Puas yog Parkinson's Disease Hereditary?
Apr 15, 2022
Ntau tus neeg mob Parkinson nug ib lo lus nug; "Parkinson tus kab mob puas kis mus rau kuv cov menyuam?" Kuv ntseeg tias qhov no kuj yog ib qho teeb meem uas ntau tus neeg mob Parkinson muaj kev txhawj xeeb tshwj xeeb. Cov niam txiv txom nyem thoob plaws ntiaj teb, txawm tias lawv raug tus kab mob Parkinson, lawv txhawj xeeb tshaj plaws rau lawv cov menyuam.
Hauv kev teb rau lo lus nug ntawm seb tus kab mob Parkinson puas yog keeb kwm:
Tseem tsis paub qhov tseeb ntawm tus kab mob Parkinson. Qhov tshwm sim ntawm Parkinson tus kab mob tuaj yeem cuam tshuam nrog kev degeneration thiab tuag ntawm dopaminergic neurons hauv substantia nigra. Cov yam ntxwv ntawm caj ces, ib puag ncig yam, kev laus, thiab kev ntxhov siab oxidative tej zaum yuav cuam tshuam rau cov txheej txheem deformation thiab tuag ntawm dopaminergic neurons hauv Parkinson tus kab mob.
Tam sim no tseem muaj cov kev tshawb fawb qhia tias dysbiosis nyob rau hauv lub plab flora tuaj yeem ua rau Parkinson tus kab mob, los yog ib qho dysregulation ntawm cov kab mob autoimmune tuaj yeem ua rau Parkinson tus kab mob.
Tau kawg, tus kab mob Parkinson kuj yog ib yam kab mob tshwm sim los ntawm ntau yam noob thiab ntau yam. Piv txwv li, thaum koj muaj cov noob LRRK2 hauv koj lub cev, mob khaub thuas yuav ua rau koj muaj tus kab mob Parkinson.
Nyem rau Cistanche bioflavonoids ntsiav tshuaj thiab cistanche Australia rau tus kab mob Parkinson
Feem ntau, cov khoom qub txeeg qub teg ntawm tus kab mob Parkinson suav rau ib feem me me, kwv yees li 5 feem pua rau 10 feem pua. Feem ntau cov neeg mob Parkinson tsis tau txais txiaj ntsig, tab sis yog tias nws yog kab mob Parkinson tus kab mob, nws muaj qee qhov kev xeeb tub.
Tom qab ntawd qee tus neeg mob Parkinson yuav nug, kuv tsev neeg, tsis raug mob Parkinson, kuv tus menyuam puas yuav muaj teeb meem? Feem ntau cov neeg uas muaj tus kab mob Parkinson tsis yog los ntawm noob neej, peb hu nws tus kab mob Parkinson tsis zoo. Cov neeg mob zoo li no tuaj yeem muaj qee qhov kev hloov pauv noob caj noob ces, uas ua rau muaj kev pheej hmoo ntawm Parkinson tus kab mob siab dua li cov uas tsis nqa lawv. Qhov ntau dua qhov chaw hloov pauv caj ces, qhov kev pheej hmoo ntawm kev tsim tus kab mob ntau dua.
