Cov neeg mob Parkinson's Disease's Prone Dementia nyob rau theem kawg, thiab cov neeg mob phais kom raws sijhawm tau txais txiaj ntsig ntxov!

Cov neeg mob Parkinson yuav muaj cov tsos mob dementia, nrog rau qhov tshwm sim ntawm 24 feem pua ​​​​rau 31 feem pua ​​​​, thiab 70 feem pua ​​​​rau 80 feem pua ​​​​ntawm cov neeg mob Parkinson tus kab mob thaum kawg tsim dementia. Parkinson's disease dementia yog ib qho mob hnyav ntawm Parkinson's disease kev paub tsis meej, thiab Parkinson's disease me me kev paub tsis meej yog ib theem ntawm Parkinson's disease cognitive function thiab Parkinson's disease dementia.

Cov kev hloov pauv pathological ntawm PD tsis pib hauv substantia nigra pars compacta tab sis tau muab faib ua 6 theem. 1. Qee tus neeg mob muaj qhov hnov ​​tsw txawv txav. Hauv theem thib ob, cov medulla oblongata thiab pontine tegmentum tau koom nrog, suav nrog cov kab mob hauv lub caudate nucleus, raphe nucleus, locus coeruleus, thiab lwm yam, thiab cov neeg mob yuav mob taub hau, pw tsaug zog, teeb meem kev xav, thiab lwm yam. Qhov no hu ua premotor 2. Nyob rau theem pib ntawm kev tawm dag zog 3, midbrain kuj pib koom nrog, cuam tshuam rau amygdala, substantia nigra pars compacta, thiab lwm yam. Tus neeg mob qhov muag xim, thermoregulation, cognition, thiab lwm yam kev ua haujlwm txawv txav, thiab kev nyuaj siab, mob nraub qaum, thiab lwm yam. tej zaum yuav tshwm sim.

Nyem rau Cistanche tshuaj ntsuab thiab Cistanche kev paub rau Parkinson tus kab mob

Cov kab mob peb-theem saum toj no txhua yam tshwm sim ua ntej pib ntawm cov tsos mob ntawm PD lub cev muaj zog, uas yog vim li cas cov tsos mob tsis yog lub cev muaj zog xws li kev nyuaj siab, pw tsaug zog, cem quav, thiab tsis hnov ​​​​tsw cuam tshuam tshwm sim thaum ntxov ntawm tus kab mob. Txog rau thaum cov kev hloov pauv pathological nkag mus rau theem plaub, thiab cov kab mob ua rau lub thalamus, cov tsos mob ntawm PD ntawm so tremor, myotonia, bradykinesia, thiab postural balance disorders yuav tshwm sim. Ntau tus neeg mob tsis nrhiav kev kho mob kom txog rau thaum lub sijhawm no, tab sis cov kev hloov pauv pathological tsis pom kev lawm. Tom qab ntawd, theem 5 qhov txhab cuam tshuam nrog neocortex, nrog cov tsos mob xws li kev hloov pauv ntawm lub cev muaj zog thiab nquag nkees.

Thaum theem 6 qhov txhab ntxiv ua rau neocortex, tsis meej pem, pom kev pom, dementia, thiab cov tsos mob ntawm lub hlwb yuav tshwm sim.

Ntau tus neeg tsis meej pem qhov kev paub tsis meej ntawm Parkinson tus kab mob nrog Alzheimer's, tab sis ob qho tib si tsis zoo ib yam. Kev paub txog kev poob qis los ntawm tus kab mob Parkinson muaj feem cuam tshuam rau kev nkag siab ntawm kev mloog, kev ua haujlwm, kev muaj peev xwm visuospatial, thiab kev nco, xws li tsis tuaj yeem kos cov duab xws li lub voos xwmfab. Dementia, ntawm qhov tod tes, cuam tshuam kev nco ntau dua, feem ntau tsis nco qab cov xwm txheej tsis ntev los no thiab nrhiav tsev.

Cov neeg mob Parkinson tus kab mob twg muaj feem yuav tsim kev dementia?

Advanced age: Hnub nyoog yog qhov tseem ceeb tshaj plaws. Hauv qhov sib piv, dementia tsis tshua muaj nyob rau hauv cov neeg mob uas muaj PD thaum ntxov. Tshwj xeeb, cov neeg mob uas pib ua ntej hnub nyoog 40 xyoo tsis tshua muaj kev mob dementia.

Cov kab mob ntev dua: Cov kab mob ntev dua, qhov kev loj hlob ntawm tus kab mob hnyav dua, thiab koj tuaj yeem tsim dementia ntau dua. Yog tias dementia tshwm sim hauv ib xyoos ntawm tus kab mob Parkinson, peb yuav tsum rov ntsuam xyuas seb nws puas yog thawj tus kab mob Parkinson lossis lwm yam kab mob xws li dementia nrog Lewy lub cev.

