Ntsiab lus:leiomyosarcoma; qog adrenal; cov leeg nqaij du

Nyem rau ntawm Cistanche Tubulosa Rau Raum Kab Mob

Yog xav paub ntxiv:

david.deng@wecistanche.com WhatApp:86 13632399501

Raws li cov kev tshawb fawb muaj feem xyuam, cistanche yog ib txwm suav tshuaj ntsuab uas tau siv rau ntau pua xyoo los kho ntau yam kab mob. Nws tau raug tshawb fawb pov thawj kom muajanti-inflammatory,anti-aging, thiabantioxidantkhoom. Cov kev tshawb fawb tau pom tias cistanche muaj txiaj ntsig zoo rau cov neeg mob uas muaj kab mob raum. Cov khoom xyaw nquag ntawm cistanche paub tias txo qhov mob,txhim kho lub raum ua haujlwmthiab restore lub raum puas hlwb. Yog li, kev sib koom ua ke cistanche hauv txoj kev npaj kho mob raum tuaj yeem muab txiaj ntsig zoo rau cov neeg mob hauv kev tswj hwm lawv tus mob.Cistanchepab txo qis proteinuria, txo qis BUN thiab creatinine qib, thiab txo qhov kev pheej hmoo ntawm lub raum puas tsuaj ntxiv. Tsis tas li ntawd, cistanche kuj pab txo cov roj cholesterol thiab triglyceride uas tuaj yeem ua rau muaj kev phom sij rau cov neeg mob uas muaj kab mob raum.

Cistanche's antioxidant thiab anti-aging zog pab tiv thaiv lub raum ntawm oxidation thiab kev puas tsuaj los ntawm dawb radicals. Qhov notxhim kho lub raum noj qab haus huvthiab txo cov kev pheej hmoo ntawm kev tsim teeb meem. Cistanche kuj tseem pab txhawb lub cev tiv thaiv kab mob, uas yog qhov tseem ceeb hauv kev tawm tsam cov kab mob raum thiabtxhawb lub raum noj qab haus huv. Los ntawm kev sib txuas cov tshuaj suav tshuaj ntsuab thiab cov tshuaj Western niaj hnub no, cov neeg muaj mob raum tuaj yeem muaj ntau txoj hauv kev los kho tus mob thiab txhim kho lawv lub neej zoo. Cistanche yuav tsum tau siv los ua ib feem ntawm txoj kev npaj kho mob tab sis tsis yog siv los ua lwm txoj hauv kev kho mob.

Leiomyosarcomas yog malignant neoplasms uas nthuav tawm cov leeg nqaij sib txawv, uas feem ntau nyob hauv retroperitoneum (12-69 feem pua) [1]. Txawm li cas los xij, lawv kuj tuaj yeem tsim los ntawm ntau cov ntaub so ntswg uas muaj cov leeg nqaij leeg. Ib qho ntawm qhov xav tau tsawg tshaj plaws ntawm cov qog no yog lub qog adrenal. Txog tam sim no, tsawg dua 50 kis tau luam tawm hauv cov ntaub ntawv Askiv. Neoplastic transformation ntawm cov leeg nqaij du ntawm lub hauv nruab nrab adrenal vein los yog nws cov tributaries yog ib tug prelude rau txoj kev loj hlob ntawm cov qog, feem ntau ncav cuag loj ntsuas. [2]

