Oleic Acid Rau Stearic Acid Ratio Tej zaum yuav yog qhov muaj peev xwm cim rau insulin tsis kam nyob rau hauv Nyiv tsis rog
Jul 17, 2023
Cov txiaj ntsig tau los ntawm kev tshawb fawb tsis ntev los no qhia tias qib siab dua ntawm oleic acid / stearic acid piv tau cuam tshuam nrog kev rog tsis zoo. Qhov no tau raug lees paub ntxiv hauv cov kev tshawb fawb crosssectional thiab interventional; Txawm li cas los xij, qhov no tsis tau kawm dav dav hauv cov pej xeem uas tsis muaj mob. Peb tau nrhiav 260 tus neeg Nyij Pooj nrog cov ntshav tsis muaj roj fatty acid uas tab tom kuaj xyuas kev noj qab haus huv. Cov kev txiav txim siab rau oleic acid / stearic acid piv tau raug tshawb xyuas siv ntau qhov kev ntsuam xyuas rov qab. Txhawm rau sib piv cov cim sib txawv, cov ntsiab lus tau muab cais raws li oleic acid / stearic acid piv thiab kev sib xyaw ntawm oleic acid / stearic acid piv thiab triglyceride qib. Qhov sib piv ntawm oleic acid / stearic acid tau pom muaj kev sib raug zoo nrog dogmatic hloov pauv triglyceride / high-density lipoprotein cholesterol piv thiab qhov ceev ceev triglyceride qabzib Performance index, ob qho tib si tau siv los ua cov cim rau insulin tsis kam. Ntau qhov kev ntsuam xyuas tau pom tau tias qhov triglyceride / high-density lipoprotein cholesterol piv thiab ceev triglyceride qabzib ntsuas tau zoo cuam tshuam nrog oleic acid / stearic acid piv. Feem ntau cov cim yog qhov phem tshaj plaws hauv pawg triglyceride siab tshaj plaws hauv ob pawg oleic acid / stearic acid. Tsis tas li ntawd, feem ntau cov cim tau phem dua nyob rau hauv cov pab pawg neeg siab oleic acid / stearic acid piv dua li cov pab pawg tsawg. Hauv kev xaus, oleic acid / stearic acid piv yuav yog ib qho txiaj ntsig zoo rau cov tshuaj insulin tsis kam rau cov neeg Nyij Pooj.
Glycoside ntawm cistanche tuaj yeem ua rau muaj kev ua haujlwm ntawm SOD hauv plawv thiab daim siab cov ntaub so ntswg, thiab txo cov ntsiab lus ntawm lipofuscin thiab MDA hauv txhua cov ntaub so ntswg, tshem tawm ntau yam reactive oxygen radicals (OH-, H₂O₂, thiab lwm yam) thiab tiv thaiv DNA puas. los ntawm OH-radicals. Cistanche phenylethanoid glycosides muaj peev xwm tshem tawm cov dawb radicals, muaj peev xwm txo tau ntau dua li cov vitamin C, txhim kho cov haujlwm ntawm SOD hauv cov phev ncua, txo cov ntsiab lus ntawm MDA, thiab muaj qee yam kev tiv thaiv ntawm cov phev ua haujlwm. Cistanche polysaccharides tuaj yeem txhim kho kev ua haujlwm ntawm SOD thiab GSH-Px hauv erythrocytes thiab ntsws cov ntaub so ntswg ntawm cov nas senescent sim los ntawm D-galactose, nrog rau txo cov ntsiab lus ntawm MDA thiab collagen hauv lub ntsws thiab ntshav, thiab nce cov ntsiab lus ntawm elastin, muaj Cov nyhuv scavenging zoo ntawm DPPH, ncua lub sijhawm ntawm hypoxia hauv cov nas senescent, txhim kho cov haujlwm ntawm SOD hauv cov ntshav, thiab ncua lub physiological degeneration ntawm lub ntsws hauv kev sim cov nas nrog cellular morphological degeneration, kev sim tau pom tias Cistanche muaj peev xwm antioxidant zoo. thiab muaj peev xwm los ua ib qho tshuaj tiv thaiv thiab kho cov kab mob ntawm daim tawv nqaij laus. Nyob rau tib lub sijhawm, echinacoside hauv Cistanche muaj lub peev xwm tseem ceeb txhawm rau txhawm rau DPPH dawb radicals thiab muaj peev xwm tshem tawm cov pa oxygen reactive thiab tiv thaiv dawb radical-induced collagen degradation, thiab kuj muaj kev kho zoo ntawm thymine dawb radical anion puas.
