Hu rau: jerry.he@wecistanche.com

Mikhail V. Blagosklonny

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA

Keywords: kho mob, kab mob, laus, rapamycin

Tau Txais: 8/15/12; Txais: 8/20/12; Luam tawm: 8/20/12

Xa mus rau: Mikhail V. Blagosklonny, MD/Ph.D.;

Copyright: © Blagosklonny. Qhov no yog ib tsab xov xwm qhib tau muab faib raws li cov ntsiab lus ntawm Creative Commons Attribution License, uas tso cai txwv tsis pub siv, faib, thiab luam tawm nyob rau hauv ib qho nruab nrab, muab tus thawj sau thiab qhov chaw raug tso cai.

Abstract: Qhov kev vam meej tsis tau pom dua hauv kev tshawb fawb txog kev laus tau qhia tias rapamycin, cov tshuaj tau pom zoo hauv tsev kho mob, yog qhov ua rau muaj kev tiv thaiv kev laus, uas tuaj yeem ua haujlwm los ncua cov kab mob uas muaj hnub nyoog, yog li txuas ntxiv lub neej noj qab haus huv. Qhov ua tau ntawm kev tiv thaiv kab mob los ntawm kev ua hluas yog qhov zoo kawg nkaus hauv nws tus kheej. Tib lub sijhawm, qhov kev nce qib no tuaj yeem txuag Medicare raws li peb paub. Ntawm no kuv tham txog yuav ua li cas tiv thaiv kev laus tuaj yeem daws cov teeb meem kev nom kev tswv uas tsis muaj kev cuam tshuam yam tsis muaj kev nce se lossis txo cov txiaj ntsig kev noj qab haus huv.

Cistanche muaj cov nyhuv anti-aging

Kev kho mob ntsoog

Social Security thiab Medicare suav txog 36 feem pua ​​​​ntawm tsoomfwv kev siv nyiaj hauv xyoo 2011, thiab raws li menyuam yaus hnub nyoog boomers, cov nqi no tau kwv yees nce ntxiv. Raws li kev kwv yees tsis ntev los no, Social Security trust fund yuav tag rau xyoo 2033, peb xyoos sai dua li qhov kev kwv yees xyoo tas los. Thiab Medicare lub tsev kho mob cov nyiaj pov hwm kev ntseeg siab yuav raug tshem tawm hauv 2024 [1]. Ib qho kev daws teeb meem yog txiav Medicare thiab lwm cov txiaj ntsig kev noj qab haus huv, kev kho mob nqaim, kom txo qis kev loj hlob ntawm cov txiaj ntsig me me rau cov neeg tau txais txiaj ntsig. Lwm qhov kev daws teeb meem yog txhawm rau nce se (txhua daim ntawv) thiab / lossis ua kom tsoomfwv cov peev nyiaj tsis txaus. Cov kev daws teeb meem no yog kev nom kev tswv. Ntawm no kuv yuav tham txog kev daws teeb meem biomedical, uas tuaj yeem nkag tau yooj yim rau hauv lawv txoj haujlwm nom tswv los ntawm Democrats thiab Republicans. Tom qab ntawd yuav tsis muaj teeb meem los nce se lossis txo cov txiaj ntsig. Tab sis ua ntej, peb yuav tham txog dab tsi yog qhov ua rau muaj kev kub ntxhov tom ntej.

Kev kub ntxhov raws li qhov tshwm sim ntawm kev kho mob zoo dua

Raws li tsis ntev los no tau sau tseg "Republicans thiab Democrats tab tom liam ib leeg rau cov teeb meem ntawm cov kev pabcuam nrov, uas muab txiaj ntsig rau ntau dua 55 lab tus tib neeg. [1]" Txawm li cas los xij, kev kho mob tsis yog qhov txhaum ntawm Republicans lossis Democrats. Qhov kev kub ntxhov yog "kev cuam tshuam" ntawm qhov ua tau zoo ntawm cov tshuaj. Qhov ntawd yog, qhov kev kub ntxhov yog qhov tsis ncaj vim yog qhov ua tau zoo ntawm cov tshuaj niaj hnub no xws li kev hloov pauv hauv nruab nrog cev, coronary stents, kev saib xyuas hnyav thiab xwm txheej ceev, tshuaj tua kab mob tiv thaiv kab mob, MRI, thiab kev sim sophisticated, tag nrho cov uas txo cov tib neeg kev txom nyem thiab tso cai rau cov neeg mob tuag taus. tej yam kev mob nyob rau ntau xyoo. Tab sis cov tshuaj cawm txoj sia no kuj yog lub luag haujlwm, ib feem, rau kev nce nqi kho mob.