Kev sib raug zoo ntawm cov tshuaj: Kev nco tsis zoo thiab kev paub tsis meej tshwm sim los ntawm cov tshuaj Parkinson tus kab mob feem ntau tshwm sim sai tom qab noj cov tshuaj, uas cuam tshuam nrog lub sijhawm siv tshuaj. Dementia hauv Parkinson tus kab mob nws tus kheej tshwm sim maj mam thaum tus kab mob no zuj zus. Cov tshuaj rau kev kho mob ntawm Parkinson tus kab mob xws li tshuaj anticholinergic, amantadine, dopamine receptor agonists, MAO-B inhibitors, thiab COMT inhibitors yuav ua rau kev puas hlwb puas hlwb, thiab cov tshuaj anticholinergic yog thawj me ntsis. Cov kev puas siab puas ntsws thiab kev txawj ntse uas tshwm sim sai sai tom qab noj cov tshuaj yuav tsum raug suav hais tias muaj feem xyuam nrog tshuaj.

Tus kab mob Parkinson muaj cov tsos mob loj heev: cov neeg mob uas muaj kev nruj, kev tsis txaus ntseeg ntawm lub cev, thiab kev cuam tshuam ntawm kev mus los (PIGD subtype) muaj feem ntau yuav ua rau dementia.

Early Mild Cognitive Impairment: Parkinson's disease cov neeg mob uas muaj kev paub tsis meej thaum ntxov muaj feem yuav tsim cov tsos mob ntawm dementia. Ntawm qhov tsis sib xws, yog tias qhov kev txawj ntse thaum ntxov zoo dua, qhov ua tau ntawm kev dementia mus ntev yog qis dua.

Kev kho mob sai ntawm Parkinson cov neeg mob tau txais txiaj ntsig ntxov

Nws feem ntau ntsib cov neeg mob Parkinson's disease tsis muaj lub sijhawm rau kev kho mob phais tom qab kev ntsuam xyuas, lossis tus kab mob kis mus rau theem kawg thiab raug mob hnyav thiab poob lub sijhawm rau kev phais. Kuj tseem muaj cov neeg mob Parkinson cov tsos mob xws li tshee hnyo thiab nruj zoo tom qab kev phais, tab sis vim muaj teeb meem mus ntev, Cov tsos mob cuam tshuam rau tus neeg mob txoj kev phais.

Yog li ntawd, peb tau ceeb toom tias kev phais mob Parkinson yuav tsum tau raws sijhawm, thiab tsis txhob tos kom muaj teeb meem loj, thaum dementia tsis tuaj yeem koom tes, thiab thaum koj laus dhau los ua kev phais, koj yuav plam txoj hauv kev kho mob.

Vim li cas Cistanche yog Cov Tshuaj Zoo Tshaj Plaws rau Parkinson's Disease

Echinacosidehauv Cistanche tuaj yeem txhim kho tus cwj pwm tsis zoo ntawm MPTP-induced PD qauv nas, nce striatal dopamine (DA) metabolite 3,4-dihydroxypheny lacetic acid (3,4-dihydroxypheny lacetic acid, DOPAC), thiab siab. Vanillic acid (homovanillic acid, HVA) cov ntsiab lus tseem ceeb inhibits qhovapoptosisntawm cerebellar granule neurons tshwm sim los ntawm kev ua kom cov caspase-3 thiab caspase-8; txo qhov overexpression ntawm biliverdin reductase B nyob rau hauv lub hlwb ntawm Parkinson cov neeg mob, qhia Cistanche Echinacoside txo qhov nce ntawm biliverdin reductase B tshwm sim los ntawmoxidativentxhov siab los ntawm nwstshuaj tiv thaiv oxidativeCov nyhuv kev ntxhov siab, thiab tiv thaiv dopaminergic neurons los ntawm oxidative kev nyuaj siab puas. NwsneuroprotectiveCov txheej txheem yuav zoo ib yam li cov kua tsib Cov qib chlorophyll reductase B muaj feem cuam tshuam; kom txo tau cov dopaminergic neurons thiab dopamine transporters hauv substantia nigra ntawm lub hlwb ntawm cov neeg mob Parkinson tus kab mob, thiab tuaj yeem txhim khoneurotrophicyam[Neurotrophic factor, NTF. hlwb-derived neurotrophic factor, BDNF) thiab cov hlab ntsha Cov kev ua ub no thiab cov protein qhia theem ntawm glial cell line-derived neurotrophic factor (GDNF) muab tau los ntawm glial cell kab tuaj yeem txo qhov piv ntawm mRNA thiab protein nyob rau hauvapoptosisthiab Bax/Bcl-2. Tsis tas li ntawd, echinacoside tuaj yeem nce cov ntsiab lus ntawm dopamine, DOPAC, thiab HVA hauv cov kua dej ntxiv ntawm cov striatum ntawm cov neeg mob Parkinson's disease.

Yog xav paub ntxiv:ali.ma@wecistanche.com