Nyem rau Desert Cistanche Cov txiaj ntsig
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Lo lus tseem ceeb:oleic acid rau stearic acid piv, triglyceride rau high-density lipoprotein cholesterol piv, triglyceride-glucose Performance index, insulin tsis kam
Cov txiaj ntsig ntawm qhov tsis ntev los no ntawm 10-xyoo longitudinal Shanghai Diabetes Study (SHDS), (1) qhia tias qib pib siab dua ntawm oleic acid / stearic acid (OA / SA), thiab qis qis ntawm stearic acid / palmitic acid (SA / PA), thiab arachidonic acid / dihomo-g-linolenic acid (AA / DGLA) piv tau cuam tshuam nrog kev hloov pauv ntau dua ntawm kev noj qab haus huv ntawm cov rog rog mus rau metabolically tsis noj qab haus huv kev rog rog. Qhov kev tshawb nrhiav no tau raug lees paub nyob rau hauv kev tshawb fawb hla ntu thiab kev cuam tshuam. Nws tau kwv yees tias qhov piv txwv ntawm [cov khoom tsis muaj roj fatty acid (FFA) / precursor FFA] yuav zoo dua cuam tshuam txog cov xwm txheej ntawm endogenous fatty acid metabolism, piv rau cov concentration ntawm ib tus neeg FFAs.
Cov tshuaj insulin-tiv taus yog txuam nrog kev cuam tshuam vascular teb rau insulin thiab endothelial dysfunction. Insulin resistance (IR) muaj feem xyuam rau ntau yam kab mob, nrog rau cov kab mob metabolic (MetS), atherosclerosis, kub siab, thiab ntshav qab zib mellitus, thiab yog li ntawd, nws yog ib qho tseem ceeb los ntsuas IR. Lub hyperinsulinemic-euglycemic clamp tseem yog tus qauv kub rau IR thiab cov qauv kev ntsuam xyuas homeostasis rau IR (HOMA-IR) yog qhov kev siv ntau tshaj plaws rau hnub tim. (2–4) Txawm li cas los xij, vim tus nqi, kev nkag tau yooj yim, rov tsim dua, thiab rov ua dua, cov kev xaiv no tsis siv tau hauv kev kho mob. (2,4–7) Tsis tas li ntawd, kev yoo mov qib insulin yuav tsum suav HOMA-IR. Txawm li cas los xij, lawv tsis niaj hnub ntsuas hauv qhov chaw kho mob.
