Ntu Ⅱ:Herba Cistanche (Rou Cong Rong): Kev Ntsuam Xyuas Ntawm Nws Phytochemistry Thiab Pharmacology
Mar 05, 2022
Hu rau: Audrey Hu Whatsapp / hp: 0086 13880143964 Email:audrey.hu@wecistanche.com
Antioxidation
Antioxidation kev ua haujlwm yog tawm tsam dawb radicals. Cov tshuaj Antioxidant tuaj yeem txo qhov kev puas tsuaj ntawm oxygen dawb radicals rau phab ntsa ntawm cov hlab ntsha, yog li ua lub luag haujlwm ntawm cov kab mob sclerosis. Shiua al.98)thawj pom tias rho tawm los ntawmCistancheCov tsiaj muaj ib qho lipid peroxidation suppression-effect thiab ib qho kev tiv thaiv kab mob. PhGs los ntawmCistanchesHerba tuaj yeem txo qis lipid hydroperoxide hauv tib neeg, uas tau suav tias yog qhov ua tau zoo rau kev tiv thaiv oxidative.99,100)phenolic hydroxyl pawg hauv PhGs yog tsim nyog rau kev ua haujlwm antioxidant. Ib txoj kev tshawb nrhiav pom tias vim yog cov qauv phenolic hydroxy, PhGs tuaj yeem ua ke nrog cov dawb radicals thiab qhib cov tshuaj tiv thaiv antioxidant, thiab los ntawm kev nce cov phenolic hydroxyl pawg, cov tshuaj tiv thaiv antioxidant yog nce.34)Hauv lwm txoj kev tshawb fawb,Cistanche glycosidespom tias inhibitory cuam tshuam ntawm lipid hydroperoxide thiab thromboxane ntau lawm hauv cov ntshav luav, qhia tias cov glycosides muaj kev tiv thaiv tiv thaiv hemorrhagic shock thiab reperfusion raug mob.101)Wuthiabal.102)pom tias PhGs los ntawmC. salsamuaj cov haujlwm antioxidant siab heev. Lwm cov kev tshawb fawb pom tias PhGs los ntawmC. deserticolaUa kom muaj zog superoxide dismutase kev ua ub no, uas txo qis malondialdehyde hauv nas lub siab, lub siab, thiab lub hlwb; Yog li, cov kws sau ntawv ntseeg tias PhGs tuaj yeem tiv thaiv cov leeg pob txha los ntawm kev raug mob oxidative los ntawm kev tshem tawm ntau dhau ntawm cov dawb radicals.103)Cov kws tshawb fawb tau tsom ntsoov rau cov tshuaj antioxidants ntuj los tiv thaiv kab mob ntshav qab zib-nephropathy thiab cov txiaj ntsig tau tshawb fawb tau qhia tias PhGs los ntawmC. deserticolatuaj yeem inhibit reactive oxygen dawb radicalshauv vitrothiab kho dawb radical puas cuam tshuam rau ntshav qab zib nephropathy.104)Liangua al.105)taw qhia tias PhGs muab rho tawm los ntawmHerbaCistanchemuaj kev tiv thaiv ntawm tib neeg phev DNA nrog oxidative puas tsuaj nyob rau hauv 2015.18 tau los ntawmCistancheCov nroj tsuag tuaj yeem ua rau pheochromocytoma cell (PC12 cell) muaj peev xwm tiv thaiv H2O2-induced cytotoxicity thiab txo tus nqi apoptotic tib lub sijhawm.106)Wang thiab Zhao107)tsim cov kev ua antioxidant ntawmC. deserticolapolysaccharideshauv vitrothiab pom tias polysaccharides tuaj yeem tshem tawm cov dawb radicals xws li hydroxyl radical, superoxide anion radical, singlet oxygen, thiab diphenyl acyl. Nyob rau hauv 2016, ib qho kev cuam tshuam ntawm ultrasonic-cellulase-pab extraction ntawmC. tubulosapolysaccharides tau tsim, thiab nws cov polysaccharides pom muaj txiaj ntsig zoo rau kev ua haujlwm antioxidant.108)Lwm txoj kev tshawb fawb taw qhia tias polysaccharides los ntawmC. tubulosakuj tseem muaj cov haujlwm antioxidant zoo thaum ntsuas rau diphenyl acyl thiab hydroxyl radicals nrog rau cov peev txheej ntawm cov tooj liab ions.hauv vitro.109)Hauv cov ntsiab lus, PhGs thiab polysaccharides hauvCistanche nroj tsuag yog lub ntsiab antioxidants.
