Ntu Ⅱ: Sab Hnub Tuaj Rau Sab Hnub Poob: Kev Tshawb Fawb Txog Kev Tshawb Fawb Hauv Suav Tshuaj Rau Kev Tiv Thaiv Kev Tiv Thaiv

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Rov qab mus rau PART Ⅰ

Nyem rau cistanche cov txiaj ntsig thiab cov kev mob tshwm sim rau Anti-aging

Pharmacological kev tshawb fawb ntawm TCMs

Heshouwu (Polygoni multiflora radix) (Polygoni multiflora radix). Heshouwu (Polygoni multiflora radix) yog lub hauv paus qhuav ntawm Polygonum multiflorum Thunb., thiab nws cov haujlwm tseem ceeb suav nrog txo cov ntshav lipid thiab ua kom muaj zog tiv thaiv kev laus xws li kev tiv thaiv kab mob thiab kev txawj ntse. Lub emodin derivative, emodin -8-o-(6'-o-malonyl)-glucoside, raug cais tawm ntawm Heshouwu (Polygoni multiflora radix) los ntawm Lo thiab al.. pituitary hlwb los ntawm activating auxin receptor, uas ua hauj lwm rau induce auxin tso tawm thiab muaj antiaging zog [70]. Tsis tas li ntawd, Chen et al. [71] pom tias aqueous extract ntawm Heshouwu (Polygoni multiflora radix) pom tseeb inhibited kev ua ntawm monoamine oxidase nyob rau hauv lub hlwb thiab daim siab cov ntaub so ntswg ntawm cov laus nas, qhia tias Heshouwu (Polygoni multiflora radix) tiv thaiv thiab kho cov kab mob senile xws li kev nyuaj siab thiab Parkinson's. kab mob-hais txog qhov teeb meem ntawm monoamines hauv lub hlwb. Tang et al. tau kawm txog cov teebmeem ntawm ethyl acetate extract ntawm Heshouwu (Polygoni multiflora radix) ntawm lub neej ntawm Caenorhabditis elegans thiab pom tau hais tias qhov nruab nrab lifespan ntawm nematodes tau ntev ntev nyob rau hauv qis, nruab nrab, thiab siab concentration pawg (25, 37.5, thiab 50 mg. /L ethyl acetate, ntsig txog, xam raws li cov tshuaj crude) dua li ntawm pawg neeg dawb huv, tshwj xeeb tshaj yog nyob rau hauv pawg nruab nrab concentration. Ib qho kev sib tham ntxiv txog kev muaj peev xwm ntawm 37.5 mg / L ethyl acetate los ncua kev laus hauv cov nematodes yam tsis muaj kev puas tsuaj rau lawv lub peev xwm ua me nyuam tau nthuav tawm [72]

Cistanche phenylethanoid glycosidesmuaj peev xwm ua tautshem tawm cov dawb radicals. Nws muaj peev xwm txo tau siab dua li ntawm cov vitamin C. Nws muaj peev xwm mus khawb diphenyl thiab trinitrohydrazine.dawb radicalsthiabanti-lipid peroxidation kev ua haujlwmyog siab tshaj ntawm cov vitamin E.Cistanche Polysaccharidestuaj yeem ua rau muaj kev ua haujlwm ntawm superoxide dismutase thiab glutathione photooxidative hauv cov ntshav liab thiab lub ntsws cov ntaub so ntswg ntawm cov neeg laus, thaum txo cov ntsiab lus ntawm malondialdehyde thiab collagen hauv ntsws thiab ntshav, thiab muaj txiaj ntsig zoo rau kev tshem tawm DPPH. Cistanche cistanche polysaccharide muaj cov txiaj ntsig zoo ntawm cov superoxide anions, pawg hydroxyl, DPPH dawb radicals thiab singlet oxygen, nce cov ntsiab lus ntawm tryptophan thiab kynurenine hauv lub lens ntawm cov neeg mob laus sai, txhim kho qhov tseem ceeb ntawm cov ntshav.SOD, thiab ncua kev laus Tus neeg mob lub physiological degeneration thiab cell morphology degeneration.