Nws tau qhia tias triglyceride (TG) / high-density lipoprotein cholesterol (HDL-C) piv tau sib raug zoo nrog IR, (8-10) thiab nws zoo li yog qhov muaj txiaj ntsig zoo rau kev txhim kho ntshav qab zib, (11) lub plawv plawv. kab mob, thiab kev tuag ntawm cov hlab plawv. (12) TG / HDL-C piv yog qhov ntsuas ntsuas zoo dua rau MetS, piv rau HOMA-IR. (13) Nws tau tshaj tawm tias, hauv cov neeg laus Nyij Pooj, lipid ratios ntawm TG / HDL-C, Total-C / HDL-C, LDL-C / HDL-C, nrog rau TG thiab HDL-C, tau txuam nrog MetS thiab IR. Cov neeg txais kev khiav hauj lwm cov yam ntxwv nkhaus kev txheeb xyuas tau qhia tias tus cim zoo tshaj plaws rau cov kev hloov pauv no yog TG / HDL-C piv, hauv cov txiv neej thiab poj niam. (14) Txawm li cas los xij, qee qhov kev tshawb fawb tsawg heev tau tshawb xyuas qhov piv txwv no raws li qhov qhia txog kev mob metabolic hauv cov neeg tshwj xeeb. (14,15)
Lub vas nthiv triglyceride-glucose (TyG) index, ib yam khoom ntawm kev yoo mov triglycerides thiab qabzib, tau nthuav tawm cov txiaj ntsig tau zoo raws li tus cim surrogate rau kev ntsuas ntawm IR.(16-18)
Txoj kev tshawb no tau tsim los tshawb xyuas seb qhov OA / SA piv puas cuam tshuam nrog IR. Txoj kev tshawb no tseem tshawb xyuas seb qhov OA / SA piv ntsuas cov metabolism hauv cov neeg laus uas tsis rog rog.
Cov ntaub ntawv thiab cov txheej txheem
Cov kawm. Tag nrho ntawm 319 qhov kev kawm, tau mus kuaj kev noj qab haus huv los tiv thaiv kev laus ntawm Lub Chaw Saib Xyuas Kev Noj Qab Haus Huv, Tokai University Tokyo Tsev Kho Mob hauv xyoo 2016, tau suav nrog hauv qhov kev tshawb fawb no. Tom qab tsis suav nrog 28 cov ntsiab lus, rau leej twg cov ntshav FFA cov ntaub ntawv tsis tau txheeb xyuas, thiab 31 cov ntsiab lus nrog cov ntaub ntawv tsis tiav, 260 cov ntsiab lus tau suav nrog hauv kev txheeb xyuas zaum kawg. Cov ntaub ntawv kho mob tau txais los ntawm kev siv cov lus nug tus kheej thiab los ntawm kev xam phaj los ntawm kws saib xyuas neeg mob.
Kev ntsuas. Lub duav ncig (WC) tau ntsuas ntawm theem ntawm lub umbilicus thaum lub sij hawm tas sij hawm me ntsis, nrog rau cov neeg koom hauv ib qho chaw sawv ntsug. Ntshav siab (BP) tau ntsuas ntawm sab caj npab sab xis siv lub ntsuas BP tsis siv neeg (TM-2655P; A&D, Tokyo, Nyiv), thaum tus neeg koom nrog zaum. Cov ntshav kuaj tau sau rau hauv cov hlab heparin-coated thaum sawv ntxov, tom qab ib hmos ceev ceev. Qhov ceev ceev ntshav qabzib (FPG) qib tau ntsuas nrog L-hom Glu 2 cov khoom siv, siv cov hexokinase/glucose-6-phosphate dehydrogenase txoj kev (Wako Pure Chemicals, Osaka, Nyiv). Cov roj lipoprotein tsawg-density (LDL-C), HDL-C, thiab TG qib tau ntsuas los ntawm kev pom pom spectrophotometry (Determiner LDL-C, Determiner L HDL-C, thiab Determiner L TG II, raws li; Kyowa Medex, Tokyo, Nyiv). Cov qib uric acid (UA) tau ntsuas nrog L-Type UA M cov khoom siv, siv cov uricase-N-(3- sulfopropyl)-3-methoxy-5-methylaniline method (Wako Pure Chemicals). Cov ntshav FFA profile tau ntsuas los ntawm kev siv roj chromatography. Lub TyG Performance index raug xam raws li dogmatic transformations (ln) [fasting triglycerides (mg / dl) ' yoo mov qabzib (mg / dl) / 2]. (16,17)
Txhua tus neeg kawm tau sau ntawv tso cai rau kev siv lawv cov ntaub ntawv kho mob rau kev tshuaj xyuas. Txoj kev tshawb no tau pom zoo los ntawm Pawg Neeg Saib Xyuas Kev Ncaj Ncees ntawm Tokai University (No. 11R-125) thiab tau ua los ntawm Kev Tshaj Tawm ntawm Helsinki.