Cistanche glycosidestxiaj ntsig
Anti-Alzheimer's Disease
AD yog ib qho teeb meem ntawm cov kab mob neurological tshaj plaws uas ntsib cov neeg laus thiab yog qhov tseem ceeb ntawm kev tshawb fawb ntau. Raws li ib tug TCM, cov kev tshawb fawb tau ua pov thawj tias cov dej thiab cawv rho tawm ntawmCistanchesHerba muaj cov txiaj ntsig zoo los tiv thaiv Alzheimer's. Consumer Price Index database ntawm Tuam Tshoj tshaj tawm tias glycosides hauvCistanchethiab Cistanche Yizhi capsules tau tso cai rau kev kho mob ntawm AD.110)Nerve growth factor (NGF) tuaj yeem txhim kho kev nco, thiab cov kws tshawb fawb Kauslim111)pom tiasCistanchesHerba tuaj yeem txhawb nqa NGF zais cia, txhim kho kev paub txog tus cwj pwm ntsig txog lub peev xwm nco. Ib qho intracisternal infusion ntawm amyloid peptide 1–42 (A 1–42) rau hauv nas feem ntau tso rau hauv lub frontal cortex thiab hippocampus, ua rau kev nco tsis txaus hauv kev coj cwj pwm thiab ua rau muaj AD-zoo li pathology. Cov extracts los ntawmC. tubulosatau raug pov thawj los txo qhov kev puas siab puas ntsws los ntawm A 1-42 los ntawm kev thim rov qab cholinergic neuronal muaj nuj nqi thiab thaiv cov amyloid deposition.112)Amyloid peptide 25–35 (A 25–35) neurotoxicity tuaj yeem ua rau cholinergic system puas tsuaj, uas yog qhov tseem ceeb ntawm kev paub tsis meej. AD. Luo113)piav qhia txog cov txiaj ntsig thiab cov txheej txheem ntawm Cistanche glycosides hauv cov qauv nas ntawm AD induced los ntawm A 25–35, tawm tswv yim tias PhGs tuaj yeem txo cov kev ua acetylcholinesterase thiab Ca2ntxivcov ntsiab lus hauv hippocampus hauv AD qauv nas, uas yuav txhawb nqa cov qib acetylcholine ib txwm thiab txhim kho kev kawm thiab kev nco muaj peev xwm ntawm AD nas.114)Ntxiv thiab,C. tubulosaextract, uas muaj PhGs, zoo ib yam li cov tebchaw2 thiab11, tuaj yeem kho qhov kev paub tsis meej uas tshwm sim los ntawm A 1–42 viavthaiv cov amyloid deposition thiab thim rov qab cholinergic thiab hippocampal dopaminergic neuronal muaj nuj nqi.115)Lithiabal.116)soj ntsuam cov teebmeem neuroprotective ntawmCistanchesHerba ntawm cov neeg mob AD thiab pom tias cov qib ntawm tag nrho tau protein, qog necrosis yam- , thiab interleukin -1 raug txo qis hauvCistanchesHerba capsule pab pawg, uas ua pov thawj tias cov nroj tsuag no muaj peev xwm tiv thaiv kab mob rau AD. PhGs muaj kev tiv thaiv ntawm kev paub tsis meej los ntawm kev txhim kho synaptic plasticity hauv AD nas qauv. Jiathiabal.117)qhia tias qhov kev tiv thaiv AD no tuaj yeem cuam tshuam cytotoxicity mediated los ntawm A 1-42 kev tswj hwm thiab txo cov kev ntxhov siab oxidant. Lwm qhov kev sim kuj pom tias PhGs tiv thaiv neurons los ntawm kev txo qis ntawm A 1–42 thiab A 1-40 protein nyob rau hauv nas hippocampus. Tag nrho cov txiaj ntsig no muab kev txhawb nqa theoretical rau kev txhim kho ntxiv ntawm cov tshuaj tshiab tawm tsam AD.118)
Anti-Parkinson's Disease
