Cistanche tiv thaiv thiab kho raum Cachexia los yog Protein-zog Wasting nyob rau hauv mob raum mob?
Mar 13, 2022
Hu rau:joanna.jia@wecistanche.com
Lub raum cachexia lossis protein-zog nkim hauv cov kab mob raum ntev: qhov tseeb thiab tus lej
Laetitia Koob1*ua al
Abstract
Keeb kwmKev poob phaus thiab homeostatic cuam tshuam ntawm ob lub zog thiab protein sib npaug yog cov yam ntxwv ntawm ntau yam mob xws li mob qog noj ntshav, plawv tsis ua haujlwm, thiabmob raum mob(CKD). Cov ntsiab lus sib txawv tau siv los piav txog cov txheej txheem kev tshem tawm no. Lub sij hawmprotein-zog nkim(PEW) tau thov rau cov neeg mob CKD los ntawm International Society of Renal Nutrition and Metabolism.
Cov Txheej Txheem Peb tau tshawb nrhiav cov ntawv tshaj tawm hauv Medline txij Lub Ob Hlis 2008 txog Lub Cuaj Hli 2018 siv PEW lossiscachexiahauv lawv lub npe.
Cov txiaj ntsigTxij li thaum nws pib, lo lus PEW tau ua tiav tshwj xeeb, tau hais los ntawm 327 thawj cov ntawv tshaj tawm hais txog PubMed tshaj 10 xyoo. Siv qhov kev faib tawm no, ntau qhov kev tshawb fawb tau lees paub tias PEW yog ib qho ntawm cov kev kwv yees muaj zog tshaj plaws ntawm kev tuag hauv cov neeg mob CKD [kev phom sij ntawm 3.03; kev ntseeg siab ntawm 1.69–5.26 hauv 1068 cov neeg mob hemodialysis thiab 1.40 (1.04–1.89) hauv 1487 cov neeg mob uas tsis tau lim ntshav hla PEW theem 0 txog 4]. Raws li qhov kev faib tawm no, qhov tshwm sim ntawm PEW yog 28 feem pua rau 54 feem pua ntawm cov neeg laus 16 434 kev kho mob lim ntshav. PEW ntau dua thaum lub raum ua haujlwm poob qis, uas yog, los ntawm<2% in="" ckd="" stages="" 1–2="" to="" 11–54%="" in="" ckd="" stages="" 3–5.="" a="" more="" general="" definition="" of="" cachexia="" for="" all="" chronic="" diseases="" proposed="" by="" the="" society="" on="" sarcopenia,="">Cachexiathiab Kev Txom Nyem Loj kuj tau luam tawm ib txhij. Hauv cheeb tsam CKD, peb pom 180 cov ntawv tshaj tawm siv 'cachexia' underlining that some confusion or overlap may exist. The definitions of PEW and cachexia are somewhat similar, and the main difference is that a loss of body weight >5 feem pua yog qhov yuav tsum tau ua rau cachexia tab sis txhawb rau PEW.
Cov lus xausKev nkag siab tsis ntev los no ntawmcachexiaphysiopathology thaum lub sij hawm CKD kev loj hlob qhia tias PEW thiab cachexia muaj feem cuam tshuam zoo thiab tias PEW cuam tshuam rau thawj lub xeev ntawm cov txheej txheem txuas ntxiv uas ua rau cachexia, cuam tshuam rau tib txoj hauv kev metabolic xws li lwm yam kab mob. Txawm hais tias muaj kev vam meej ntawm lub ntsiab lus ntawm PEW, siv lub ntsiab lus zoo xws li 'raumkab mob cachexia' tuaj yeem pab tau ntau dua los tsim kev tshawb fawb yav tom ntej los ntawm kev sib koom tes ntawm cov kws tshawb fawb nrog rau kev tsom mus rau cachexia.