Ua ntej, pom tseeb tab sis tsis tseem ceeb tshaj, cov kev xaiv kho mob no kim heev. Piv txwv li, kev hloov khoom nruab nrog cev yuav raug nqi ntau pua txhiab nyiaj. Kev txhim kho cov tshuaj tua kab mob tshiab tiv thaiv kab mob tiv thaiv kab mob yuav tsum tau siv nyiaj ntau rau kev tshawb fawb. Qhov thib ob, thiab qhov tseem ceeb tshaj plaws, qhov tseeb vim tias cov tshuaj tau ua haujlwm zoo hauv kev cawm neeg txoj sia, qhov no ua rau cov neeg laus cov neeg mob uas muaj mob ntev thiab ntau yam kab mob (Daim duab 1 ntawm A txog B), uas yuav tsum tau siv ntau yam kev kho mob tag nrho cov nyiaj tau los. Tsis muaj leej twg tuag los ntawm kev laus nws tus kheej, txhua tus tib neeg tuag los ntawm hnub nyoog cov kab mob xws li mob qog noj ntshav, atherosclerosis, kub siab, ntshav qab zib, osteoporosis, lossis los ntawm lawv cov teeb meem. Yog li ntawd txhua tus neeg laus dhau los ua tus neeg mob ntawm qee lub sijhawm. Cov kev pab kho mob ncua kev tuag los ntawm cov kab mob uas muaj hnub nyoog, feem ntau tsis kho lawv. Piv txwv li, tau txais kev cawmdim los ntawm defibrillation los ntawm kev tuag tam sim ntawd vim yog coronary atherosclerosis, tus neeg mob tuaj yeem nyob tau ntau xyoo (nrog kev kho mob) thiab tej zaum yuav tuag los ntawm lwm yam kab mob uas muaj hnub nyoog. Nrog rau kev kho mob thiab kev saib xyuas neeg mob, cov neeg mob macular degeneration, Alzheimer's thiab Parkinson's kab mob, hom II mob ntshav qab zib, kub siab, coronary atherosclerosis, sarcopenia, thiab osteoporosis tuaj yeem nyob tau ntau xyoo. Mob qog noj ntshav kuj dhau los ua kab mob ntev. Tau kawg, qhov no yog kev kho mob thiab kev sib raug zoo. Raws li "ib qho kev mob tshwm sim," txawm li cas los xij, qhov no ua rau cov neeg laus cov neeg laus muaj cov kab mob uas muaj hnub nyoog ntev hauv kev xav tau kev kho mob tas li ( leej twg yuav tsis tuag). Txij li cov kab mob ntawm kev laus yuav maj mam txhim kho nrog lub hnub nyoog, xws li tus neeg mob raug kev txom nyem los ntawm ntau yam thiab qee zaum ntau yam kab mob. Kev sib xyaw ua ke ntawm kev rog rog, ntshav qab zib, atherosclerosis, kub siab, retinopathy, osteoporosis yog ntau heev. Yog li ntawd, ib txhij muaj kev nce ntawm cov kab mob cuam tshuam rau txhua tus neeg laus thiab kev nce ntawm cov neeg mob zoo li no.

Hauv cov ntsiab lus, cov tshuaj tam sim no muaj txiaj ntsig zoo hauv kev tiv thaiv kev tuag ntawm cov kab mob muaj hnub nyoog yam tsis muaj kev ncua sij hawm pib, yog li ua rau cov neeg muaj cov kab mob uas muaj hnub nyoog thiab cov kab mob cuam tshuam rau txhua tus neeg laus. Tsis tas li ntawd, txhua tus kab mob ntawm kev laus yog tam sim no kho nyias, uas yog kim thiab tuaj yeem ua rau muaj kev cuam tshuam tsis zoo. Piv txwv li, chemotherapy, siv rau kev kho mob qog noj ntshav, muaj kev cuam tshuam tsis zoo rau cov ntaub so ntswg thiab lub cev. Thiab rov qab, insulin, uas yog siv rau kev kho mob ntshav qab zib mellitus, yog qhov ua rau muaj kev laus [2] thiab tuaj yeem ua rau qee yam kab mob xws li mob qog noj ntshav [3], [4]. (Faj seeb: Hauv qhov sib piv, vim qee qhovanti-agingcov dej num, cov tshuaj tiv thaiv kab mob ntshav qab zib metformin tiv thaiv qog noj ntshav [5]). Ib qho kev daws teeb meem yog ncua cov kab mob uas muaj hnub nyoog, yog li ncua lub neej noj qab haus huv. Tab sis nws puas ua tau?

