Part 2: Lub Koom Haum Ntawm Toxoplasma Gondi IgG Antibody Thiab Kab Mob Raum Mob Biomarkers

Yog xav paub ntxiv. tiv taujtina.xiang@wecistanche.com

3. Cov txiaj ntsig

3.1.Data Summary

Cov ntsiab lus piav qhia (feem pua ​​​​ntawm qhov ntsuas qhov hnyav lossis txhais tau tias thiab cov qauv tsis raug) ntawm cov kev hloov pauv uas siv hauv kev tshuaj ntsuam tau nthuav tawm hauv Table 1. Tag nrho cov piv txwv ntawm cov neeg koom siv hauv qhov kev tshuaj ntsuam no yog 4692, uas 47.7 feem pua ​​​​yog txiv neej thiab 52.3 feem pua. poj niam. Lub hnub nyoog nruab nrab yog 47.9 xyoo, thiab feem pua ​​​​ntawm Mev Asmeskas, lwm haiv neeg Mev, tsis yog neeg Mev dawb, tsis yog neeg Mev dub, thiab lwm haiv neeg yog 8.4, 4.8, 70.3,9.9, thiab 6.5, raws li. . Qhov feem pua ​​​​ntawm cov neeg koom nrog T.gondi IgG-zoo yog 15.2 feem pua, thaum feem pua ​​​​ntawm cov neeg koom nrog albuminuria yog 6.9 feem pua ​​(thawj) thiab 4.0 feem pua ​​(thib ob). Qhov feem pua ​​​​ntawm cov neeg koom nrog tsis tu ncua albuminuria yog 3.5 feem pua, thiab qhov nruab nrab eGFR yog 87.8 mL / min / 1.73 m². Qhov feem pua ​​​​ntawm cov neeg koom nrog CKD-zoo yog 10 feem pua, suav nrog 0.9 feem pua ​​​​hauv theem 1,1.5 feem pua ​​​​hauv theem 2,7.1 feem pua ​​​​hauv theem 3, thiab 0.5 feem pua ​​​​ntawm cov neeg koom nrog CKD me me yog 2.4 feem pua ​​, thiab cov uas muaj nruab nrab-rau- mob hnyav CKD yog 7.6 feem pua.

Nyem qhov no kom paub txog cistanche tubulosa

3.2. Association ntawm Toxoplasma thiab CKD Biomarkers thiab CKD Status

Table 2 nthuav qhia cov koom haum ntawm T. gondii lgG raws li txoj cai thiabCKDbiomarkers tsis suav rau ib qho kev sib koom ua ke. Tus qauv tsim-raws li t-test los yog Rho-Scott chi-square tau siv los ntsuas qhov tseem ceeb ntawm cov koom haum no. Cov txiaj ntsig tau qhia tias muaj kev sib koom ua ke tseem ceeb ntawm T.gondii xwm txheej thiab txhua qhov thib ob albumin-to-creatinine piv (p=0.0376), thib ob albuminuria (p=0.0005), thiab tsis tu ncua albuminuria (piv<0.0001), ckdstatus="" (p="0.0001)," and="" ckdstages="" (p="0.0004)." the="" highest="" proportion="" of="" t.gondi-positive="" patients="" occurred="" in="" stage="" 4,="" while="" the="" mean="" of="" egfr="" was="" lower="" among="" the="" t.gondi-positive="" participants,="" but="" it="" was="" not="" statistically="" significant(p="0.0913)." however,="" the="" level="" of="" egfr="" was="" significantly="" different="" among="" positive="" and="" negative="" participants="" (p="0.0014)." the="" elevated="" level="" of="" egfr="" (stages="" 4="" and="" 5)had="" higher="" proportions="" of="" positive="" participants="" than="" the="" negative="" participants(figure="" 1).="" furthermore,="" there="" was="" a="" statistically="" significant="" association="" between="" the="" t.gondi="" status="" and="" ckd="" levels="" with="" higher="" proportions="" of="" mild="" and="" moderate-to-severe="" levels="" of="" ckd="" among="" the="" positive="" participants="" when="" compared="" to="" the="" negative="" participants="" (p=""><>