Ib tug txiv neej muaj hnub nyoog 66- xyoo tau mus rau lub chaw kho mob xwm txheej ceev vim mob hnyav hauv nws lub plab sab xis. Tus neeg mob tau ris lub nra ntawm arterial hypertension thiab ntshav qab zib hom II. Tsis tas li ntawd, nws tau txais atrial cryoablation vim yog atrial fibrillation. Kev kuaj mob plab ultrasound qhia tau tias muaj ntau qhov loj nyob hauv cov qog adrenal sab xis (Fig. 1). Adrenal adenoma yog thawj qhov kev txiav txim siab. Yog li ntawd, ib tug adrenal computer tomography raws tu qauv raug tswj. Qhov tau txais cov duab hluav taws xob tau lees paub tias muaj cov qog nqaij hlav loj nrog heterogeneous circumferential li kev sib piv. Cov kab mob tau nyob ib sab ntawm lub siab lobe thiab sab sauv ntawm lub raum sab xis. Qhov txawv txav ntawm lub cev nyob ib puag ncig tau raug cais tawm. Qhov chaw adrenal ntawm cov qog nrog cov hlab ntshav siab qhia tias pheochromocytoma. Yog li, kev ntsuam xyuas ntxiv tau ua los xyuas qhov kev txiav txim siab no. Lub sijhawm 24-teev kev kuaj mob ntawm ACTH, cortisol, thiab methyl catecholamine tsis pom muaj kev puas tsuaj. Tsis tas li ntawd, qhov tseeb tshaj nrog 1 mg dexamethasone tau pom. Cov txiaj ntsig tau tseem tsis tau paub meej, thiab pheochromocytoma tseem raug txiav txim siab hauv cov txheej txheem kuaj mob. Yog li ntawd, rab koob coarse biopsy tsis tuaj yeem ua. Tus neeg mob tau mus rau General thiab Oncological Surgery Clinic thaum Lub Kaum Hli 2020. Txawm li cas los xij, kev phais thawj zaug tau raug ncua vim atrial fibrillation. Txoj cai laparoscopic adrenalectomy tau ua 2 hnub tom qab. Kev phais thiab kev phais tom qab phais tsis zoo, thiab tus neeg mob tau tawm hauv tsev kho mob hauv lub cev zoo. Kev tshuaj xyuas histopathological tau nthuav tawm ib qho encapsulated (11 × 8 × 6.5 cm) mesenchymal qog tsim ntawm spindle neoplastic hlwb (Fig. 2) nrog cytologic pleomorphism, qhia immunohistochemical qhia ntawm cov cim ntawm cov leeg sib txawv: actin, desmin, thiab caldesmon (Fig. 3) . Cov hlwb tsis zoo rau staining ntawm SOX10, EMA, MDM2, S100, CD10, thiab CD34. Kev loj hlob Performance index yog kwv yees li 10-15 feem pua ​​​​, thiab mitotic index yog 3 rau 10 lub zog loj (HPFs). Thaum kawg, leiomyosarcoma G1 nyob rau hauv txoj cai qog adrenal tau kuaj pom. Kev kho ntxiv ntxiv tsis tau qhia los ntawm pab pawg neeg ua haujlwm ntau. Kev soj ntsuam tom qab lub computer tomography tau ua tiav 3 lub hlis tom qab ua haujlwm thiab tsis tau qhia qhov rov tshwm sim dua.

Cov txheej txheem kuaj mob ntawm sarcomas nyob rau hauv retroperitoneum yog qhov nyuaj vim nws qhov chaw kho mob asymptomatic, uas tau pom nyob rau hauv lwm hom neoplasms ib yam nkaus [3]. Kev loj hlob zuj zus ntawm leiomyosarcoma thaum kawg yuav siv lub siab rau cov qauv uas nyob ib sab, ua rau mob plab, uas yuav tshwm sim ntau yam kab mob. Yog li, cov neeg mob tuaj yeem ceeb toom rau lub tsev kho mob nrog kev ntsuas tseem ceeb ntawm cov qog. Nyob rau hauv cov ntaub ntawv nthuav tawm, qhov mob sab xis sab xis yog tib yam tsos mob ntawm cov qog nqaij hlav, uas yog impalpable.

