Part 1: Chronic Interstitial Nephritis nyob rau hauv Agricultural Zej Zog Yog Ib Tug Toxin-induced Proximal Tubular Nephropathy

Hu rau: Audrey Hu Whatsapp / hp: 0086 13880143964 Email:audrey.hu@wecistanche.com

Benjamin A.Vervaet', Cynthia C. Nast', Channa Jayasumana³, Gerd Schreurs', Frank Roels4, Chula Herath', Nika Kojc degree, Vahid Samaee', Sonali Rodrigo³,

Swarnalata Gowrishankar, Christiane Mousson, Rajeewa Dassanayake', Carlos M. Orantes1, Vincent Vuiblet 2, Claire Rigothier13 Patrick C. D'Haese' thiab Marc E. De Broe

'Laboratory of Pathophysiology, University Antwerp, Antwerp, Belgium; 2Cedars-Sinai Medical Center, Los Angeles, California, USA;3Faculty of Medicine, Rajatrata University of Sri Lanka, Anuradhapura, Sri Lanka; 4Department of Pathology, Ghent University, Gent, Belgium; 5Department of Nephrology, Sri Jayewardenepura General Hospital, Colombo, Sri Lanka;°Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia; 'Electron Microscopy for Materials Science (EMAT), University of Antwerp, Antwerp, Belgium; °Department of Pathology, Apollo Hospitals, Hyderabad, India; >Department of Nephrology, Center Hospitalier Universitaire de Dijon, Dijon, Fabkis; Lub raum, Tsev Kho Mob General, Polonnaruwa, Sri Lanka;' National Institute of Health, Ministry of Health ntawm EI Salvador, San Salvador, EI Salvador;'Departments of Nephrology thiab Renal Pathology, Center Hospitalier Universitaire de Reims, Reims, Fabkis; thiab 13Service Nephrologie, Transplantation, Dialyse thiab Aphéreses, Center Hospitalier Universitaire de Bordeaux, Bordeaux, Fabkis

cistanche cov txiaj ntsig kev noj qab haus huv: tiv thaiv lub raum tsis ua haujlwm

Yuav luag 30 xyoo tom qab kuaj pom tus mob interstitial nephritis nyob rau hauv cov zej zog ua liaj ua teb (CINAC) nws cov etiology tseem tsis paub. Txhawm rau pab txhais qhov no peb tau tshuaj xyuas 34 lub raum biopsies los ntawm Sri Lanka, EI Salvador, India, thiab Fabkis ntawm cov neeg mob raum mob ntev 2-3 thiab kuaj CINAC los ntawm lub teeb thiab hluav taws xob microscopy. Ntxiv nrog rau kev paub txog histopathology, peb tau txheeb xyuas qhov tshwj xeeb ntawm qhov sib thooj ntawm cov tubular cell tshawb pom nrog rau cov dysmorphic lysosomes loj nrog lub teeb-nruab nrab electron-dense matrix uas muaj dispersed tsaus electron-dense non-membrane khi "aggregates".

cistanche cov txiaj ntsig: kho mob raum kab mob

Cov aggregates no muaj feem xyuam nrog ntau qib ntawm cellular / tubular atrophy, pom meej ntawm cov tawg tawg, thiab tsis muaj zog ntawm cov tubular cell proliferative muaj peev xwm. Cov kab mob lysosomal zoo ib yam, txheeb xyuas los ntawm electron microscopy, tau pom nyob rau hauv 9 feem pua ​​​​ntawm lub raum hloov pauv hauv lub raum implantation biopsies tab sis muaj ntau dua nyob rau hauv rau lub hlis (50 feem pua) thiab 12 lub hlis (67 feem pua) raws tu qauv biopsies thiab indication biopsies (76 feem pua) ntawm calcineurinor inhibitor. - kho cov neeg mob hloov chaw. Cov phenotype kuj pom muaj cuam tshuam nrog cov tshuaj nephrotoxic (lomustine, clomiphene, lithium, cocaine) thiab hauv qee cov neeg mob uas muaj teeb pom kev zoo tubulopathy, txhua yam kev mob uas tuaj yeem cuam tshuam ncaj qha lossis tsis ncaj qha rau calcineurin pathway inhibition lossis modulation.

suab puam cistanche cov txiaj ntsig: lub raum ua haujlwm zoo dua

Ib puas biopsies ntawm lub raum ib txwm, tshuaj / tshuaj lom neeg nephropathies, thiab cov neeg mob proteinuric overt ntawm cov etiologies sib txawv rau qee qhov tuaj yeem ua rau pom lub teeb microscopic proximal tubular cell hloov, tab sis tsis tshua muaj electron microscopic lysosomal nta. Cov nas kho nrog calcineurin inhibitor cyclosporine rau plaub lub lis piam tau tsim cov kev hloov pauv ntawm cov tubular cell lysosomal zoo sib xws, uas tsis muaj nyob rau hauv pawg lub cev qhuav dej. Zuag qhia tag nrho, kev tshawb pom ntawm qhov zoo ib yam ntawm cov tubular cell (lysosomal) qhov txhab hauv CINAC thiab calcineurin inhibitor nephrotoxicity nyob rau hauv ntau thaj tsam qhia tau hais tias ib qho piv txwv uas CINAC cov neeg mob tau txais ib tug tubulotoxic mechanism zoo ib yam li calcineurin inhibitor nephrotoxicity.

cistanche extract

Hauv kaum xyoo dhau los ntawm lub xyoo pua 20th, cov kws kho mob ceeb toom hauv Central America thiab Sri Lanka tau piav qhia ntau tus neeg mob hauv lawv cov zej zog ua liaj ua teb nyob deb nroog nrog cov kab mob raum mob hnyav (CKD) uas tsis muaj ntshav siab lossis ntshav qab zib. Cov txiv neej tau cuam tshuam feem ntau, suav nrog cov neeg ua haujlwm qab zib hauv Central America thiab cov neeg ua liaj ua teb hauv Sri Lanka. Hauv Central America, tus kab mob no tau hu ua "Meso-American Nephropathy" (MeN), thaum nyob rau hauv Sri Lanka, "CKD ntawm un-known etiology" (CKDu) yog cov nyiam terminology.

cistanche hmoov

Raws li kev sib piv cov chaw kho mob, kab mob, thiab kab mob kis tau tus kab mob, lub sij hawm Chronic Interstitial Nephritis nyob rau hauv Agricultural Communities (CINAC) tau npaj siab los piav qhia txog ob qho tib si. Cov kev ntsuas kev noj qab haus huv thiab kev ua haujlwm feem ntau suav nrog huab cua kub kub, kev txom nyem, thiab raug rau cov tshuaj lom neeg agrochemical los ntawm kev noj cov zaub mov tsis huv, dej haus los ntawm qhov dej ntiav, nqus tau thiab lwm yam.