Danggui (Angelicae Sinensis radix) (Angelicae Sinensis Radix). Danggui (Angelicae Sinensis Radix) yog lub hauv paus qhuav ntawm Angelica Sinensis (Oliv.) Diels. Cov kev sim tshuaj niaj hnub no tau pom tias Danggui (Angelicae Sinensis radix) muaj ntau yam kev tiv thaiv kev laus ntawm ntau lub tshuab [73]. Qi et al. [74] siv D-galactose-induced aging nas raws li kev tshawb fawb qauv los kawm txog kev tiv thaiv kev laus ntawm Danggui (Angelicae Sinensis Radix). Cov dej decoction ntawm Danggui (Angelicae Sinensis radix) qhia tau hais tias zoo antiaging zog uas yog nyob ntawm koob tshuaj. Tsis tas li ntawd, cov txheej txheem tiv thaiv kev tiv thaiv ntawm Danggui (Angelicae Sinensis radix) suav nrog nce kev ua haujlwm ntawm Ca2 ntxiv -ATP enzyme thiab stabilizing cov concentrations ntawm nitric oxide synthase thiab Ca2 ntxiv, yog li ntsuas cov ntsiab lus ntawm NO. Tsis tas li ntawd, An et al. [75] pom tias Danggui (Angelicae Sinensis radix) tuaj yeem txo cov protein qhia ntawm p16 hauv cov ntaub so ntswg hauv hlwb thiab txo cov haujlwm ntawm monoamine oxidase hauv lub hlwb thiab lub raum cov ntaub so ntswg thaum txhim kho cov haujlwm ntawm CAT hauv daim siab thiab lub raum cov ntaub so ntswg. Yog li, cov txheej txheem tiv thaiv kev laus ntawm Danggui (Angelicae Sinensis radix) tuaj yeem cuam tshuam nrog kev txhim kho antioxidant muaj peev xwm, txo qis ntawm p16 qhia, thiab inhibition ntawm kev laus cell proliferation. Tsis tas li ntawd, Danggui (Angelicae Sinensis radix) kuj tseem tuaj yeem ua rau muaj kev ua haujlwm SOD hauv cov ntshav thiab cov ntaub so ntswg thiab txhim kho cov dawb radical scavenging peev xwm, uas ua rau txo MDA ntau lawm, protein dissolution, thiab protein denaturation, yog li ua kom muaj kev ncaj ncees ntawm cov cell membrane qauv thiab kev ua haujlwm. thiab tom qab ncua qhov tshwm sim ntawm apoptosis [76].

Gouqizi (Lycii fructus) (Lycii fructus). Gouqizi (Lycii Fructus), ib hom tshuaj noj zaub mov homologous tshuaj, yog cov txiv hmab txiv ntoo qhuav ntawm Lycium barbarum L. Ib txoj kev tshawb fawb dhau los siv tib neeg lub ntsws diploid fibroblasts (2BS hlwb) ua qauv kev laus los kawm txog kev tiv thaiv kev laus ntawm Gouqizi (Lycii Fructus) thiab pom tau hais tias cov aqueous extract ntawm Gouqizi (Lycii Fructus) tuaj yeem ceev tus nqi ntawm DNA synthesis nyob rau hauv fusion hlwb ntawm 2BS thiab yog li ncua lawv lifespan [77]. Medlar polysaccharide (MP) yog ib hom dej-soluble polysaccharide uas muaj rau monosaccharide Cheebtsam; Nws yog lub luag haujlwm tseem ceeb ntawm Gouqizi (Lycii Fructus) thiab ntseeg tau tias yog thawj cov khoom muaj lub luag haujlwm rau kev tiv thaiv kev laus ntawm Gouqizi (Lycii Fructus), qhia nws lub luag haujlwm tseem ceeb hauv cov tshuaj pharmacological tseem ceeb ntawm Gouqizi (Lycii Fructus). Tsis tas li ntawd, nws tau pom tias MP tuaj yeem nce SOD kev ua haujlwm thiab txo MDA cov ntsiab lus hauv cov nas laus [78]. MP kuj tseem tuaj yeem nce glutathione peroxidase thiab SOD cov dej num thiab txo MDA cov ntsiab lus hauv cov ntshav ntawm MP-kho laus nas nrog cavernous paj hlwb [79]. Tsis tas li ntawd, nws tau pom tias MP plays lub luag haujlwm tiv thaiv kev laus los ntawm kev ua kom cov haujlwm ntawm endogenous antioxidant enzymes kom qeeb cov txheej txheem cuam tshuam nrog kev puas tsuaj oxidative, thiab cov txheej txheem no yuav cuam tshuam nrog kev ua kom Nrf2 / ARE txoj hauv kev los ntawm MP [80] .