Kev txheeb cais.Cov ntaub ntawv raug qhia raws li qhov nruab nrab ± SD lossis nruab nrab (inter-quartile ntau). Kev kuaj tau zoo siv qhov kev xeem Kolmogorov-Smirnov. Bonferroni ntau qhov kev sib piv tau siv los sib piv cov txiaj ntsig ntawm peb lossis ntau pawg. Txhawm rau sib piv ntau yam cim, cov ntsiab lus tau muab faib ua peb pawg raws li OA / SA piv, thiab ua rau rau pawg raws li kev sib txuas ntawm OA / SA piv thiab TG qib. Kev txiav txim siab ntawm OA / SA piv tau txheeb xyuas los ntawm ntau qhov kev txheeb xyuas kab rov tav. Ob pawg ntawm cov kev hloov pauv tau raug txiav txim siab: ib txheej rau TG / HDL-C piv [poj niam txiv neej, hnub nyoog, lub cev qhov hnyav (BMI), WC, systolic thiab diastolic BP, FPG, TG / HDL-C ratio, LDL-C, UA] , thiab lwm yam teeb tsa rau TyG index (poj niam txiv neej, hnub nyoog, BMI, WC, systolic thiab diastolic BP, TyG index, HDL-C, LDL-C, UA). Cov kev txiav txim siab rau sab sauv ntawm OA / SA tau txheeb xyuas los ntawm ntau qhov kev soj ntsuam kev rov qab los ntawm kev siv tib qho kev sib txawv uas siv rau hauv ntau qhov kev txheeb xyuas kab rov tav Ib txheej txheej txheem tau siv los xaiv qhov sib txawv rau ntau qhov kev ntsuam xyuas regression. Txhua qhov kev txheeb xyuas txheeb cais tau ua tiav siv SAS Studio ver. 3.4 (SAS Institute, Cary, NC). Tag nrho cov p-tus nqi yog ob-tailed, thiab p-tus nqi ntawm<0.05 was defined as statistically significant.
Cov txiaj ntsig
Tag nrho cov yam ntxwv uas tau soj ntsuam hauv txoj kev tshawb fawb no yog sawv cev hauv Table 1. Tawm ntawm 260 cov kev kawm, 105 (40.4 feem pua) yog poj niam. Qhov nruab nrab hnub nyoog, BMI, FPG, nruab nrab TG, txhais tau tias TyG Performance index, HDL-C qib, thiab nruab nrab TG / HDL-C piv yog 53.9 xyoo, 22.4 kg / m2, 95.9 mg / dl, 84.0 mg / dl, 8.30, 64.4 mg / dl, thiab 1.31, feem.
Cov koom haum muaj peev xwm ntawm TG / HDL-C piv thiab TyG index, nrog OA / SA piv tau tshawb xyuas siv Pearson qhov sib txheeb coefficient. Raws li pom hauv daim duab 1, OA/SA piv tau nthuav tawm qhov kev sib raug zoo nrog ob qho tib si, ln (TG/HDL-C ratio) [r=0.735, 95 feem pua ntawm kev ntseeg siab (CI) 0. 674–{8}}, ib., p<0.0001; Fig. 1A], and TyG index [r = 0.690, 95% CI 0.620–0.748, p<0.0001; Fig. 1B].
