Puas yog Qhov Kev Ua Phem Tsis Txaus Siab Los Teb Rau COVID-19 Kev txhaj tshuaj tiv thaiv cov neeg siv TNF cuam tshuam?
Mar 28, 2022
Hu rau: Audrey Hu Whatsapp / hp: 0086 13880143964 Email:audrey.hu@wecistanche.com
COVID-19 tus kab mob kis thoob ntiaj teb tau ua rau muaj kev mob hnyav, kev tuag, thiab kev nyuaj siab rau cov kev pabcuam kev noj qab haus huv thoob plaws ntiaj teb, ua rau ntau dua 5 lab tus neeg tuag txij thaum pib. Kev txhaj tshuaj tiv thaiv kab mob hauv lub cev tuaj yeem ua rau muaj kev pheej hmoo ntawm COVID-19- cov teeb meem cuam tshuam nrog, thiab, vim li ntawd, cov tib neeg uas muaj cov tshuaj tiv thaiv kab mob hauv lub cev los yog tau txais kev txhaj tshuaj tiv thaiv kab mob yog qhov tseem ceeb rau kev txhaj tshuaj tiv thaiv thiab tau txais koob tshuaj ntxiv. Kwv yees li ib feem peb ntawm cov neeg uas muaj kab mob plab hnyuv (IBD) siv cov tshuaj tiv thaiv kab mob hauv lub cev mus ntev, thiab 5-10 feem pua ntawm cov neeg uas muaj IBD hauv ib xyoos twg raug rau corticosteroids. CLARITY-IBD txoj kev tshawb fawb1 yog thawj zaug uas qhia tias kev tiv thaiv kab mob rau tib koob tshuaj tiv thaiv COVID-19 tau txo qis hauv cov neeg mob kho nrog cov tshuaj tiv thaiv qog nqaij hlav necrosis (TNF) tshuaj. Txawm li cas los xij, seb qhov kev tiv thaiv kab mob no txo qis ntawm cov tib neeg ntawm kev kho TNF puas tseem nyob hauv cov neeg uas tau txais koob tshuaj tiv thaiv kab mob COVID{10}} tom ntej no tsis tau piav qhia zoo, thiab qhov ua tau zoo ntawm kev txhaj tshuaj tiv thaiv COVID-19 hauv tib neeg ntawm kev tiv thaiv kab mob. Feem ntau siv hauv IBD tseem tsis tau raug ntsuas.
Hauv Lancet Gastroenterology & Hepatology, James L Alexander thiab cov npoj yaig2 tau hais txog qhov kev paub tseem ceeb no, uas qhia txog kev txo qis hauv kev tiv thaiv SARS-CoV-2 spike protein antibody titres ntawm cov tib neeg uas muaj IBD raug kho nrog infliximab (geometric piv txwv 0·12, 95 feem pua CI 0·08–0·17; p<0·0001) and="" tofacitinib="" (0·43,="" 0·23–0·81;="" p="0·0095)" in="" the="" 53–92="" days="" following="" the="" second="" dose="" of="" a="" covid-19="" vaccine.="" importantly,="" ustekinumab,="" vedolizumab,="" and="" thiopurine="" monotherapy="" did="" not="" affect="" the="" immunogenicity="" of="">
Antibody titres raug lees paub tias yog ib qho tseem ceeb qhia txog kev ua tau zoo ntawm cov tshuaj tiv thaiv hauv cov pej xeem, nrog cov tshuaj tiv thaiv qis dua tom qab COVID-19 txhaj tshuaj tiv thaiv tau cuam tshuam nrog kev pheej hmoo siab dua ntawm kev kis kab mob.3,4 Ntiaj teb no, txo cov tshuaj tiv thaiv kab mob titres nrog lub sijhawm. tau coj mus rau qhov kev siv dav dav ntawm cov koob tshuaj tiv thaiv kab mob thiab kev tiv thaiv los ntawm COVID-19- cuam tshuam txog kev mus pw hauv tsev kho mob thiab kev tuag. Alexander thiab cov npoj yaig cov kev tshawb pom qhia tias feem ntau ntawm cov neeg mob uas muaj IBD tuaj yeem ua haujlwm tsis tau txhaj tshuaj, txawm tias ua raws li cov tshuaj tiv thaiv kev pom zoo thaum lub sijhawm, thiab qhia tias cov tib neeg uas muaj IBD ntawm cov tshuaj tiv thaiv TNF yuav xav tau cov tshuaj tiv thaiv ntxov ntxov lossis kev pom zoo serological. ntawm ib qho tshuaj tiv thaiv kab mob rau kev txhaj tshuaj. Hauv qee lub tebchaws, koob thib plaub tau muab rau cov tib neeg raug kho nrog cov tshuaj tiv thaiv kab mob vim muaj kev txhawj xeeb txog cov lus teb zoo tshaj plaws rau kev txhaj tshuaj tiv thaiv COVID-19.
