Kev nce qib hauv kev kuaj mob thiab kev kho mob ntawm tus mob plab hnyuv loj thaum ntxov Ⅰ
Aug 28, 2023
Cov ntsiab lus
Constipation ntev yog ib qho ntawm cov kab mob ua haujlwm zoo tshaj plaws. Qhov xwm txheej tau nce zuj zus txhua xyoo, ua rau muaj kev phom sij loj rau kev noj qab haus huv ntawm lub cev, thiab qhov xwm txheej tshwm sim tsawg dua. Kev cem quav thawj zaug muaj xws li cem quav tsis zoo, qhov quav khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob Nrog rau kev nkag siab tob zuj zus ntawm kev nkag siab ntawm thawj qhov mob cem quav, kev kuaj mob tshiab thiab cov tswv yim kho mob tau siv rau hauv chaw kho mob. Tsab ntawv xov xwm no nthuav tawm cov ntsiab lus tam sim no, kev faib tawm, cov yam ntxwv kis mob, cov txheej txheem pathophysiological, thiab kev nce qib hauv kev kuaj mob thiab kev kho mob ntawm cov plab hnyuv siab raum tsis cuam tshuam nrog kev tsim txom opioid, txhawm rau txhim kho kev nkag siab ntawm cem quav thiab muab kev kho mob zoo rau cem quav - kev kuaj mob thiab cov tswv yim kho mob. .
Kev cem quav ntev yog ib yam kab mob plab hnyuv. Nrog rau kev laus ntawm cov pejxeem thiab kev hloov ntawm txoj kev ua neej, qhov tshwm sim yog nce, thiab nws tau dhau los ua ib qho ntawm cov kab mob uas cuam tshuam rau tib neeg lub neej zoo. Kev cem quav tsis yog tsuas yog cuam tshuam loj rau kev ua haujlwm thiab lub neej ntawm cov neeg mob, tab sis kuj ua rau muaj kev puas siab puas ntsws thiab kev puas siab puas ntsws, uas ua rau muaj kev cuam tshuam rau tsev neeg thiab zej zog. Yog li ntawd, kev kuaj mob thiab kev kho mob cem quav yog qhov tseem ceeb heev rau lub neej noj qab haus huv, tab sis tam sim no kev nkag siab txog kev cem quav yog feem ntau tsis muaj. Kab lus no tshuaj xyuas qhov kev nce qib ntawm kev cem quav thawj zaug.
I. Txheej txheem cej luam
1. Kev txhais thiab kev faib tawm: Kev cem quav ntev yog ib yam kab mob hauv plab, uas yog hais txog kev ua haujlwm cem quav, uas yog, tsis yog cov organic txo qis zaus ntawm qhov tso quav los yog qhov nyuaj ntawm qhov quav. Rome IV tau taw qhia tias kev cem quav tsis tu ncua feem ntau tshwm sim los ntawm kev txo qis qis qis, tsis yooj yim rau kev tso quav, lossis kev nkag siab ntawm qhov quav tsis tiav, uas tuaj yeem nrog mob plab, mob plab, thiab lwm yam tsos mob, tab sis nws tsis ua raws li cov txheej txheem kuaj mob. chim siab plob tsis so tswj, thiab cov tsos mob tau tshwm sim tsawg kawg yog 6 lub hlis. Thiab muaj cov tsos mob hauv 3 lub hlis dhau los. Raws li ntau yam ua rau, cem quav ntev tuaj yeem muab faib ua thawj cem quav thiab cem quav thib ob, uas yog cem quav ntau dua. Kev cem quav thawj zaug suav nrog 3 hom: kev cem quav ib txwm-transit constipation (NTC), qeeb-transit constipation (STC), thiab qhov quav khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob khoob.
