Nano-Drug Design Raws li Lub Cev Muaj Zog Ntawm Glutathione Ⅱ

Nano-Drug nrog -Smono thioether daim ntawv cog lus (-S-) raws li ib tug binder yog dav siv nyob rau hauvtshuaj tiv thaiv qogthiab nano-drug xa system tsim. Cong et al. [73] ntse tsim ib qho tshiab dual redox-responsive prodrug nanosystem (PTX-S-OA/TPGS NPs) sib sau ua ke los ntawm hydrophobic me-molecule prodrugs. PTX-S-OA/TPGS NPs yog qhov tseem ceeb tshaj plaws rau disulfide conjugate (PTX-2S-OA) nyob rau hauv cov nqe lus ntawm dual redox-sensitive tshuaj tso tawm thiab hauv vivoantitumor kev ua tau zoo. PTX-S-OA / TPGS NPs muaj cov khoom siv tshuaj zoo siab thiab muaj txiaj ntsig zoo hauv kev xaiv tso tshuaj ntawm cov qog nqaij hlav, raws li qhia hauv daim duab5A. Meng et al. [74] synthesized ib tug tshiab prodrug DTX-S-LA, uas siv mono thioether daim ntawv cog lus raws li ib tug linker rau choj linoleic acid (LA) thiab docetaxel (DTX). DTX-S-LA nws tus kheej sib sau ua ke nrog DEPEG-PEG los tsim cov nanoparticles nrog cov tshuaj thauj khoom muaj peev xwm ntawm 53.4 feem pua. Cov nanoparticles no muaj cov yam ntxwv ntawm qhov loj me me, cov ntshav siab ruaj khov, thiab cov tshuaj tso tawm sai hauv cov qog hlwb thiab muaj cov qog inhibition ntau dua hauv vivo piv nrog DTX dawb, raws li qhia hauv daim duab.5B. Zhang et al. [75] synthesized ib hom CUR-S-CUR prodrug los ntawm kev sib txuas ob CUR molecules nrog mono-thioether bonds rau GSH- teb tshuaj xa, raws li qhia hauv daim duab5C. Cov CUR-S-CUR NPs tau pom zoo colloid stability, muaj txiaj ntsig ntawm cellular uptake, thiab intracellular / nuclear tshuaj xa piv rau dawb CUR.

Daim duab 5. Schematic tsim ntawm txawv GSH- tebtshuaj anticancernrog -S-. (A) Schematic sawv cev ntawm kev npaj ntawm PEGylated prodrug NPs ntawm PTX-S-OA thiab cleavage los ntawm GSH los yog ROS [73]; (B) schematic sawv cev ntawm DTX-S-LA tus kheej sib sau ua ke hauv dej thiab cleavage nrog GSH hauv qog hlwb [61]; (C) schematic sawv cev ntawm CUR-S-CUR prodrug self-assemble thiab nws uptake los ntawm qog hlwb [75].

Nano-Drug nrog Pt-O

Pt-O daim ntawv cog lus tuaj yeem txo thiab cleaved los ntawm GSH kom tso tawm cov metabolite Pt (II). Raws li qhov kev xav no, Ling et al. [76] tsim GSH-sensitive prodrug nanoparticles Pt(IV) rau kev xa tshuaj zoo thiab kho mob qog noj ntshav. Pt(IV) nano-drugs tuaj yeem tiv thaiv thiol-mediated detoxification los ntawm GSH depletion. Tom qab Pt(IV) nanoparticles raug txo los ntawm GSH, Pt-O tsoo thiab tso tawm txaus Pt(II) metabolites, uas covalently bonded nrog lub hom phiaj DNA thiab induced apoptosis (Daim duab 6A). Huang et al. [77] pom tias Pt(IV)NP-cRGD nthuav tawm cov cim muaj zog echogenic thiab zoo heev ncha persistence nyob rau hauv ultrasound imaging. Tsis tas li ntawd, GSH-rhiab tshuaj xa cov kab ke tsis yog tsuas yog ua kom muaj txiaj ntsig zoo tshaj plaws tab sis kuj txo cov tshuaj toxicity ntawm cov tshuaj kho mob. Pt(IV)NP-cRGD, ua ke nrog ultrasound imaging, depleted GSH, thiab nce ROS theem, ua rau mitochondria-mediated apoptosis (Daim duab 6B).