3.3.Age Factor

Daim duab 2 qhia tau hais tias cov neeg koom nrog Toxoplasma tau loj dua li cov neeg koom nrog tsis raug (56 xyoo vs.49 xyoo, p-value<0.0001). similarly,="" the="" participants="" with="" positive="" ckd="" were="" significantly="" older="" than="" the="" negative="" participants="" (67="" years="" vs.48="" years,=""><0.0001). we="" investigated="" the="" possibility="" of="" the="" confounding="" effect="" of="" age="" on="" the="" association="" between="" t.gondi="" exposure="" and="" ckd="" status.="" the="" magnitude="" of="" the="" confounding="" effect="" of="" age="" was="" evaluated="" by="" calculating="" the="" ckdrisk="" ratio="" within="" each="" age="" stratum(younger,="" older)="" and="" comparing="" it="" with="" the="" unstratified="" risk="" ratio="" (table3).="" the="" unstratified="" risk="" ratio="" of="" ckd(rrcrude="1.27,95%" ci:1.09-1.49)="" indicated="" that="" participants="" with="" positive="" toxoplasma="" had="" a="" significantly="" higher(27%="" higher)="" risk="" of="" having="" ckd="" than="" the="" negative="" participants.="" while="" the="" stratified="" risk="" ratio="" was="" higher="" among="" the="" older="" participants="" than="" the="" younger="" participants="" (1.11="" vs.="" 0.76),="" the="" risk="" ratio="" was="" insignificant="" in="" both="" age="" groups,="" as="" indicated="" by="" the="" corresponding="" 95%="" confidence="" intervals.="" the="" unstratified="" and="" stratified="" effect="" estimates="" differ="" by="" 17%,="" indicating="" the="" magnitude="" of="" the="" confounding="" factor="" of="" age.="" the="" overall="" risk="" ratio="" was="" calculated="" by="" pooling="" the="" stratified="" risk="" ratios="" using="" the="" mantel-haenszel="" formula="" [34](rrmh="1.09,95%" ci:0.93-1.28),="" which="" indicated="" an="" insignificant="" difference="" between="" the="" positive="" and="" negative="" t.gondi="" participants.="" these="" results="" clearly="" indicate="" that="" age="" is="" an="" important="" confounding="" factor="" that="" must="" be="" accounted="" for="" when="" studying="" the="" association="" between="" t.="" gondii="" exposure="" and="" ckd.="" to="" account="" for="" other="" potential="" covariates="" in="" addition="" to="" age,="" we="" made="" use="" of="" multivariable="" logistic="" regression="" models="" as="" detailed="">

Cov txheej txheem hnub nyoog tau pom zoo los ntawm NHANES tau siv los tshem tawm qhov tsis txaus ntseeg ntawm lub hnub nyoog thaum muab piv rau qhov muaj ntau ntawm CKD los ntawm Toxoplasma hauv Asmeskas cov pej xeem. Kev faib tawm hnub nyoog yog tus qauv siv 2000 US suav pej xeem. Daim duab 3 qhia tau hais tias qhov kev nthuav dav ntawm CKD yog siab dua ntawm Toxoplasma zoo dua Toxoplasma tus neeg tsis zoo (10.45 vs. 8.99).