Kev laus qeeb yog tshwm sim raws li kev laus noj qab haus huv

Muaj ib tug misconception tias ibanti-agingtshuaj yuav ua rau cov neeg mob mob ntau ntxiv vim lawv laus lawm. Ntawm qhov tsis sib xws, nws yuav txo qhov piv ntawm cov neeg tsis noj qab haus huv rau cov neeg noj qab haus huv (Daim duab 1C) vim tias ib qhoanti-agingtshuaj yuav ncua qhov pib ntawm kev laus, kab mob, thiab lawv cov teeb meem thaum muaj hnub nyoog laus [6- 8]. Cov tsiaj uas muaj hnub nyoog sai (cov nas) tsim cov kab mob ntawm kev laus sai, thaum cov kab mob qeeb qeeb xws li tib neeg kis tau cov kab mob no thaum muaj hnub nyoog 40 npaug tshaj cov nas. Centenarians, cov neeg uas nyob ntau tshaj 100 xyoo, muaj hnub nyoog maj mam thiab feem ntau muaj kev noj qab haus huv mus txog rau thaum laus heev, thaum cov kab mob uas tua lawv thaum kawg tshwm sim [8-12]. Tsis tas li ntawd, lub sij hawm ntawm morbidity tsis tsuas yog ncua, tab sis kuj shortened [8]. (Tej zaum, cov neeg laus laus heev (chronologically) cov neeg mob tsis tau txais kev kho mob hnyav piv nrog cov neeg mob hluas).

Daim duab 1. Los ntawm lub neej ntev mus rau kev noj qab haus huv ntev (thiab lub neej ncua). Los ntawm A mus rau B: Cov tshuaj txheem ua kom muaj sia nyob los ntawm kev tiv thaiv kev tuag ntawm cov kab mob uas muaj hnub nyoog. Nws ib txhij nce tus naj npawb ntawm cov neeg laus uas muaj cov kab mob uas muaj hnub nyoog. Qhov ratio ntawm kev noj qab haus huv rau lifespan yog txo. Los ntawm B txog C: Kev cuam tshuam los tiv thaiv kev laus yuav qeeb kev laus thiab ncua qhov pib ntawm cov kab mob uas muaj hnub nyoog. Qhov no nyob rau hauv txoj kev xav yuav rov qab qhov piv ntawm kev noj qab haus huv rau lifespan.

Yav dhau los, cov neeg feem coob tuag (los ntawm qhov xwm txheej, kev kis kab mob, kev noj zaub mov tsis zoo, thiab kev tua neeg) ua ntej lawv ua tiav lub hnub nyoog ntawm cov kab mob ntsig txog hnub nyoog. Piv txwv li, nyob rau hauv lub xyoo pua 17th nyob rau London, tsuas yog 25 feem pua ​​​​ntawm cov neeg muaj sia nyob mus txog rau thaum muaj hnub nyoog 26 xyoo (saib cov ntaub ntawv [7]). Los ntawm nruab nrab ntawm 20-xyoo pua kev vam meej thiab tshuaj tau tso cai rau cov neeg feem coob nyob ntev txaus kom tuag los ntawm kev laus los yog hais lus nruj me ntsis los ntawm cov kab mob uas muaj hnub nyoog (Daim duab 1A). Tseem, txog thaum tsis ntev los no, tib neeg tuag sai sai tom qab lawv mus txog hnub nyoog ntawm cov kab mob uas muaj hnub nyoog los ntawm cov teeb meem ntawm cov kab mob muaj hnub nyoog (Daim duab 1 A). Tam sim no cov kev pab kho mob tau zoo tuaj yeem ua rau tus neeg mob muaj sia nyob txawm tias muaj kab mob ntsig txog hnub nyoog (Daim duab 1B). Qhov no nce qhov piv ntawm cov neeg tsis noj qab haus huv rau cov neeg noj qab haus huv (Daim duab 1B). Qhov xav tau yog kom ncua cov kab mob uas muaj hnub nyoog (Daim duab 1C). Thiab los ntawm kev muaj hmoo zoo, qhov no tuaj yeem ua tiav tam sim no, muaj peev xwm tiv thaiv kev noj qab haus huv (saib ntawv).