Daim duab 6. Self-assembled Pt (IV) nanoparticles rau kev xa cov tshuaj Pt. (A) Pt (IV) raug txo nrog GSH rau Pt (II) [76]. (B) Pt(IV)NP-cRGD raug txo nrog GSH rau Pt (II) [77].

Nano-Drug nrog Se-Se Diselenide-conjugated daim ntawv cog lus (Se-Se) muaj qhov tshwj xeeb dual redox rhiab heev. Kev qhia siab ntawm GSH hauv cov qog lossis ROS tiam los ntawm oxidative kev nyuaj siab, xws li H2O2, tuaj yeem rhuav tshem cov diselenide-conjugated daim ntawv cog lus kom ua tiav cov lus teb redox. Manjare et al. [78] tau tsim ib qho tshiab GSH txo qis-ua rau fluorescent sojntsuam (A) los ntawm kev txuas ob lub molecules ntawm BODIPY-Se los ntawm diselenide-conjugated daim ntawv cog lus, uas tuaj yeem siv los kuaj GSH lossis H2O2 hauv cov qog nqaij hlav cancer. Diselenide-conjugated daim ntawv cog lus ntawm fluorescent sojntsuam (A) tau cleaved los ntawm GSH, ces reacted nrog ROS kom emit fluorescence. Han et al. [79] npaj cov fluorescent molecule diselenide SeDSA nanoparticles uas muaj 9, 10-distyrylanthracene (DSA) derivative (SeDSA) nrog aggregation-induced emission (AIE). SeDSA tuaj yeem sib sau ua ke nrog cov tshuaj tiv thaiv kab mob thiab diselenide-muaj paclitaxel (SePTX), los ua SeDSA-SePTX Co-NPs (Co-NPs). SeDSA-SePTX Co-NPs sai sai disintegrate thiab tso tawm AIE dye thiab PTX nyob rau hauv qhov txo qis ib puag ncig, uas ua lub luag hauj lwm ntawm qog imaging thiab qog kho mob. Zhao et al. [80] tsim diselenide-crosslinked polymer gels (SeSey-PAA-TPEx) ntawm dawb radical copolymerization. Lub diselenide crosslinker nyob rau hauv cov gels yuav fragmented nyob rau hauv lub xub ntiag ntawm H2O2 los yog GSH vim nws redox- teb cov cuab yeej rau kev kuaj mob ntawm ib tug qog.

Nyem qhov no kom tau txais Cistanche tshuaj ntsuab rau Anti- Mob qog noj ntshav

Nano-Drug nrog Se-N

Lub conjugate daim ntawv cog lus ntawm Se-N yog ib qho tshiab dual redox-sensitive daim ntawv cog lus, uas tsis yog tsuas yog teb nrog GSH los ua Se-H, tab sis kuj teb nrog H2O2 los ua Se-N, ua tiav cov nyhuv dual redox teb. Xu et al. [81] tau tsim ib qho tshiab dual redox-sensitive flfluorescent sojntsuam (Cy-O-Eb) raws li qhov kev xav no, uas tuaj yeem taug qab cov kev hloov pauv ntawm H2O2 thiab GSH hauv cov cell nyob, thiab ncaj qha saib xyuas cov xwm txheej redox ntawm cov hlwb. Cov txheej txheem apoptosis ntawm HepG2 qog tau ua tiav los ntawm Cy-O-Eb. Hauv tsab ntawv tshaj tawm no, kev tawg thiab tsim ntawm Se-N daim ntawv cog lus hauv cov qauv ua rau muaj kev hloov pauv hauv fluorescence hauv fluorescent sojntsuam hauv ob qhov chaw sib txawv. Raws li qhov kev txiav txim ntawm GSH, Se-N daim ntawv cog lus tawg thiab tsim Se-H qauv, thiab cov fluorescence siv tau txo qis heev. Ntawm qhov tsis sib xws, Se-N daim ntawv cog lus tau rov tsim dua thiab cov fluorescence tau rov qab los raws li cov txiaj ntsig ntawm H2O2, raws li qhia hauv daim duab 7.

