Ntev COVID Thiab Mob Nkeeg Mob Ntev: Kev Tshawb Fawb Ntawm Cov Poj Niam Cov Neeg Laus muaj txoj sia nyob hauv Egypt

Menna AEG Aly|Heba G. Saber

Geriatrics thiab Gerontology Department, Kws Qhia Ntawv ntawm Tshuaj, Ain Shams University, Cairo, Egypt

Yog xav paub ntxiv:ali.ma@wecistanche.com

Abstract

Lub hom phiaj

Qhov kev tshawb fawb no tsom rau kev tshawb nrhiav tom qab-COVID-19 cov tsos mobntawm cov poj niam laus thiab seb lawv puas tuaj yeem ua rau muaj kev pheej hmoo rau kev tsim mob qog noj ntshav ntev (CFS) tom qab.

Txoj kev:

Qhov no yog ib qho kev tshawb nrhiav rov qab-seem ntu, hauv daim ntawv tshawb fawb online. Tag nrho ntawm 115 cov lus teb thaum kawg suav nrog.

Cov txiaj ntsig

Qhov nruab nrab hnub nyoog yog 73.18 ± 6.42. Yim caum cuaj qhia cov tsos mob hauv lub sijhawm rov qab los; ntawm 54 no tsis muaj cov tsos mob ntawm CFS, 60 tau ua tau, thiab tsuas yog 1 qhov tshwm sim. Kev qaug zog tau tshaj tawm los ntawm 66, cov tsos mob musculoskeletal los ntawm 56, thiab teeb meem pw tsaug zog los ntawm 73. Nees nkaum cuaj tus neeg mob tau mus ntsib kws kho mob qhov chaw ua haujlwm. Cov tsos mob tom qab rov zoo tau cuam tshuam nrog kev ntxhov siab, kev tu siab thiab kev pw tsaug zog. Tsis tas li ntawd, kev ntxhov siab, kev tu siab, kev pw tsaug zog, qaug zog, kev puas siab puas ntsws, thiab kev poob rov tshwm sim yog txhua yam cuam tshuam nrog cov tsos mob zoo li CFS.

Cov lus xaus

Los ntawm peb qhov kev tshawb pom, qhov muaj kev qaug zog, kev paub tsis meej, kev ntxhov siab, kev tu siab, kev pw tsaug zog tsis zoo thiab rov tshwm sim hauv lub sijhawm rov qab los yog tag nrho cuam tshuam nrog cov tsos mob zoo li CFS. Los xaus nws yuav tsim nyog rau kev tshuaj ntsuam ntevCOVIDthiab xav txog lub peev xwm los tsim CFS tom qab. Txawm hais tias nws tuaj yeem ua rau muaj kev pheej hmoo rau kev tsim CFS-zoo li lwm yam kab mob kis tau yuav xav tau kev tshawb fawb loj dua kom paub meej qhov no