2. Morbidity thiab pheej hmoo yam: Lub ntiaj teb no feem ntau ntawm cem quav ntev yog nyob nruab nrab ntawm 12% thiab 19% [1]. Piv nrog rau Asia, cem quav muaj ntau dua nyob rau hauv North America thiab Europe, uas tej zaum yuav muaj feem xyuam rau kev noj haus, kab lis kev cai, ib puag ncig, thiab lwm yam. Tej yam uas ua rau cem quav muaj xws li hnub nyoog, poj niam txiv neej, kev sib raug zoo, kev khwv nyiaj txiag, theem ntawm lub cev, tshuaj, thiab kev puas siab puas ntsws [2]. Cov kev tshawb fawb tau pom tias kev ntxhov siab kuj yog ib qho tseem ceeb uas ua rau cem quav [1]. Qhov tshwm sim ntawm cem quav nyob rau hauv cov poj niam yog siab dua li ntawm cov txiv neej, thiab nws yog zoo correlated nrog lub hnub nyoog. Qhov tshwm sim ntawm cem quav hauv cov neeg laus dua 60 xyoo yog siab li 33%. Cov poj niam cev xeeb tub feem ntau ua rau cem quav vim qhov nce ntxiv ntawm cov tshuaj hormones kev sib deev, txo cov plab hnyuv siab raum, thiab kev hloov pauv hauv kev ntxhov siab uas ua rau lub plab zom mov.
3. Kev phom sij: cem quav ntev tuaj yeem ua rau muaj kab mob ntev (xws li ntshav qab zib thiab mob rheumatism), nrog rau cov teeb meem loj, xws li fecal impaction, incontinence, hemorrhoids, anal fissure, los ntshav, thiab txawm tias txoj hnyuv perforation, thiab lwm yam. Piv nrog rau cov tib neeg zoo tib yam, kev noj qab haus huv thiab lub neej zoo ntawm cov neeg mob cem quav yog qhov tsis zoo, thiab lawv muaj kev ntxhov siab ntau dua, kev ntxhov siab, kev nyuaj siab, thiab lwm yam kab mob puas siab ntsws.
2. Kev tswj cov hnyuv
Muaj txog 1013 txog 1014 hom kab mob hauv tib neeg lub plab zom mov. Cov kab mob no tau muab faib ua ntau txoj haujlwm hauv txoj hnyuv, cuam tshuam rau lub cev kev ua haujlwm ntawm txoj hnyuv thiab koom nrog cov haujlwm tseem ceeb ntawm tus tswv tsev [4]. Cov kab mob hauv plab tuaj yeem koom nrog hauv tus tswv tsev metabolism, xws li cov roj (cholesterol) thiab cov kua tsib acid metabolism, cov tshuaj hormone metabolism, thiab lwm yam, thiab tsim cov metabolites, qee yam (xws li indole derivatives, theem nrab bile acids, short-chain fatty acids) tswj lub cev. Kev sib npaug ntawm cov dej thiab cov electrolytes hauv cov hnyuv, cov qauv ntawm cov hnyuv, thiab txawm tias tiv thaiv kab mob, plab hnyuv ua haujlwm, thiab kev tiv thaiv kab mob ua lub luag haujlwm tseem ceeb. Piv txwv li, luv-chain fatty acids muaj kev tswj ncaj qha rau ntawm plab hnyuv motility hauv cov neeg mob cem quav [5].
plab hnyuv dysbiosis tshwm sim nyob rau hauv cov mob ntawm plab hnyuv flora tsis txaus, uas induces los yog aggravates cov kab mob ntev. Kev nce qib tsis ntev los no hauv kev siv phom tua phom sij txo qis cov nqi sequencing, thiab kev nce qib hauv bioinformatics cov cuab yeej tau ua rau muaj kev nkag siab ntau dua ntawm lub plab microbiota thiab nws lub peev xwm ua haujlwm. Tus thawj tswj xyuas kev sib koom tes ntawm 16S rDNA sequencing thev naus laus zis cov ntaub ntawv tau pom tias muaj pes tsawg leeg ntawm cov kab mob plab hnyuv hauv cov neeg mob cem quav yog qhov txawv ntawm cov tib neeg ib txwm muaj. Cov tsiaj muaj ntau haiv neeg ntawm cov microbiota hauv cov neeg mob kuaj tau qis dua hauv cov kev noj qab haus huv, thiab nws kuj tau nrog kev txo qis ntawm Bifidobacteria thiab Lactobacilli thiab nce ntau ntawm Desulfovibriolaceae. Tsis tas li ntawd, qib ntawm butyrate-ua cov kab mob (xws li Faecalibacterium) hauv cov neeg mob cem quav tau qis dua [5]. Txawm li cas los xij, muaj ntau cov ntaub ntawv tsis sib xws ntawm cov kev hloov hauv plab hnyuv hauv cov neeg mob cem quav, thiab tsis muaj kev pom zoo rau kev sib raug zoo ntawm cov hnyuv thiab cov plab hnyuv loj.