3.4. Kev sib koom tes ntawm Toxoplasma thiab CKD tom qab kho rau Co-Variates

Ob peb lub qauv logistic regression tau tsim los tshawb xyuas qhov kev koom tes ntawm CKD raws li txoj cai (tsis zoo vs. zoo) thiab Toxoplasma raug (tsis zoo vs. zoo) thaum suav txog cov muaj peev xwm covariates. Thawj tus qauv piav qhia txog kev koom tes ntawm CKD raws li txoj cai thiab Toxoplasma raug kho rau pej xeem covariates (hnub nyoog, poj niam txiv neej, thiab haiv neeg / haiv neeg) thiab BMl. Table 4 qhia txog cov txiaj ntsig ntawm thawj tus qauv no. Hauv cov qauv no, T.gondi tau cuam tshuam nrog CKD(OR= 1.40,95 feem pua ​​​​CI=1.06-1.84, p-value=0.00447) .Tshwj xeeb, qhov zoo T.gondi ua rau muaj qhov sib txawv ntawm kev muaj CKD, tuav tag nrho lwm cov kev hloov pauv tsis hloov. Hnub nyoog kuj tseem muaj txiaj ntsig zoo nrog CKD (LOSSIS=8.89,95 feem pua ​​CI=6.31-12.51, p-value<0.0001), with="" the="" participants="" 45+="" years="" old="" being="" 8.89="" times="" more="" likely="" to="" have="" ckd="" than="" those="" who=""><45 years="" old.="" additionally,="" the="" model="" showed="" that="" female="" participants="" were="" more="" likely="" to="" have="" ckd(27%="" higher="" odds="" than="" males,="" p-value="0.0352)," whereas="" there="" were="" no="" significant="" differences="" among="" the="" different="" race/ethnicity="" groups.="" bmi="" had="" slight="" positive="" association="" with="" ckd(or="1.04," 95%="" ci="1.02-1.06," p-value="">

Hauv tus qauv thib ob, ntxiv covariates ntxiv, suav nrog kev siv cawv thiab ntshav qab zib (Table 5). Cov nyhuv ntawm T.gondi tsis tseem ceeb hauv cov qauv no; Txawm li cas los xij, hnub nyoog tseem muaj kev sib raug zoo nrog CKD raws li txoj cai (OR=8.59, 95 feem pua ​​CI=5.48-13.47, p-value =0.0002) . Tsis zoo li thawj tus qauv, poj niam txiv neej tsis muaj kev koom tes tseem ceeb nrog CKD xwm txheej hauv tus qauv thib ob. Haiv neeg / haiv neeg tsis tau qhia txog kev koom tes tseem ceeb nrog CKD raws li txoj cai, uas zoo ib yam li cov lus xaus tau los ntawm thawj tus qauv. Tsis tas li ntawd, cov neeg koom nrog uas tsis muaj keeb kwm muaj ntshav qab zib muaj 60 feem pua ​​​​ntawm qhov tsis muaj CKD (OR=0.40,95 feem pua ​​​​CI=0.27-0.61, p-value{{18} }.0075) dua li cov uas muaj keeb kwm mob ntshav qab zib. Kev siv cawv tsis muaj kev cuam tshuam nrog CKD (p-value=0.7102). Tus qauv hauv Table 5 muab qhov zoo me ntsis rau cov ntaub ntawv zoo dua li cov qauv hauv Table4, raws li tau hais los ntawm cov ntaub ntawv zoo dua qub (qis AIC thiab siab dua Pseudo R-Square rau tus qauv hauv Table 5).

Ib tus qauv thib peb tau tsim rau CKDstatus ntawm T.gondii lIgG antibody los ntawm kev poob qis hnub nyoog los ntawm tus qauv thib ob tab sis khaws tag nrho lwm cov kev sib txuas. Cov qauv no tau qhia txog kev sib raug zoo ntawm T.gondi raug thiab CKD raws li txoj cai (OR=1.56,95 feem pua ​​CI=1.20-2.04, p-value=0. 0168). Txawm li cas los xij, tus qauv thib ob (tus qauv hauv Table5) haum cov ntaub ntawv zoo dua li tus qauv thib peb (Table6), raws li qhia los ntawm AIC thiab R-Square qhov tseem ceeb rau ob tus qauv.

Cov kev hloov pauv ntxiv, suav nrog kev haus luam yeeb thiab kev siv yeeb tshuaj, tau ntxiv rau tus qauv thib peb los tshawb xyuas cov koom haum ntawm Toxoplasma thiab CKD nyob rau hauv cov xwm txheej no (Table 7 thiab 8). Kev koom tes ntawm Toxoplasma yog qhov tseem ceeb hauv CKD xwm txheej thaum muaj kev pheej hmoo haus luam yeeb (p=0.0325); Txawm li cas los xij, qhov sib ntxiv ntawm cov tshuaj siv tshuaj txo qis tus qauv loj mus rau 1551 thiab defused cov nyhuv ntawm Toxoplasma thiab lwm yam Variables.