1|Taw qhia

Nyob rau ob peb lub hlis dhau los, cov kev tshwm sim tom qabCOVID-19tab tom ua kom pom tseeb. Cov ntsiab lus xws li "ntevCOVID," "postCOVIDsyndrome" thiab "Chronic COVID Syndrome," tab tom tau txais kev saib xyuas kev tshawb fawb. Lawv hais txog qhov ua tsis tau ntawm COVID-19 cov tsos mob hauv cov neeg muaj sia nyob, nws muaj kev cuam tshuam ntev, lossis tsim teeb meem kev puas hlwb.1 Lub UKCov tsos mobkev tshawb fawb qhia tias 10 feem pua ​​​​ntawmCOVIDntxiv rau cov neeg mob tseem tsis zoo tom qab ntau tshaj 3 lub lis piam, nrog cov tsos mob qhia suav nrog; qaug zog, mob taub hau, hnoos, mob caj pas, mob hauv siab thiab tsis meej pem.2 Oddly qhov hnyav ntawm tus kab mob tsis tau txiav txim siab qhov tshwm sim ntawm kev tsim cov tsos mob tom qab COVID. Qhov zoo sib xws ntawm cov tsos mob no nrog rau mob nkees nkees (CFS), uas yog tus cwj pwm los ntawm kev qaug zog, kev pw tsaug zog tsis zoo thiab kev paub txog teeb meem 3 yog qhov txaus ntshai, ua rau nco ntsoov tias kev kis kab mob tom qab kis tau yog ib qho kev pheej hmoo txaus ntshai.4 Ib tsab xov xwm tseem ceeb hauv Frontiers ntawm Tshuaj kuj tau muab lo lus nug no; COVID-19 puas tuaj yeem ua rau CFS?5 Muaj kev txhawj xeeb ntau ntxiv tias COVID-19 tuaj yeem ntxiv rau cov lej ntawm CFS uas tsis tau lees paub.6 Hauv cov ntaub ntawv tsis ntev los no, muaj kev cuam tshuam rau kev paub ntxov ntawm CFS cov tsos mob hauv cov neeg rov zoo. los ntawm COVID. Perrin thiab al ua pov thawj pom thaum ntxov thiab kev kho mob ntawm kev qaug zog tom qab kis kab mob los pab tiv thaiv ntxiv rau lub nra uas twb muaj lawm ntawm CFS ntawm kev pabcuam kev noj qab haus huv. Lawv kuj tseem hais ntxiv tias qhov no yuav tsum yog qhov tseem ceeb rau kev tshawb fawb.7 Hauv cov neeg laus laus mob nkees nkees yog ib qho teeb meem tseem ceeb uas tuaj yeem cuam tshuam rau lawv txoj kev noj qab haus huv thiab lub neej zoo, 8 thiab CFS nyiam cov poj niam ntau dua.9 Tsis tas li ntawd, cov neeg mob laus yog kuj tseem muaj kev cuam tshuam ntau dua los ntawm COVID kev kis mob thiab nws cov teeb meem, tshwj xeeb yog cov uas muaj cov kab mob uas twb muaj lawm.10 Lub hom phiaj ntawm txoj haujlwm no yog los kawm txog qhov muaj cov tsos mob tom qab COVID-19 ntawm cov poj niam laus Egyptian rov zoo los ntawm COVID-19 thiab tshawb nrhiav kev sib raug zoo nrog CFS uas tuaj yeem yog qhov teeb meem ntev ntev.