Ntuj Herbal Tshuaj Rau Relieving cem quav-Cistanche
Cistanche yog ib tug genus ntawm parasitic nroj tsuag uas belongs rau tsev neeg Orobanchaceae. Cov nroj tsuag no paub txog lawv cov khoom siv tshuaj thiab tau siv hauv Cov Tshuaj Suav Tshuaj (TCM) rau ntau pua xyoo. Cov hom Cistanche feem ntau pom muaj nyob hauv thaj av qhuav thiab suab puam ntawm Tuam Tshoj, Mongolia, thiab lwm qhov chaw ntawm Central Asia. Cistanche nroj tsuag yog tus cwj pwm los ntawm lawv cov nqaij tawv, yellowish stems thiab muaj nuj nqis heev rau lawv cov txiaj ntsig kev noj qab haus huv. Hauv TCM, Cistanche ntseeg tau tias muaj cov khoom siv tonic thiab feem ntau yog siv los kho lub raum, txhim kho qhov tseem ceeb, thiab txhawb kev ua haujlwm ntawm kev sib deev. Nws kuj yog siv los daws cov teeb meem ntsig txog kev laus, qaug zog, thiab kev noj qab haus huv tag nrho. Thaum Cistanche muaj keeb kwm ntev ntawm kev siv tshuaj ib txwm siv, kev tshawb fawb tshawb fawb txog nws txoj kev ua tau zoo thiab kev nyab xeeb tsis tu ncua thiab txwv. Txawm li cas los xij, nws paub tias muaj ntau yam bioactive tebchaw xws li phenylethanoid glycosides, iridoids, lignans, thiab polysaccharides, uas tuaj yeem ua rau nws cov teebmeem tshuaj.
Wecistanche covcistanche hmoov, cistanche ntsiav tshuaj, cistanche capsules, thiab lwm yam khoom tsim los sivsuab puamcistancheraws li cov khoom siv raw, txhua yam muaj txiaj ntsig zoo rau kev tshem tawm cem quav. Cov txheej txheem tshwj xeeb yog raws li hauv qab no: Cistanche ntseeg tau tias muaj cov txiaj ntsig zoo rau kev tshem tawm cem quav raws li nws cov kev siv ib txwm siv thiab qee cov tshuaj uas nws muaj. Txawm hais tias kev tshawb fawb tshawb fawb tshwj xeeb ntawm Cistanche qhov cuam tshuam rau cem quav yog txwv, nws tau xav tias muaj ntau lub tswv yim uas yuav ua rau nws muaj peev xwm txo tau cem quav. Laxative nyhuv:Cistanchetau ntev tau siv nyob rau hauv tsoos suav tshuaj raws li ib tug tshuaj rau cem quav. Nws ntseeg tau tias muaj cov nyhuv laxative me me, uas tuaj yeem pab txhawb kev zom zaub mov thiab ua rau cem quav. Cov nyhuv no tuaj yeem raug ntaus nqi rau ntau lub tebchaw nyob hauv Cistanche, xws li phenylethanoid glycosides thiab polysaccharides. Moistening cov hnyuv: Raws li kev siv ib txwm siv, Cistanche suav hais tias muaj cov khoom siv moisturizing, tshwj xeeb yog tsom rau cov hnyuv. Txhawb nqa dej thiab lubrication ntawm cov hnyuv yuav pab tau cov cuab yeej soften thiab yooj yim dua, yog li no relieving cem quav. Anti-inflammatory Effect: cem quav tej zaum yuav txuam nrog o nyob rau hauv lub plab zom mov. Cistanche muaj qee qhov sib txuas, suav nrog phenylethanoid glycosides thiab lignans, uas ntseeg tau tias muaj cov tshuaj tiv thaiv kab mob. Los ntawm kev txo cov kab mob hauv cov hnyuv, nws tuaj yeem pab txhim kho kev zom zaub mov tsis tu ncua thiab txo qhov cem quav.