Kawm txog cov tshuaj tiv thaiv kab mob TCM

Qhov tshwj xeeb kev nkag siab ntawm cell senescence thiab antiaging raws li muaj feem xyuam rau TCM cov tshuaj muaj txiaj ntsig zoo, tau txais txiaj ntsig zoo los ntawm cov kws tshawb fawb Suav tshwj xeeb.

Pharmacological kev tshawb fawb ntawm cov tshuaj tiv thaiv TCMs

Ntau tshaj 100 daim ntawv tshuaj tiv thaiv TCMs muaj. Qee cov ntawv sau tseem ceeb tau sau tseg hauv qab no:

Cov tshuaj classic ntawm Liuwei Dihuang ntsiav tshuaj. Hauv kev tshawb fawb ntawm Liuwei Dihuang ntsiav tshuaj (LWDH), ib txwm muaj kev laus ICR nas tau kho nrog LWDH rau 30 hnub, thiab cov khoom tiv thaiv kev laus ntawm LWDH tau tshawb xyuas siv cov tshuaj metabonomics. Hauv qhov kev tshawb fawb dhau los no, 10 biomarkers ntsig txog kev tiv thaiv kev tiv thaiv ntawm LWDH tau txais thiab ntau yam kev tiv thaiv kev laus raug txheeb xyuas, suav nrog cov cuam tshuam rau linoleic acid metabolism, pantothenate, thiab CoA biosynthesis, glycerophospholipid metabolism, thiab amino qab zib thiab nucleotide qab zib metabolism [81] . Tsis tas li ntawd, Zhou et al. tau tshaj tawm tias LWDH tuaj yeem cuam tshuam qhov cuam tshuam thiab tus nqi ntawm tus viv ncaus chromatid pauv hauv nas pob txha hlwb raug rau cyclophosphamide, uas muaj cov txiaj ntsig zoo DNA puas. Cov txiaj ntsig no qhia tias LWDH ua lub luag haujlwm hauv kev ncua kev laus los ntawm kev txhim kho lub peev xwm ntawm lub cev los tiv thaiv DNA kev puas tsuaj [82]. Tsis tas li ntawd, LWDH tuaj yeem nce SOD kev ua haujlwm thiab txo MDA thiab lipid peroxide cov ntsiab lus hauv cov ntshav ntawm cov nas; Nws kuj nthuav tawm lub peev xwm zoo tshem tawm cov dawb radicals hauv lub cev [83].

Classic cov tshuaj niaj hnub ntawm Jingui Shenqi ntsiav tshuaj. Yan et al. tau kawm txog cov tshuaj pharmacological ntawm Jingui Shenqi ntsiav tshuaj (JGSQ) ntawm autoimmune encephalomyelitis nas qauv thiab pom tau tias JGSQ txo cov qhab nia ua haujlwm ntawm lub paj hlwb, txo cov kab mob, thiab tswj qhov sib piv ntawm CD4 / CD8 hlwb thiab tus naj npawb ntawm NK hlwb hauv lub hlwb. autoimmune encephalomyelitis nas qauv [84]. Hauv lwm txoj kev tshawb fawb, cov teebmeem ntawm JGSQ ntawm telomerase hauv daim siab thiab lub hlwb ntawm cov qauv nas laus tau kawm los ntawm kev siv enzyme-txuas immunosorbent assay thiab qRT-PCR ntawm qib protein thiab transcription, feem. Cov txiaj ntsig tau pom tias qhov kev qhia ntawm telomerase hauv cov ntaub so ntswg ntawm cov nas laus tau txhim kho tom qab JGSQ tswj hwm. Nws ntseeg tau tias cov teebmeem kev kho mob ntawm JGSQ ntawm cov nas laus muaj feem xyuam nrog kev txhawb nqa ntawm telomerase qhia hauv qee cov ntaub so ntswg [85]. Ntxiv mus, JGSQ tuaj yeem txwv tsis pub apoptosis ntawm lub raum cov ntaub so ntswg los ntawm inhibiting kev qhia ntawm qog necrosis factor receptor superfamily tswv cuab 6, txhawb kev qhia ntawm Bcl -2, thiab nce qib ntawm testosterone thiab testicular SOD nyob rau hauv cov ntshav ntawm nas, qhia. tias nws muaj cov khoom zoo antioxidant [86].

