Yuav Ua Li Cas Xaiv Txoj Kev Kho Mob Rau Membranous NephropathyⅠ
Jan 26, 2024
Membranous nephropathy yog ib qho kab mob autoimmune uas cuam tshuam nrog glomeruli thiab yog ib qho ntawm feem ntau ua rau nephrotic syndrome. Yog tsis muaj kev kho mob, 35% ntawm cov neeg mob tsim cov kab mob raum kawg. Kev tshawb pom ntawm autoantibodies xws li phospholipase A2 receptor 1, anti-thrombopoietin, thiab neuroepidermal kev loj hlob zoo li protein 1 pab kom nkag siab txog cov kab mob ntawm tus kab mob no thiab muab lub hauv paus rau kev kuaj mob thiab kho tus kab mob no. Nyob ntawm cov teeb meem ntawm nephrotic syndrome, cov neeg mob uas muaj tus kab mob no tau txais kev txhawb nqa nrog diuretics, ACE inhibitors lossis angiotensin receptor blockers, lipid-txo cov neeg ua haujlwm, thiab cov tshuaj tiv thaiv kab mob. Tom qab ntsuas qhov kev pheej hmoo ntawm kev mob raum mus rau theem kawg, cov neeg mob tau txais kev kho mob tiv thaiv kab mob nrog ntau yam tshuaj, xws li cyclophosphamide, steroids, calcineurin inhibitors, lossis rituximab. Vim tias cov tshuaj tiv thaiv kab mob tuaj yeem ua rau muaj kev phom sij rau lub neej thiab txog li 30% ntawm cov neeg mob tsis teb rau kev kho mob, cov kev kho tshiab siv cov tshuaj xws li adrenocorticotropic hormone, belimumab, anti-plasma cell antibodies, los yog cov tshuaj qhia ntxiv tam sim no raug sim. Txawm li cas los xij, kev saib xyuas tshwj xeeb yuav tsum tau them rau cov kev xaiv kho mob hauv cov ntaub ntawv thib ob lossis cov xwm txheej tshwj xeeb, xws li kab mob membranous hauv menyuam yaus, cov poj niam cev xeeb tub, thiab cov neeg mob raum hloov pauv.
Nyem rau Cistanche rau mob raum
1 Kev Taw Qhia
Membranous nephropathy (MN) is an autoimmune disease affecting the glomerulus and is one of the most common causes of nephrotic syndrome (NS) in adults. Its prevalence has changed over time, resulting in it becoming the most dominant pathological finding in China between 2015 and 2019, accounting for 15% of renal biopsies performed in Singapore between 2008 and 2018, and in the past decade, downward trends were observed in the United States, United Kingdom, and Italy. Clinically, MN ranges from asymptomatic proteinuria (occurring in approximately one-third of patients) to complete NS (presenting in the remaining two-thirds of patients). The latter is a disorder characterized by proteinuria >3.5 g ib 24 teev, hypoalbuminemia, edema, hypercholesterolemia, thiab lipuria; Tsis tshua muaj tshwm sim yog kub siab thiab thromboembolic txheej xwm. Lub raum tsis zoo ntawm kev kuaj mob yog qhov tsis tshua muaj yam tsis muaj lwm yam mob. Nyob rau hauv tsis muaj ib qho kev kho mob immunosuppressive, prognosis tej zaum yuav txawv. Tsib xyoos tom qab kuaj pom, txog li 30% ntawm cov neeg mob tuaj yeem ua tiav kev tshem tawm, txhais tau tias yog proteinuria tsawg dua 200 mg hauv 24 teev, thaum txog li 40% ntawm cov neeg mob tuaj yeem pom cov lus teb ib nrab, txhais tau tias yog proteinuria tsawg dua 2000 mg hauv 24 teev. Tom qab 10 xyoo, 35% ntawm cov neeg mob tsim lub raum tsis ua haujlwm; Txawm li cas los xij, tsuas yog 2% ntawm cov neeg mob uas tsis tau tsim NS lub sijhawm no tau ua tiav cov kab mob raum kawg (ESKD).