Txhawm rau tshawb xyuas qhov kev sib koom ua ke ntawm kev nce qib hauv CKD theem thiab Tox-oplasma thaum hloov kho qhov muaj peev xwm covariates, peb tau tsim cov qauv logistic regression raws li tau piav qhia hauv Table 9. Tus qauv qhia txog kev koom tes tseem ceeb ntawm T.gondi raug thiab CKDstages(LOSSIS {{ 2}}.41,95 feem pua ​​CI=1.07-1.86, p-value=0.0424), uas qhia tias qhov zoo T.gondi nce qhov txawv ntawm CKD kev nce qib. Hauv cov qauv no, hnub nyoog, poj niam txiv neej, thiab BMI tau cuam tshuam nrog CKD kev loj hlob, tab sis haiv neeg / haiv neeg tsis yog.

Cov qauv ntxiv tau tsim los tshawb xyuas cov koom haum ntawm Toxoplasma thiab CKD siv ob theem ntawm CKD (mob thiab mob hnyav). Kev sib koom ua ke ntawm Toxoplasma tsis pom meej thaum muaj hnub nyoog muaj nyob hauv cov qauv (Table 10). Txawm li cas los xij, tsis suav nrog hnub nyoog los ntawm tus qauv (Table 1l) tau qhia txog kev sib koom ua ke tseem ceeb ntawm qib CKD thiab Toxoplasma (p =0.0371)

4. Kev sib tham

4.1. Txheej txheem cej luam ntawm cov txiaj ntsig thiab qhov cuam tshuam

Lub Chaw Tiv Thaiv thiab Tiv Thaiv Kab Mob (CDC) kwv yees tias 15 feem pua ​​​​ntawm Asmeskas cov neeg laus muaj CKD, nrog rau 90 feem pua ​​​​ntawm cov neeg no tsis paub txog lawv tus mob. Yog li ntawd, nws yog ib qho tseem ceeb uas yuav tsum tau soj ntsuam kom txaus cov kev pheej hmoo cuam tshuam nrog CKD los saib xyuas thiab kuaj pom nws txaus thaum nws pib.

Kev kis tus kab mob T. gondii tuaj yeem ua rau mob hnyav lossis mob ntev rau lub raum, ua rau raug mob, uas tuaj yeem cuam tshuam qhov kis tau ntawm lawv lub neej. Cov kev tshawb fawb ua ntej tau pom qhov sib txuas ntawm kev lim ntshav thiab nce tus nqi ntawm T. gondii tus kab mob [35,36], tab sis tseem tsis tau muaj kev tshawb fawb txog kev sib koom tes ntawm Toxoplasma nrog CKD hauv Asmeskas cov pej xeem. Yog li, lub hom phiaj ntawm txoj kev tshawb no yog los tshawb xyuas qhov kev koom tes no nrog rau kev pheej hmoo ntawm CKD.

Kev tshawb nrhiav tau pib los ntawm kev tshuaj xyuas qib ntawm txhua tus neeg CKD biomarker ntawm Toxoplasma-zoo thiab tsis zoo koom nrog. Peb pom tias cov theem ntawm qhov thib ob albumin-rau-creatinine piv, qhov thib ob albuminuria, thiab cov albuminuria tsis tu ncua tau nce siab dua ntawm cov neeg koom nrog Toxoplasma zoo thaum piv nrog cov neeg koom nrog T.gondi-tsis zoo (Table 2). Cov biomarkers no yog cov cim qhia ntawmmob raumthiabCKDkev ua si [23]. Lwm cov kev tshawb fawb tau txuas tus kab mob Toxoplasma mus rau qib siab ntawm cov ntshav creatinine thiab ntshav urea nitrogen [30], thiab cov txiaj ntsig ntawm txoj kev tshawb no tau lees paub tias qhov tsis zoo ntawm CKD biomarkers cuam tshuam nrog Toxoplasma kab mob. Txawm hais tias qhov kev tshawb pom tias theem ntawm kwv yees GFR tsis tau qis dua ntawm Toxoplasma-zoo piv rau cov neeg koom nrog tsis zoo, qhov feem ntau ntawm cov qib siab ntawm eGFR tau ntau dua ntawm cov neeg koom nrog zoo piv rau cov neeg tsis zoo (p=0014) , Table 2 thiab daim duab 1).