Hais txog qhov no, txhua tus yuav txhawj xeeb. Puas yog txhais tau tias thaum peb mob, peb cov menyuam yuav muaj teeb meem tiag tiag? Qhov tseeb tsis yog. Txawm hais tias koj muaj qhov txiaj ntsig zoo ntawm cov noob tshuaj ntsuam xyuas, nws tsis tas txhais tau tias koj muaj tus kab mob. Ib yam li cov neeg uas muaj cov ntshav lipids siab tuaj yeem ua rau mob stroke, nws tsis tau txhais hais tias cov ntshav lipids siab yuav ua rau mob stroke. Thiab cov neeg uas muaj ntshav lipids tsawg tsis tas yuav tiv thaiv kab mob. Risk noob ua lub luag haujlwm zoo sib xws hauv cov kab mob. Ntxiv nrog rau cov noob caj noob ces, lwm yam kev pheej hmoo thiab kev tiv thaiv yuav tsum tau txiav txim siab nyob rau hauv lub pathogenesis ntawm Parkinson tus kab mob. Cov tib neeg uas tsis muaj cov noob caj noob ces yuav muaj kev pheej hmoo siab dua li cov uas muaj cov noob caj noob ces zoo yog tias lawv muaj ntau yam kev pheej hmoo. Yog li ntawd, cov kev pheej hmoo ntawm tus kab mob Parkinson yuav tsum tau saib xyuas kom meej thiab lub hom phiaj kom raug thiab raug kwv yees qhov kev pheej hmoo ntawm tus kab mob thiab tsim cov tswv yim daws teeb meem.
Cov neeg mob uas muaj keeb kwm ntawm tsev neeg keeb kwm ntawm Parkinson feem ntau muaj ob yam hauv qab no:
1. Muaj kev ua tau zoo ntawm tsev neeg sib sau ua ke, thiab muaj cov neeg nyob hauv yuav luag txhua tiam neeg.
2. Thaum muaj hnub nyoog pib: Nws feem ntau tshwm sim ua ntej hnub nyoog 40 xyoo, thiab tus kab mob no sai heev. Hom tsev neeg tshee muaj qhov tshwm sim ntau dua thiab tsawg tsev neeg keeb kwm ntawm kev nruj, uas tej zaum yuav yog qhov qub txeeg qub teg.
Parkinson tus kab mob, raws li ib tug tshwm sim ntawm neurodegenerative kab mob, feem ntau tshwm sim nyob rau hauv cov neeg laus, nrog rau qhov nruab nrab hnub nyoog pib ntawm 60 xyoo. Qhov tseeb etiology ntawm cov kab mob no tseem tsis tau paub meej, yam tseem ceeb ntawm caj ces, ib puag ncig, kev laus, oxidative kev nyuaj siab, thiab lwm yam tuaj yeem ua rau tus kab mob no.
Qhov ua rau Parkinson's disease feem ntau muab faib ua cov hauv qab no:
Qhov tshwm sim ntawm tus kab mob Parkinson nce nrog lub hnub nyoog, thiab nws muaj ntau dua rau cov neeg muaj hnub nyoog 60 xyoo. Nyob rau hauv xyoo tas los no, qhov tshwm sim ntawm tus kab mob Parkinson kuj tseem muaj cov hluas dua. Qhov tshwm sim ua ntej hnub nyoog 40 xyoo yog hu ua juvenile Parkinson's disease, thiab qhov tshwm sim me me.
Cov noob caj noob ces yog txuam nrog tsev neeg Parkinson tus kab mob. 5 ~ 10 feem pua ntawm cov neeg mob Parkinson tus kab mob muaj keeb kwm hauv tsev neeg, thiab cov caj ces tseem yog ib qho ntawm cov kab mob ntawm cov kab mob Parkinson. Yog li ntawd, cov neeg mob uas muaj cov noob caj noob ces, xws li LRRK2 gene thiab tsev neeg keeb kwm, feem ntau yuav muaj tus kab mob Parkinson. mob.
Qhov kev siv tshuaj, raug tshuaj tua kab mob, thiab tshuaj tua kab tuaj yeem ua rau tus kab mob Parkinson tau yooj yim, thaum haus luam yeeb thiab haus caffeine muaj qee yam kev tiv thaiv, ua rau tib neeg tsim tus kab mob Parkinson nyuaj.