Daim duab 7. Cov tshuaj tiv thaiv dual ntawm kev sojntsuam (Cy-O-Eb) nrog GSH/H2O2 [81]. Se-N daim ntawv cog lus (muaj zog fluorescence) hauv Cy-O-Eb raug txo nrog GSH los ua Se-H daim ntawv cog lus (tsis muaj zog fluorescence). Se-N tau rov tsim dua thiab cov fluorescence tau rov qab los ntawm cov nyhuv ntawm H2O2.

Nano-Drug nrog -Se Mono selenium daim ntawv cog lus (-Se-) yog ib qho oxidation stimuli teb daim ntawv cog lus, uas yog tsuas yog oxidized los ntawm ROS, xws li H2O2, thiab ruptured tso tawm nano-tshuaj. Wang et al. [82] npaj cov tshuaj-loaded polymeric nanoparticles ntawm selenium-inserted copolymer (I/D Se-NPs). I/D-Se-NPs sai sai dissociate nyob rau hauv ob peb feeb kho los ntawm ROS thiab txhawb cov kev tso tawm tsis tu ncua ntawm cov tshuaj tiv thaiv qog. Tsis tas li ntawd, Jiang et al. [83] tsim dual stimuli-responsive thiab wormlike micelle system (C11-Se-C11) siv ib tug switchable selenium-muaj surfactant. Zhang et al. [84] tsim cov viscoelastic wormlike micellar tov raws li cov tshuaj redox-responsive surfactant, uas yog sodium dodecylselanylpropyl sulfate (SDSePS). Cov nyiaj selenium saum toj no hauv nanoparticles tuaj yeem oxidized los ntawm H2O2 los ua Se=O los ua si txheeb ze.

5.3.4 ib. Glutathione Responsive Photodynamic Therapy

Phototherapy tuaj yeem muab faib ua photothermal therapy (PTT) thiab photodynamic therapy (PDT). PTT yog ib txoj kev kho mob tua cov qog los ntawm kev txhaj tshuaj photothermal rau hauv lub cev thiab irradiating lawv nrog ze-infrared teeb (750 ~ 1400 nm). Thaum cov qog nqaij hlav / cov cell raug rhuab mus rau 40-45 ◦C, cell membranes thiab nucleic acids puas los yog mitochondrial dysfunction tshwm sim nyob rau hauv tus txheej txheem ntawm hyperthermia. Kev raug kub kub ntev ntev ua rau cov qog nqaij hlav/hlwb tuag. Thaum lub sij hawm PTT, cov qog nqaij hlav/hlwb muaj qhov kub siab siab dua li cov ntaub so ntswg/hlwb. Yog li, nws muaj peev xwm xaiv tua cov qog nqaij hlav / hlwb los ntawm kev siv lub peev xwm ntawm cov qog nqaij hlav hauv zos, thaum tsis ua mob rau cov nqaij mos / hlwb [85].

PDT tau tshwm sim los ua cov txheej txheem rau kev kho kab mob uas yuav tsum tau muaj peb yam tseem ceeb: photosensitizers (PS), qhov tshwj xeeb wavelengths ntawm lub teeb (ultraviolet light, pom thiab ze-infrared teeb), thiab oxygen. Lub teeb excitation ntawm qhov chaw tshwj xeeb ua rau cov tshuaj tiv thaiv photochemical hauv PS uas ua rau tsim cov pa oxygen reactive (ROS), uas tom qab ntawd ua rau cov ntaub so ntswg / cell puas thiab tuag. PDT tuaj yeem muab qhov kev txhawb siab zoo uas ua rau ROS ntau lawm ntawm lub sijhawm teev tseg thiab qhov chaw tshwj xeeb uas ua rau muaj qhov txo qis ntawm cov txiaj ntsig tsis zoo ntawm cov ntaub so ntswg noj qab haus huv [86,87].

