Omicron Severity: Milder Tab sis tsis me

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In The Lancet, Nicole Wolter and colleagues1 report data from more than 11000 individuals (>80·0% hnub nyoog 19–59 xyoo; 55·9% poj niam) nrogCOVID-19Hauv South Africa qhia txog qhov txo qis ntawm kev nkag mus rau hauv tsev kho mob rau cov neeg mob uas muaj tus kab mob omicron SARS-CoV-2 variant of concern (B.1.1.529) piv rau lwm yam SARS-CoV-2 variants nyob rau tib lub sijhawm (Kaum Hli 1–Nov 3{{10}}, 2021; kho qhov sib txawv piv txwv [aOR] {{20}}·2, 95 feem pua ​​CI {{24 }}·1–0·3) thiab txo qis qhov sib txawv ntawm cov kab mob hnyav ntawm cov neeg mob kis los ntawm omicron variant dua li cov neeg mob kis tus kab mob delta variant (B.1.617.2) hauv cov kab mob sib kis ua ntej (aOR 0·3, 0· 2–0 · 5). Cov kev tshawb pom muaj txiaj ntsig zoo no - muab los ntawm lub teb chaws theemCOVID-19Cov ntaub ntawv soj ntsuam hauv tsev kho mob txuas nrog cov ntaub ntawv, chav kuaj, thiab cov ntaub ntawv genomic - sawv cev rau kev lees paub ntawm cov cim qhia thaum ntxov uas omicron variant tuaj yeem ua rau muaj kab mob tsawg dua thiab kev cuam tshuam hauv zej zog, thiab muaj kev cuam tshuam rau tsev kho mob cov peev txheej, dua li cov kev hloov pauv uas ua rau muaj kev sib kis ua ntej dhau los. . Thaum tsis muaj genotyping thoob plaws ntawm kev paub tseeb SARS-CoV-2 kab mob, Wolter thiab cov npoj yaig1 tau siv qhov ua kom tsis muaj zog ntawm cov noob caj noob ces (S gene phiaj tsis ua haujlwm [SGTF]) ntawm TaqPath PCR assay ua tus tso npe rau omicron variant. SGTF yog tus cim tsim nyog rau qhov sib txawv ntawm omicron uas tau muab rau lwm qhov kev hloov pauv hloov pauv tsis muaj tus yam ntxwv no thaum lub sijhawm kawm.1 Hauv cov ntsiab lus ntawm kev nthuav dav omicron sib txawv sib kis, qib ntawm kev nthuav dav ntawm cov ntaub ntawv South African mus rau lwm qhov kev txiav txim thiab lub sijhawm yog ntawm qhov tseem ceeb thoob ntiaj teb.

suab puam cistanche cov txiaj ntsighauv kev ua haujlwm ntawmtiv thaiv kab mob

Yog tias qhov kev txo qis ntawm qhov kev pheej hmoo ntawm tus kab mob hnyav nrog omicron variant, zoo ib yam li tau pom hauv tebchaws Askiv, 2 tuaj yeem raug suav hais tias yog qhov ua rau qis qis, nws yuav ua rau muaj kev lees paub rau pej xeem thiab cov neeg saib xyuas kev noj qab haus huv uas tsis ntev los no muaj kev ceeb toom loj heev.COVID-19Cov ntaub ntawv xov xwm pom thoob ntiaj teb yuav tsis txhais mus rau qhov tsis tuaj yeem tswj tau nce hauv tsev kho mob, nrog rau kev cuam tshuam rau kev nruj lossis kev so ntawm txoj cai tswj hwm kab mob. Txawm li cas los xij, South Africa tau rov nthwv dej ntau ntxiv, thiab qhov twg qhov xwm txheej no tuaj yeem piav qhia txog qhov txo qis ntawm SGTF tus kab mob nyob rau xyoo 2021 yog qhov tsis meej. SARS-CoV-2 reinfections yog me me ntawm qhov nruab nrab ntawm thawj kis kab mob, 3 thiab, los ntawm lub Kaum Ob Hlis 2021, ntau dua 70 feem pua ​​​​ntawm cov neeg South Africa tau muaj kev tiv thaiv tam sim no.SARS-CoV-2cov tshuaj tiv thaiv raws li qhov tshwm sim ntawm tus kab mob los yog tshuaj tiv thaiv.4 Hauv kev tshawb fawb los ntawm Wolter thiab cov npoj yaig, 1 qhov tsis sib xws ntawm tus kab mob yav dhau los tau nyob ib puag ncig 23- lub sij hawm siab dua hauv SGTF-mob piv rau cov neeg mob delta variant-infected, uas tuaj yeem yog vim muaj qhov txawv txav ntawm omicron lub peev xwm rau kev tiv thaiv kev tiv thaiv uas tuaj yeem ua rau muaj feem cuam tshuam ntawm cov kab mob me me.5 Qhov muaj peev xwm ntawm qee cov neeg mob tau mus pw hauv tsev kho mob nrog, tsis yog rau, SARS-CoV-2 kab mob kuj tuaj yeem cuam tshuam qhov kev soj ntsuam qhov hnyav tau muab ze-universal. , ua ntej tsev kho mobCOVID-19kuaj thiab cov pejxeem coob zuj zus tuaj ntawm tus kab mob.6

dab tsi yog cistanche: txhim khotiv thaiv kab mob

Hauv kev sim kom tsis txhob muaj qhov hnyav ntawm cov neeg tiv thaiv, Wolter thiab cov npoj yaig1 tau txheeb xyuas qhov mob hnyav los ntawm kev sib piv cov neeg nyob hauv tsev kho mob nrog omicron (SGTF) piv rau lwm yam txawv (tsis yog-SGTF) siv qhov sib xyaw ntsuas ntawm qhov hnyav, uas suav nrog kev nkag mus rau qhov hnyav. chav saib xyuas, mob ua pa nyuaj, kho cov pa oxygen, thiab kev tuag.1 Qhov kev ntsuam xyuas no tsis muaj tseeb, tej zaum yog vim muaj qhov tshwm sim me me; Txawm li cas los xij, muaj kev lom zem plausibility rau qee qhov kev txo qis hauv qhov hnyav ntawm cov kab mob omicron, raws li qhia los ntawm cov kev tshawb fawb hauv chaw soj nstuam uas qhia txog kev txo cov kab mob hauv tus tsiaj qauv7 thiab txo qis kev muaj peev xwm ntawm tib neeg lub ntsws hlwb rau omicron piv rau lwm yam txawv.8