Classic daim ntawv qhia ntawm Erzhi ntsiav tshuaj. Zhang et al. [87] kho cov nas muaj hnub nyoog raug ntxias nrog D-galactose nrog Erzhi ntsiav tshuaj (EZ) thiab pom tau tias kev ua haujlwm ntawm cov ntshav peroxides thiab cov ntsiab lus ntawm lipid peroxides tau nce siab dua hauv EZ-kho nas dua li cov nas tswj, qhia tias EZ txhim kho. lub peev xwm antioxidant thiab ncua cov txheej txheem kev laus. Tsis tas li ntawd, Yao et al. [88] pom tias EZ tuaj yeem nce qhov loj ntawm spleen lymphocytes; phagocytosis ntawm lub plab macrophages; thiab theem ntawm IL-1, IL-2, thiab IL-12 hauv cov ntshav tom qab EZ tswj hwm, qhia tias EZ muaj cov tshuaj tiv thaiv kab mob ntsig txog kev txhim kho mRNA kev qhia ntawm T-lymphocyte factor. Zhao et al. siv EZ-muaj cov kuab tshuaj rau kab lis kev cai ntawm daim siab mob qog noj ntshav kab BEL-7402 thiab kab mob ntsws cancer kab A549 thiab pom tias qhov inhibition ntawm ob kab mob qog noj ntshav tau ntau dua li cov kab mob ntshav qab zib, qhia tias EZ muaj inhibitory cuam tshuam ntawm qog loj hlob [89]. Tsis tas li ntawd, nws kuj tau tshaj tawm tias EZ muaj ntau yam tshuaj xws li txo cov ntshav lipid [90], txhim kho hlau deficiency anemia [91], thiab tiv thaiv osteoporosis [92].

Classic ancient tshuaj ntawm Sijunzi decoction. Cov txheej txheem tiv thaiv kev laus ntawm SJZ tau kawm hauv D-galactose-induced aging nas, thiab cov txiaj ntsig tau pom tias Sijunzi decoction (SJZ) tuaj yeem nce glutathione peroxidase qib thiab MDA cov ntsiab lus hauv cov ntaub so ntswg (xws li, lub hlwb thiab daim siab cov ntaub so ntswg) thiab cov ntshav ntawm cov laus. nas, yog li txhim kho cov khoom tiv thaiv oxidative ntawm SJZ thiab ncua kev laus [93]. Pang [94] kuj tau kawm txog cov txheej txheem tiv thaiv kev laus ntawm SJZ thiab pom tias SJZ tuaj yeem txhim kho kev ua haujlwm ntawm mitochondrial respiratory chain enzyme complex, txo kev puas tsuaj rau mtDNA, thiab ua kom cov synthesis ntawm ATP hauv hlwb mitochondria hauv cov nas laus. Cov txiaj ntsig no qhia tias SJZ nthuav tawm cov khoom tiv thaiv kev laus los ntawm kev tiv thaiv mtDNA. Tsis tas li ntawd, Yang [95] tau kawm txog cov teebmeem ntawm SJZ ntawm kev ua haujlwm telomerase hauv plawv, hlwb, thiab daim siab ntawm cov nas laus. Cov txiaj ntsig tau pom tias SJZ tuaj yeem ua rau muaj kev ua haujlwm telomerase hauv thymus ntawm D-galactose-induced aging nas thiab hais tias cov nyhuv no cuam tshuam rau kev ua kom T lymphocytes hauv thymus. Tsis tas li ntawd, Liu et al. [96] tau kawm txog cov teebmeem ntawm SJZ ntawm plab hnyuv dysbacteriosis hauv cov nas laus thiab pom tias plab hnyuv Enterobacter, Enterococcus, Bifidobacterium, thiab Lactobacillus rov qab mus rau qib qub thiab lub neej ntawm cov nas laus tau ntev tom qab kev tswj hwm ntawm SJZ. Tsis tas li ntawd, SJZ tuaj yeem cuam tshuam lub hom phiaj ntawm cov tsiaj nyeg ntawm rapamycin signaling txoj kev thiab txo qhov kev qhia ntawm p70 ribosomal protein S6 kinase los ntawm kev txo qis kev ua kom phosphoinositide-3-kinase txo qhov kev puas tsuaj los ntawm oxidative kev nyuaj siab, yog li ncua kev laus [97 ].