PD yog ib qho mob neurodegenerative mob ntev uas tshwm sim los ntawm kev poob ntawm dopaminergic neurons nyob rau hauv substantia nigra, thiab nws cov kev kho mob tseem ceeb xws li dyskinesia, nqaij tawv, postural instability, thiab so tremors.119)Txog niaj hnub no, etiology ntawm PD tseem tsis tau qhia tag nrho. Txawm li cas los xij, cov kev tshawb fawb yav dhau los xav txog oxidative kev ntxhov siab vim yog kev ua haujlwm ntawm tes ntawm tes ntawm kev tsim khoom thiab kev tshem tawm ntawm cov dawb radicals raws li lub hauv paus txheej txheem cuam tshuam nrog kev tuag neuronal.110)Echinacoside (11), PhG compound, tau raug pov thawj los ntawm ntau cov kev tshawb fawb kom muaj kev tiv thaiv PD. Cov tshuaj no tau pom tias muaj kev tiv thaiv neuroprotection hauv PD nas induced nrog 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP).120)Gengthiabal.121)pom qhov sib xyaw11 tuaj yeem txhim kho tus cwj pwm thiab cov txiaj ntsig ntawm cov tshuaj neuro-chemical hauv MPTP nas qauv ntawm PD, uas tau qhia tias nws tuaj yeem siv los ua cov tshuaj kho mob rau PD. Tsis tas li ntawd, Chenua al.122)kuj xaus qhov kev sib txuas11 tuaj yeem tiv thaiv striatal dopaminergic neurons los ntawm kev nce qib ntawm monoamine neurotransmitters suav nrog dopamine, 3,4-dihydroxyphenylacetic acid, thiab homovanillic acid hauv 6hydroxydopamine (6-OHDA) kab mob nas thiab tej zaum yuav muaj txiaj ntsig zoo hauv kev tiv thaiv thiab kho mob. PD. Compound11 kuj tseem tiv thaiv PC12 hlwb tawm tsam 6-OHDA los ntawm kev ua kom cov mitochondrial membrane muaj peev xwm thaum txo qis mitochondria-mediated apoptosis tus nqi, uas txo cov cytotoxicity thiab ua rau muaj txiaj ntsig zoo neuroprotective.123)Tsis tas li ntawd, acteoside (2), ib qho isomer ntawm compound11, yog lwm qhov tseem ceeb active PhG compound los ntawmCistanche hom uas pom tias muaj peev xwm tiv thaiv PD los ntawm inhibiting 1-methyl-4-phenylpyridinium ion (MPP)ntxiv)-induced SH-SY5Y cell apoptosis; lub mechanism ntawm kev txiav txim kuj elucidated.124)Tsis tas li ntawd, compound2 kuj muaj kev tiv thaiv tseem ceeb rau MPPntxiv-induced cerebellar granule neurons, uas tej zaum yuav yog vim inhibition ntawm active caspase-3 thiab proteolytic poly polymerase fragment qhia.125)Cov tshuaj18 thiab37, uas yog bioactive compounds los ntawmCistanchenroj tsuag, kuj tau qhia tias muaj cov txiaj ntsig zoo neuroprotective tiv thaiv PD.126,127)
Kev Tswj Xyuas Kev Ua Haujlwm Endocrine
Androgen plays lub luag haujlwm tseem ceeb hauv kev tsim cov txiv neej cov ntaub so ntswg, thiab nws qhov kev tsis txaus ntseeg tuaj yeem ua rau muaj cov tsos mob, suav nrog rau lub raum tsis ua haujlwm. Raws li peb txhua tus paub,CistanchesHerba yog ib qho ntawm feem ntau siv tshuaj tonic nyob rau hauv cov tshuaj rau invigorating lub raum-yang. Kev tshawb fawb tau lees paub tias muaj ob txoj hauv kev tseem ceeb los ntxiv rau lub raum-yang. Ib qho yog los ntawm kev txhim kho kev ua haujlwm ntawm hypothalamus-pituitary-adrenal axis thiab txhawb