Xyoo 2021 Cov Kab Mob Raum Txhim Kho Ntiaj Teb Cov Txheej Txheem (KDIGO) cov lus qhia pom zoo siv rituximab (RTX) lossis calcineurin inhibitor (CNI) ua thawj zaug kev kho mob rau cov neeg mob uas muaj kev pheej hmoo ntawm kev kis kab mob, thaum thawj kab cyclophosphamide (CYC) Pom zoo kom muaj kev pheej hmoo siab. cov neeg mob. Hauv qhov sib piv, cov neeg mob uas muaj kev pheej hmoo qis dua tsis tas yuav siv tshuaj tiv thaiv kab mob thiab yuav tsum tau txais kev txhawb nqa nkaus xwb. Txawm li cas los xij, txog li 30% ntawm cov neeg mob tsis teb rau cov qauv kev kho mob. Qee cov neeg mob muaj kev tsis haum tshuaj los yog muaj kev phiv loj heev, tshwj xeeb yog kis kab mob. Tsis tas li ntawd, relapses yog tshwm sim. Yuav tsum tau nrhiav cov tshuaj tshwj xeeb thiab zoo dua rau cov tshuaj tiv thaiv kab mob txhawm rau txhim kho kev ua tau zoo mus ntev. Cov kev kho tshiab uas ncaj qha rau cov hlwb B, cov ntshav plasma, thiab cov tshuaj tiv thaiv kab mob tau pom cov txiaj ntsig tau zoo, tshwj xeeb tshaj yog rau cov neeg mob uas tsis zoo los yog ua rau tsis zoo rau cov kev kho mob. Kab lus no yuav piav qhia txog cov kev kho mob rau membranous glomerulonephritis, los ntawm kev txhawb nqa mus rau kev siv cov tshuaj diuretics thiab proteinuria-txo cov tshuaj, kev kho mob nephrotic syndrome, kev kho tshuaj tiv thaiv kab mob, thiab kev hloov kho tshiab. Peb kuj tseem yuav tham txog kev kho mob ntawm cov membranous glomerulonephritis theem nrab thiab kev kho mob tshwj xeeb xws li cev xeeb tub thiab hloov lub raum.
2. Membranous nephropathy: pathophysiology thiab autoantibodies
MN yog ib hom kab mob tiv thaiv kab mob. Pathogenesis pib nrog kev khi ntawm cov tshuaj tiv thaiv kab mob mus rau podocyte antigens. Txawm li cas los xij, hauv cov laj thawj thib ob, qhov pib tshwm sim tuaj yeem yog qhov tso tawm ntawm lub cev tiv thaiv kab mob hauv qhov chaw subepithelial.
Thawj cov kev tshawb fawb ntawm pathogenesis ntawm tus kab mob hnub rov qab mus rau 1980 thiab yog cov kev tshawb fawb ntawm nas qauv ntawm Heymann nephritis; Txawm li cas los xij, antigen lub luag haujlwm rau tus kab mob, megalin, tsis tau pom hauv tib neeg. Nws tsis yog txog xyoo 2002 uas thawj tus tib neeg cov ntaub ntawv tau pom tom qab kis ntawm tus menyuam mos MN nyob rau hauv uas tus niam uas tau txhaj tshuaj tiv thaiv thaum cev xeeb tub dhau los tau hloov cov tshuaj tiv thaiv tawm tsam nruab nrab endopeptidase (NEP). Me nyuam. Xyoo 2009, kev tshawb pom ntawm antigens tsom phospholipase A2 receptor 1 (PLA2R1) tau dhau los ua qhov tseem ceeb hauv kev nkag siab txog cov kab mob ntawm 70% ntawm cov neeg laus MN. Hauv xyoo 2014, qhov thib ob antigen, thrombospondin, tau tshawb pom. Tsis ntev los no pom antigens suav nrog exostosis 1 thiab 2 (txog rau ANA, dsDNA, thiab anti-Ro/LA, tam sim no nyob rau hauv 50% ntawm qeb V lupus nephritis) thiab neural-tissue-encoding proteins nrog EGF-zoo li rov ua cov protein nrog EGF-zoo li rov ua dua. , NELL)-1. Tsis tas li ntawd, autoantibodies tiv thaiv contactins tau pom nyob rau hauv cov neeg mob inflammatory neuropathy thiab MN; Txawm hais tias lawv qhov kev kuaj pom tsis yog kuaj pom tus kab mob, lawv cov qib sib cuam tshuam nrog chav kho mob. Hauv cov menyuam yaus, semaphorin 3B kuj tau pom tsis ntev los no los ua ib