Tau kawg, txhua tus tsis tuaj yeem haus luam yeeb ntau npaum li kev haus luam yeeb, thiab haus kas fes muaj kev tiv thaiv, vim tias kev haus luam yeeb yuav ua rau muaj kev pheej hmoo ntawm mob qog noj ntshav thiab kab mob plawv thiab cerebrovascular. Kev haus luam yeeb txhawm rau tiv thaiv tus kab mob Parkinson ua rau muaj kev pheej hmoo ntawm mob ntsws cancer thiab kab mob plawv thiab cerebrovascular.
Hauv kev xaus, qhov pathogenesis ntawm tus kab mob Parkinson tseem tsis meej, thiab muaj ntau yam kev xav. Yog tias koj muaj tus kab mob Parkinson, tsis txhob ntshai. Kev kho mob nquag, tswj cov tsos mob, thiab txhim kho lub neej zoo yog peb lub hom phiaj.
Kuv yuav ua li cas kho tus kab mob Parkinson,
Tam sim no nrog kev txhim kho ntawm cov cuab yeej siv kho mob, cov tshuaj sab hnub poob, thiab cov tshuaj suav tshuaj suav tau ua rau muaj txiaj ntsig zoo rau kev kho tus kab mob Parkinson. Raws li ib txwm siv thev naus laus zis, cov tshuaj suav tshuaj muaj txiaj ntsig zoo rau kev tiv thaiv thiab kho tus kab mob Parkinson, tshwj xeeb tshaj yog cov tshuaj ntsuab cistanche ntawm tus kab mob Parkinson. Cov kev kho mob tuaj yeem tau txais txiaj ntsig zoo inhibitory, thiab nyob rau hauv cov txheej txheem ntawm kev noj cov tshuaj, nws tuaj yeem zam cov kev mob tshwm sim los ntawm cov tshuaj sab hnub poob, tiv thaiv lub siab thiab lub raum ua haujlwm ntawm tus neeg mob, thiab cov nyhuv ntawm cov tshuaj yuav ruaj khov dua.
EchinacosidehauvCistanchetuaj yeem txhim kho tus cwj pwm tsis zoo ntawm MPTP-induced PD qauv nas, nce striatal dopamine (DA) metabolite 3,4-dihydroxypheny lacetic acid (3,4-dihydroxypheny lacetic acid, DOPAC), thiab siab Vanillic acid. (homovanillic acid, HVA) cov ntsiab lus tseem ceeb inhibits qhovapoptosisntawm cerebellar granule neurons tshwm sim los ntawm kev ua kom cov caspase-3 thiab caspase-8; txo qhov overexpression ntawm biliverdin reductase B nyob rau hauv lub hlwb ntawmParkinson tus kab mobcov neeg mob, qhiaEchinacosidetxo qhov nce ntawm biliverdin reductase B tshwm sim los ntawm oxidative kev nyuaj siab los ntawm nws cov anti-oxidative kev nyuaj siab, thiab tiv thaiv dopaminergic neurons los ntawm oxidative kev nyuaj siab puas. Nws cov txheej txheem tiv thaiv neuroprotective yuav zoo ib yam li cov kua tsib Cov qib ntawm chlorophyll reductase B muaj feem xyuam; kom txo tau cov dopaminergic neurons thiab dopamine transporters nyob rau hauv lub substantia nigra ntawm lub paj hlwb ntawm cov neeg mob Parkinson tus kab mob, thiab tuaj yeem txhim kho neurotrophic factor [neurotrophic factor, NTF. hlwb-derived neurotrophic factor, BDNF) thiab cov hlab ntsha Cov kev ua ub no thiab cov protein qhia theem ntawm glial cell line-derived neurotrophic factor (GDNF) muab tau los ntawm glial cell kab tuaj yeem txo qhov piv ntawm mRNA thiab protein nyob rau hauvapoptosisthiab Bax/Bcl-2. Tsis tas li ntawd, echinacoside tuaj yeem nce cov ntsiab lus ntawm dopamine, DOPAC, thiab HVA hauv cov kua dej ntxiv ntawm cov striatum ntawm cov neeg mob Parkinson's disease.