Kev txiav txim siab ntawm OA/SA piv tau raug txheeb xyuas los ntawm ntau qhov kev txheeb xyuas kab rov tav (Table 2). Ob pawg ntawm kev hloov pauv tau raug txiav txim siab: ib qho teeb tsa rau TG / HDL-C piv, thiab lwm qhov teeb tsa rau TyG Performance index. Ntawm cov variables suav nrog rau TG / HDL-C piv (poj niam txiv neej, hnub nyoog, BMI, WC, systolic thiab diastolic BP, FPG, TG / HDL-C ratio, LDL-C, UA), ob qhov sib txawv (TG / HDL-C ratio. , thiab UA) raug xaiv los ntawm cov txheej txheem stepwise (Table 2A). Ntawm cov variables suav nrog rau TyG Performance index (poj niam txiv neej, hnub nyoog, BMI, WC, systolic thiab diastolic BP, TyG index, HDL-C, LDL-C, UA), plaub qhov sib txawv (hnub nyoog, TyG index, HDL-C, LDL-C ) raug xaiv los ntawm cov txheej txheem stepwise (Table 2B). Kev tshuaj xyuas tau qhia tias TG / HDL-C piv, UA, thiab TyG qhov ntsuas tau zoo cuam tshuam nrog OA / SA piv, thaum muaj hnub nyoog, HDL-C, thiab LDL-C tsis zoo cuam tshuam nrog OA / SA piv (Table 2A thiab B).
Kev txiav txim siab rau sab sauv ntawm OA / SA tau txheeb xyuas siv ntau qhov kev txheeb xyuas kev rov qab los (Table 3). Thaum peb txheeb xyuas tib qhov sib txawv hauv ntau qhov kev ntsuam xyuas kab rov tav rau TG / HDL-C piv, peb qhov sib txawv (hnub nyoog, TG / HDL-C ratio, thiab UA) raug xaiv siv cov txheej txheem stepwise (Table 3A). Rau TyG Performance index, ob qhov sib txawv (hnub nyoog thiab TyG Performance index) raug xaiv siv cov txheej txheem stepwise (Table 3B). Cov txiaj ntsig ntawm kev tshuaj ntsuam tau qhia tias TG / HDL-C, UA, thiab TyG Performance index tau zoo cuam tshuam nrog rau sab sauv ntawm OA / SA piv. Hnub nyoog tsis zoo cuam tshuam nrog rau sab sauv tertile ntawm OA / SA piv.
Txhawm rau ntsuas qhov cuam tshuam ntawm OA / SA piv rau ntau yam cim, cov ntsiab lus tau muab faib ua peb pawg OA / SA. Table 4 sawv cev rau cov yam ntxwv ntawm cov kev kawm stratified raws li OA/SA piv. BMI, WC, FPG, TG, TyG index, TG / HDL-C ratio, LDL-C, non-HDL-C, UA, OA, SA, thiab OA / SA piv tau nce raws li OA / SA piv tau nce. Ntawm qhov tsis sib xws, HDL-C poob qis vim OA / SA piv tau nce.
Txhawm rau ntsuas qhov cuam tshuam ntawm TG qib ntawm ntau cov cim hauv OA / SA pawg neeg sib tw, cov kev kawm tau muab faib ua peb pawg TG. Table 5 sawv cev rau cov yam ntxwv ntawm cov kev kawm stratified raws li OA/SA piv thiab TG qib. Feem ntau cov cim tshwj tsis yog hnub nyoog yog qhov phem tshaj hauv pawg TG siab tshaj plaws hauv ob pawg OA / SA. Tsis tas li ntawd, feem ntau cov cim tshwj tsis yog hnub nyoog, BP, FPG, LDL-C, tsis-HDL-C, thiab SA tau phem dua hauv OA / SA piv ³2.85 dua.<2.85.
Kev sib tham
Hauv txoj kev tshawb no, feem ntau cov cim tshwj tsis yog hnub nyoog yog qhov phem tshaj hauv pawg TG siab tshaj plaws hauv ob pawg OA / SA. Tsis tas li ntawd, feem ntau cov cim tshwj tsis yog hnub nyoog, BP, FPG, LDL-C, tsis-HDL-C, thiab SA tau phem dua hauv OA / SA piv ³2.85 dua.<2.85. We showed that the measurement of the OA/SA ratio may be a useful indicator of IR, and it may be used to evaluate MetS in non-obese subjects.
