Cog Stem Cells Thiab Lawv Daim Ntawv Thov: Tshwj Xeeb Rau Lawv Cov Khoom Muag

1 Amity Institute of Pharmacy, Amity University, Noida,Uttar Pradesh 201313, Is Nrias teb

2 Department of Botany, Ege University, Izmir, Qaib ntxhw

Abstract

cistanche stems

Taw qhia

Cog qia hlwb yog innately undifferentiated hlwb tam sim no nyob rau hauv cov ntaub so ntswg meristematic, muab lawv vitality thiab ib tug khov kho ntawm precursor hlwb uas tom qab sib txawv rau ntau qhov chaw los yog cov ntaub so ntswg (Batygina 2011). Ob qhov tseem ceeb ntawm cov qia hlwb hauv cov nroj tsuag yog apical thiab lateral meristematic cov ntaub so ntswg (Dodueva li al. 2017). Cov yam ntxwv ntawm cov hlwb no yog rov ua dua tshiab thiab muaj peev xwm tsim cov hlwb sib txawv (Xu thiab Huang 2014). Cog qia hlwb tsis dhau cov txheej txheem ntawm kev laus thiab senescence, lawv tau txais kev sib txawv los tsim cov hlwb tshwj xeeb thiab tsis tshwj xeeb. Nyob rau hauv tas li ntawd, cov no muaj peev xwm tsim mus rau hauv ib lub cev los yog cov ntaub so ntswg. Yog li ntawd, cov nroj tsuag qia hlwb hu ua totipotent cells. Cov hlwb no muaj peev xwm rov tsim dua tshiab thiab yog li ua rau tsim cov kabmob tshiab hauv lub neej ntawm ib hom (Dinneny thiab Benfey 2008). Nroj tsuag qia hlwb yog ib hom kev hloov pauv tab sis vim lawv qhov tsis muaj zog, nws nyuaj rau cov nroj tsuag los tiv thaiv kev txaus ntshai thiab kev ntxhov siab. Nws tau raug pom zoo tias cov qia hlwb pab cov nroj tsuag kom muaj sia nyob hnyav sab nraud yog li khaws cia cov nroj tsuag lub neej (Sena 2014). Cov hlwb no txawv raws li lawv qhov kev ua (Table 1) (Crespi and Frugier 2008; Kretser 2007; Sablowski 2007; Verdeil et al. 2007; Vijan 2016) lossis qhov chaw (Table 2) (Bäurle and Laux 2003; Byne; . 2003; Stahl and Simon 2005).

Propagation ntawm cov nroj tsuag qia hlwb hauv kab lis kev cai

Qee yam tseem ceeb uas ua rau kev saib xyuas cov qia hlwb hauv cov nroj tsuag paub. Cov no suav nrog cov teeb liab kis tau los ntawm microenvironment thiab epigenetic tswj ntawm qia hlwb zoo ib yam li cov tsiaj hauv tsiaj (Weigel thiab Jurgens 2002). Mature cog qia hlwb muaj cov kab mob totipotent uas muaj peev xwm rov tsim dua tshiab rau hauv cov nroj tsuag tshiab. Cov txheej txheem ntawm cov ntaub so ntswg kab lis kev cai yog tsom rau cov txheej txheem ntawm cov nroj tsuag qia cell propagation uas tshwm sim nyob rau hauv lub tsim ntawm tag nrho cov tshiab cog los yog cov ntaub so ntswg los yog specifc hom ntawm tib lub hlwb nyob rau hauv kab lis kev cai rau lub hom phiaj ntawm harvesting cog metabolites (Sang et al. 2018 ). Cov txheej txheem no yog siv los ua tus qauv tsim cov khoom cog hauv cov xwm txheej tsis muaj menyuam, tsis muaj kev txwv ib puag ncig. Yuav luag txhua cov ntaub so ntswg tuaj yeem siv los tsim cov ntaub so ntswg (Takahashi thiab Suge 1996). Cov ntaub so ntswg uas tau txais rau kab lis kev cai yog hu ua explant, uas nws qhov chaw txiav muab qhov tsim nyog rau cov hlwb tshiab. Qhov no zoo ib yam li qhov txhab-kho cov tshuaj tiv thaiv. Cov hlwb txuas ntxiv dedifferentiate, poob cov yam ntxwv ntawm cov nroj tsuag ib txwm muaj los tsim cov xim tsis muaj xim hu ua callus, nyob rau hauv cov qia hlwb piv rau cov hauv thaj tsam meristematic. Callus hlwb raug coj los ua ib lub hlwb lossis cov cell me me hauv cov kab lis kev cai ua kua kom muaj txiaj ntsig ntau dua (Imseng li al. 2014; Pavlovic thiab Radotic 2017; Perez-Garcia thiab Moreno Risueno 2018). Ntau cov kauj ruam thiab cov txheej txheem koom nrog hauv cov txheej txheem ntawm kev nthuav tawm thiab tshem tawm cov qia hlwb los ntawm cov nroj tsuag tau qhia hauv daim duab 1.