2|Cov khoom siv thiab cov txheej txheem

Peb tau ua ib qho kev tshawb fawb rov qab los, hauv daim ntawv tshawb fawb online tsom rau cov poj niam hnub nyoog tshaj rau caum xyoo, ua txij nruab nrab lub Cuaj Hli mus txog rau nruab nrab Lub Kaum Hli 2020. Daim ntawv nug tau muab faib online ntawm social media platforms. Cov kev tshawb fawb tau ua tiav kev coj ncaj ncees raws li World Medical Association tshaj tawm ntawm Helsinki, thiab txhua tus neeg koom tau txais kev pom zoo. Cov txheej txheem suav nrog suav nrog hnub nyoog tshaj 6 xyoo0, ua poj niam uas muaj keeb kwm ntawm COVID-19 tus kab mob tau lees paub los ntawm PCR, thiab tsawg kawg 1 lub hlis yuav tsum tau dhau mus txij li kuaj tsis zoo rau COVID-19 . Cov xwm txheej tsis tau lees paub los ntawm PCR raug cais tawm, nrog rau cov neeg uas muaj keeb kwm ntawm kev nyuaj siab ua ntej, CFS, lossis fibromyalgia, nrog rau cov lus teb tsis tiav. Cov qauv loj tau suav nrog siv PASS program version 15, teeb tsa hom -1 yuam kev ( ) ntawm 0.05 thiab kev ntseeg siab ntawm qhov dav ntawm 0.06 (pab ntawm qhov yuam kev 7.5 feem pua ​​). Cov txiaj ntsig los ntawm kev tshawb fawb yav dhau los11 tau pom tias qhov tshwm sim ntawm qhov mob idiopathic qaug zog ntawm cov neeg muaj sia nyob yog 10 feem pua. Kev suav ua raws li cov txiaj ntsig no ua rau tus qauv me me ntawm 97 tus neeg mob. Tag nrho ntawm 121 tus poj niam teb tab sis 6 ntawm cov no raug cais tawm thiab 115 thaum kawg suav nrog. Daim ntawv nug (saib Daim Ntawv Ntxiv) muaj nyob rau hauv Arabic thiab Lus Askiv thiab hais txog cov hauv qab no: Lub sijhawm rov qab los, lub sijhawm ua kom tiav cov tsos mob, muaj cov tsos mob tom qab rov zoo, feem ntau cov tsos mob (neurological, pw tsaug zog, nasopharyngeal, gastrointestinal, hauv siab, mob plawv, musculoskeletal thiab nephrological), txawm tias lawv tau mus ntsib kws kho mob tsis ntev los no vim li cas. Raws li qhov tseem ceeb ntawm kev lees paub sai li sai tau thaum muaj peev xwm tsim cov tsos mob CFS, peb tau sau cov qauv thaum ntxov ntawm kev sib kis. Peb lub hom phiaj yog los qhia txog qhov ua tau lossis qhov tshwm sim ntawm kev tsim CFS yav tom ntej. Yog li, cov neeg teb tau raug muab faib ua pawg raws li lawv cov tsos mob raws li cov neeg uas muaj cov tsos mob ntawm CFS tab sis 4 lub hlis tsis tau dhau mus (muaj peev xwm), cov tsos mob thiab 4 lub hlis dhau los (tej zaum) thiab thaum kawg cov uas tsis muaj cov no. Kev txheeb xyuas txheeb cais tau ua los ntawm kev siv SPSS 25.0 program. Qhov nruab nrab, tus qauv sib txawv (± SD) thiab ntau yam tau siv rau cov ntaub ntawv tus lej parametric, thaum qhov nruab nrab thiab qhov sib txawv (IQR) rau cov ntaub ntawv tsis yog parametric. Fisher qhov kev ntsuas tseeb tau siv los tshuaj xyuas qhov kev sib raug zoo ntawm ob qhov kev hloov pauv zoo thaum qhov kev cia siab suav tsawg dua 5 hauv ntau dua 20 feem pua ​​​​ntawm cov hlwb. P-tus nqi<.05 was="" considered="" statistically="">