Kev nce qib FFA tau ntseeg tias ua lub luag haujlwm hauv kev tsim cov kab mob ntawm qee hom mob ntshav qab zib hom 2 los ntawm ob qho tib si, inhibiting insulin-stimulated peripheral qabzib uptake, thiab ua rau B-cell tsis ua haujlwm. (19,20) Qhov no ua rau muaj kev pheej hmoo ntxiv ntawm MetS, hom 2 mob ntshav qab zib mellites, thiab CVD. Cov kev tshawb fawb hla dhau los tau qhia tias cov neeg mob rog rog metabolically tau nce qib ntawm tag nrho FFA, piv rau cov neeg rog rog metabolically. (21)
FAs feem ntau muab faib ua FA (SFA) lossis monounsaturated fatty acids, raws li cov qauv biochemical. Txawm li cas los xij, FA nyob rau hauv ib pawg txheej txheem yuav tsis sib npaug metabolically. P / S (polyunsaturated FA / SFA) piv yog ib qho yooj yim Performance index uas feem ntau yog siv los sawv cev rau kev noj haus FA muaj pes tsawg leeg ntawm cov zaub mov, los yog raws li ib tug biomarker ntawm FA, nyob rau hauv kev tshawb fawb kab mob. (22) Feem ntau ntawm n-3 FAs thiab qis n-6 FAs hauv cov ntaub so ntswg tej zaum yuav muaj txiaj ntsig zoo rau kev noj qab haus huv, tshwj xeeb tshaj yog txog CVD. (23) Cov ntawv ceeb toom tsis ntev los no tau qhia tias cov roj ntses (nplua nuj nyob rau hauv n-3 FA) supplementation ua ke nrog kev siv lub sijhawm ua haujlwm siab yog qhov zoo tshaj rau kev cuam tshuam cov roj ntses vim tias nws cuam tshuam ntau dua ntawm kev tswj glycemic, IR, CVD kev pheej hmoo, thiab rog. pawg. (24)
Kev ntsuas tus kheej FFA yog qhov nyuaj vim qhov tsis yooj yim, nrawm, thiab txhim khu kev qha los ntsuas cov feem me me ntawm FFA hauv kev ncig. Cov ntaub ntawv pov thawj qhia txog ntau yam teebmeem ntawm tus kheej FA, ntawm tib neeg kev noj qab haus huv thiab kab mob. Piv txwv li, txiv roj roj, nplua nuj nyob rau hauv OA, yuav tsum tau nthuav tawm cov nyhuv modulatory nyob rau hauv ntau yam ntawm physiological functions. Qee cov kev tshawb fawb kuj qhia tias nws muaj txiaj ntsig zoo rau kev mob qog noj ntshav, autoimmune thiab inflammatory kab mob, thiab pab kho qhov txhab. (25) Nws kuj tau tshaj tawm tias kev noj zaub mov nplua nuj hauv SA ua rau qis qis ntawm LDL-C thiab HDL-C. (26–28) Txawm li cas los xij, qee qhov kev tshawb fawb tau siv cov khoom lag luam FFA / precursor FFA piv los tshawb xyuas kev sib raug zoo ntawm FFA thiab tib neeg kev noj qab haus huv thiab kab mob. Qhov piv txwv no tuaj yeem cuam tshuam txog kev ua haujlwm ntawm elongase thiab desaturase thaum lub sijhawm endogenous FA metabolism thiab tej zaum yuav yog qhov kev kwv yees zoo dua rau MetS dua li tus neeg FAs. Cov kev tshawb fawb ntxaws ntxiv txog kev sib raug zoo ntawm cov khoom FFA / precursor FFA thiab ntau yam kev mob yuav tsum tau ua.