Anti-aging cistanche tubulosa

Muaj peev xwm ntawm cov nroj tsuag qia hlwb

Cov kev hloov tshiab hauv cov tshuaj pleev ib ce muaj xws li cov tshuaj tiv thaiv kev laus uas muaj cov nroj tsuag ua haujlwm tau los ntawm Mirabilis jalapa thiab Indian gooseberry txiv hmab txiv ntoo Phyllanthus Emblica (Choi li al. 2015). Ntxiv rau cov no, qee cov khoom siv tshuaj kho plaub hau peppermint kuj tau muab los ntawm kev siv cov txheej txheem ntawm cov kab lis kev cai cog qoob loo (Barbulova thiab Apone 2014). Qee cov khoom muaj xws li kev sib xyaw ntawm cov nroj tsuag thiab tib neeg qia cell-raws li cov khoom, uas tropoelastin yog cov khoom tsim los ntawm tib neeg embryonic qia hlwb. Ntau lub tuam txhab tshuaj pleev ib ce thov kev siv cov qia cell hauv lawv cov khoom (Schmid et al. 2008). Cov kws tshaj lij tshuaj pleev ib ce muaj xws li active derivatives ntawm extracts los ntawm cov nroj tsuag qia hlwb thiab tsis nyob rau cov nroj tsuag qia hlwb. Yog li, cov txiaj ntsig tau thov xws li cov tawv nqaij du thiab ruaj khov yog vim muaj cov antioxidants hauv cov nroj tsuag rho tawm (Schmid li al. 2008). Cov nroj tsuag tseem ceeb xws li cov tshuaj tiv thaiv oxidant thiab cov tshuaj tiv thaiv kab mob muaj nyob hauv ntau cov nroj tsuag xws li txiv hmab txiv ntoo (Vitis vinifera), lilacs (Syringa vulgaris), thiab Swiss txiv apples (Uttwiler spatlauber). Cov tshuaj pleev ib ce uas muaj cov extracts no muaj peev xwm nthuav tawm cov duab tiv thaiv tiv thaiv UV rays vim kev puas tsuaj (Reisch 2009). Txiv hmab txiv ntoo raws li cov tshuaj tiv thaiv oxidant xws li anthocyanin thiab curcumin muaj nyob rau hauv txiv hmab txiv ntoo thiab turmeric feem, whereas kua qia hlwb raug suav hais tias yog nplua nuj nyob rau hauv phytonutrients xws li carotenoids thiab flavonoids (Prhal li al. 2014). Ntau qhov chaw botanical tam sim no tau tsim los ua cov khoom lag luam kom zoo nkauj, xws li txiv lws suav (Solanum Lycopersicum), txiv apples (Malus Domestica), qhiav (Zingiber ntawm canale), cloudberries (Rubus chamaemorus), edelweiss (Leontopodium nivale), thiab argan buds. (Argania Spinosa), thiab lwm yam. (Georgiev et al. 2018; Tito et al. 2011; Fu et al. 2001).