Nyob rau hauv cov ntaub ntawv no, thawj adrenal leiomyosarcoma tshwm sim nyob rau hauv tus neeg mob nrog arterial hypertension thiab plawv palpitation, uas qhia pheochromocytoma. Vim qhov tsis tshua muaj neeg ntawm leiomyosarcomas, lawv tsis suav nrog hauv kev kuaj mob sib txawv. Ntxiv mus, lwm yam qog nqaij hlav qog nqaij hlav qog nqaij hlav qog nqaij hlav qog nqaij hlav tuaj yeem pom, xws li tsis ua haujlwm adenoma, myelolipoma, lossis adrenal cortical carcinoma, uas yog cov mob qog nqaij hlav ntau tshaj plaws [4, 5]. Yog li ntawd, plasma ACTH thiab cortisol kuaj ua ke nrog dexamethasone suppression test feem ntau yog ua kom paub meej lossis tsis suav nrog kev kuaj mob thawj zaug. Ib qho adrenal biopsy tsis raug qhia vim qhov kev xaiv ntawm adrenal ntsoog lossis qog hlav hlav. Yog li ntawd, kev phais tseem yog tus qauv kub hauv kev kho mob. Tseem tsis muaj cov cim cim ntawm qhov malignancy no, yog li kev kuaj mob yog nyob ntawm qhov muaj cov neoplastic spindle hlwb hauv histopathological pom zoo rau actin, desmin, thiab caldesmon. Yog li ntawd, qhov kawg leiomyosarcoma txheeb xyuas tshwj xeeb yog nyob ntawm kev kuaj histopathological. Qhov ntsuas kev loj hlob (Ki-67) ntawm tus neeg mob qhia tau kwv yees li 10–15 feem pua. Piv nrog rau lwm qhov xwm txheej, feem ntau ntawm cov qog kuaj rau Ki-67 tau ntau dua [2, 4]. Kev txheeb xyuas cov qog nyob rau theem pib zoo li yog qhov tseem ceeb kom tsis txhob cuam tshuam ntawm neoplastic hlwb mus rau cov ntaub so ntswg thiab nyob deb ntawm metastasis. Cov kws kho mob tom qab phais ntxiv tsis tau pom zoo los ntawm tus account ntawm Ki-67 qis thiab tsis muaj cov kab mob nyob ib puag ncig thiab tsis muaj metastasis. Thaum xav tau, kev kho adjuvant feem ntau muaj xws li doxorubicin thiab dacarbazine [6]. Nyob rau hauv cov ntaub ntawv ntawm cov neeg mob uas tsis muaj rov tshwm sim los yog metastasis, kev kuaj mob raws sij hawm yog suav hais tias tsim nyog kev kho mob tom qab phais.

Kev them nyiaj yug

Tsis muaj leej twg tshaj tawm.

Kev tsis sib haum xeeb

Cov kws sau ntawv tshaj tawm tias tsis muaj qhov tsis sib haum xeeb ntawm kev txaus siab.

Cov ntaub ntawv

1. Marko J, Wolfman DJ. Retroperitoneal Leiomyosarcoma Los ntawm Radiologic Pathology Archives. Xov tooj cua. 2018; 38(5): 1403–1420, doi: 10.1148/rg.2018180006, indexed in Pubmed: 30207936.

2. Jabarkhel F, Puttonen H, Hansson L, et al. Primary Adrenal Leiomyosarcoma: Clinical, Radiological, thiab Histopathological yam ntxwv. J En docr Soc. 2020; 4(6): bvaa055, doi: 10.1210/jendso/bvaa055, indexed in Pubmed: 32537544.

3. Janczak D, Mimier M, Mimier A, et al. Loj alveolar mos ib feem sarcoma ntawm lub retroperitoneum - ib rooj plaub. Pol J Pathol. 2014; 65(4): 327–330, doi 10.5114/pp.2014.48195, indexed in Pubmed: 25693088.

4. Bhargava P, Sangster G, Haque K, et al. Multimodality Review ntawm Adrenal Tumors. Curr Probl Diagn Radiol. 2019; 48(6): 605–615, doi: 10.1067/j. cpradiol.2018.10.002, indexed in Pubmed: 30472137.

5. Toutunchi S, Pogorzelski R, Wołoszko T, et al. Adrenal-sparing phais rau cov qog ua haujlwm hormonally - ib qho kev paub dhau los. Endokrynol Pol. 2020; 71(5): 388–391, doi: 10.5603/EP.a2020.0033, indexed in Pubmed: 33140380.

6. Sakellariou M, Dellaportas D, Peppa M, et al. Kev tshuaj xyuas cov ntaub ntawv ntawm Leiomyoma thiab Leiomyosarcoma ntawm Adrenal Gland: Kev Ntsuam Xyuas Txheej Txheem ntawm Cov Ntaub Ntawv. Hauv Vivo. 2020; 34(5): 2233–2248, doi: 10.21873/in vivo.12034, indexed in Pubmed: 32871746.

Yog xav paub ntxiv: david.deng@wecistanche.com WhatApp:86 13632399501