Qhov concentration ntawm intracellular ROS ncaj qha txiav txim siab cov nyhuv ntawm photodynamic kho. Yog li, qhov poob ntawm GSH tuaj yeem nce qib ntawm ROS thiab txhawb nqa cell apoptosis, uas muab cov kev xav tseem ceeb rau kev kho photodynamic. Ruan et al. [88] tsim lub nanosystem, Cu-tryptone nanoparticles (Cu-Sim NPs), uas txhawb nqa kev kho photodynamic los ntawm kev noj GSH. Nws pom tau tias Cu-Try NPs tuaj yeem ua rau GSH nce ntxiv rau hauv lub cell ROS thiab txhim kho kev kho photodynamic. Chen et al. [89] tsim ib hom hydrophobic cysteine-based polydisulfide amide (Cys-PDSA) polymers thiab siv lawv li dub phosphorus quantum dots nanocarrier. Paclitaxel (PTX) tau ntim rau hauv nanoparticles kom ua tiav kev sib xyaw ua ke ntawm cov tshuaj khomob thiab kev kho mob photothermal rau kev mob qog noj ntshav los ntawm GSH txo kev sib kho los ntawm daim ntawv cog lus disulfide. Yang et al. [90] tau npaj ib hom tshiab ntawm pH/GSH multi-response chitosan nanoparticles (SA-CS-NAC), thiab SA-CS NAC-loaded photosensitizer ICG los tsim cov amphoteric mercapto chitosan nanoparticles (SA-CS-NAC@ICG NPs) los ntawm kev sib sau ua ke. SA-CS-NAC @ ICG NPS tau ua tiav ntau cov lus teb los tso tawm ICG hauv microenvironment nrog qis pH thiab siab GSH hauv cov qog hlwb. Nyob rau tib lub sijhawm, kev sim hauv vitro cell tau lees paub tias SA-CS-NAC @ ICG NPS muaj lub peev xwm ntawm cell uptake, tsis muaj biotoxicity, thiab zoo qog inhibition.

6. Nano-Drug Design Raws li lub luag hauj lwm ntawm GSH nyob rau hauv Neurological kab mob

GSH yuav siv sij hawm koom nrog hauv kev hloov pauv neurodegenerative ntawmTus kab mob Parkinson, feem ntau tawm tsam kev tsim tawm ntawm intracellular ROS thaum oxidative kev nyuaj siab. Qhov concentration ntawm GSH nyob rau hauv substantia nigra nyob rau hauv cov neeg mob uas muaj tus kab mob Parkinson tau txo qis, qhia txog kev sib raug zoo ntawm GSH, oxidative kev nyuaj siab, thiab Parkinson tus kab mob. Raws li txoj kev xav saum toj no, Ma et al. [91] npaj Ag44(SR)30 silver nanoclusters nrog ib lub ligand ntawm 5-mercapto-2-nitrobenzoic acid thiab ua tiav qhov kev kuaj xyuas siab ntawm GSH, uas ua rau muaj kev kuaj pom tseeb dua thiab kev ntsuam xyuas ntawm Parkinson tus kab mob. Nws tau raug tshaj tawm tias cov kab mob autism spectrum disorders (ASD) kuj tau txuam nrog GSH [92–95]. Kev tshawb fawb pom tias ob qho tib si txo GSH thiab tag nrho GSH qib qis dua hauv pawg ASD ntau dua li hauv pawg tswj hwm [96]. Tsis tas li ntawd, qee qhov kev tshawb fawb tau pom tias kev kho mob nrog GSH tuaj yeem tiv thaiv lub raum tubular epithelial hlwb, txo qhov tshwm sim ntawm lub raum puas lossis txawm tias lub raum tsis ua haujlwm, thiab txhim kho kev ciaj sia ntawm cov neeg mob ntshav siab [97]. Txawm hais tias GSH ncaj qha los yog tsis ncaj qha cuam tshuam rau hauv cov kab mob ntawm cov kab mob neurological, nano-tshuaj tsim raws li lub luag haujlwm ntawm GSH hauv oxidative stress tsis tau tshaj tawm. Qhov no yog qhov tsis muaj zog thiab qhov muag tsis pom kev hauv kev tshawb fawb nanoscience, peb tuaj yeem siv tag nrho cov txiaj ntsig ntawm nanotechnology, sib txuas cov yam ntxwv ntawm cov kab mob paj hlwb los tsim cov tshuaj nano-tshuaj tshiab.