Kev sib piv ntawm cov nroj tsuag thiab tsiaj qia hlwb

Stem cells yog ib pawg ntawm cov hlwb uas tsis muaj qhov sib txawv, muaj peev xwm tsim tau ntau lub hlwb tshwj xeeb - yog li ua tus yuam sij tus tswv. Xws li cov cell yog qhov tseem ceeb rau kev loj hlob thiab tsim cov ntaub so ntswg. Hauv cov tsiaj nyeg, qhov teeb meem loj tshaj plaws ntawm cov qia hlwb yog tias cov hlwb tshwj xeeb tsis tuaj yeem rov qab mus rau lawv qhov qub tsis txawv txav. Qhov kev txwv no tau kov yeej nyob rau hauv rooj plaub ntawm cov qia hlwb uas muaj peev xwm rov qab mus rau lawv lub xeev qub yam tsis muaj kev cuam tshuam sab nraud. Cov nroj tsuag ua raws li cov txheej txheem kev tsim kho tshiab txhawm rau txhawm rau ntxiv lawv cov qia hlwb (Heidstra thiab Sabatini 2014). Txawm hais tias cov proteins hauv cov kab mob ntawm cov tsiaj txhu thiab cov nroj tsuag qia cell sib txawv hauv qhov xwm txheej, qhov zoo sib xws tuaj yeem pom nyob rau hauv txoj kev uas lawv cuam tshuam nrog ib leeg. Piv txwv li, cov txheej txheem uas qia hlwb ntxiv dag zog rau ib leeg (Zubov 2016; Greb thiab Lohmann 2016). Tsiaj cells yog qhov yooj yim rau reverting rov qab mus rau lub cev qia hlwb raws li qhov tshwm sim ntawm kev siv sab nraud. Txawm li cas los xij, cov txheej txheem cuam tshuam nrog cov kauj ruam xws li nce qhov concentration ntawm cov proteins tshwj xeeb uas ua rau nws tsis tshua muaj neeg muag thiab nyuaj. Los ntawm kev nkag siab zoo dua rau cov laj thawj uas ua rau yooj yim manipulation ntawm cov nroj tsuag hauv kev sib piv rau cov tsiaj hlwb, qhov chaw kho mob ntawm cov cell reprogramming hauv tib neeg tuaj yeem txhim kho (Koj li al. 2014). Cov qauv lej tuaj yeem siv los ua cov cuab yeej siv tau zoo los ua qhov kev soj ntsuam ntawm kev sib cuam tshuam ntawm cov proteins thaum lub sijhawm hloov pauv ntawm cov qia hlwb, nrog rau kev sib cuam tshuam ntawm cov protein thiab cov noob txuas nrog cov txheej txheem ntawm cov qia cell tsim (Sablowski 2004) (Daim duab 2).

Cog qia hlwb v/s cog qia cell rho tawm

Ntau lub tuam txhab tshuaj pleev ib ce hais tias lawv cov khoom muaj cov qia hlwb thaum muaj tseeb lawv muaj cov qia cell rho tawm thiab tsis nyob qia hlwb. Terminology yog ib qho tseem ceeb nyob rau hauv cov nqe lus ntawm cov lus thov los ntawm cov tuam txhab tshuaj pleev ib ce. Txhawm rau kom tau txais kev pom zoo rau 'cov qia cell' thov los ntawm cov tuam ntxhab, kev nkag siab ntawm cov khoom xyaw hauv cov khoom kom zoo nkauj yog xav tau. Qhov no yuav koom nrog kev siv cov qia hlwb rho tawm los ntawm cov hlwb qub (Lohmann 2008). Ntau yam khoom tu tawv nqaij thiab cov tuam txhab tsim tshuaj pleev ib ce tau tshaj tawm lawv cov khoom lag luam nrog kev thov siv cov thev naus laus zis thev naus laus zis rau ntau lub hom phiaj. Ib qho piv txwv zoo li no yog Image Skincare uas muaj cov khoom lag luam xws li cov tshuaj tiv thaiv kev laus, cov nplaum nplaum, cov tshuaj ntxuav kom pom kev, thiab cov tshuaj pleev ib ce (Draelos, 2012). Tsis tas li ntawd, qee yam qia cell cov khoom xws li Dermaquest Stem cell 3D HydraFirm serum, Peptide qhov muag firming serum, thiab lwm yam yog ua lag luam nrog kev lees paub ntawm cov qia hlwb tau los ntawm cov nroj tsuag xws li gardenia (Gardenia jasminoides), Echinacea (Echinacea purpurea), lilac (Sylac). vulgaris) thiab txiv kab ntxwv (Citrus sinensis) (Barbulova thiab Apone 2014). Cov pov thawj tshawb fawb los ntawm kev tshawb fawb-raws li cov ntaub ntawv ntawm cov nroj tsuag qia hlwb siv hauv kev tu tawv nqaij qhia tau hais tias lawv muaj peev xwm tiv thaiv tawv nqaij, tiv thaiv kev laus, thiab cov tshuaj tiv thaiv wrinkle. Txawm li cas los xij, cov qia hlwb siv hauv cov tshuaj pleev ib ce twb tuag lawm. Extracts los ntawm qia hlwb tsis ua raws li ib yam li cov active qia hlwb. Cov txiaj ntsig ntawm riam phom ntawm cov tawv nqaij du thiab ruaj khov tshwm sim vim muaj lwm cov khoom siv cog qoob loo xws li cov tshuaj tua kab mob antioxidants thiab cov tshuaj tua kab mob los ntawm cov qia hlwb. Txhawm rau kom tau txais tag nrho cov txiaj ntsig zoo thiab cov txiaj ntsig zoo los ntawm cov qia hlwb thiab cia lawv ua haujlwm raws li lawv tau piav qhia hauv cov khoom siv tawv nqaij, lawv yuav tsum tau muab tso ua ke ua cov hlwb ua haujlwm thiab yuav tsum nyob twj ywm hauv cov tshuaj pleev ib ce (Reisch 2009).