3|TSEEM CEEB

Tag nrho ntawm 115 cov lus teb tau sau tseg, txhua tus yog poj niam. Qhov nruab nrab hnub nyoog yog 73.18 ± 6.42. Hais txog kev txij nkawm; 87 (75.7 feem pua) tau sib yuav, 6 (feem pua ​​​​5.2) yog ib leeg / sib nrauj, thiab 22 (19.1 feem pua) yog poj ntsuam. Thaum nug txog kev kawm 6 (5.2 feem pua) tau kawm tiav qib pib, 45 (39.1 feem pua) muaj tsev kawm ntawv theem nrab, thiab 64 (55.7 feem pua) muaj tsev kawm ntawv theem siab lossis siab dua. Yim caum cuaj (77.4 feem pua) qhia tias muaj cov tsos mob hauv lub sijhawm rov qab los; ntawm 54 (47 feem pua ​​​​) tsis muaj cov tsos mob ntawm CFS, 60 (52.2 feem pua) tau ua tau, thiab tsuas yog 1 qhov tshwm sim. Table 1 qhia qhov zaus ntawm cov tsos mob qhia hauv lub sijhawm rov qab los. Ntawm qhov kev ceeb toom, qaug zog tau tshaj tawm los ntawm 66 (57.4 feem pua) cov neeg teb, cov tsos mob musculoskeletal los ntawm 56 (48.6 feem pua), thiab teeb meem pw tsaug zog los ntawm 73 (63.47 feem pua). Nees nkaum cuaj (25.2 feem pua) cov neeg mob tau mus ntsib kws kho mob lub chaw ua haujlwm. Lub xub ntiag ntawm cov tsos mob tom qab rov zoo tau cuam tshuam nrog kev ntxhov siab (P=.005), kev tu siab (P=.007) thiab kev pw tsaug zog tsis zoo (P < .001)="" txawm="" tias="" nce,="" tawg="" lossis="" insomnia.="" table="" 2="" qhia="" txog="" kev="" sib="" raug="" zoo="" ntawm="" ntau="" yam="" ntawm="" cov="" tsos="" mob="" tom="" qab="" rov="" qab="" los="" thiab="" cfs="" (raws="" li="" tau="" teev="" tseg="" saum="" toj="" no).="" kev="" ntxhov="" siab,="" kev="" tu="" siab,="" kev="" pw="" tsaug="" zog,="" nrog="" rau="" kev="" qaug="" zog,="" kev="" paub="" tsis="" meej,="" thiab="" kev="" poob="" rov="" tshwm="" sim="" yog="" txhua="" yam="" cuam="" tshuam="" nrog="" cov="" tsos="" mob="" zoo="" li="" cfs.="" txawm="" li="" cas="" los="" xij,="" lub="" sijhawm="" mus="" txog="" qhov="" rov="" zoo="" thiab="" cov="" hnub="" dhau="" los="" txij="" li="" kev="" rov="" zoo="" tsis="" cuam="" tshuam="" nrog="" cfs-zoo="" li="" cov="" tsos="" mob="" nrog="" p-tus="" nqi="" ntawm="" .304="" thiab="" .234,="">

4|Kev sib tham

Qhov kev tshawb fawb no tsom rau cov poj niam laus thiab tsom mus soj ntsuam tom qab-COVID-19 cov tsos mob thiab seb lawv puas tuaj yeem ua rau muaj kev pheej hmoo rau kev tsim CFS tom qab. Cov tsos mob tshwm sim rau ntau tshaj ib hlis hauv 33 feem pua ​​​​ntawm cov neeg teb. Qhov no yog me ntsis siab dua qhov kev tshawb pom ntawm "UK COVID Symptom Symptom Study"2 tab sis ze dua rau ntau lub xeev kev tshawb fawb hauv Teb Chaws Asmeskas uas pom tias 35 feem pua ​​​​tsis tau rov qab mus rau lawv lub xeev li ib txwm ntawm 2-3 lub lis piam tom qab kuaj tsis zoo rau COVID. -19.12

Ib txoj kev tshawb fawb Italian tau tshaj tawm tias 87 feem pua ​​​​ntawm cov neeg tawm hauv tsev kho mob tsawg kawg yog ib qho tsos mob 2 lub hlis tom qab.13 Qhov tseem ceeb, tsuas yog 25.2 feem pua ​​​​ntawm cov neeg koom tau sau cov kws kho mob tshiab los ntawm cov tsos mob no. Qhov tsis sib xws no yuav qhia tau tias tsis muaj kev paub txog qhov cuam tshuam ntev dua ntawm tus kab mob COVID-19. Kev tawm tswv yim rau kev ua raws li cov neeg mob COVID tej zaum yuav zoo li tsim nyog. Kev qaug zog, cov tsos mob musculoskeletal, teeb meem pw tsaug zog, mob taub hau, teeb meem kev paub, mob caj pas, malaise, kiv taub hau thiab palpitations, thiab lwm yam tau nquag qhia los ntawm cov neeg teb. Qhov kev tsis txaus siab dav dav no zoo ib yam li Assaf thiab al uas tseem tshawb fawb txog cov tsos mob ntawm tus kab mob COVID.14 qhov xwm txheej thiab qhov ze ntawm cov tsos mob no rau CFS ua rau peb kawm txog qhov kev sib raug zoo no.