7. Fluorescent Nano-Probe Design Raws li Physiological Properties of GSH

Cov txheej txheem ib txwm siv rau kev txiav txim siab qhov pom ntawm intracellular ROS thiab GSH feem ntau yog kev ntsuas ntsuas. Txawm li cas los xij, tus qauv ua ntej kev kho mob yog qhov nyuaj, qhov kev txiav txim siab yog siv sijhawm, thiab GSH thiab ROS hauv vivo tsis tuaj yeem saib xyuas hauv lub sijhawm. Nyob rau hauv sib piv, fluorescent sojntsuam technology muaj qhov zoo ntawm siab rhiab heev, zoo xaiv, thiab zoo real-time kev ua tau zoo, uas qhia tau hais tias zoo heev nta rau saib xyuas GSH thiab ROS nyob rau hauv vivo thiab nyob rau hauv vitro [98–100]. Cov hauv qab no yog cov lus qhia txog kev tsim cov fluorescent nano-probes raws li lub cev muaj zog ntawm GSH, vam tias yuav muab qee cov ntaub ntawv siv rau kev kho mob ntawm nano-probes los ntawm cov ntsiab lus ntawm daim ntawv no.

Liu et al. [101] synthesized ib tug tshiab ob-photon fluorescence sojntsuam MT-1 rau kev tshawb pom ntawm biological mercaptans mas GSH nyob rau hauv mitochondria. 4-dinitrobenzene sulfonyl pawg (DNBS) nyob rau hauv ib qho kev sojntsuam fluorescent, uas ua raws li pawg neeg teb ntawm GSH. Lub Fluorescence ntawm qhov kev sojntsuam yuav raug quenched vim yog electron-absorbing kev txiav txim ntawm DNBS. Tab sis thaum qhov kev sojntsuam hnov ​​​​mob nrog GSH hauv mitochondria, DNBS raug tshem tawm, thiab cov fluorescence ntawm kev sojntsuam tau rov qab los saib xyuas cov tshuaj lom neeg mercaptan hauv cov hlwb thiab cov ntaub so ntswg, uas tau siv los kuaj thiab saib xyuas cov xwm txheej ntawm tes. Chen et al. [102] tau npaj ib qho kev sojntsuam fluorescent rau kev kuaj pom GSH hauv cov kua dej thiab cov hlwb uas muaj sia nyob los ntawm kev qhia dinitrophenyl ether rau hauv 2-(20 -hydroxy-30 -}ethoxyphenyl) benzothiazole. Lub fluorescence ntawm qhov kev sojntsuam raug quenched vim muaj zog electron-absorbing ntawm pawg nitro, tab sis thaum lub sojntsuam raug txo los ntawm GSH, lub fluorophore raug tso tawm kom emit ib tug muaj zog fluorescence ntawm 485 nm. Ob qho ntawm cov qauv saum toj no qhia cov pab pawg muaj zog electron-absorbing rau hauv cov qauv sojntsuam, thiab cov fluorescence ntawm kev sojntsuam yog quenched los yog sawv rov los tom qab GSH kev cai. Kuj tseem muaj qee qhov kev siv rau daim ntawv thov ntawm tus qauv no [103–109].

