Tsis yog-Coding RNAs nyob rau hauv keeb kwm ntawm lub raum Disorders Part 3

9. miRNAs hauv Fabry Kab Mob

Nyem rau Cistanche Kev Muag Khoom

Nug ntau ntxiv: david.deng@wecistanche.com WhatApp:86 13632399501

Jaurretche et al. tshuaj xyuas cov kev qhia ntawm urinary miRNAs suav nrog miR-21, miR- 29, miR-192, miR-200, thiab miR-433 (cov miRNAs paub nrog rau lub raum fibrosis ) hauv cov tib neeg ib txwm muaj thiab cov neeg mob Fabry [117]. Lawv pom tias cov urinary miR-29 thiab miR-200 uas suppress lub raum fibrosis tau txo qis hauv Fabry tus kab mob, thaum theem ntawm miR-21, miR-192, thiab miR{{10} }} uas txhawb nqa lub raum fibrosis tsis muaj qhov sib txawv loj. Ib qho kev sib raug zoo ntawm cov zis miR-21 thiab cov zis albumin/creatinine piv kuj tau pom hauv cov neeg mob Fabry [117]. Tsis tas li ntawd, kev nthuav dav miRNA profile hauv Fabry tus kab mob tau kawm los ntawm kev ua microRNA sequencing ntawm cov qauv kuaj ntshav, thiab 10 miRNAs tau qhia txawv ntawm cov neeg mob Fabry kab mob piv rau cov tib neeg ib txwm [118]. Cov kab mob miR199a-5p thiab miR{17}}p tau hloov kho hauv cov neeg mob Fabry, uas tuaj yeem ua rau cov neeg mob Fabry zoo tom qab ERT [118]. Txhawm rau txiav txim siab ntxiv seb puas yog ERT hloov pauv qib ntawm miRNAs hauv cov neeg mob Fabry, Xiao li al. ua microRNA sequencing rau cov qauv kuaj ntshav los ntawm Fabry cov neeg mob uas muaj lossis tsis muaj ERT [119]. Tag nrho ntawm 145 miRNAs raug txheeb xyuas los ntawm ERT. Ntawm cov miRNAs, miR-1307-5p, miR-21-5p, miR-152-5p, thiab miR-26a-5p tau raug lees paub tias yuav txo qis hauv cov ntshav ntawm Fabry cov neeg mob tom qab ERT nyob rau hauv ib tug validation cohort [119]. Cov kev tshawb fawb no tau qhia tias cov zis thiab cov miRNAs tuaj yeem siv los ua cov cim biomarkers los ntsuas cov kab mob kev loj hlob thiab kev ua tau zoo ntawm ERT hauv Fabry cov neeg mob.

10. Cov lus xaus thiab cov kev xav yav tom ntej

Cov ntaub ntawv pov thawj tshiab txhawb nqa tias miRNAs thiab lncRNAs yog cov neeg kho mob tseem ceeb hauv cov kab mob ntawm lub raum. Qhov kev tshawb pom ntawm miRNAs tau hais tawm tsis zoo hauv PKD tau txhais cov txheej txheem tshiab molecular ntawm cystogenesis thiab muab lub laj thawj rau kev txhais cov kev tshawb fawb miRNAs rau hauv qhov chaw kho mob. Cov tuam txhab tshuaj thiab biotech feem ntau ua haujlwm ntawm ob hom khoom: miRNA mimics thiab antagomirs. Kev ruaj ntseg thiab xa mus rau qhov chaw xav tau ntawm kev ua haujlwm yog ob qhov kev sib tw loj ntawm miRNA-based tshuaj. Txawm hais tias miRNA-raws li kev kho mob tseem tsis tau mus txog qhov kev tshuaj ntsuam xyuas, kev soj ntsuam kev soj ntsuam tsis ntev los no ntawm kev kho mob anti-miR-122 tau qhia txog kev txhawb nqa kev nyab xeeb thiab kev ua tau zoo hauv cov neeg mob uas muaj tus kab mob HCV [120]. Kev kho mob anti-miR-17 hauv cov neeg mob nrog ADPKD, anti-miR-21 kev kho mob hauv cov neeg mob Alport nephropathy, thiab miRNA ua rau cov neeg mob malignant pleural mesothelioma thiab cov qog nqaij hlav tsis me hauv lub ntsws tsis tu ncua. Kev ua tiav ntawm cov kev sim tshuaj no yuav txhawb ntxiv qhov tseem ceeb ntawm miRNA-raws li kev kho mob hauv tib neeg lub raum kab mob. Ntau cov kev tshawb fawb tau tsom mus rau lncRNAs hauv ntshav qab zib nephropathy, mob raum raug mob, thiab lub raum cell carcinoma, thaum cov kev tshawb fawb no tseem piav qhia. Lub elucidation ntawm lub luag haujlwm ntawm lncRNAs hauv PKD thiab lwm yam kab mob hauv lub raum tseem nyob hauv nws cov menyuam mos. Kev loj hlob ntawm lub raum tshwj xeeb ncRNAs raws li kev kho lub hom phiaj thiab biomarkers nyob rau hauv cov kab mob hauv lub raum yuav yog ib qho kev tshawb fawb zoo heev.

Raws li kev tshawb fawb cuam tshuam,cistancheyog ib txwm suav tshuaj ntsuab uas tau siv rau ntau pua xyoo los kho ntau yam kab mob. Nws tau raug pov thawj scientific kom muaj cov tshuaj tiv thaiv kab mob, tiv thaiv kev laus, thiab antioxidant zog. Cov kev tshawb fawb tau qhia tiascistanchemuaj txiaj ntsig zoo rau cov neeg mob kev txom nyem los ntawmkab mob raum. Cov khoom xyaw nquag ntawm cistanche paub tias txo qhov mob,txhim kho lub raum ua haujlwmthiab restore lub raum puas hlwb. Yog li, kev sib koom ua ke cistanche hauv txoj kev npaj kho mob raum tuaj yeem muab txiaj ntsig zoo rau cov neeg mob hauv kev tswj hwm lawv tus mob.

Cistanchepab txo qis proteinuria, txo qis BUN thiab creatinine qib, thiab txo qhov kev pheej hmoo ntawm lub raum puas tsuaj ntxiv. Tsis tas li ntawd, cistanche kuj pab txo cov roj cholesterol thiab triglyceride qib uas tuaj yeem ua rau muaj kev phom sij rau cov neeg mobkab mob raum.

Cistanche's antioxidantthiab cov khoom tiv thaiv kev laus pab tiv thaiv lub raum los ntawm oxidation thiab kev puas tsuaj los ntawm cov dawb radicals. Qhov no txhim kho lub raum noj qab haus huv thiab txo cov kev pheej hmoo ntawm kev tsim teeb meem. Cistanche kuj tseem pab txhawb lub cev tiv thaiv kab mob, uas yog qhov tseem ceeb hauv kev tawm tsam cov kab mob raum thiab txhawb lub raum noj qab haus huv.

Los ntawm kev sib txuas cov tshuaj suav tshuaj ntsuab thiab cov tshuaj niaj hnub sab hnub poob, cov neeg txom nyem los ntawmkab mob raumtuaj yeem muaj ntau txoj hauv kev los kho tus mob thiab txhim kho lawv lub neej zoo.Cistancheyuav tsum tau siv los ua ib feem ntawm txoj kev npaj kho mob tab sis tsis yog siv los ua lwm txoj hauv kev kho mob.

Cov ntaub ntawv 

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