Anti-inflammatory cistanche extract

Daim ntaub ntawv Tiv thaiv tib neeg qia hlwb

Cells muab rho tawm los ntawm cov ntshav tam sim no nyob rau hauv txoj hlab ntaws yog ib tug ethically txais qhov chaw ntawm qia hlwb ntawm tib neeg keeb kwm. Cov extract ntawm qia hlwb los ntawm Uttwiler spatlauber hom tau kawm thiab pom rau nws cov txiaj ntsig ntawm kev loj hlob ntawm qia hlwb tau los ntawm cov hlab ntsha hauv cov ntshav hauv ob txoj kev tshawb fawb sib txawv. Thawj txoj kev tshawb fawb tau tsim los soj ntsuam cov txiaj ntsig ntawm cov hlwb rho tawm ntawm kev ua haujlwm loj ntawm tib neeg qia hlwb. Nws tau pom tias cov nyhuv yog concentration-dependent. Qhov kev sim thib ob tau ua los ntawm kev ua kom cov qia hlwb nyob rau hauv ib puag ncig kev ntxhov siab uas siv cov txheej txheem irradiation nrog lub teeb UV raws li qhov tsim nyog wavelength. Nws tau txiav txim siab tias 50 feem pua ​​​​ntawm cov cell cultured nyob rau hauv qhov kev loj hlob nruab nrab ib leeg tuag, whereas lub hlwb uas tau cultured nyob rau hauv lub xub ntiag ntawm ib tug extract ntawm qia hlwb los ntawm Uttwiler spatlauber tau pom tias tau ntsib tsuas yog ib tug me me poob nyob rau hauv cov nqe lus ntawm lawv kev muaj peev xwm ( Schmid et al. 2008).

Reversing cov cim ntawm senescence nyob rau hauv fibroblast hlwb

Senescence tau piav raws li cov txheej txheem ntuj tsim nyob rau hauv uas tom qab faib 50 zaug (kwv yees), lub cell poob nws lub peev xwm los mus rau lwm qhov kev faib tawm. Txawm li cas los xij, senescence kuj tseem tuaj yeem tshwm sim ua ntej hauv lub neej voj voog ntawm lub neej ntawm tes raws li qhov tshwm sim ntawm kev raug mob xws li kev kho cov lus teb rau cov cellular DNA puas. Kev laus ntxov ntxov tuaj yeem suav hais tias yog qhov phem tshwj xeeb tshaj yog thaum nws tsoo qia hlwb vim tias lawv yog qhov tseem ceeb rau cov txheej txheem ntawm cov ntaub so ntswg. Tus qauv cellular rau kev ua qauv qhia thiab tiv thaiv kev laus ntxov ntxov tau tsim los ntawm cov hlwb fibroblast. Tom qab kev kho mob nrog Hydrogen Peroxide rau ib lub sij hawm ntawm 2 h, cov cim qhia ntawm senescence tau pom nyob rau hauv lub hlwb. Cov qauv no tau tsim los tsim kom muaj kev tiv thaiv kev ua haujlwm ntawm cov qia hlwb los ntawm Uttwiler spatlauber (Fig. 3) (Schmid et al. 2008).

