Kev txo qis Uric acid tsis yog txhawm rau tiv thaiv gout! Tshawb xyuas 9 Qhov Tseem Ceeb Tseem Ceeb Ntawm Hyperuricemia
Jan 12, 2024
Thaum nws los txog rau hyperuricemia (HUA), thawj yam uas los rau hauv siab yog gout. Tab sis qhov tseeb, lub sij hawm ntev uric acid ntau kuj yuav ua rau erectile kawg, txiv neej plaub hau poob, kab mob plawv, thiab kab mob raum.
Nyem rau Cistanche rau mob raum
1. Lub ntsiab lus zais ntawm HUA thiab "txiv neej"
Ib txoj kev tshawb fawb luam tawm nyob rau hauv phau ntawv journal Andrology soj ntsuam kev sib raug zoo ntawm HUA thiab erectile kawg ntawm cov txiv neej. Tom qab kev tshuaj ntsuam xyuas, cov kws tshawb fawb tau ua qhov kev tshuaj xyuas zoo ntawm 8 qhov kev tshuaj xyuas thiab kev tshuaj ntsuam meta. Kev tshuaj xyuas pom tau tias 1/3 ntawm cov txiv neej nrog HUA yuav txhim kho erectile kawg, thiab hauv cov kev tshawb fawb ntawm tus kheej, tus lej no tseem muaj txog li 76%.
Cov kws tshawb fawb ntseeg tias hyperuricemia yog ib qho ntawm cov yam ntxwv ntawm cov kab mob metabolic, thiab cov neeg mob kuj tuaj yeem nrog kev rog rog, kub siab, dyslipidemia, thiab ntshav qab zib. Xav txog tias cov no yog cov teeb meem muaj feem cuam tshuam rau endothelial tsis ua haujlwm / raug mob, Cov Txheej Txheem Tag Nrho tuaj yeem ua rau vasogenic erectile kawg, txawm hais tias lub luag haujlwm ncaj qha ntawm uric acid hauv kev txhawb nqa endothelial dysfunction tsis tuaj yeem txiav tawm.
2. HUA thiab txiv neej plaub hau poob
Cov kws tshawb fawb los ntawm kuv lub tebchaws tau soj ntsuam kev sib raug zoo ntawm HUA thiab androgenic alopecia (AGA) ntawm 3,936 tus txiv neej hnub nyoog 18-50. Txoj kev tshawb nrhiav pom tias qib uric acid hauv AGA cov neeg mob tau nce siab dua li cov hauv pawg tswj hwm (P<0.001), and men with AGA had a higher risk of developing HUA (OR=1.72, P<0.001).
Hauv kev tshuaj xyuas ntawm cov neeg mob ntawm cov hnub nyoog sib txawv, nws tau pom tias kev sib raug zoo ntawm ob yog tshwj xeeb tshaj yog nyob ze ntawm cov hnub nyoog 18-30 nrog rau thaum ntxov-pib AGA:
➤ Ntawm cov neeg muaj hnub nyoog 18-30 xyoo, qib uric acid ntawm pawg AGA tau siab dua li ntawm pawg tswj hwm (P<0.001), and the prevalence of hyperuricemia was also significantly higher than that of the control group (26.2% vs. 15.4%, OR=1.95, P<0.001).
Hauv kev xaus, txoj kev tshawb no ntawm cov pej xeem Suav tau pom tias muaj kev sib raug zoo ntawm hyperuricemia thiab AGA hauv cov txiv neej, tshwj xeeb tshaj yog cov neeg mob uas pib ntxov ntxov AGA (<30 years old).
3. HUA and gout
HUA yog qhov tseem ceeb ntawm kev pheej hmoo rau gout. Hauv txoj kev tshawb fawb "Standardized Aging", cov kws tshawb fawb tau faib cov pej xeem mus rau hauv pawg raws li cov ntshav uric acid, uas yog.<7.0mg/dL, 7.0-8.9mg/dL, and ≥9.0mg/dL, respectively. The incidence rates of gout were 0.1%, 0.5%, and 4.9% respectively. That is, as the blood uric acid level increases, the incidence rate of gout increases significantly.
Hauv lwm qhov kev tshawb nrhiav rov qab, thaum cov ntshav uric acid ntau dua lossis sib npaug li 6 mg / dL, raws li cov ntshav uric acid qib nce, kev tawm tsam gout nce ntxiv piv nrog thaum cov ntshav uric acid nqi yog.<6.0 mg/dL. As the uric acid content increased, the risk value increased. also increased significantly. Among people with asymptomatic HUA, 5%-12% will eventually develop gout.
4. HUA yog ib qho kev pheej hmoo ntawm kev mob ntshav siab
HUA yog ib qho kev pheej hmoo ntawm kev mob ntshav siab. Cov kev tshawb fawb pom tau hais tias rau txhua qhov kev nce hauv cov ntshav uric acid theem ntawm 59.5umol / L, tus txheeb ze kev pheej hmoo ntawm ntshav siab nce 25%.