Tsis tas li ntawd, cov neeg koom nrog Toxoplasma-zoo muaj feem ntau ntawm CKD (p =0.0001, Table 2)) thaum ob qho tib si eGFR thiab persistent albuminuria tau siv los ntsuas CKD.

Tsis tas li ntawd, kev loj hlob ntawm me me mus rau nruab nrab-rau-hnyav theem ntawm CKD yog txuam nrog Toxoplasma (p<0.0001, table="" 2),="" and="" progression="" to="" each="" stage="" of="" ckd="" was="" associated="" with="" toxoplasma="" infection="" in="" this="" study="" (p="0.0004," table="">

Hauv qhov kev tshawb fawb no, qhov muaj feem yuav muaj CKD ntau dua nrog kev kis tus kab mob Toxoplasma ntau dua li qhov tsis tau raug (RR=1.27 95 feem pua ​​​​CI:1.09-1.49, Table3). Qhov kev pheej hmoo ntawm tus txheeb ze muaj ntau dua ib qho, qhov qhia tau tias CKD feem ntau tshwm sim nrog T.gondii kab mob.

Ua ntej CKD thiab Toxoplasma kev tshawb fawb hauv Teb Chaws Asmeskas cov pej xeem qhia tias qhov muaj ntau ntawm CKD lossis Toxoplasma yog txuam nrog hnub nyoog [1,27]. Hauv txoj kev tshawb no, cov neeg koom nrog Toxoplasma zoo lossis CKD tau laus dua li cov neeg koom nrog tsis zoo (p<0.0001, figure="" 2).="" this="" significant="" association="" between="" age="" and="" each="" ckd="" and="" toxoplasma="" indicated="" that="" age="" might="" serve="" as="" a="" confounding="" factor="" in="" the="" association="" between="" ckd="" and="" toxoplasma.="" this="" observation="" was="" supported="" by="" the="" age-stratified="" analysis.="" after="" age="" adjustments,="" the="" prevalence="" of="" ckd="" was="" higher="" among="" toxoplasma-positive="" participants="" compared="" to="" the="" toxoplasma-negative="" participants(10.45="" vs.8.99,="" figure="">

Kev sib koom ua ke ntawm Toxoplasma thiab CKD tau tshawb xyuas ntxiv siv cov qauv sib txawv los suav rau ntau yam muaj feem cuam tshuam nrog CKD. Cov feem ntau txaus ntshai yam uas qhia los ntawm cov kev tshawb fawb yav dhau los yog hnub nyoog, poj niam txiv neej, haiv neeg / haiv neeg, thiab BMI. Peb qhov kev soj ntsuam tau lees paub tias muaj kev sib raug zoo ntawm Toxoplasma thiab CKD tom qab hloov kho rau cov xwm txheej no, qhov twg Toxoplasma kab mob tau pom tias muaj feem cuam tshuam nrog kev muaj CKD (los yog=1.40,95 feem pua ​​CI=1. {4}}.84,p=0.0447, Table4). Tsis tas li ntawd, lub hnub nyoog muaj feem cuam tshuam nrog CKD cov xwm txheej, qhov twg cov neeg laus muaj feem ntau yuav muaj CKD(OR=8.59,95 feem pua ​​​​CI=5.48-13.47,p{{15 }}.0002, Table 4).