Clinical study of antiaging prescriptions LWDH. Qing et al. tshawb xyuas cov teebmeem ntawm LWDH ntawm Alzheimer's disease; 50 tus neeg mob hauv pab pawg kho mob tau tswj hwm LWDH thiab 52 hauv pawg tswj hwm tau muab cov tshuaj piracetam (ib hom tshuaj rau Alzheimer's disease), thiab qhov kev sim tau siv sijhawm li 6 lub hlis. Cov txiaj ntsig ntawm qhov kev tshawb fawb soj ntsuam no tau pom tias LWDH muaj cov txiaj ntsig zoo dua ntawm kev txhim kho kev txawj ntse, muaj peev xwm ua neej nyob, thiab nco txog cov neeg mob Alzheimer's ntau dua li cov ntsiav tshuaj piracetam [98]. Hauv lwm txoj kev tshawb fawb, Zhong et al. tau kawm txog cov teebmeem ntawm LWDH ntawm Parkinson's disease hauv 53 tus neeg mob uas tau kho nrog ob hom tshuaj Parkinson tus kab mob thiab LWDH ( pab pawg kho mob) thiab 36 tus neeg mob uas tau kho nrog cov tshuaj Parkinson tus kab mob ib leeg (tswj pab pawg). Lub sijhawm ntawm kev tswj hwm yog 6 lub hlis, thiab cov txiaj ntsig tau pom tias tag nrho cov txiaj ntsig ntawm kev kho mob thiab pab pawg tswj hwm yog 81 feem pua ​​​​thiab 61.5 feem pua, raws li qhia tias LWDH muaj cov txiaj ntsig zoo hauv kev txhim kho Parkinson tus kab mob ntau dua li cov tshuaj ib txwm siv [99] . Tsis tas li ntawd, Zhang et al. kawm LWDH rau kev kho mob ntshav qab zib hom 2. Hauv kev sim tshuaj, 150 tus neeg mob tau kho nrog LWDH (6 ntsiav tshuaj ib hnub) rau 6 lub hlis. Cov txiaj ntsig tau pom tias cov ntshav qabzib yoo mov, cov ntshav qabzib tom qab noj mov, thiab qib glycosylated hemoglobin tau txo qis, thaum qib C-peptide nce ntxiv tom qab kev tswj hwm LWDH. Tsis tas li ntawd, tsis muaj qhov tshwm sim tsis zoo xws li lub plawv, lub siab, lossis lub raum ua haujlwm puas tsuaj tom qab noj tshuaj [100].