Retarding senescence nyob rau hauv cais cov plaub hau follicles

Follicles ntawm tib neeg cov plaub hau raug cais los ntawm cov txheej txheem ntawm microdissection los ntawm cov khoom tawg ntawm daim tawv nqaij uas tau tso tseg tom qab txoj kev phais facelift. Rau lub hom phiaj no, cov follicles uas muaj nyob rau hauv lawv cov theem anagen yog siv. Cov hauv paus plaub hau tuaj yeem muab piv rau cov kab ke ntawm cov kabmob me me uas ua raws li cov qauv ntawm kev sib koom ua ke ntawm cov qia hlwb ntawm epidermal thiab melanocyte keeb kwm nrog rau cov hlwb sib txawv. Cov follicles no tau khaws cia rau hauv ib qho kev loj hlob nruab nrab uas lawv tso cai rau elongate rau ib lub sij hawm ntawm 14 hnub, tom qab uas cov follicle hlwb nkag mus rau theem ntawm senescence los yog undergo tus txheej txheem ntawm apoptosis ie programmed cell tuag. Vim tsis muaj ntshav ncig, cov hauv paus plaub hau cais tsis tuaj yeem nyob thiab loj hlob rau lub sijhawm ntev. Txawm li cas los xij, cais cov hauv paus plaub hau raug kuaj txhawm rau txiav txim siab txog cov dej num uas ua rau muaj kev ncua sij hawm ntawm cov txheej txheem necrosis (Fig. 4) (Schmid et al. 2008; Nishimura et al. 2005).

Anti-wrinkle nyhuv

Cov kev ua los tiv thaiv wrinkle ntawm PhytoCellTec ™ Malus Domestica tau tsim tsa thaum lub sij hawm kev sim tshuaj uas tau ua nyob rau hauv ib lub sij hawm ntev ntawm 4 lub lis piam. Ib lub qab zib uas muaj 2 feem pua ​​​​PhytoCellTec ™ Malus Domestica extract tau muab ob zaug ib hnub twg ntawm tus kab mob ko taw. Qhov tob ntawm qhov wrinkle tau txheeb xyuas los ntawm kev siv PRIMOS system tom qab lub sijhawm teem sijhawm txhawm rau txiav txim siab cov nyhuv ntawm cov qab zib. Cov duab digital ntawm thaj tsam ko taw tau muab coj los ua ntej kev tswj hwm cov tshuaj nplaum thiab muab piv nrog cov uas tau coj los ntawm qhov kawg ntawm txoj kev tshawb no. Daim ntawv thov ntawm PhytoCell TecTMMalus Domestica cream tau qhia kom txo qis qhov tob ntawm qhov tawv nqaij tom qab 2 lub lis piam thiab tom qab ntawd 4 lub lis piam. Cov nyhuv tuaj yeem pom tau zoo los ntawm kev tsim cov duab 3D ntawm cov ntsiab lus rau kev sib piv. Cov kev ua los tiv thaiv wrinkle kuj tuaj yeem pom los ntawm cov duab digital (Fig. 5) (Schmid et al. 2008; Sengupta et al. 2018).

cistanche tubulosa extract muaj txiaj ntsig: tiv thaiv kev laus

Cov khoom lag luam

Stem cell extracts tau los ntawm cov nroj tsuag los ntawm ntau yam txuj ci extraction yog tam sim no tau siv ob qho tib si rau kev tsim cov khoom zoo nkauj niaj hnub (siv los ntawm cov neeg siv khoom txhua hnub) nrog rau kev saib xyuas cov khoom kom zoo nkauj. Cov no yog cov tshuaj ntxuav hniav dawb xws li arbutin, cov khoom siv tau los ntawm cov nroj tsuag Catharanthus roseus, thiab ntau yam phytological pigments xws li safflower thiab savoring tau los ntawm C.tincorius. Cov qia hlwb tau los ntawm ib hom tsis tshua muaj txiv apples cog hauv Switzerland tau pom tias muaj cov khoom khaws cia zoo heev. Qhov no extract ntawm cov kab lis kev cai qia hlwb tau txais tom qab ib qho kev rho tawm uas cuam tshuam nrog cog cell lysis nyob rau hauv high-pressure homogenization (Oh thiab Snyder 2013; Trehan li al. 2017). Lub tuam txhab tshuaj pleev ib ce Mibelle AG Biochemistry nyob rau hauv Buchs, Switzerland tau ua thwmsim nyob rau hauv tib neeg fibroblast hlwb tau incubated thiab cov yam ntxwv cov tsos mob ntawm cDNA puas tau induced nyob rau hauv cov hlwb cultured nyob rau hauv ib tug 2 feem pua ​​extract ntawm Uttwiler spatlauber qia hlwb. Cov qia hlwb no muaj peev xwm thim rov qab cov txheej txheem ntawm kev laus ntawm daim tawv nqaij fibroblast hlwb los ntawm kev ua kom muaj kev tswj hwm ntawm ntau cov noob tseem ceeb rau kev loj hlob thiab kev loj hlob ntawm cov hlwb thiab tseem txhawb kev nthuav tawm ntawm qhov xav tau antioxidant enzyme hu ua haemeoxygenase{{5} }. Qhov kev sim no kuj tau tsim qhov kev ua tau zoo ntawm kev txhim kho lub neej ntawm cov qia hlwb tau los ntawm cov hlab ntsha ntawm cov hlab ntsha thiab ua rau muaj kev vam meej.