Tag nrho cov saum toj no yog me me molecular flfluorescent sojntsuam, thiab lawv cov qog nqaij hlav tsis muaj peev xwm thiab solubility tau txwv lawv daim ntawv thov hauv vivo. Txhawm rau kom nkag mus rau cov qog ua tau zoo, tshwj xeeb tshaj yog cov qog nqaij hlav nrog ntom stroma, Niko li al. [110] tsim ib lub GSH teb flfluorescent sojntsuam nyob rau hauv uas cov amphiphilic fluorescent khoom NR12D yog nws tus kheej-assembled thiab coated nrog ib tug polymer DSP uas muaj disulfide bonds. Li et al. [111] npaj micelles los ntawm covalently txuas cov NIR fluorescent dye dimethyl-4H-pyran (DCM) nrog cov tshuaj tiv thaiv qog gemcitabine siv ib daim ntawv cog lus disulfide ua tus choj kom ua tiav lub hom phiaj thiab kho cov nyhuv ntawm nanoprobe. Zhang et al. [112] synthesized GSH-responsive sojntsuam siv cov khoom siv fluorescent amantadine-naphthalimide thiab cov tshuaj tiv thaiv kabmob kheesxaws camptothecin kom ua tiav cov duab fluorescence hauv cov qog nqaij hlav cancer. Lu et al. [113] siv hollow mesoporous carbon (HMC) coated nrog doxorubicin thiab grafted reduction-sensitive ze-infrared dye (HMC SS-CDPEI) los npaj ib nanoprobe los saib xyuas qhov tso tawm ntawm doxorubicin. Choi et al. [114] tsim thiab sib txuas ua ke GSH- teb fluorescent carbon nanoprobe. Tag nrho cov kev sojntsuam no cuam tshuam raws li kev ua ntawm GSH, thiab cov fluorescence emission tuaj yeem saib xyuas cov tshuaj tso tawm hauv lub sijhawm.

8. Nano-Imaging Design Raws li Physiological Properties ntawm GSH

Nano-imaging thev naus laus zis yog tsim GSH- teb nanoparticles uas cov ntaub ntawv nano-imaging yog encapsulated nyob rau hauv nanoparticles rau dual-mode imaging thiab kev kho mob ua ke. Li et al. [115] tau tshaj tawm tias cov tshuaj paclitaxel (PTX) thiab hydroxyethyl starch tau sib raug zoo los ntawm disulfide daim ntawv cog lus, thiab tom qab ntawd cov fluorophore DiR tau ntim rau hauv nanoparticle nucleus thaum lub sij hawm nws tus kheej, thaum lub sij hawm uas DiR fluorescence tau quenched. Thaum cov nanoparticles tau endocytosed los ntawm qog hlwb, cov disulfide bonds tau cleaved los ntawm ntau GSH, uas ua rau ib txhij tso tawm ntawm DiR thiab PTX nyob rau hauv lub nanoparticles. Cov fluorescence ntawm DiR zoo tu qab thiab tuaj yeem siv rau hauv photoacoustic imaging. Yang et al. [116] synthesized GSH-responsive hyaluronic acid (HA) thiab poly (ε-caprolactone) copolymer nanoparticle encapsulated nrog DOX thiab superparamagnetic hlau oxide (SPIO). Nyob rau hauv qhov kev txiav txim siab ntawm GSH, disulfide daim ntawv cog lus ntawm cov nanoparticles tawg, tso tawm sab hauv DOX thiab SPIO. SPIO tuaj yeem siv rau hauv kev sib nqus resonance imaging, thaum DOX tau siv rau hauv kev kho mob, tso cai rau kev sib xyaw ntawm cov duab thiab tshuaj kho mob. Yang et al. [117] qhia tias amphiphilic dextran derivatives tau tsim los ntawm disulfide-txuas dextran-g-poly-(N-3-carbobenzyloxy-L-lysine) graft polymer (Dex-g-SS-PZLL) thiab siv los ua theranostic nanocarriers rau chemotherapy thiab magnetic resonance imaging. Yog li ntawd, cov kev txo qis-rhiab nanoparticles tau cog lus theranostic nanocarriers rau magnetic resonance imaging thiab chemotherapy.