Cov kev tshawb fawb ua ntej tau qhia tias tus cwj pwm coj cwj pwm xws li haus cawv, haus luam yeeb, siv yeeb tshuaj, thiab keeb kwm kho mob (xws li, muaj ntshav qab zib) ua rau muaj kev pheej hmoo ntawm CKD. Yog li, cov xwm txheej no tau suav nrog hauv cov qauv kev kwv yees los tshawb xyuas lub koom haum ntawm T.gondi thiab CKD. Tom qab ntxiv cov yam ntxwv no rau tus qauv, tus naj npawb ntawm cov qauv txo qis vim qhov tsis muaj qhov tseem ceeb hauv cov kev hloov pauv no, thiab lub koom haum ntawm T.gondi tsis pom meej. Txawm li cas los xij, kev koom tes ntawm Toxoplasma hauv cov qauv no tau pom tseeb thaum qhov muaj zog ntawm qhov muaj hnub nyoog raug tshem tawm ntawm tus qauv (Tables 5-8).

Tsis tas li ntawd, cov txiaj ntsig ntawm qhov kev tshawb fawb no tau pom tias qhov zoo Toxoplasma nce qhov txawv txav mus rau theem hnyav dua ntawm CKD(OR=1.41,95 feem pua ​​​​CI=1.07-1.{{ 5}}, p=0.0424, Table 9) tom qab hloov kho rau lwm yam xwm txheej (hnub nyoog, poj niam txiv neej, haiv neeg / haiv neeg, thiab BMI.

Kev faib tawm ntxiv ntawm CKD tau txiav txim siab hauv kev tshawb xyuas Toxoplasma koom haum los ntawm kev faib CKD rau hauv ob theem: me me thiab nruab nrab-rau-hnyav CKD. Tus qauv twv ua ntej tsim nrog qhov kev faib tawm CKD no tsis qhia txog kev sib koom ua ke tseem ceeb ntawm Toxoplasma; Txawm li cas los xij, kev koom tes tau pom tseeb tom qab tsis suav hnub nyoog los ntawm tus qauv (OR=1.42,95 feem pua ​​CI=1.07-1.90, p=0.0371, Table 11 ).

Peb txoj kev tshawb fawb tau lees paub tias muaj kev koom tes ntawm T.gondi kab mob thiab CKD. Lub koom haum no tuaj yeem muaj ob txoj kev qhia: (1) kis kab mob CKD ua rau muaj kev pheej hmoo ntawm T.gondii kab mob, lossis (2) kab mob T.gondii ua rau muaj kev pheej hmoo ntawm CKD. Cov kev tshawb fawb ua ntej qhia tias CKD txo cov tshuaj tiv thaiv kab mob rau T.gondi raug lossis rov ua kom muaj Toxoplasma latent hauv lub cev [29,31]. Ntawm qhov tod tes, latent T.gondi kab mob tuaj yeem ua rau mob thiab ua rau lub raum puas [8].

Lub tshuab uas T. gondii raug puas tsuaj rau lub raum tsis meej. Cov kev tshawb fawb yav dhau los tau pom tias tus kab mob Toxoplasma ua rau muaj kev nce ntxiv ntawm nitric oxide thiab reactive oxygen hom (ROS) hauv cov hlwb, ua rau oxidative stress [37]. Qhov kev ntxhov siab oxidative no txuas nrograum tsis ua haujlwmthiab ua rau cov lus teb thawj zaug uas tau kho los ntawm cov neeg kho mob proinflammatory TNF-alpha thiab IL-1b, thiab ib qho kev hloov pauv, NF-KB. Tom qab theem ntawmmobinduces ib qho kev nce hauv TGF-beta ntau lawm, ua rau cov synthesis ntawm extracellular matrix[38]. Yog li, cov nyhuv ntev ntawm oxidative kev nyuaj siab ntawm lub raum cov ntaub so ntswg yog kho los ntawm o, thiab cov ntaub so ntswg puas, ua rau lub cev tsis ua haujlwm [38]. Cov txheej txheem no yuav tsum tau nkag siab nyob rau hauv cov ntsiab lus ntawm cov cim ntawm kev txaus siab nyob rau hauv txoj kev tshawb no albumin, creatinine, thiab eGFR.Lub raum tsis ua haujlwmntsuas los ntawm qib albumin thiab creatinine hauv cov ntshav - lub raum noj qab haus huv tswj hwm qib albumin hauv cov ntshav thiab lim creatinine pov tseg los ntawm cov ntshav. Yog li, CKD biomarkers tau tshawb xyuas hauv qhov kev tshawb fawb no, suav nrog albuminuria thiab eGFR, muab kev pom rau kev koom tes ntawm Toxoplasma Gondii thiab CKD. Kev tshawb fawb los ntawm Gupta et al. tau qhia tias biomarkers ntawm o yog inversely cuam tshuam nrog rau kev ntsuas ntawm lub raum kev ua haujlwm thiab zoo nrog albuminuria, nrog rau qhov mob tau nce siab ntawm cov neeg uas qis dua eGFR thiab cov zis ntau dua albumin rau creatinine piv [39].