ntawm cov tib neeg cov plaub hau cais tawm (Schmid et al. 2008). Lwm cov khoom tsim los ntawm kev siv txoj kev tsim khoom muaj peev xwm koom nrog cloudberry (Rubus chamaemorus) hlwb. Nyob rau hauv rooj plaub no bioreactors los ntawm entrenched callus thiab ncua kev kawm kab lis kev cai ntawm Rubus chamaemorus tau siv nyob rau hauv, Murashige thiab Skoog yog cov nruab nrab opulent nyob rau hauv phytohormones xws li kinetin thiab -naphthalene acetic acid. Cov khoom lag luam cloudberry ntawm tes tau txais los ntawm txoj kev no muaj peev xwm siv los ua cov khoom siv raw hauv kev lag luam tshuaj pleev ib ce ntawm cov nplai loj. Cov txheej txheem txheej txheem no yog cov txheej txheem yav tom ntej rau kev tsim cov cell tshiab los yog cov khoom seem ntawm tes, cov khoom sib cais uas muaj cov haujlwm lom neeg muaj zog, cov khoom lag luam ntawm tes khov, cov tshuaj tsw qab lossis cov xim pleev xim, thiab lwm yam. (Martinussen li al. 2004). Cov kab mob qog noj ntshav los ntawm cov txiv lws suav (Lycopersicon esculentum) cov hlwb tau pom tias muaj peev xwm loj heev hauv cov ntsiab lus ntawm kev tiv thaiv daim tawv nqaij los ntawm kev tsis zoo tshwm sim los ntawm kev mob toxicity ntawm cov hlau hnyav. Ib qho hydrophilic cosmetic active ingredient yog tsim los ntawm cov kua kab lis kev cai ntawm L.esculentum nrog comparatively siab concentrations ntawm tej yam Cheebtsam xws li flavonoids thiab phenolic acids xws li rutin, coumaric, protocatechuic, thiab chlorogenic acids.

Qhov no extract ntawm txiv lws suav qia hlwb muaj ntau cov ntsiab lus ntawm antioxidants thiab chelating tus neeg sawv cev phytochelatins uas yog lub luag hauj lwm rau chelation ntawm hnyav hlau. Qhov no nyob rau hauv lem captures cov hlau thiab tiv thaiv tej yam kev puas tsuaj rau cellular cov ntaub ntawv thiab organelles. Nws kuj tau pom tias cov extract tau los ntawm txoj kev no tau nthuav tawm lwm cov kev siv zoo tshaj plaws hauv thaj tsam ntawm cov tshuaj pleev ib ce rau lub hom phiaj ntawm kev txhawb nqa kev noj qab haus huv ntawm daim tawv nqaij thiab kev saib xyuas (Tito li al. 2011). Refined Ginger (Zingiber Officinale) muaj cov kab mob nquag ntawm cov nroj tsuag los ntawm kev ua tiav ib qho kev sib xyaw biotechnological ntawm cov nroj tsuag cell dedifferentiation thiab cov nroj tsuag kab lis kev cai uas yog lub luag hauj lwm rau kev tswj cov synthesis ntawm active molecules nyob rau hauv lub cell. Hauv kev tshawb fawb soj ntsuam ua los ntawm cov chaw tsim khoom, nws tau pom tias cov poj niam tau qhia txog kev txhim kho hauv 50 feem pua ​​​​ntawm lawv cov qauv ntawm daim tawv nqaij vim qhov txo qhov pore thiab cov nyhuv mattifying. Cov nyhuv no tau txhim kho los ntawm qhov txo qis hauv kev ci ntsa iab hauv lawv cov tawv nqaij thiab tseem txo qis ntawm sebum. Kev nce hauv kev sib txuas ntawm elastin fibers hauv daim tawv nqaij tau pom nyob rau hauv vitro kev ntsuam xyuas uas ua rau txo qis ntawm sebum ntau lawm (Trehan li al. 2017).