9. Daim ntawv thov ntawm Nanoscale GSH hauv Food Field

Kev tsim ntawm sodium alginate thiab chitosan bilayer-hloov GSH nanoliposomes tau tshaj tawm los ntawm Wei li al. [118]. Cov txiaj ntsig ntawm kev ruaj khov thiab kev ruaj ntseg hauv plab tau pom tias sodium alginate thiab chitosan bilayer-hloov liposomes tsis tsuas yog txhim kho qhov ruaj khov ntawm GSH tab sis tseem ceeb txo qhov tso tawm ntawm GSH hauv plab hnyuv. Yog li ntawd, nyob rau hauv ib tug complex txheej txheem ua zaub mov, kev siv ntawm sodium alginate thiab chitosan bilayer-hloov liposomes yuav zam tau qhov tso tawm sai sai ntawm GSH, ua rau kom muaj kev ruaj ntseg ntawm GSH, thiab yog li txhawb kev nqus ntawm GSH los ntawm lub plab zom mov, thiab txhim kho cov khoom noj khoom haus. nqi khoom noj. Txoj kev tshawb no muab cov ntaub ntawv pov thawj thiab cov ntaub ntawv txhawb nqa rau kev siv GSH nanoliposomes hloov kho los ntawm sodium alginate thiab chitosan hauv zaub mov fifield.

10. Cov ntsiab lus thiab Kev Pom Zoo

GSH ntsiav tshuaj thiab GSH txhaj tshuaj yog dav siv hauv chaw kho mob. GSH yog ib hom polypeptide, uas tsis muaj nyob ruaj khov thaum caij tsheb thauj mus los thiab khaws cia, uas ua rau muaj kev nyuaj raukev khaws cia, kev thauj mus los, thiab kev thov. Yog li ntawd, nws tseem ceeb heev rau kev txhim khonano tshuajthiab technologies raws li covpathological yam ntxwv ntawm GSHkom GSH tuaj yeem ua lub luag haujlwm ntau dua hauv kev kho mob. Txawm li cas los xij, GSH nanoparticles tau txwv rau cov kev sim yooj yim thiab tsis tau siv dav hauv kev kho mob. Nyob rau hauv qhov kev pom ntawm cov teeb meem ntsib los ntawm nanotechnology hauv kev kho mob, nws yog ib qho tsim nyog los tsim cov nanoparticles ntse nrog kev pab cuam ntawm kev sib koom ua ke. Nanoparticles kho lawv cov tshuaj lom neeg thiab kev ua haujlwm lom neeg los ntawmstimulating responsive kev hloov pauv, yog li kom paub txog kev siv tshuaj biomedical ntse, uas yog kev tshawb fawb kev kawm tshiab.

ntawm GSH thiab tsim cov txheej txheem tsim tshuaj nano-tshuaj zoo heev, uas muab qhov tseem ceeb ntawm kev tshawb fawb thiab daim ntawv thov tus nqi rau kev tshawb fawb txog cov kab mob uas GSH koom nrog.

Cov Nyiaj Txiag: Cov kws sau ntawv ua tsaug rau Harbin Medical University Daqing Campus Yu Weihan Cov Nyiaj Pab Rau Cov Hluas (DQYWH201603) thiab Heilongjiang Xeev cov kev kawm tiav qib siab rau cov tub ntxhais hluas cov kev qhia tshiab tshiab (UNPYSCT-2015036). National Natural Science Foundation ntawm Tuam Tshoj (82173153).

Kev tsis sib haum xeeb ntawm kev txaus siab: Cov neeg sau ntawv tshaj tawm tsis muaj teeb meem ntawm kev txaus siab.

Cov ntaub ntawv

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