JGSQ. Cov kev kho mob ntawm JGSQ tau kawm hauv 76 cov neeg mob uas muaj Alzheimer's tus kab mob uas tau muab faib ua pawg kho mob thiab pab pawg tswj hwm, nrog 38 tus neeg mob hauv txhua pab pawg. Txoj kev tshawb no tau ua los soj ntsuam cov teebmeem ntawm JGSQ ntawm Alzheimer's disease. Txog qhov kawg no, pab pawg kho mob tau tswj hwm JGSQ, thiab pawg tswj hwm tau tswj hwm piracetam ntsiav tshuaj. Cov kev ua ub no ntawm kev ua neej nyob txhua hnub thiab cov qhab nia ua haujlwm tau raug txiav txim siab 3 lub hlis tom qab kho. Cov txiaj ntsig kev sim tau pom tias tag nrho cov kev kho mob tau zoo yog 82.05 feem pua ​​​​hauv pab pawg kho mob thiab 39.74 feem pua ​​​​hauv pawg tswj hwm, qhia tias JGSQ nthuav tawm cov txiaj ntsig zoo ntawm kev txhim kho Alzheimer's disease [101]. Cao tau kho 24 tus neeg mob laus nrog cov kab mob fungal thib ob nrog JGSQ thiab fluconazole. Cov txiaj ntsig tau pom tias txhua tus neeg mob tau kho tsuas yog 1 tus neeg mob mob ntsws cancer uas tuag ntawm ntau lub cev tsis ua haujlwm, qhia tias JGSQ tsis tsuas yog kho ntau yam kab mob hauv cov neeg laus tab sis kuj tiv thaiv cov kev mob tshwm sim ntawm fluconazole [102]. Zhao tau kawm 30 cov neeg mob laus uas muaj ntshav siab uas yuav tsum tau kho nrog JGSQ. Ntawm lawv, 12 tus mob hyperlipidemia, 6 tsim kab mob plawv, thiab 2 mob ntshav qab zib. Cov txiaj ntsig kev kho mob tau pom tias cov ntshav siab systolic ntawm qee cov neeg mob tau txo qis mus rau qhov qub, thiab cov ntshav lipid kuj tseem zoo dua tom qab kho [103].

SJZ. Yang et al. siv SJZ los kho 62 cov neeg mob laus uas muaj cem quav thiab kawm txog kev kho mob ntawm SJZ; Cov neeg mob no tau muab faib ua pawg kho mob (31 tus neeg mob) thiab pawg tswj hwm (31 tus neeg mob). Pab pawg kho mob tau tswj hwm SJZ, thaum pawg tswj hwm tau muab tshuaj phenolphthalein ntsiav tshuaj (ib hom tshuaj rau kev kho mob cem quav). Cov txiaj ntsig ntawm txoj kev tshawb fawb no tau pom tias tag nrho cov txiaj ntsig kev kho mob hauv cov pab pawg kho mob thiab tswj tau yog 87.09 feem pua ​​thiab 54.83 feem pua. Kev ua tau zoo ntawm SJZ ua ke nrog saxagliptin (ib yam tshuaj rau kev tswj cov ntshav qabzib) hauv kev kho cov neeg laus nrog hom 2 mob ntshav qab zib mellitus kuj tau kawm, thiab qhov kev sib xyaw no tau pom tias muaj txiaj ntsig zoo hauv kev txo cov ntshav qabzib thiab txhim kho cov tshuaj insulin ntsig txog. Tsis tas li ntawd, qhov kev kho mob no tseem tswj hwm nesfatin-1 thiab kev sib deev hormone-binding globulin qib, yog li txhim kho insulin tsis kam thiab txo qhov kev pheej hmoo ntawm kev mob ntshav qab zib [104].