cistanche stems
Txawm hais tias muaj kev txhawj xeeb nyob ib puag ncig lub zog ntawm lub cev tiv thaiv kab mob rau kev txhaj tshuaj tiv thaiv ntawm cov neeg tau txais kev kho mob los tiv thaiv TNF, cov neeg mob tib yam no tsis zoo li yuav muaj kev pheej hmoo ntau ntxiv ntawm kev cog lus COVID-19 piv nrog cov neeg uas muaj IBD tsis nyob rau hauv kev kho mob lom. thiab cov hnub nyoog sib npaug ntawm cov pej xeem.5–7 Qhov tseeb, kev siv tshuaj tiv thaiv TNF tuaj yeem yog qhov kev tiv thaiv tiv thaiv COVID hnyav-19- cuam tshuam txog cov txiaj ntsig ntawm cov tib neeg uas muaj kab mob autoimmune,8 uas tuaj yeem yog vim cov kev kho mob no inhibiting qhov tsis zoo. kab mob inflammatory teb uas feem ntau characterizes tus mob hnyav COVID-19. Qhov kev txo qis ntawm qhov kev pheej hmoo ntawm qhov tshwm sim hnyav kuj tseem muaj feem cuam tshuam nrog kev sib koom ua ke ntawm kev kho TNF thiab txo IBD cov kab mob ntsig txog kev ua haujlwm; Kev ua haujlwm ntawm cov kab mob ntau dua hauv IBD tau pom tias yuav ua rau muaj kev pheej hmoo ntawm qhov tsis zoo ntawm COVID{11}} cuam tshuam cov txiaj ntsig.9 Tsis tas li ntawd, cov tib neeg uas muaj IBD tau pom tias muaj kev ua raws li kev ua raws li lub cev nyob deb thiab cov lus pom zoo nyob ib leeg, uas yuav txo qis. lawv yuav kis tau tus kab mob.10
Muab qhov tsis txaus ntawm cov ntaub ntawv qhia txog kev sib raug zoo ntawm cov tshuaj tiv thaiv kab mob humoral titres thiab SARS-CoV-2 kev pheej hmoo kis mob rau cov tib neeg ntawm kev kho mob TNF, thiab tsis muaj pov thawj tias tshuaj tiv thaiv TNF ua rau muaj kev pheej hmoo ntawm tus kab mob khaub thuas hnyav heev{{4} }, nws tseem tsis tau paub meej txog seb cov neeg puas tau kho nrog cov tshuaj tiv thaiv TNF tiag tiag yuav tsum tau txhaj tshuaj sai sai lossis saib xyuas cov tshuaj tiv thaiv kab mob. Kev pom zoo ntxiv lossis ua ntej koob tshuaj ntxiv tsis yog yam tsis muaj qhov tsis zoo; vim tias cov neeg mob IBD feem ntau muaj kev ntxhov siab txog kev noj qab haus huv, cov lus tshaj tawm uas cov neeg siv tshuaj tiv thaiv TNF tuaj yeem tiv thaiv tsis txaus los ntawm COVID-19 txhaj tshuaj tiv thaiv tuaj yeem muaj qhov cuam tshuam rau kev mob hlwb lossis ua rau muaj kev sib raug zoo ntxiv.11 Tseem muaj ib qho kev txhawj xeeb uas qhov kev txhawj xeeb no nce siab txog qhov txo qis hauv kev tiv thaiv kab mob rau kev txhaj tshuaj tiv thaiv yuav ua rau muaj kev tsis txaus siab hauv kev pib kho mob biologic uas tau qhia lwm tus ntawm cov tib neeg uas muaj mob hnyav-rau- mob IBD.
cistanche tshuaj yej: txhim kho kev tiv thaiv
Qhov kev ntxhov siab tshaj plaws, txawm tias muaj kev hloov pauv sai ntawm cov tiam thiab tshaj tawm cov kev tshawb pom tshiab, qhov kev hloov pauv ntawm tus kabmob kis tau sai dua. Nrog rau qhov tshwm sim ntawm omicron variant (B.1.1.529) thiab kev hloov mus rau endemicity, qhov cuam tshuam ntawm qhov kev tshawb pom no tau ploj mus. Cov kws kho mob tam sim no txhawj xeeb txog lub sijhawm ntawm koob thib plaub ntawm COVID-19 tshuaj tiv thaiv hauv cov tshuaj tiv thaiv kab mob, thiab yog li kev tshawb fawb soj ntsuam cov tshuaj tiv thaiv kab mob titres tom qab ob koob tshuaj tuaj yeem txo qhov kev siv tshuaj kho mob ntau dua li nws tau ua thaum lub phiaj xwm no tau xeeb tub thiab ua tiav.
Raws li COVID-19 kev kis thoob qhov txhia chaw, cov kws kho mob yuav tsum tau hloov kho lawv cov kev coj ua ntxiv raws li cov pov thawj tshwm sim hais txog kev ua tau zoo thiab cuam tshuam ntawm cov tshuaj tiv thaiv COVID-19 ntawm cov neeg mob IBD thiab kev pheej hmoo ntawm COVID{1} {2}}Cov txiaj ntsig ntsig txog ntawm cov neeg tau txais kev kho mob nrog cov tshuaj immunomodulating. Lub sijhawm no, txhawb nqa cov koob tshuaj ntawm cov tib neeg ntawm cov tshuaj tiv thaiv TNF 3-4 lub hlis tom qab cov tshuaj tiv thaiv tsis ntev los no yog qhov tsim nyog, tshwj xeeb tshaj yog rau cov uas muaj kev pheej hmoo ntxiv rau qhov mob hnyav rau COVID-19, xws li hnub nyoog laus thiab lwm yam cim ntawm frailty. Kev kawm tus neeg mob yuav yog qhov tseem ceeb tshaj plaws; Cov koob tshuaj tiv thaiv thawj zaug thiab tom qab yuav tsum tau ntxiv dag zog ntxiv raws li qhov kev ntsuas tseem ceeb tshaj plaws los tiv thaiv COVID-19 hauv cov neeg mob IBD thaum peb nkag mus rau theem tom ntej ntawm kev sib kis.
cistanche tubulosa extract: txhim kho kev tiv thaiv
Tarun Chhibba, *Laura E Targownik laura.
Division of Gastroenterology thiab Hepatology, Department of Medicine, University of Toronto, Toronto, ON, Canada (TC, LET); Mount Sinai Tsev Kho Mob IBD Center, Division of Gastroenterology, Mount Sinai Tsev Kho Mob, Toronto, ON M5G 1X5, Canada (LET)
Kev siv
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