Lub koom haum ntawm Biotechnological tshawb fawb tshuaj xyuas cov kev tiv thaiv thiab muaj zog los tiv thaiv collagenase nrog rau hyaluronidase kev ua ntawm ib tug anti-aging tivthaiv tau los ntawm qia cell extracts ntawm edelweiss (Leontopodium alpinum). Nws yog nplua nuj nyob rau hauv leontopodic acids A thiab B, uas yog lub luag hauj lwm rau nthuav tawm lub zog thiab muaj zog antioxidant nyhuv ntawm daim tawv nqaij (Trehan li al. 2017). Cov patented qia cell technology muab los ntawm XtemCell siv cov nroj tsuag nquag los ntawm cov nroj tsuag tsis tshua muaj thiab cov organic nutrient-nplua nuj nyob rau hauv thiaj li yuav tsim tau cov hlwb tshiab uas muaj cov ntshiab ntshiab thiab zoo. patented thev naus laus zis tau cog lus siab siab ntawm lipids, proteins, amino acids, thiab phytoalexins raws li qhov tshwm sim ntawm cov txheej txheem rho tawm hauv qhov sib piv rau cov txheej txheem kev rho tawm cov tshuaj. Hauv kev tshawb fawb soj ntsuam ua los ntawm cov chaw tsim khoom nws tau tsim tias cov hlwb siv hauv XtemCell cov khoom tau absorbed nyob rau hauv lub hlwb sab nraud ntawm lub epidermis yuav luag tam sim ntawd; yog li tso cai rau kev rov ua dua tshiab ntawm daim tawv nqaij, ua kom cov khoom nqus nqus, thiab txhim kho tus naj npawb ntawm filaggrin proteins hauv daim tawv nqaij. Cov no yog lub luag haujlwm tiv thaiv daim tawv nqaij los ntawm kev puas tsuaj ntxiv los ntawm kev raug tshav ntuj thiab kev laus (Trehan li al. 2017).

Kev ua lag luam thoob ntiaj teb

Cog stem cell-based tshuaj pleev ib ce yog suav tias yog ib qho ntawm ntau hom kev lag luam thiab kev lag luam uas muaj ntau tus neeg tsim khoom muaj cov ceg txheem ntseeg siab thiab cov npe tseem ceeb uas cuam tshuam nrog kev lag luam tshuaj pleev ib ce. Dominating lub npe nyob rau hauv lub lag luam no yog Mibelle pawg industries, L'Oreal tshuaj pleev ib ce, Estee Lauder, Channel 21, Christian Dior, Clinique cosmeceuticals, MyChelle Dermaceuticals, Juice Beauty, thiab ntse Nutrients (Oh thiab Snyder 2013). Cov kev txav tseem ceeb hauv kev lag luam tshuaj pleev ib ce muaj xws li hauv qab no:

• Kev xav tau ntau ntxiv rau cov nroj tsuag qia cell-based tshuaj pleev ib ce nyob rau hauv cov cheeb tsam chaw kub thiab muaj xyoob ntoo los ntawm kev raug mob UV rays thiab ua rau muaj kev pheej hmoo ntawm kev laus (Blanpain and Fuchs 2006).

• Xav tau cov as-ham uas tuaj yeem nqus ncaj qha los ntawm daim nyias nyias ntawm daim tawv nqaij kom ua tau raws li qhov xav tau ntawm cov khoom noj khoom haus thiab hydration ntawm daim tawv nqaij los ntawm kev tsim kom muaj kev xav tau ntau ntxiv rau cov nroj tsuag qia cell-based tshuaj pleev ib ce (Barthel and Aberdam 2005). • Hauv ob peb lub xyoo dhau los, kev zoo nkauj, tiv thaiv kev laus, thiab lwm yam txheej txheem tau tsom mus rau cov poj niam nkaus xwb. Txawm li cas los xij, tsis ntev los no cov khoom lag luam muag tshuaj pleev ib ce kuj tau tsom rau cov txiv neej (Trehan li al. 2017).