qho antigen tshiab; Nws qhov kev nthuav dav yog 1% mus rau 3% hauv cov neeg laus MN, tab sis nws muaj ntau dua hauv cov neeg mob menyuam yaus, suav txog 1% ntawm cov neeg mob MN. 15% ntawm tag nrho; Ntxiv mus, nws qhov kev tshawb pom muaj ntau dua nyob rau hauv cov xwm txheej ntawm tsev neeg keeb kwm zoo. Hauv membranous lupus nephritis, neural cell adhesion molecule 1 (NCAM1) thiab transforming growth factor beta receptor 3 (TGFBR3) tau pom tias yog cov antigens tshiab, thaum protocadherin Cov protein FAT1 yog txuam nrog hematopoietic stem cell transplantation (HSCT)-MN. Yog tias peb qhov kev tawm tsam dhau los yog xav tias muaj feem xyuam nrog LES lossis HSCT, immunohistochemistry / immunofluorescence tuaj yeem ua kom tau txais cov lus qhia ntxiv. Thaum kawg, ob lub xyoos dhau los, pawg spectrometry tau siv los txheeb xyuas cov protocadherin 7 (PCDH7) (txuas nrog mob qog noj ntshav tab sis nrog kev pom zoo), cov serine protease HTRA1 (4% ntawm PMNs), thiab netrin G1 (NTNG1) yog pom tias yog lub hom phiaj tshiab antigen, thiab nws txoj haujlwm kuaj mob thiab kho mob tseem yuav raug txiav txim siab.
PLA2R yog transmembrane receptor tsev neeg mannose receptor, thiab nws lub luag haujlwm hauv tib neeg lub hlwb tsis meej. Feem ntau ntawm cov tshuaj tiv thaiv PLA2R hauv thawj MN yog 70% txog 80%, thiab nws muaj kev kuaj mob, kev kuaj mob, thiab kev kwv yees tus nqi. Qhov kev kuaj pom zoo ntawm cov tshuaj tiv thaiv no yog 78% thiab qhov tshwj xeeb yog 99%; Tsis tas li ntawd, thaum PLA2R hauv cov ntshav tau ntxiv los ntawm lub raum biopsy staining, qhov tshwj xeeb tau mus txog 100%. Cov kev tshawb pom no ua rau nws muaj peev xwm kuaj tau MN txawm tias muaj cov kab mob biopsies nyuaj, xws li hauv cov neeg mob uas muaj ib lub raum lossis muaj kev pheej hmoo los ntshav. Anti-PLA2R cov tshuaj tiv thaiv tuaj yeem kwv yees qhov ploj ntawm cov proteinuria ob peb lub hlis tom qab kev kho mob, thiab qhov sib txawv, qhov rov tshwm sim ntawm tus kab mob. Thaum kawg, qhov siab dua cov tshuaj tiv thaiv kab mob titer, qhov kev mob tshwm sim zuj zus tuaj thiab qeeb cov lus teb rau kev kho mob. Hink et al. ua qauv qhia nyob rau hauv ib txoj kev tshawb nrhiav ib sab caj npab nrog rau 65 tus neeg mob nrog PLA2Rab biopsy-confirmed MN tias kev saib xyuas cov tshuaj tiv thaiv ib txwm tso cai rau kev tsim kho cov kev kho mob raws li PLA2R cov tshuaj tiv thaiv kab mob. Qhov ncauj cyclophosphamide (1.5 mg / kg / d) ntxiv rau cov tshuaj methylprednisolone (1000 mg rau hnub 1 txog 3 rau 3 hnub sib law liag) ua raws li qhov ncauj prednisone (0.5 mg / kg / d) rau tag nrho 8 lub lis piam; yog tias cov tshuaj tiv thaiv kab mob tom qab tau txais txiaj ntsig tsis zoo, CYC raug txiav tawm thiab cov tshuaj steroids yog tapered; los yog, yog tias tsis pom cov tshuaj tiv thaiv ploj lawm, kev kho mob tau muab ntxiv rau 8 lub lis piam, nrog rau qhov siab tshaj plaws ntawm ob txoj kev kho CYC rau qhov siab kawg ntawm 24 lub lis piam. Yog tias kev tso cai tsis ua tiav tom qab 24 lub lis piam, cov neeg mob tau titrated rau MMF + steroid therapy thiab CYC raug txiav tawm. Nco ntsoov, cov neeg mob kho nrog cov txheej txheem serology-coj coj tau txais kev txo qis ntawm CYC piv nrog cov neeg mob tsis tau saib xyuas cov tshuaj tiv thaiv (11.8 g vs. 18.9 g).