4.2. Qhov cuam tshuam ntawm Kev Tshawb Fawb

Nws yog ib qho tseem ceeb los tshawb nrhiav kev koom tes ntawm T. gondii thiab CKD, vim tias cov kab mob parasitic cuam tshuam rau cov kab mob raum tsis tau kawm. Qhov no yog qhov tseem ceeb tshwj xeeb vim tias kev tshawb fawb tau txav mus rau kev nkag siab txog qhov tshwm sim, uas yog, tag nrho ntawm qhov tshwm sim uas ua rau muaj qhov tshwm sim tsis zoo. Kev tshuaj xyuas qhov cuam tshuam ntawm T.gondi pab kaw qhov sib txawv hauv cov ntaub ntawv hais txog yuav ua li cas T. gondii thiab cov kab mob apicomplexan zoo sib xws ua rau muaj kev cuam tshuam rau lub raum tsis zoo nyob rau lub sijhawm luv thiab dhau lub neej. Nrog rau qhov kev nkag siab no, cov kev tshawb fawb yav tom ntej yuav zoo dua tuaj yeem txheeb xyuas qhov cuam tshuam ntawm T.gondii raug rau hauv cov ntsiab lus ntawm lwm qhov cuam tshuam, xws li ib puag ncig thiab kev sib raug zoo.

4.3.Kev txwv

Thaum txoj kev tshawb fawb no tau tsom mus rau kev tsim kev koom tes ntawm Toxoplasma kab mob thiab CKD, xav tau kev tshawb fawb ntxiv los tshawb xyuas cov kev taw qhia ntawm lub koom haum no. Tsuas yog muab tso tseg, vim yog qhov kev tsim ntawm ntu ntu ntawm txoj kev tshawb fawb, lub cev tsis tuaj yeem txiav txim siab. Yog li ntawd, txoj kev tshawb fawb ntev yuav muab kev pom zoo dua rau cov kev taw qhia ntawm qhov tshwm sim thiab qhov tshwm sim. Cov ntaub ntawv siv tau suav nrog qee cov txheej txheem biomarkers; Ntxiv biomarkers xws li cystatin C, -trace protein (BTP), thiab Neutrophil gelatinase-associated lipocalin (NGAL) yuav tsum raug txiav txim siab hauv kev tshawb fawb yav tom ntej.

Tsis tas li ntawd, ib qho piv txwv loj dua yuav tso cai rau kev tshuaj xyuas ntau dua ntawm cov qauv hauv qhov kev tshawb fawb no. Yog li, yuav tsum tau ceev faj thaum txhais cov txiaj ntsig.

5. Cov lus xaus

Qhov zoo ntawm T.gondii IgG antibody yog txuam nrog CKD thiab kev nce qib ntawm CKD. Lub koom haum no pom meej dua ntawm cov neeg laus. Kev tshawb nrhiav ntxiv yog xav tau los tshuaj xyuas cov kev tshawb pom no hauv thaj chaw sib txawv thiab ntawm cov neeg sib txawv.