Slowing aging ob qho tib si nce lifespan thiab ncua cov kab mob. Ib tug txawm hais tiasanti-agingkev cuam tshuam ua rau lub neej nce ntxiv los ntawm kev ncua cov kab mob. Yog li, kev txwv calories qeeb qeeb kev laus thiab ncua kev loj hlob ntawm tag nrho cov hnub nyoog cov kab mob hauv cov tsiaj nrog rau cov tsis yog tib neeg thiab tib neeg primates [13-18]. Thiab vice versa ntau cov khoom noj uas ua rau rog rog thiab accelerates kev laus kuj accelerates txoj kev loj hlob ntawm tag nrho cov hnub nyoog cov kab mob los ntawm hom II mob ntshav qab zib rau atherosclerosis mus rau mob cancer. Ib qho txo ​​qis ntawm cov roj visceral txo qis kev tuag [19]. Txawm li cas los xij, kev txwv tsis pub calorie hnyav tuaj yeem ua rau tsis muaj zaub mov noj. Tej zaum nws yuav siv tau cov kev txwv tsis pub muaj calorie xws li rapamycin es tsis txhob txwv calorie. Muaj pov thawj tias rapamycin tuaj yeem ua rau kev laus qeeb thiab ncua qhov pib ntawm cov kab mob uas muaj hnub nyoog.

Kev laus thiab Lub Hom Phiaj ntawm rapamycin (TOR)

Nws tau ntev xav tias kev laus yog tshwm sim los ntawm kev sib sau ntawm random molecular puas tsuaj thiab hnav thiab tsim kua muag. Yog li, nws tau xav tias cov kab mob tuaj yeem kho tau tab sis kev laus tsis tuaj yeem. Cov kev tshawb fawb tau nce zuj zus ntxiv tau tsim kom ntseeg tau tias inhibition ntawm qee cov teeb liab-transduction molecules txuas lub neej ntev hauv ntau hom [20-26]. Cov proteins no tsim cov kev taw qhia, uas paub cov khoom noj khoom haus (qabzib, fatty acids, amino acids), insulin thiab lwm yam tshuaj hormones, oxygen, cytokines, thiab kev loj hlob. Kev ua kom muaj txoj hauv kev zoo li no txhawb kev loj hlob thiab, thaum kev loj hlob tiav, kev laus [27]. Cov khoom noj-sensing thiab kev loj hlob-txhim kho TOR (Lub Hom Phiaj ntawm Rapamycin) sawv tawm rau plaub qhov laj thawj tseem ceeb. Ua ntej, feem ntau ntawm cov pro-aging thiabanti-agingmolecules tuaj yeem kos duab ua ib feem ntawm TOR txoj kev [28, 29]. Thib ob, mammalian TOR (mTOR) txuas cellular thiab organismal aging [28, 30]. Yog li, mTOR koom nrog hauv cellular aging [31-33]. Inhibition ntawm mTOR suppresses hloov dua siab tshiab ntawm post-mitotic hlwb mus rau senescent hlwb [34, 35]. Nyob rau hauv so hlwb, reactivation ntawm mTOR ua rau senescence (geroconversion) [36]. Rapamycin tiv thaiv hyperactivation thiab qaug zog ntawm qia hlwb hauv lub cev [37, 38]. Qhov thib peb, ntau cov kev tshawb fawb preclinical tau qhia tias mTOR muaj feem cuam tshuam rau feem ntau cov kab mob uas muaj hnub nyoog xws li mob qog noj ntshav, atherosclerosis, neurodegeneration, thiab hnub nyoog ntsig txog macular degeneration [28, 29, 39-43]. Plaub, thiab qhov tseem ceeb tshaj plaws, rapamycin thiab nws cov analogues (rapalogs) yog cov tshuaj pom zoo hauv kev kho mob.