Kev xaus thiab kev cia siab yav tom ntej

Cog qia hlwb thiab lwm yam thev naus laus zis yog cov ncauj lus tseem ceeb hauv kev kho mob thiab kev lag luam tshuaj pleev ib ce. Cog qia hlwb muaj ntau yam kev siv hauv ob qho tib si txawm li cas los xij, lawv lub peev xwm tiag tiag tseem tsis tau tshawb nrhiav vim tsis muaj pov thawj tshawb fawb thiab ntau yam fora muaj rau kev sim. Kev siv cov nroj tsuag rho tawm thiab lawv qhov chaw xws li txiv hmab txiv ntoo, paj, nplooj, stems, keeb kwm, thiab lwm yam yog tsim nyob rau hauv lub tshav pob ntawm tshuaj pleev ib ce thiab tshuaj txij thaum ancient sij hawm. Daim ntawv thov ntawm cov nroj tsuag thiab lawv cov extracts nyob rau hauv cov tshuaj pleev ib ce yog li dav thiab cov khoom formulated muaj ntau yam kev siv xws li whitening, de-tanning, moisturizing, cleansing, thiab lwm yam. Ntau yam kev loj hlob tsis ntev los no ntawm cov nroj tsuag thiab tib neeg qia hlwb raug txiav txim siab. qhov tseem ceeb tseem ceeb hauv kev tshawb nrhiav qhov tseem ceeb ntawm tib neeg cov ntaub so ntswg rov ua dua tshiab. Feem ntau, tib neeg cov tawv nqaij rov ua dua lawv tus kheej hauv cov txheej txheem txuas ntxiv txhawm rau tiv thaiv lub cev tiv thaiv kev raug mob, kis kab mob, thiab kev puas tsuaj vim qhov tshwm sim ntawm lub cev qhuav dej. Nrog rau lub hnub nyoog nce ntawm cov qia hlwb, qhov txo qis hauv lawv lub peev xwm kho tau raug pom nrog rau kev ua kom nrawm ntawm cov ntaub so ntswg tam sim no hauv daim tawv nqaij. Yog li ntawd, kev tiv thaiv thiab kev txhawb nqa ntawm cov qia hlwb yog qhov tseem ceeb rau cov tawv nqaij noj qab haus huv. Cov tuam txhab tsim khoom tau nthuav qhia cov khoom lag luam sai sai uas siv cov cuab yeej siv cog qoob loo.

Cov khoom zoo li no feem ntau pab tiv thaiv cov tawv nqaij qia hlwb los ntawm ntau yam kev puas tsuaj, tshwj xeeb tshaj yog kev laus. Lub propensity rau txoj kev loj hlob ntawm cov khoom tu tawv nqaij raws li cov nroj tsuag qia cell rho tawm yog ib qho kev tshwm sim tam sim no vim muaj peev xwm loj ntawm cov qia hlwb uas muaj peev xwm txhim kho mus rau ntau hom hlwb. Tam sim no ntau hom ntawm cov nroj tsuag qia hlwb thiab cov khoom tau los ntawm lawv cov extracts yog coj mus muag rau kev lag luam tshuaj pleev ib ce. Cov koom haum cog qoob loo tau pom tias muaj ntau npaum li cas ntawm cov nroj tsuag qia hlwb nrog rau lwm yam kev kho cov khoom cog xws li phytohormones thiab antioxidants. Cov nplua nuj biodiversity tam sim no nyob rau hauv peb ntiaj chaw muaj ntau lub peev xwm rau kev siv. Lawv cov khoom thiab cov khoom siv tau tseem tsis tau tshawb nrhiav thiab tsis siv los siv los ua qhov chaw ntawm cov nroj tsuag qia hlwb thiab siv hauv kev lag luam kom zoo nkauj rau ntau lub hom phiaj. Txawm hais tias tag nrho cov kev cog lus no nyob rau thaj tsam ntawm cov qia hlwb thiab lawv cov kev siv ntau yam, nws tseem tsis tau paub meej yog tias cov nroj tsuag muab rho tawm thiab cov los ntawm cov qia hlwb muaj cov haiv neeg tshwj xeeb rau tib neeg. Yog tias muaj, nws tuaj yeem pab nrhiav tus tswv tsev tswj hwm txhua qhov txiaj ntsig zoo ntawm cov thev naus laus zis thev naus laus zis. Nws yuav ua pov thawj tias yog qhov txiaj ntsig zoo heev yog tias cov noob muaj lub luag haujlwm rau kev sib tham txog cov txiaj ntsig zoo ntawm cov qia hlwb rau tib neeg raug txheeb xyuas. Qhov no yuav ua kom ceev cov txheej txheem ntawm kev kho kom zoo, ua tiav lwm lub hom phiaj ntawm kev kho mob.

cistanche txiaj ntsig: anti-aging

Cov ntaub ntawv

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