HUA tuaj yeem txhawb nqa qhov tshwm sim thiab kev loj hlob ntawm cov ntshav siab los ntawm kev ua kom lub renin-angiotensin system, txo cov nitric oxide synthesis hauv vascular endothelial hlwb, stimulating vascular du nqaij proliferation, thiab ua rau vascular remodeling. Tsis tas li ntawd, kev kub siab ntev ntev kuj cuam tshuam rau uric acid metabolism los ntawm glomerular arteriosclerosis thiab lwm txoj hauv kev, ua rau HUA hnyav dua.
5. HUA muaj feem cuam tshuam nrog lub plawv tsis ua haujlwm
Lub plawv tsis ua hauj lwm yog qhov chaw kawg ntawm cov kab mob plawv feem ntau, thiab hyperuricemia yog qhov muaj feem cuam tshuam rau lub plawv tsis ua hauj lwm thiab muaj feem cuam tshuam nrog nws qhov tshwm sim, kev loj hlob, thiab kev kwv yees.
Feem ntau ntawm hyperuricemia hauv cov neeg mob uas muaj lub plawv tsis ua haujlwm yog siab li 55%-60%, thiab qhov hnyav dua lub plawv tsis ua haujlwm, tus neeg mob cov ntshav uric acid ntau dua.
6. HUA muaj feem cuam tshuam rau atherosclerosis
Soluble uric acid tuaj yeem cuam tshuam ncaj qha rau vascular endothelial hlwb. Qhov siab dua qhov concentration ntawm uric acid, qhov cuam tshuam ntau dua ntawm endothelium. Hauv cov neeg mob uas muaj HUA, urate crystals tuaj yeem ua rau nag thiab tso rau ntawm phab ntsa ntawm cov hlab ntsha thiab ua rau cov hlab ntsha endothelium puas tsuaj los ntawm inducing ib qho inflammatory teb.
Tsis tas li ntawd, HUA cuam tshuam nrog ntshav siab, hyperlipidemia, thiab hyperglycemia los koom ua ke txhawb kev tsim ntawm atherosclerosis. Qee qhov kev tshawb fawb tau pom tias urate-txo txoj kev kho tuaj yeem ua rau qeeb ntawm atherosclerosis.
7. HUA muaj feem cuam tshuam rau lub raum puas
Meta-analysis qhia tau hais tias gout yog ib qho kev pheej hmoo ntawm tus kab mob raum ntev (CKD) thiab pob zeb raum. Cov kev tshawb fawb ntsig txog kuj tau pom tias HUA tuaj yeem ua rau lub raum puas, yog li ua kom nrawm ntawm CKD.
Tsis tas li ntawd, cov tshuaj urate-lowering muaj kev tiv thaiv ntawm lub raum ua haujlwm hauv cov neeg mob HUA asymptomatic, tab sis cov txheej txheem ntawm kev ua haujlwm yuav tsum tau kawm ntxiv. Qhov tshwm sim ntawm gout hauv cov neeg mob CKD kuj tseem siab dua li cov pej xeem. Hauv cov neeg mob CKD, HUA yog qhov muaj feem cuam tshuam rau txhua qhov kev tuag thiab kev tuag ntawm cov hlab plawv. Cov qib uric acid hauv cov neeg mob no kuj tsim nyog saib xyuas.
8. HUA muaj kev cuam tshuam zoo rau cov ntshav lipid metabolism
Hyperuricemia muaj feem cuam tshuam nrog ntau yam ntawm cov kab mob metabolic thiab tshwj xeeb tshaj yog cuam tshuam nrog lipid metabolism tsis zoo. Txoj kev tshawb nrhiav pom tias qhov tshwm sim ntawm triglycerides siab thiab cov lipoprotein tsawg-density hauv cov neeg mob hyperuricemia tau nce siab dua li ntawm pawg tswj hwm. Nws kuj tau pom tias qhov tshwm sim ntawm hyperuricemia hauv cov neeg mob hyperlipidemia kuj tseem siab dua.
Muaj kev sib cuam tshuam ntawm uric acid metabolism thiab lipid metabolism. Hyperuricemia yuav ua rau txo qis hauv lipase kev ua haujlwm, yog li cuam tshuam rau lipid metabolism. Tsis tas li ntawd, HUA thiab hyperlipidemia yog ib qho kev pheej hmoo ntawm kev pheej hmoo rau kev mob plawv thiab ntshav siab.
9. HUA muaj feem cuam tshuam nrog ntshav qab zib
Cov neeg uas muaj HUA muaj kwv yees li ob zaug yuav muaj ntshav qab zib li cov neeg ib txwm muaj. HUA tsis tuaj yeem cuam tshuam ncaj qha rau kev ua haujlwm ntawm pancreatic beta hlwb, cuam tshuam rau insulin secretion, thiab ua rau cov ntshav qab zib, tab sis kuj ua rau cov kab mob metabolic thiab insulin tsis kam rau cov neeg mob ntshav qab zib, thiab txhawb qhov tshwm sim ntawm macrovascular thiab microvascular teeb meem hauv cov neeg mob ntshav qab zib. Nyob rau tib lub sijhawm, ntshav qab zib nephropathy thiab insulin tsis kam kuj tuaj yeem ua rau muaj qhov hnyav ntawm hyperuricemia.