Cov neeg koom nrog uas yws yws txog kev qaug zog, teeb meem kev paub, kev ntog rov qab, kev ntxhov siab, kev tu siab, thiab teeb meem pw tsaug zog tau cuam tshuam nrog CFS muaj peev xwm lossis qhov tshwm sim. Islam thiab al's tshuaj xyuas tsab xov xwm kuj tseem qhia txog qhov muaj peev xwm txuas ntxiv ntawm kev qaug zog tom qab-COVID thiab CFS.15 Txawm hais tias qhov tseeb etiology ntawm CFS tsis paub muaj kev pom zoo tias nws yog ib lub koom haum multifactorial uas tuaj yeem pib los ntawm ntau yam. Ib qho kev paub txog kev txhawb nqa yog kis kab mob. Lub koom haum no tau tsim muaj nrog EBV, mob khaub thuas thiab lwm yam kab mob coronaviruses. Cov txheej txheem tau npaj tseg yog ua rau muaj kev mob tshwm sim thiab autoimmune cov lus teb nrog rau qhov tshwm sim neurological sequelae tom qab kis kab mob neuro-invasion. Qhov twg ua rau muaj qhov tshwm sim ntawm CFS.16 Txawm hais tias tus kab mob COVID-19 tuaj yeem pib tib cov lus teb tau tham los ntawm ntau tus kws sau ntawv. Rodriguez et al tau lees paub tias COVID-19 tuaj yeem ua rau muaj qhov cuam tshuam loj thiab tsis muaj zog tiv thaiv kab mob, 17 thiab kev tshawb fawb hauv Mev tau pom tias cov tsos mob ntawm CFS sib tshooj ntau nrog cov neeg mob ntev COVID.18 Qhov kev txwv ntawm txoj haujlwm no yog qhov cov qauv me me thiab nws tsuas yog tsom rau ib pawg ntawm cov neeg mob.

5|XAIV

Los ntawm peb qhov kev tshawb pom, muaj kev qaug zog, kev paub tsis meej, kev ntxhov siab, kev tu siab, kev pw tsaug zog, thiab rov tshwm sim hauv lub sijhawm rov qab los yog tag nrho cuam tshuam nrog cov tsos mob zoo li CFS. Txhawm rau xaus nws yuav tsim nyog los tshuaj xyuas COVID ntev thiab xav txog lub peev xwm los tsim CFS tom qab. Txawm hais tias nws tuaj yeem ua rau muaj kev pheej hmoo rau kev tsim CFS-zoo li lwm yam kab mob kis yuav xav tau kev tshawb fawb loj dua kom paub meej qhov no.

Nov yog peb cov khoom tiv thaiv kev qaug zog! Nyem rau daim duab rau cistanche qia cov khoom

REFERENCES

1. Mahase E. Covid-19: Peb paub dab tsi txog "covid ntev"?BMJ. 2020;370:m2815. 

2. Sudre C, Lee K, Lochlainn M. Cov tsos mob pawg hauv COVID-19: ib qho cuab yeej siv tshuaj ntsuam xyuas los ntawm COVID Symptom Study app.Sci Adv. 2021; 7. https://doi.org/10.1126/sciadv.abd4177

3. Jason LA, Sundquist M, Brown A, thiab al. Kev tshuaj xyuas cov ntaub ntawv txhais cov txheej txheem rau mob nkees nkees thiab myalgic encephalomyelitis.Kev qaug zog. 2014;2:40-56. 

4. Lam MH, Wing YK, Yu MW, et al. Kev puas siab puas ntsws thiab qaug zog ntev nyob rau hauv cov mob hnyav ua pa nyuaj rau cov neeg muaj sia nyob: kev rov qab mus ntev.Arch Intern Med. 2009;169:2142-2147. 

5. Komaroff AL, Bateman L. Puas yuav COVID-19 ua rau myalgic encephalomyelitis/chronic fatigue syndrome?Pem hauv ntej Med. 2021;18:1132. 