kev tso tawm ntawm cov neurotransmitters thiab cov tshuaj hormones hauv lub cev, lwm qhov yog los ntawm kev tawm tsam qaug zog thiab txhim kho lub cev ua haujlwm.128) Cistanchetuaj yeem ua rau muaj pes tsawg tus pituitary hlwb, txhawb kev tso tawm ntawm zes qe menyuam progesterone, txhim khu kev qhia ntawm estrogen receptor thiab progesterone receptor ntawm gonadal axis, thiab inhibit qhov kev qhia ntawm interleukin -2 receptor hauv zes qe menyuam thiab interstitial. Nyob rau tib lub sijhawm, nws kuj tuaj yeem txhawb kev tsim cov androgen vim qhov tshwm sim ntawm ib qho kev sim uas qhov ntsuas ntawm prostate thiab testis nce qhov tseem ceeb hauv pawg nas castrated piv nrog cov pab pawg noj qab haus huv.129–132)PhGs hauvCistanchemuaj qee qhov kev cuam tshuam ntawm lipid peroxidation kev puas tsuaj ntawm cov phev membrane hauv cov nas kuaj, thiab lawv kuj ua lub luag haujlwm tiv thaiv hauv cov qauv thiab kev ua haujlwm ntawm cov phev membrane.133)Cov kev tshawb fawb tau pom tias PhGs muaj qhov pom tseeb kev kho mob ntawm cov kab mob spermatogenic uas tshwm sim los ntawm cyclophosphamide hauv cov nas, thiab nws cov txheej txheem yuav cuam tshuam txog kev txhim kho qib testosterone hauv cov qog ntshav.134)PhGs muaj kev ua haujlwm ntawm inhibiting qhov teeb meem ntawm kev sib deev cov tshuaj hormones hauv perimenopausal qauv nas thiab nas, kho qhov tsis txaus ntawm androgen receptor thiab estrogen receptor thiab txhim kho cov kev hloov pauv ntawm lub tsev menyuam, thymus, spleen, thiab pituitary.135)Tsis tas li ntawd, ib tug decoction ntawmCistanchetuaj yeem txhim kho kev tiv thaiv kev qaug zog ntawm yang deficiency nas.136)Xyoo 2004, Pan thiab Min137)pom tias cov cawv muab rho tawm los ntawmCistanchetuaj yeem tiv thaiv atrophy ntawm adrenal cortex hauv nas nrog raum-yang tsis txaus, thiab tseem muaj qee yam kev tiv thaiv ntawm lub raum ua haujlwm. Wuthiabal.138)xav tiasC. deserticolathiabC. tubulosaOb leeg muaj qee yam tonic ntxim rau lub raum-yang, thiab lawv cov decoction tuaj yeem ua rau qhov hnyav nce ntxiv thiab pom tseeb ua kom lub sijhawm txias txias ntawm lub raum yang tsis txaus tus qauv nas.C. deserticoladecoction tau tshaj tawm tias muaj peev xwm nce cov ntsiab lus ntawm cov ntshav testosterone thiab qhov hnyav ntawm cov hlab ntsha thiab cov qog prostate hauv cov txiv neej nas.139)Hauv lwm qhov kev tshawb fawb,C. deserticoladecoction eased cov tshuaj toxicity nyob rau hauv txiv neej nas tshwm sim los ntawm Leigongteng glycoside.140)Jiangthiabal.141)taw qhia tias 70 feem pua ethanol extract ntawmC. tubulosatuaj yeem thim rov qab qog ntshav thiab phev puas hauv Sprague-Dawley (SD) nas los ntawm kev tswj hwm cov steroidogenesis enzymes hauv gonad axis, thiab cov khoom sib xyaw.11 yog ib tug ntawm cov active constituents. Tsis tas li ntawd, Wangthiabal.142)pom tiasC. tubulosaextracts tuaj yeem txhim kho SD nas progesterone thiab testosterone qib. Xyoo 1996, Zongthiabal.143)