Kev paub ntau npaum li cas omicron ua rau mob hnyav yog qhov tseem ceeb. Tab sis, txawm tias qhov kev nthuav qhia kho mob me me tuaj yeem raug cuam tshuam los ntawm kev kis tus kab mob ntau ntxiv nrog omicron variant, nrog lub peev xwm ua rau muaj kev cuam tshuam loj hauv zej zog los ntawm kev mob, kev tsim khoom ploj, kev nyuaj siab, thiab kev siv zog ntxiv rau kev kho mob vim cov neeg ua haujlwm tsis tuaj. . Piv txwv li, thaum Lub Ib Hlis 6, 2022, nws tau kwv yees tias ib ntawm 25 tus neeg hauv tebchaws Askiv muaj cov tsos mob ntawm COVID-19.9 Kev cais tus kheej ntawm cov neeg mob, thiab kev yeem los yog yuav tsum tau cais tawm ntawm lawv cov kev sib cuag tuaj yeem cuam tshuam ntau tus neeg. ntawm cov neeg.

Cov kab mob sib kis hauv zej zog ntawm omicron variant tej zaum yuav muaj kev cuam tshuam tsawg dua rau kev noj qab haus huv piv nrog yav dhau los COVID-19 nthwv dej hauv ntau qhov chaw vim tias muaj kev tiv thaiv cov pej xeem nce ntxiv thiab qhov ua tau txo qis hauv qhov hnyav ntawm cov kab mob omicron. Txawm li cas los xij, nyob rau hauv feem ntau cov tub ntxhais hluas South African pejxeem, 21 feem pua ​​​​ntawm cov neeg mob pw hauv tsev kho mob tau kis tus kab mob SARS-CoV-2 omicron variant tau txais txiaj ntsig kev kho mob hnyav, 1 qhov kev faib ua feem uas yuav nce ntxiv thiab ua rau muaj kev cuam tshuam loj heev thaum muaj kev sib kis hauv cov neeg sib txawv. cov pej xeem thiab qib qis ntawm kev kis kab mob los yog tshuaj tiv thaiv kab mob. Daim ntawv tshaj tawm no ntawm cov kab mob me me tom qab kis kab mob nrog omicron piv rau delta variant hauv South Africa tau txhawb nqa, tab sis peb yuav tsum tsis txhob xav tias omicron sib txawv sib kis yuav muaj kev noj qab haus huv tsawg nyob rau lwm qhov.

cov txiaj ntsig cistancherau lub cev tiv thaiv kab mob

Kev siv

1 Wolter N, Jassat W, Walaza S, et al. Kev ntsuam xyuas ntxov ntawm kev kho mob hnyav ntawm SARS-CoV-2 omicron variant hauv South Africa: kev tshawb nrhiav cov ntaub ntawv txuas. Lancet 2022; luam tawm online Jan 19.

2 UK Health Security Agency. SARS-CoV-2 variants of concern and variants under investigative in England. Kev qhia luv luv: hloov tshiab ntawm kev mus pw hauv tsev kho mob thiab tshuaj tiv thaiv zoo rau omicron VOC-21NOV-01 (B.1.1.529). Peb Hlis 31, 2021.

3 Abu-Raddad LJ, Chemaitelly H, Bertollini R. Severity of SARS-CoV-2 reinfections as piv nrog thawj kab mob. N Engl J Med 2021; 4 385:

4 Madhi SA, K 2487–89. dej G, Myers JE, et al. South African pej xeem tiv thaiv thiab mob hnyav Covid-19 nrog omicron variant. medRxiv 2021; luam tawm online Dec 21.

5 SARS-CoV-2 neutralizing antibodies. Cao Y, Wang J, Jian F, et al. Omicron khiav tawm feem ntau ntawm Nature 2021 uas twb muaj lawm; luam tawm online Dec 23.

6 Sastry SR, Pryor R, Raybould JE, et al. Kev tshuaj ntsuam thoob ntiaj teb rau tus kab mob SARS-CoV-2 ntawm kev nkag mus hauv tsev kho mob hauv thaj chaw uas muaj tus kab mob COVID-19 tsawg. Kev Tswj Kab Mob Hosp Epidemiol 2020; 41: 1231–33. 7 Pob Zeb Diamond M, Halfmann P, Maemura T, et al.

7 The SARS-CoV-2 B.1.1.529 omicron virus ua rau muaj kev kis tus kab mob thiab kab mob hauv nas thiab hamsters. Hauv Kev Ntsuam Xyuas Xwm Txheej Txheem 2021; luam tawm online Dec 29.

8 Chan MCW, Hui KPY, Ho J, et al. SARS-CoV-2 omicron variant replication in human respiratory tract ex vivo. 2021.

9 ZOE COVID Study. Cov ntaub ntawv tshaj tawm. Omicron kis tau qeeb tab sis cov neeg mob hnyav dua 75s. Peb Hlis 6, 2022.

ceg tcmhauvtiv thaiv kab mob