Kev cia siab thiab cov ntsiab lus

Cov kev siv tau zoo los ncua kev laus tau kawm ntau yam nrog cov txiaj ntsig tau zoo. Tseeb tiag, nrog kev txhim kho hauv cov tshuaj niaj hnub thiab molecular biology, kev ua tiav zoo tau ua tiav hauv kev kawm txog kev laus cov txheej txheem. Txawm li cas los xij, kev nkag siab tag nrho ntawm cov txheej txheem kev laus tsis tau ua tiav vim kev laus yog cov txheej txheem lom neeg uas tshwm sim los ntawm ntau yam. Yog li ntawd, vim hais tias ntawm complexity thiab uncertainty nyob ib ncig ntawm lub aging txheej txheem, kev laus tsis tuaj yeem piav qhia los ntawm ib lub tswv yim tab sis yuav tsum tau tshawb xyuas ntau yam thiab nyob rau theem tob. Raws li cov ntsiab lus ntawm kev laus, nws tau txiav txim siab tias yuav tsum muaj qee qhov kev sib txuas sab hauv hauv kev tshawb fawb ntawm cov txheej txheem kev laus. Kev tshawb fawb ntxiv ntawm qhov kev sib txuas no yuav tsum pab nthuav peb txoj kev nkag siab ntawm cov txheej txheem kev laus. Raws li qhov tseem ceeb ntawm kev tshawb fawb interdisciplinary, kev sib xyaw ntawm kev tshawb fawb los tiv thaiv kev laus nrog cell biology, molecular biology, genomics, metabolomics, thiab lwm yam kev qhuab qhia yuav tsum nthuav dav cov kev tshawb fawb tshawb fawb txog kev tshawb fawb txog kev laus yav tom ntej.

Kev saib xyuas txav tau dav siv hauv cov tswv yim tiv thaiv kev laus vim tias lawv yog ntuj, yooj yim, thiab tsis txwv los ntawm ib qho khoom siv lossis qhov chaw. Txawm hais tias kev saib xyuas kev txav mus los muaj qhov zoo tshwj xeeb hauv cov tswv yim tiv thaiv kev laus, lawv kuj yuav muaj kev cuam tshuam tsis zoo yog tias lawv tsis haum rau ib tus neeg mob. Yog li ntawd, nws tau txiav txim siab tias qhov txiaj ntsig zoo tshaj plaws cuam tshuam txog kev tiv thaiv kev tiv thaiv ntawm kev saib xyuas kev txav mus los yog ua tiav los ntawm kev xaiv txoj kev kho mob tsim nyog rau cov neeg mob. Qhov no xav kom cov tib neeg los txhim kho kev ua tau zoo thiab kev kho mob zoo thiab txhawb kev txhim kho lawv lub cev thiab lub hlwb raws li lawv lub cev thiab cov kws kho mob cov lus qhia. Qhov tseeb, lub tswv yim no suav nrog cov kev xav sib txawv, suav nrog cov uas cuam tshuam nrog kev noj zaub mov, kev saib xyuas kev noj qab haus huv, kev mob hlwb, thiab kev ua si thiab kev tawm dag zog.

Nrog rau txoj kev loj hlob ntawm kev tshawb fawb technologies niaj hnub txuam nrog TCMs, ntau thiab ntau antiaging TCMs tau raug tshawb pom. Tseeb tiag, kev tshawb fawb thiab kev tsim cov tshuaj tiv thaiv kab mob tshiab raws li TCMs yuav tsum tau coj mus rau hauv tshooj tshiab. Txawm li cas los xij, muaj qee qhov tsis txaus ntseeg hauv TCM kev tshawb fawb txog kev tiv thaiv kev laus. Ua ntej, feem ntau ntawm cov kev tshawb fawb ntawm antiaging mechanisms ntawm TCMs tau tsom mus rau kev tiv thaiv kev tiv thaiv kab mob thiab kev tiv thaiv kab mob. Yog li ntawd, kev tshawb fawb yuav tsum tshawb nrhiav cov txheej txheem tiv thaiv kev laus ntxiv yav tom ntej. Tsis tas li ntawd, kev sib txuas cov tswv yim los ntawm qhov kev xav ntawm ntau yam kev tiv thaiv kev tiv thaiv nrog rau lub tswv yim ntawm kev ncaj ncees thiab kev ua haujlwm yuav tsum ua rau kev tshawb fawb thiab kev tsim khoom noj qab haus huv thiab tshuaj tiv thaiv. Qhov thib ob, tsuas yog ib feem me me ntawm cov khoom xyaw tiv thaiv kev tiv thaiv ntawm TCMs tau raug txheeb xyuas tam sim no, nrog ntau cov khoom xyaw tshuaj tiv thaiv tseem xav tau kev tshawb fawb tshuaj ntxiv. Thib peb, kev tshawb fawb ntxiv ntawm cov tshuaj pharmacokinetics ntawm TCMs yuav pab txhawb kev thoob ntiaj teb thiab kev lees paub ntawm TCMs. Txawm li cas los xij, rau ntau tus TCMs, tshwj xeeb tshaj yog cov uas muaj feem xyuam nrog cov ntawv sau tshuaj, cov khoom xyaw yog qhov nyuaj heev, yog li cuam tshuam rau qhov ua tau ntawm kev ntsuas qhov tob thiab kev ntsuas tshuaj pharmacodynamic. Yog li ntawd, nws yog ib qho tsim nyog los tshawb nrhiav cov kev tshawb fawb ntxiv ntawm cov tshuaj pharmacology nrog kev sib xyaw ntawm TCM txoj kev xav thiab kev tshawb fawb niaj hnub thiab thev naus laus zis.