Cistanche kho mob raum li cas?
Cistancheyog ib hom tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho ntau yam mob, suav nrog kab mob raum. Nws yog muab los ntawm qhuav stems ntawmCistanchedeserticola, ib tsob nroj nyob rau hauv cov suab puam ntawm Tuam Tshoj thiab Mongolia. Cov khoom tseem ceeb ntawm cistanche yog phenylethanoid glycosides,echinacoside cov tshuaj, thiabacteoside, uas tau pom tias muaj txiaj ntsig zoo rau lub raum kev noj qab haus huv.
Kab mob raum, tseem hu ua kab mob raum, hais txog ib yam mob uas lub raum ua haujlwm tsis zoo. Qhov no tuaj yeem ua rau muaj cov khoom pov tseg thiab cov co toxins hauv lub cev, ua rau muaj ntau yam tsos mob thiab teeb meem. Cistanche tuaj yeem pab khoraumkab mobase los ntawm ntau yam mechanisms.
Ua ntej, cistanche tau pom tias muaj cov nyhuv diuretic, txhais tau tias nws tuaj yeem ua rau cov zis ntau ntxiv thiab pab tshem tawm cov khoom pov tseg ntawm lub cev. Qhov no tuaj yeem pab txo lub nra ntawm lub raum thiab tiv thaiv kev tsim cov co toxins. Los ntawm kev txhawb nqa diuresis, cistanche kuj tseem tuaj yeem pab txo qis ntshav siab, ib qho teeb meem ntawm cov kab mob raum.
Ntxiv mus, cistanche tau pom tias muaj cov teebmeem antioxidant. Kev ntxhov siab oxidative, tshwm sim los ntawm qhov tsis sib xws ntawm kev tsim cov dawb radicals thiab lub cev tiv thaiv antioxidant, ua lub luag haujlwm tseem ceeb hauv kev mob raum. ies pab neutralize dawb radicals thiab txo Oxidative kev nyuaj siab, yog li tiv thaiv lub raum los ntawm kev puas tsuaj. Cov phenylethanoid glycosides pom hauv cistanche tau tshwj xeeb hauv kev tshem tawm cov dawb radicals thiab inhibiting lipid peroxidation.
Tsis tas li ntawd, cistanche tau pom tias muaj cov tshuaj tiv thaiv kab mob. Kev mob yog lwm yam tseem ceeb hauv kev loj hlob thiab kev loj hlob ntawm cov kab mob raum. Cistanche's anti-inflammatory zog pab txo cov zus tau tej cov pro-inflammatory cytokines thiab inhibit qhov ua kom o yuav tsum tau txoj kev, yog li alleviating o nyob rau hauv lub raum.
Tsis tas li ntawd, cistanche tau pom tias muaj cov teebmeem immunomodulatory. Hauv cov kab mob hauv lub raum, lub cev tiv thaiv kab mob tuaj yeem ua rau tsis zoo, ua rau muaj kev mob ntau dhau thiab cov ntaub so ntswg puas. Cistanche pab tswj lub cev tiv thaiv kab mob los ntawm kev hloov kho thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob, xws li T hlwb thiab macrophages. Txoj cai tiv thaiv kab mob no pab txo qhov mob thiab tiv thaiv kev puas tsuaj ntxiv rau lub raum.
Ntxiv mus, cistanche tau pom los txhim kho lub raum kev ua haujlwm los ntawm kev txhawb nqa kev tsim kho ntawm lub raum hlab nrog cov hlwb. Lub raum tubular epithelial hlwb ua lub luag haujlwm tseem ceeb hauv kev pom thiab rov nqus cov khoom pov tseg thiab electrolytes. Hauv kab mob raum, cov hlwb no tuaj yeem raug puas tsuaj, ua rau lub raum ua haujlwm puas. Cistanche lub peev xwm los txhawb kev tsim kho ntawm cov hlwb no pab kho lub raum kom zoo thiab txhim kho lub raum tag nrho.
Ntxiv nrog rau cov kev cuam tshuam ncaj qha rau lub raum, cistanche tau pom tias muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev hauv lub cev. Txoj hauv kev zoo rau kev noj qab haus huv no yog qhov tseem ceeb hauv kab mob raum, vim tias tus mob feem ntau cuam tshuam rau ntau lub cev thiab lub cev. che tau pom tias muaj kev tiv thaiv rau lub siab, lub plawv, thiab cov hlab ntsha, uas feem ntau cuam tshuam los ntawm kab mob raum. Los ntawm kev txhawb nqa kev noj qab haus huv ntawm cov kabmob no, cistanche pab txhim kho lub raum tag nrho thiab tiv thaiv kev mob ntxiv.
Hauv kev xaus, cistanche yog cov tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho mob raum. Nws cov active Cheebtsam muaj diuretic, antioxidant, anti-inflammatory, immunomodulatory, thiab regenerative teebmeem, uas pab txhim kho lub raum ua haujlwm thiab tiv thaiv ob lub raum los ntawm kev puas tsuaj ntxiv. , cistanche muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev, ua rau nws txoj hauv kev zoo rau kev kho mob raum.