Raws li kev yoo mov cov tshuaj tiv thaiv kab mob insulin tsis muaj, peb siv TG / HDL-C piv thiab TyG Performance index ua tus cim tus cim ntawm IR. Peb tsis ntev los no tau tshaj tawm tias, hauv kev noj qab haus huv hauv Nyij Pooj, TG / HDL-C piv nrog IR, cov khoom ntawm MetS, kev tawm dag zog, kev ua si lub cev, thiab haus luam yeeb. Txawm li cas los xij, nws tsis cuam tshuam nrog kev haus cawv. (29) TyG Performance index tau sib raug zoo nrog HOMA-IR (r=0.41; p<0.001) and showed a strong positive association with TG/HDL-C (r = 0.84; p<0.001). (30) Another report suggested that the TyG index was correlated to the adiposity, metabolic, and atherosclerosis markers related to IR, and it presented a moderate degree of agreement with a hyperglycemic clamp. (31)
Txoj kev tsim qauv ntawm qhov kev tshawb fawb no yog nws qhov kev txwv loj, vim nws cuam tshuam qhov kev txiav txim siab ntawm kev sib raug zoo ntawm OA / SA piv thiab IR. Cov ntaub ntawv hais txog kev yoo mov immunoreactive insulin tsis muaj nyob rau hauv txoj kev tshawb no, thiab yog li ntawd, IR ntsuas los ntawm TG / HDL-C thiab TyG index tsis tau muab piv nrog HOMA-IR. Tsis tas li ntawd, cov ntaub ntawv hais txog kev noj haus ntawm FA tsis muaj. Tag nrho cov neeg koom rau hauv txoj kev tshawb no yog cov hnub nyoog nruab nrab thiab Nyij Pooj; Yog li, peb tsis tuaj yeem txiav txim siab seb qhov kev sib raug zoo ntawm OA / SA piv thiab cov cim kev kho mob qhia ntawm no puas cuam tshuam los ntawm haiv neeg. Thaum kawg, peb cov ntaub ntawv me me, thiab peb qhov kev tshawb pom yuav tsis siv rau txhua tus neeg Nyij Pooj.
Hauv kev xaus, peb cov txiaj ntsig tau qhia tias OA / SA piv yuav yog qhov qhia tau zoo rau IR thiab tuaj yeem siv los ntsuas cov metabolism hauv cov neeg laus uas tsis rog rog.
Tsis sib haum xeeb
Cov kws sau ntawv tau tshaj tawm tias tsis muaj kev cuam tshuam txog kev txaus siab txog kev tshawb fawb, txoj cai, thiab / lossis kev tshaj tawm ntawm kab lus no.
Cov ntaub ntawv
1 Zhao L, Ni Y, Ma X, et al. Ib lub vaj huam sib luag ntawm cov roj fatty acids pub dawb los kwv yees kev txhim kho ntawm cov metabolism hauv kev tsis zoo hauv cov neeg rog rog. Sci Rep 2016; 6: 28418 ib.
2Tam CS, Xie W, Johnson WD, Cefalu WT, Redman LM, Ravussin E. Defining insulin resistance from hyperinsulinmic-euglycemic clamps. Kev Kho Mob Ntshav Qab Zib 2012; 35: 1605–1610.
3 Bonora E, Targher G, Alberiche M, et al. Kev ntsuam xyuas tus qauv Homeostasis tsom iav cov txheej txheem ntawm cov piam thaj hauv kev ntsuam xyuas ntawm insulin rhiab heev: kev tshawb fawb hauv cov kev kawm nrog ntau qib ntawm cov piam thaj ua siab ntev thiab insulin rhiab heev. Mob Ntshav Qab Zib 2000; 23:57–63.
4 Wallace TM, Levy JC, Matthews DR. Siv thiab tsim txom ntawm HOMA qauv. Diabetes Care 2004; 27: 1487–1495.
5 Espinel-Bermúdez MC, Robles-Cervantes JA, del Sagrario VillarrealHernández L, et al. Insulin tsis kam nyob rau hauv cov neeg laus thawj cov neeg mob uas muaj qhov ntsuas tus neeg sawv cev, Guadalajara, Mexico. 2012. J Invest Med 2015; 63: 247–250.
6 Borai A, Livingstone C, Ferns GA. Kev ntsuam xyuas biochemical ntawm insulin tsis kam. Ann Clin Biochem 2007; 44 (Pt 4): 324–342.
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