Rapamycin thiab lwm yam rapalogs

Tau ib xyoo caum, rapamycin (Sirolimus) thiab nws cov tshuaj analogues tau siv ntau hauv cov neeg mob hloov pauv. Nyob rau hauv cov koob tshuaj siab thiab ntev ntev, ua ke nrog cov tshuaj tiv thaiv kab mob (kom tiv thaiv kev hloov pauv hauv nruab nrog cev), rapamycin muaj qee qhov cuam tshuam rov qab. Raws li "kev mob tshwm sim" rapamycin tiv thaiv qog noj ntshav hauv cov neeg mob raum hloov pauv [44-46]. Muaj qee qhov "kev mob tshwm sim" xws li lipolysis [40]. Muaj kev nkag siab yuam kev tias rapamycin tuaj yeem ua rau muaj kev pheej hmoo ntawm mob qog noj ntshav thiab lymphomas. Hloov chaw, rapamycin thiab lwm yam rapalogs tiv thaiv thiab kho mob qog noj ntshav thiab lymphomas. Rapamycin tiv thaiv ntau yam kab mob uas muaj hnub nyoog hauv cov qauv tsiaj. Hauv cov neeg mob, qhov ncauj rapamycin txo qis atherosclerotic re-stenosis [47-49]. Thaum kawg, nws qeeb kev laus thiab ncua lub neej ntev ntawm yoov [50, 51] thiab nas [52-57].

Raws li ibanti-agingtshuaj, txawm li cas los xij, rapamycin yuav tsum tau siv ntawm cov koob tshuaj tsawg thiab cov sijhawm sib nrug [58, 59] ("Intermittent rapamycin" hauv kev npaj). Qhov tseeb, kev kho tsis tu ncua nrog rapamycin tseem txuas ntxiv txoj sia nyob hauv nas [54, 55]. Ib yam li ntawd, kev txwv tsis pub muaj calorie ncua ntev lub neej nyob hauv cov nas. Cov koob tshuaj tsawg, kev tswj xyuas tsis tu ncua thiab kev sib xyaw ua ke nrog cov tshuaj xws li metformin (piv txwv li cov tshuaj tiv thaiv kab mob) yuav paub qhov txawv.anti-agingschedules of rapamyicin from its use to prevent organ rejection. Doses and schedules always make the difference. Consider arsenic, the most famous poison, used for millennia by murderers. In different doses and schedules, arsenic is now used as the most effective treatment for acute promyelocytic leukemia. Potassium chloride is one of the most useful drugs widely used in medicine. In different administrations, potassium chloride is also used in lethal injections for capital punishment. In comparison with other drugs, rapamycin is exceptionally non-toxic, and it cannot be possibly used in lethal injections. The oral dose that is lethal to mice cannot be actually achieved since LD50>2500 mg/kg. (Thiab qhov no yog ib txhiab lub sij hawm ntau tshaj txawm tias ib koob tshuaj kho mob siab). Ib koob tshuaj rapamycin tsis ua rau tuag taus ntawm ib koob thiab tsis tas li ntawd tsis muaj kev phiv hauv cov neeg ua haujlwm noj qab haus huv, muab ib qho laj thawj rau cov sijhawm sib cuam tshuam. Tau kawg, kev sim tshuaj ntxiv ntawm cov koob tshuaj tsawg ntawm rapamycin yuav tsim nyog los ua kom pom tias nws txo qis qhov tshwm sim ntawm cov kab mob uas muaj hnub nyoog. Kuv yuav tsum tau hais qhia tias tsis muaj pov thawj tias rapamycin nce tib neeg txoj sia. (Qhov no yuav siv sij hawm tib neeg lub neej los ua pov thawj). Tab sis cov pov thawj zoo li no tsis xav tau. Rau cov hom phiaj siv tau, kom nyab xeeb Medicare, nws yog ib qho tseem ceeb kom ncua cov kab mob uas muaj hnub nyoog. Raws li tau tham hauv kev nthuav dav [40], qhov kev sim tshuaj no yuav siv sijhawm li ob peb xyoos los ua. Thiab yog tias txhua yam kab mob yuav raug ncua, ces ob qho tib si kev noj qab haus huv thiab lub neej ntev yuav nce ntxiv.

Yuav siv li cas thiab kev txhim kho yav tom ntej?

Tsoom fwv thiab pej xeem kev siv zog tau zoo heev los txo kev haus luam yeeb hauv Teb Chaws Asmeskas Qhov no tau ua tiav txawm tias qhov tseeb tias kev haus luam yeeb muaj kev quav yeeb quav tshuaj! Hauv kev sib piv, qhov kev qhia dav dav ntawm cov koob tshuaj qis / sib quas ntus ntawm covanti-agingtshuaj rapamycin, uas los ntawm txoj kev txo qis qhov tshwm sim ntawm cov pa luam yeeb ntsig txog mob qog noj ntshav hauv cov nas ntawm 90 feem pua ​​(!)[60], zoo li tsis yooj yim. Feem ntau, qhov no yuav muab piv rau kev qhia txog kev txhaj tshuaj tiv thaiv, uas tsoomfwv thiab lwm cov kev pabcuam tau ua tau zoo heev. Thiab kev qhia txog rapamycin tsuas yog thawj kauj ruam hauv kev txhim khoanti-agingkev cuam tshuam. Ib txoj haujlwm ntawm yuav ua li cas txuas lub neej ntev hauv peb lub neej tsis ntev los no tau tham txog [61].