Thrombospondin-1-domain-muaj 7a (THSD7A) yog ib qho transmembrane protein faib hauv podocytes. Feem ntau ntawm cov tshuaj tiv thaiv thrombopoietin yog siab li 5% ntawm tag nrho cov neeg mob NM thiab siab li 10% ntawm cov neeg uas tsis muaj PLA2R cov tshuaj tiv thaiv. Qee qhov kev tshawb fawb tau tshaj tawm txog kev koom tes nrog malignancy; Yog li ntawd, yuav tsum tau kuaj mob hnyav ntxiv hauv cov neeg mob no. Tsis tas li ntawd, muaj cov tshuaj tiv thaiv kab mob hauv cov qog nqaij hlav thiab, qhov tseem ceeb tshaj, qhov txo qis ntawm cov tshuaj tiv thaiv kab mob thiab cov proteinuria tom qab kws khomob tau piav qhia. Zoo li PLA2R cov tshuaj tiv thaiv kab mob, cov tshuaj tiv thaiv thrombopoietin antibody titers kwv yees kev kho mob thiab kev kho mob rov qab los ntawm ob peb lub hlis. Txawm li cas los xij, raws li KDIGO 2021, tam sim no muaj cov ntaub ntawv tsis txaus rau MN kev kuaj mob los ntawm kev tiv thaiv THSD7A tshuaj tiv thaiv ib leeg.
Neural-tissue-encoding protein nrog EGF-zoo li rov ua dua (NELL)-1 yog glycoprotein uas qhia tsis zoo rau cov neeg laus cov ntaub so ntswg tab sis ua lub luag haujlwm tseem ceeb hauv ossification thaum lub sij hawm loj hlob ntawm cov menyuam yaus. Qhov tseem ceeb, yog qhov thib ob feem ntau autoantigen tsis ntev los no nrhiav pom. Nws ua rau muaj kev sib kis ntawm MN li ntawm 5% mus rau 10%, suav nrog cov kab mob thawj thiab theem nrab. Ntawm cov tom kawg, NELL-1 MN tau cuam tshuam nrog cov kab mob malignancies, tshuaj, kab mob autoimmune, hloov pauv, kab mob siab, thiab sarcoidosis. Ntawm qhov kev ceeb toom, ib txoj kev tshawb fawb tau tshaj tawm tias muaj mob hnyav li 33%; yog li ntawd, qhov kev tshawb pom ntawm NELL-1 yuav tsum tau lees paub qhov kev ntsuam xyuas ntxaws ntxiv ntawm cov laj thawj thib ob.
Txawm li cas los xij, yuav ua li cas cov autoantibodies no tsim tseem tsis paub meej. Genetics plays lub luag haujlwm tseem ceeb, thiab kev koom tes nrog ib leeg nucleotide polymorphisms ntawm HLA-DQA1 locus tau piav qhia. Cov kev tshawb fawb hauv Suav teb tau pom qhov sib txawv ntawm qhov sib txawv hauv cov cheeb tsam nyob deb nroog thiab industrialized, underscoring lub luag hauj lwm ntawm ib puag ncig muaj kuab paug. Txoj kev loj hlob ntawm cov autoantigens no yuav raug ntaus nqi los ntawm kev poob ntawm peripheral lossis central kam rau ua, kev hloov hauv cov lus qhia antigen, lossis kev hloov pauv hauv molecular mimicry mechanisms. Txawm li cas los xij, kev khi ntawm cov tshuaj tiv thaiv no rau cov antigens sib xws los yog tso tawm ntawm lub cev tiv thaiv kab mob ua rau lub raum puas tsuaj los ntawm kev sib ntxiv-dependent thiab-kev ywj pheej mechanisms. Raws li txoj cai, muaj cov IgG subclasses uas ua kom muaj zog ntxiv, xws li IgG3, tuaj yeem cuam tshuam nrog qhov kev mob tshwm sim tsis zoo, thaum muaj IgG4, uas yog suav tias yog qhov tsis muaj zog ntxiv ua kom muaj zog, tej zaum yuav yog qhov zoo dua prognostic. Txawm li cas los xij, cov lus qhia txhawb nqa cov kev xav no tsis muaj.
