Lub raum Toxicity Screening hauv Early-Stage Drug Discovery
Mar 12, 2022
Hu rau: Audrey Hu Whatsapp / hp: 0086 13880143964 Email:audrey.hu@wecistanche.com
Masanori
HIZUE Pfizer R&D Nyiv
Ntsiab lus:raum
cistanche pab rau lub raum
Covraumyog raug rau cov tshuaj tseem ceeb concentrations ntawm lub cev raug vim lub raum ntshav txaus thiab ib tug siab ntawm compound clearance. Drug-induced nephrotoxicity yog nce lees paub tias yog ib qho teeb meem uas cuam tshuam rau kev kho tshuaj kho mob. Qhov tsis ua tiav ntawm kev tshuaj ntsuam hauv vitro los txheeb xyuas cov tshuaj nephrotoxic tuaj yeem raug ntaus nqi rau ntau yam. Qhov loj tshaj plaws yog qhov tsis muaj qhov siv tau hauv vitro qauv uas tau rov ua duaraumphenotype.
Cov tshuaj ntsuab tshuaj ntsuab cistanche: txhim kho lub raum ua haujlwm
Kev txhim kho ntawm cov qauv hauv vitro kom ua tiav kev kwv yees cov tshuaj tiv thaivraumtoxicity yuav tsum muaj kev nkag siab zoo ntawm lub hom phiaj ntawm tes, hom o kev ua ntawm cov ntsaum nephrotoxic, thiab teeb tsa cov biomarkers txhim khu kev qha ntawm nephrotoxicity. Cov tubule proximal yog qhov txaus siab tshwj xeeb vim nws qhov kev tawm dag zog, reabsorption, thiab intracellular concentration. Ntau yam tshuaj txuam nrograumproximal tubule toxicity yog hydrophilic, qhia hais tias active uptake ntawm transporters tsav lub cell tsub zuj zuj rau xws li tsawg permeable tshuaj.
Cov txiaj ntsig ntawm tshuaj ntsuab cistanche
Txawm li cas los xij, cov hlwb feem ntau siv nyob rau hauv vitro toxicity kev tshawb fawb tsis muaj kev qhia txog kev thauj mus los, uas tuaj yeem ua rau cov txiaj ntsig tsis zoo. Hauv qhov kev nthuav qhia no, peb qhov kev sim rau kev soj ntsuam cov kab mob toxicity ntawm cov tubules uas siv transporter overexpression cell kab yuav qhia thiab sib tham. Tsis tas li ntawd, peb yuav muab cov ntsiab lus tseem ceeb ntawm cov txheej txheem tsis ntev los no rau kev txhim kho cov qauv tshiab hauv vitro tshuaj ntsuam cov qauv uas tuaj yeem siv los tsim kom muaj lub cev muaj txiaj ntsig ntau dua nrog lub peev xwm los txhim kho tus nqi kwv yees rau kev tshuaj ntsuam xyuas tubule toxicity.
Cistanche ntxiv: txhim kho kev sib deev muaj nuj nqi
Lus Cim: Cov tshuaj suav tshuaj suav tshuaj ntsuab cistanche (tseem hu ua "daj tshuaj ntsuab" thiab "tso suab puam ginseng"), loj hlob tsuas yog hauv cov suab puam qhuav thiab sov. Raws li ib qho ntawm cuaj cov tshuaj tsis txawj tuag, Cistanche (cistanche tubulosa / cistanche deserticola / desertliving cistanche / cistanche salsa) cov ntsiab lus nrog cov khoom xyaw nplua nuj xws li echinacoside, acteoside, tag nrho phenylethanoid glycosides, flavonoids, polysaccharides, thiab lwm yam. nourishing tshuaj ntsuab thiab khoom noj khoom haus rau tib neeg lub cev tiv thaiv kab mob, cov kab mob hauv nruab nrog cev, thiab hlwb hlwb thiab neurons, thiab lwm yam. Cov kev tshawb fawb tshuaj niaj hnub no tau lees paub cov txiaj ntsig ntawm cistanche (cov txiaj ntsig ntawm cistanche): txhim kho kev tiv thaiv; txhim kho kev ua haujlwm ntawm kev sib deev thiab lub raum ua haujlwm; tiv thaiv qaug zog; anti-aging; txhim kho kev nco; anti-Parkinson tus kab mob; anti-Alzheimer tus kab mob; antioxidation; yooj yim- cem quav; anti-inflammatory; txhawb cov pob txha loj hlob, ua kom tawv nqaij dawb; tiv thaiv daim siab; lwm.