Cov lus kaw: qhov no zoo li yog qhov kev daws teeb meem zoo tshaj plaws

Txhua tus pom zoo tias cov nqi nce ntxiv ntawm Medicare yuav tsum tau qeeb. Tau kawg, cov nqi tuaj yeem raug txo qis hauv ib feem los ntawm kev ua kom muaj kev noj qab haus huv zoo dua qub, tshem tawm txhua yam kev tsim txom ntawm kev noj qab haus huv los ntawm cov tuam txhab pov hwm, kev lag luam thiab cov kws kho mob. Cov teeb meem no tau hais zoo los ntawm cov nom tswv. Txawm li cas los xij, cov nqi tuaj yeem qeeb tab sis tsis tuaj yeem khov. Hmoov tsis zoo, tib txoj hauv kev los txwv cov nqi nce ntawm Medicare kiag li yog los tiv thaiv kev siv cov kev kho mob zoo dua (thiab kim) thiab kom tsis txhob muaj kev tshawb fawb txog biomedical ntxiv. Qhov kev xaiv draconian no yuav ua rau cov neeg laus tuag ntau tshaj plaws, txo cov nqi Medicare ntxiv. Tau kawg, qhov no yog qhov tsis txaus ntseeg. Yog li cov nqi yuav tsum tau nce ntxiv. Tab sis qhov no tsis tas yuav ua rau muaj teeb meem nyiaj txiag, muab qhov ntawdanti-agingtshuaj tuaj yeem ua rau muaj kev noj qab haus huv ntxiv thiab yog li qhov piv ntawm kev noj qab haus huv rau cov neeg tsis noj qab haus huv hauv cov neeg laus. Nrog rau kev nce hauv kev noj qab haus huv, lub hnub nyoog ntawm cov nyiaj laus tuaj yeem nce ntxiv. Qhov no yuav ua rau tsoomfwv cov nyiaj tau los nce ntxiv thiab muab txoj hauv kev los them cov nqi nce ntawm Medicare. Txawm li cas los xij, hnub nyoog tsim nyog tau txais txiaj ntsig tag nrho yog tam sim no maj mam nce. Rau cov neeg yug tom qab 1960, nws yuav yog 67. Qee cov nom tswv yuav nce nws ntxiv, tso cai rau nws nce ntxiv nrog rau kev nce hauv lub neej ntev. Txawm li cas los xij, txawm hais tias kev ua neej nyob ntev zuj zus, qhov nce sai ntawm Medicare cov nqi yog vim kev tiv thaiv kev tuag los ntawm cov kab mob uas muaj hnub nyoog, tsis yog rau kev tiv thaiv kab mob lawv tus kheej.Anti-agingCov kev cuam tshuam tuaj yeem ncua cov kab mob, yog li ua rau lub hnub nyoog laus zuj zus, vim tias thaum 87 tus neeg yuav muaj kev lom zem 67 thiab xav tias noj qab nyob zoo thiab muaj zog zoo li nws tam sim no ua ntawm 67.

Cov ntsiab lus

1. Anti-agingCov kev cuam tshuam tuaj yeem ua rau muaj kev noj qab haus huv ntau ntxiv, ua rau muaj hnub nyoog ntawm kev xiam oob khab tso cai rau cov neeg laus uas muaj hnub nyoog laus dua. Qhov no ib txwm ua rau muaj hnub nyoog laus zuj zus, nce cov nyiaj tau los yam tsis tau nce se.

2. Tam sim no, tsis muaj lwm txoj kev daws teeb meem. Lwm txoj hauv kev, ob qho tib si tsis tuaj yeem siv tau, yog cia cov neeg laus (tsis noj qab haus huv) tuag los ntawm kev txwv cov txiaj ntsig kho mob, lossis ib xyoos ib zaug kom nce se.

TXOJ CAI

Kuv ua tsaug Andrzej Bartke, Nir Barzilai, thiab David Stipp rau qhov kev nyeem ntawv tseem ceeb ntawm phau ntawv no thiab cov lus qhia muaj txiaj ntsig.

Daim ntawv qhia tsis sib haum xeeb

Tus sau ntawm tsab xov xwm kev xav no yog tus kws sau ntawv xov xwm Aging