3. Cov lus nug qhib: Puas yog PLA2R antibody + cov neeg mob tseem xav tau kev kuaj ntshav?
Raws li qhov tseeb KDIGO cov lus qhia, anti-PLA2R antibody-positive NS cov neeg mob tsis tas yuav tsum tau kuaj xyuas tus kab mob; Txawm li cas los xij, nws yuav raug txiav txim siab hauv qee qhov xwm txheej tshwj xeeb. Muaj cov ntaub ntawv tsis txaus ntawm anti-THS7DA los txuas ntxiv cov lus pom zoo rau cov tshuaj tiv thaiv no.
Txawm li cas los xij, lub raum biopsy tuaj yeem siv rau lub hom phiaj tsis yog kev kuaj mob. Kev tshawb nrhiav rov qab los ntawm Mayo Clinic los ntawm 2015 txog 2018 tau tshuaj xyuas 97 tus neeg mob nrog thawj MN uas tau zoo rau PLA2R tshuaj tiv thaiv tab sis tseem tau kuaj pom. Ntawm lawv, 60 tus neeg mob muaj eGFR ntau dua 60 mL / min. Txawm hais tias nyob rau hauv ob tus neeg mob tau kuaj pom muaj ntshav qab zib nephropathy lossis focal segmental glomerulosclerosis (FSGS), lub raum biopsy yuav tsis hloov kho lossis kho txhua txoj hauv kev. Kev tswj tus neeg mob. Ntawm qhov tod tes, lwm qhov kev tshawb pom pom nyob rau hauv pab pawg neeg mob nrog eGFR tsawg dua 60 mL / min, xws li mob interstitial nephritis thiab crescents, yeej muaj kev cuam tshuam rau kev kho mob, qhia txog kev kho mob hnyav dua thiab kuaj vasculitis Antibody ntxiv. Tsis tas li ntawd, qhov kev tshawb pom ntawm concurrent mob ntshav qab zib nephropathy tuaj yeem piav qhia qhov kev pheej hmoo ntawm cov proteinuria thaum taug qab txawm tias ploj ntawm PLA2R cov tshuaj tiv thaiv. Ib yam li ntawd, Wiech et al tau tshuaj xyuas 263 tus neeg mob nrog kev kuaj mob histological ntawm MN, suav nrog 194 tus neeg mob uas tau zoo rau cov tshuaj tiv thaiv PLA2R. Ntawm qhov kawg, 12 (6%) tau txais kev kuaj mob ntxiv xws li mob ntshav qab zib nephropathy (n{15}}), interstitial nephritis (n{16}}), thiab IgA nephropathy (n=2). Ntawm qhov tod tes, cov neeg mob kuaj mob ntxiv yog cov uas muaj creatinine siab tshaj plaws thiab qis tshaj eGFR qhov tseem ceeb. Interestingly, ntawm cov neeg mob anti-PLA2R antibody-tsis zoo, muaj ib tug me ntsis ntau dua ntawm cov neeg mob uas kuaj mob uas tsis yog MN.
Txawm li cas los xij, KDIGO cov lus qhia pom zoo rau lub raum biopsy nyob rau hauv qhov chaw ntawm kev kho mob txawv txav, xws li kev poob qis hauv kwv yees glomerular filtration rate (eGFR), serology txawv txav, lossis yog tias tus neeg mob tsis teb rau cov tshuaj tiv thaiv kab mob thiab txawm tias PLA2R cov tshuaj tiv thaiv ploj. , tab sis eGFR lossis sustained NS maj mam txo. Txawm li cas los xij, qhov muaj peev xwm ntawm lub raum biopsy yuav tsum raug ntsuas raws li qhov xwm txheej, suav nrog tus nqi thiab tus neeg mob pheej hmoo.
Cistanche kho mob raum li cas?
Cistancheyog ib hom tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho ntau yam mob, suav nrograumkab mob. Nws yog muab los ntawm qhuav stems ntawmCistanchedeserticola, ib tsob nroj nyob rau hauv cov suab puam ntawm Tuam Tshoj thiab Mongolia. Lub ntsiab active Cheebtsam ntawm cistanche yogphenylethanoidglycosides, echinacoside cov tshuaj, thiabacteoside, uas tau pom tias muaj txiaj ntsig zoo rau lub raum kev noj qab haus huv.