Hauv lub cev, kev laus thiab kev tsim dua tshiab tshwm sim ib txhij, thiab cov txheej txheem ntawm kev laus tshwm sim thaum lub peev xwm ntawm kev tsim dua tshiab tsis tuaj yeem phim qhov kev laus. Yog hais tias cov hlwb yog immortalized, cov txheej txheem ntawm cov ntaub so ntswg laus yuav tsum tau ncua los yog txawm thaiv. Autologous qia hlwb yog ib chav kawm ntawm ntau lub hlwb nrog rau nws tus kheej-renewal thiab self-replication peev xwm. Raws li qee qhov xwm txheej, cov hlwb no tuaj yeem sib txawv rau ntau hom neeg laus pluripotent qia hlwb. Pluripotent hlwb ntxiv thiab tswj cov kab mob, qhib lub zog ntawm cov hlwb laus, ua kom cov hlwb ib txwm muaj, txhim kho cov hlwb zoo, tiv thaiv thiab ncua cov kab mob ntawm cov hlwb, thiab rov ua kom lub cev muaj zog ntawm cov hlwb. Tam sim no, autologous qia hlwb tau muab cov txiaj ntsig zoo hauv kev kho mob ntawm qee yam kab mob xws li myeloma [105], kab mob plawv [106], thiab thyroid tsis ua haujlwm [107]. Tsis tas li ntawd, cov hlwb no muaj qhov zoo ntawm kev nyab xeeb thiab kev ntseeg siab, nrog rau kev tiv thaiv kev tiv thaiv tsawg, yog li nthuav tawm lub tswv yim zoo rau kev tshawb fawb txog kev tiv thaiv yav tom ntej.

Xaus

Hauv txoj kev tshawb no, kev nce qib hauv kev tshawb fawb ntawm cov tswv yim tiv thaiv kev tiv thaiv los ntawm sab hnub tuaj mus rau sab hnub poob tau raug tshuaj xyuas, nrog rau kev tsom mus rau kev tiv thaiv kev tiv thaiv ntawm ntau yam TCMs. Cov tshuaj Western tau ua tiav cov txiaj ntsig zoo hauv kev tshawb fawb txog kev laus cov txheej txheem, thiab TCM tau ua lub luag haujlwm tseem ceeb hauv kev kawm txog kev tiv thaiv kev laus. Nrog rau kev nce qib tsis ntev los no hauv cov txheej txheem molecular biology, kev tshawb fawb ntau ntxiv ntawm kev tiv thaiv kev laus TCMs tau ua los ntawm cov cuab yeej siv niaj hnub no, uas muab lub sijhawm rau kev kawm tob txog kev tiv thaiv kev laus. Txawm li cas los xij, txawm hais tias qhov kev nce qib no, cov kev txwv xws li tsis paub meej thiab tsis pom cov khoom sib xyaw ua ke thiab ib qho kev tshawb fawb txog kev tiv thaiv TCMs xav tau cov neeg tshawb xyuas thoob plaws kev qhuab qhia los ua haujlwm ua ke. Nyob rau hauv xyoo tas los no, cov hau kev tsom rau ncua kev laus siv autologous qia cell transplantation tau tshaj tawm, uas tuaj yeem sawv cev rau cov kev taw qhia tshiab hauv kev tshawb fawb los tiv thaiv kev laus.

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