Impact On Grafted raum Function Ntawm Rocuronium-sugammadex Vs Cisatracurium Neostigmine Strategy Rau Neuromuscular Block Management Ⅱ.

Cov txiaj ntsig

Tsis muaj qhov sib txawv tseem ceeb hauv cov pej xeem lossis lwm tus neeg mob tus yam ntxwv tau pom ntawm cov piam thaj tsim thiab neostigmine pawg (Table 1). Tsuas yog rau NMBAs thiab cov tshuaj thim rov qab, tsis muaj qhov sib txawv ntawm cov tshuaj loog thiab phais cov yam ntxwv ntawm ob pawg (Table 2). Sugammadex tau tswj hwm rau kev thim rov qab ntawm qhov nruab nrab thiab sib sib zog nqus NMB hauv 57.7% thiab 42.3% ntawm cov neeg mob, feem. Hauv lub sijhawm ua haujlwm tom qab, pawg sugammadex tau pom tias muaj qhov tshwm sim tsawg dua ntawm hypoxemia, luv PACU nyob, thiab txo qis kev nkag mus rau ICU (Table 2). Tsis muaj tus neeg mob nyob rau hauv ob pab pawg tau nthuav tawm cov pov thawj kho mob ntawm cov teeb meem loj tom qab phais.

Nws yuav siv sij hawm ntev npaum li cas rau CISTANCHE ua haujlwm?

Hais txog perioperativelub raum ua haujlwm,ntshav creatinine(596.0 [478.0-749.0] vs 639. p {{1{21}}}. 30}}}}.0] mmol/L, p=0.0486) qis dua, thaum eGFR (8.0 [6.0-11.0] vs 8.0 [6. {32}}.0], p=0.0473) tau siab dua hauv pawg sugammadex dua li hauv pawg neostigmine tom qab phais (Table 3, Fig. 1). Serum urea tseem qis dua hauv thawj 3 hnub tom qab phais (Table 3). Tsis muaj qhov sib txawv hauvlub raum ua haujlwmtau pom ntawm cov neeg mob nruab nrab thiab sib sib zog nqus ntawm sugammadex (Table 3). Kev faib ua feem ntawm cov neeg mob nrog ibnce hauv cov ntshav creatininerau > 44 μmol / L tau siab dua hauv pawg sugammadex dua li hauv pawg neostigmine (thawj hnub tom qab phais: 40 [22.9%] vs 33 [18.9%], p=0.43{{16 }}; thib tsib hnub tom qab: (15 [8.6%] vs 14 [8.0%], p=1 {{30}}}). postoperative dialysis yog siab dua nyob rau hauv cov pab pawg neeg neostigmine tshaj nyob rau hauv cov pab pawg neeg sugammadex (21 [12%] vs 18 [10.3%], p=0.734 lub cev hnyav (CC {{24 }}.282; p < 0 0001), qhov siab (CC=0.281; p < 0.0001), lub cev qhov hnyav (BMI) (CC=0 .165; p=0.0019), preoperative serum creatinine (CC=0.779; p < 0.0001), thiab neostigmine (CC=−0.265; p < 0.001) correlated nrog postoperative serum creatinine (Daim duab. 2). }}.988; t=3.127 p=0.0019) thiab preoperative serum creatinine (EC=0.706; SE=0.027; t {{59}; }} −25.64; p < 0.0001) tsuas yog qhov sib txawv uas cuam tshuam nrog qib siab dua tom qab phaisntshav creatinine, thaum rocuronium tau cuam tshuam nrog qib qis ntawm kev ua haujlwm tom qabntshav creatinine(EC {{0}}} −0.607; SE=0.227; t=−2.666; p=0.008).

Table 1 Tus neeg mob tus yam ntxwv

Table 2 Perioperative lub sij hawm

Table 3 Perioperative raum Function Varia

Fig. 1 Box plots comparing sugammadex to neostigmine onlub raum ua haujlwmua ntej thiab tom qab phais. Cov thawv sawv cev rau nruab nrab thiab IQR. "Whiskers" (yam tsawg kawg thiab siab tshaj plaws) sawv cev qhov tseem ceeb 1.5 npaug ntawm IQR [(1st quartile–1.5 × IQR) thiab (3rd quartile+1.5 × IQR)]. IQR interquartile ntau, pp tus nqi nrog qhov tseem ceeb ntawm < 0.05, NEO pab pawg ntawm cov neeg mob tau txais neostigmine rau kev thim rov qab ntawm cisatracurium-induced neuromuscular block (NMB), SUG pawg ntawm cov neeg mob tau txais sugammadex rau kev thim rov qab ntawm rocuronium-induced NMB , PRE lub hauv paus tus nqi (ua ntejhloov raum), POST thawj qhov ntsuas tau txais hnub hloov lub raum,creatinine uathiaburea serum creatininethiab ntshav urea, eGRF kwv yees glomerular pom tus nqi