6. Araja D, Berkis U, Lunga A, Murovska M. Duab ntxoov ntxoo lub nra ntawm kev kuaj mob uas tsis tau kuaj pom tus mob myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) ntawm tib neeg: rov qab los thiab yav tom ntej—hauv qhov pom ntawm COVID-19.J Clin Med. 2021;10:3017. 

7. Perrin R, Riste L, Hann M, Walther A, Mukherjee A, Heald A. Rau hauv lub iav saib: post-viral syndrome post-COVID-19.Med Hypotheses. 2020;144:110055. 

8. Zengarini E, Ruggioro C, Pérez-Zepeda MU, et al. Fatigue: rel evance thiab cuam tshuam rau cov neeg laus.Exp Gerontol. 2015;70:78-83. 

9. Jason LA, Taylor RR, Kennedy CL, Song S, Johnson D, Torres S. Chronic fatigue syndrome: kev ua hauj lwm, kev siv kho mob, thiab cov subtypes hauv cov qauv hauv zej zog.J Nerv Ment Dis. 2000;188:568-576. 

10. Wang L, He W, Yu X, et al. Tus kab mob Coronavirus 2019 hauv cov neeg mob laus: cov yam ntxwv thiab cov tsos mob tshwm sim raws li 4- kev tshuaj xyuas lub lim tiam.J Kab mob. 2020;80:639-645. 

11. Simani L, Ramezani M, Darazam IA, et al. Kev nthuav dav thiab muaj feem cuam tshuam ntawm tus mob qaug zog ntev thiab kev nyuaj siab tom qab muaj kev nyuaj siab tom qab kis tus kab mob COVID-19.J Neurovirol. 2021;27:154-159. 

12. Tenforde MW, Kim SS, Lindsell CJ, et al. Cov tsos mob ncua sij hawm thiab muaj feem cuam tshuam rau ncua kev rov qab mus rau kev noj qab haus huv ib txwm muaj ntawm cov neeg mob sab nraud nrog COVID-19 hauv ntau lub xeev cov kab ke kev noj qab haus huv network - Tebchaws Meskas, Lub Peb Hlis-Lub Rau Hli 2020.MMWR Morb Mortal Wkly.Rep. 2020;69:993-998. 

13. Carfì A, Bernabei R, Landi F; Gemelli Tawm tsam COVID-19 Pab Pawg Saib Xyuas Kev Kho Mob Tom Qab. Cov tsos mob tsis tu ncua hauv cov neeg mob tom qab mob covid-19.JAMA. Xyoo 2020; 324: 603-605. doi: 10.1001/JAMA.2020.12603

14. Assaf G, Davis H, McCorkell L, et al. Cov neeg mob-coj kev tshawb fawb sib koom tes: embedding cov neeg mob nyob rau hauv cov lus piav qhia ntev COVID.PAIN Reports. 2021; 6: e913. https://doi.org/10.1097/pr9.0000000000000913

15. Islam MF, Cotler J, Jason LA. Post-viral nkees nkees thiab COVID-19: cov lus qhia los ntawm kev sib kis dhau los.Kev qaug zog. 2020;8:61-69. 

16. Poenaru S, Abdallah SJ, Corrales-Medina V, Cowan J. COVID-19 and post-infectious myalgic encephalomyelitis/chronic fatigue syndrome: a narrative review.Ther Adv Infect Dis. 2021;8:20499361211009385. 

17. Rodríguez Y, Novelli L, Rojas M, et al. autoinflammatory thiab autoimmune tej yam kev mob ntawm txoj kev hla ntawm COVID-19.J Autoimmun. 2020;114:102506. 

18. González-Hermosillo JA, Martínez-López JP, Carrillo-Lampón SA, et al. Tom qab mob COVID-19 cov tsos mob, qhov muaj peev xwm txuas nrog myalgic encephalomyelitis/chronic fatigue syndrome: 6-hloov kev tshawb fawb hauv ib pawg neeg Mev.Lub hlwb Sci. 2021;11:760.