Kab mob raum, tseem hu ua kab mob raum, hais txog ib yam mob uas lub raum ua haujlwm tsis zoo. Qhov no tuaj yeem ua rau muaj cov khoom pov tseg thiab cov co toxins hauv lub cev, ua rau muaj ntau yam tsos mob thiab teeb meem. Cistanche tuaj yeem pab kho mob raum ase los ntawm ntau lub tswv yim.
Ua ntej, cistanche tau pom tias muaj cov nyhuv diuretic, txhais tau tias nws tuaj yeem ua rau cov zis ntau ntxiv thiab pab tshem tawm cov khoom pov tseg ntawm lub cev. Qhov no tuaj yeem pab txo lub nra ntawm lub raum thiab tiv thaiv kev tsim cov co toxins. Los ntawm kev txhawb nqa diuresis, cistanche kuj tseem tuaj yeem pab txo qis ntshav siab, ib qho teeb meem ntawm cov kab mob raum.
Ntxiv mus, cistanche tau pom tias muaj cov teebmeem antioxidant. Kev ntxhov siab oxidative, tshwm sim los ntawm qhov tsis sib xws ntawm kev tsim cov dawb radicals thiab lub cev tiv thaiv antioxidant, ua lub luag haujlwm tseem ceeb hauv kev mob raum. ies pab neutralize dawb radicals thiab txo Oxidative kev nyuaj siab, yog li tiv thaiv lub raum los ntawm kev puas tsuaj. Cov phenylethanoid glycosides pom hauv cistanche tau tshwj xeeb hauv kev tshem tawm cov dawb radicals thiab inhibiting lipid peroxidation.
Tsis tas li ntawd, cistanche tau pom tias muaj cov nyhuv anti-inflammatory. Kev mob yog lwm yam tseem ceeb hauv kev loj hlob thiab kev loj hlob ntawm cov kab mob raum. Cistanche's anti-inflammatory zog pab txo cov zus tau tej cov pro-inflammatory cytokines thiab inhibit qhov ua kom o yuav tsum tau txoj kev, yog li alleviating o nyob rau hauv lub raum.
Tsis tas li ntawd, cistanche tau pom tias muaj cov teebmeem immunomodulatory. Hauv kab mob raum, lub cev tiv thaiv kab mob tuaj yeem ua rau tsis zoo, ua rau muaj kev mob ntau dhau thiab cov ntaub so ntswg puas. Cistanche pab tswj lub cev tiv thaiv kab mob los ntawm kev hloov kho kev tsim khoom thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob, xws li T hlwb thiab macrophages. Txoj cai tiv thaiv kab mob no pab txo qhov mob thiab tiv thaiv kev puas tsuaj ntxiv rau lub raum.
Ntxiv mus, cistanche tau pom los txhim kho lub raum kev ua haujlwm los ntawm kev txhawb nqa kev tsim kho ntawm lub raum hlab nrog cov hlwb. Lub raum tubular epithelial hlwb ua lub luag haujlwm tseem ceeb hauv kev pom thiab rov nqus cov khoom pov tseg thiab electrolytes. Hauv kab mob raum, cov hlwb no tuaj yeem raug puas tsuaj, ua rau lub raum ua haujlwm puas. Cistanche lub peev xwm los txhawb kev tsim kho ntawm cov hlwb no pab kho lub raum kom zoo thiab txhim kho lub raum tag nrho.
Ntxiv nrog rau cov kev cuam tshuam ncaj qha rau lub raum, cistanche tau pom tias muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev hauv lub cev. Txoj hauv kev zoo rau kev noj qab haus huv no tseem ceeb tshwj xeeb hauv cov kab mob raum, vim tias tus mob feem ntau cuam tshuam rau ntau lub cev thiab lub cev. che tau pom tias muaj kev tiv thaiv rau lub siab, lub plawv, thiab cov hlab ntsha, uas feem ntau cuam tshuam los ntawm kab mob raum. Los ntawm kev txhawb nqa kev noj qab haus huv ntawm cov kabmob no, cistanche pab txhim kho lub raum tag nrho thiab tiv thaiv kev mob ntxiv.
Hauv kev xaus, cistanche yog cov tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho mob raum. Nws cov active Cheebtsam muaj diuretic, antioxidant, anti-inflammatory, immunomodulatory, thiab regenerative teebmeem, uas pab txhim kho lub raum ua haujlwm thiab tiv thaiv ob lub raum los ntawm kev puas tsuaj ntxiv. , cistanche muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev, ua rau nws txoj hauv kev zoo rau kev kho mob raum.
