntawv; qee cov ntawv sau tshuaj tau ua tiav kev tshawb fawb ntawm lawv cov txheej txheem ntawm kev ua, tab sis cov pov thawj kho mob tseem tsis tau txaus; qee cov tshuaj npaj rau tus kheej nrog kev kho mob zoo tsis muaj kev tshawb fawb soj ntsuam raws li kev cai. Kev nce qib thiab daim ntawv thov raug txwv; qee cov tshuaj suav tshuaj suav tshuaj uas tau kuaj xyuas los ntawm lub sijhawm ntev tsis tuaj yeem tau txais cov ntaub ntawv pov thawj txaus raws li cov qauv kev tshawb fawb niaj hnub no, thiab kev tshawb fawb txog kev siv tshuab tsis sib sib zog nqus, thiab lwm yam. Yog li ntawd, ntawm ib sab, peb yuav tsum tau siv tag nrho thiab muab kev ua si tag nrho rau kev xav thiab kev ua tau zoo ntawm cov tshuaj suav tshuaj hauv kev tiv thaiv thiab kev kho mob ntawm AD, thiab ntau qhov tsim nyog sib xyaw cov tshuaj sib txawv rau kev siv tshuaj kho mob, nqa tawm ntau qhov chaw, qauv loj, mus sij hawm ntev. standardized soj ntsuam kev tshawb fawb, thiab tau high-standard soj ntsuam kev tshawb fawb. Ntawm qhov tod tes, nws yog ib qho tsim nyog yuav tsum tau ua ntau qhov kev tshawb fawb tob txog kev ua tau zoo ntawm cov tshuaj siv tau zoo, thiab nthuav tawm ntau lub hom phiaj cuam tshuam ntawm cov khoom sib txawv thiab kev sib raug zoo ntawm cov tshuaj suav tshuaj hauv ib qho sib sib zog nqus, yog li. txhawm rau tsim cov tshuaj suav tshuaj uas muaj txiaj ntsig zoo rau kev tiv thaiv thiab kev kho mob ntawm AD., los pab txhawb Suav kev daws teeb meem rau kev tiv thaiv thiab kev kho mob ntawm AD.