Ntsiab lusCachexia;Protein-zog nkim zog; Mob raum mob; Kev siv zog; Noj tsis txaus; cistanche
cistanche yog qhov zoo rau mob raum mob thiab Cachexia
Taw qhia
Mob raum mobbelongs rau pawg ntawm TCM, edema, thiab hysteresis. Kev kho mob feem ntau ua raws li cov hauv paus ntsiab lus sau tseg hauv phau ntawv kho mob Suav thaum ub. Lub pathogenesis ntawm kev saib xyuas hemodialysis yog ua raws li tus po thiab lub raum yin thiab yang tsis ua haujlwm, dampness thiab turbidity, thiab cov ntsiab lus sab hauv ntawm co toxins raws li tus qauv. , Cov tshuaj ib leeg thiab cov ntawv sau rau kev txhawb nqa cov ntshav ncig thiab tshem tawm cov ntshav stasis tiv thaiv lub raum tsis ua haujlwm thiab tiv thaiv cov teeb meem. Txawm hais tias tus sawv cev tshuaj rhubarb muaj cov txiaj ntsig ntawm kev tiv thaiv kab mob raws plab thiab turbidity thiab tiv thaiv cov seem.raum, siv sij hawm ntev tuaj yeem ua rau cem quav thiab ua rau kev noj qab haus huv. Nws tsis haum rau kev haus dej mus ntev vim qhov txwv ntawm decoction thiab saj.Cistancheyog cuaj tus neeg tsis txawj tuag ntawm Tuam Tshoj, muaj txiaj ntsig rau lub raum-tonifying suav tshuaj ntsuab.CistancheTsis tsuas yog moisturizes cov hnyuv, tab sis kuj ntxiv cov ntsiab lus thiab cov ntshav, thiab yog tsim nyog rau cov neeg mob dialysis.Cistancheyog qab zib thiab ntsev, sov nyob rau hauv qhov, moist thiab muaj kua, nkag mus rau hauv lubraumthiab cov plab hnyuv loj meridian, nws tuaj yeem tsis tsuas yog ua kom lub raum yang, tab sis kuj txhawb cov essence thiab cov ntshav, thiab moisturize dryness. Nws lub zog yog soothing, nourishing tab sis tsis hnyav, nourishing nruab nrab, thiab nourishing greasiness, nws yuav siv sij hawm ntev, thiab nws muaj txiaj ntsig zoo rau kev kho mobmob raum mob.
Protein-zog nkim/cachexia prevalence
Kev noj zaub mov tsis txaus tau ntev tau lees paub tias yog qhov tsis zoo ntawmmob raum mob(CKD) thiab muaj feem cuam tshuam nrog kev ua kom lub cev tsis muaj zog thiab tsis muaj sia nyob.1–5 Txawm li cas los xij,cachexiayog txhais tsis zoo thiab tswj tau nyob rau hauv cov neeg mob no, thiab yuav tsum muaj kev txhais kom meej ntawm tus mob no. Qhov tseeb, cov ntsiab lus nkim, cachexia, tsis muaj zaub mov noj, protein-zog noj tsis txaus, thiab kev noj zaub mov tsis txaus - mob atherosclerosis (los yog cachexia) syndrome tau siv sib hloov, uas yuav ua rau muaj kev ntxhov siab. Li no, cov txheej txheem tseeb siv los txheeb xyuas qhov tshwm sim ntawm cachexia thiabprotein-zog nkim(PEW) hauv CKD tsis zoo ib yam ntawm cov kev tshawb fawb, ua rau nws nyuaj rau kev sau cov ntaub ntawv. Siv cov kev ntsuas kev noj zaub mov zoo xws li kev ntsuas kev ntsuas thoob ntiaj teb lossis los ntawm kev ntsuas thoob ntiaj teb lossis cov qhab nia malnutrition-o, feem ntau ntawmcachexia/PEW tau pom tias yog 28- 80 feem pua ntawm cov neeg laus uas tab tom kho ntshav lim ntshav6–9thiab raws li kev nce ntxiv thaum lub raum ua haujlwm poob qis. Tseeb, nyob rau theem 1-2 CKD, qhov kev nthuav dav no tsawg dua 2 feem pua9,10thiab nyob rau theem, 3-5 yog kwv yees li 11-46 feem pua.10–13Hauv kev txheeb xyuas meta kawg, suav nrog 16 434 cov neeg mob ntawm kev saib xyuas kev lim ntshav, 25-75 feem pua ntawm PEW feem ntau yog 28- 54 feem pua.14Thaum lub sij hawm theem 3-5 hauv 1778 cov neeg mob, PEW feem ntau yog li ntawm 11 feem pua rau 54 feem pua.14
Lub ntsiab lus ntawm protein-zog nkim thiab lub raum cachexia
Lub sij hawm 'nkim' tau thov los ntawm Lub Koom Haum Saib Xyuas Kev Noj Qab Haus Huv Ntiaj Teb hauv xyoo 1983 thiab tau txhais tias yog qhov tsis txaus ntseeg ntawm qhov hnyav ntawm ntau dua 10 feem pua ntawm tus neeg mob tus nqi yav dhau los thaum tsis muaj kev kis mob, mob qog noj ntshav, lossis mob raws plab. Kev khib lossis kev noj zaub mov tsis zoo yog ib zaug ntseeg tau tias yuav tshwm sim los ntawm kev noj zaub mov tsis txaus thiab yuav tsum tau tshwj tseg rau qhov xwm txheej no nkaus xwb. Yog tias khib nyiab feem ntau tshwm sim hauv CKD hauv cov lus teb rau kev noj zaub mov tsis txaus, nws tsis yog ib feem ntawm kev hloov khoom noj khoom haus. Txhawm rau koom ua ke cov lus piav qhia ntawm lub ntiaj teb kev tsis sib haum xeeb nrog rau kev poob ntawm homeostatic tswj ntawm ob lub zog thiab cov protein sib npaug, cov kws tshaj lij tau koom nrog cov txheej txheem kev pom zoo. Tom ntej no generic txhais ntawmcachexia(rau txhua hom cachexia) tau luam tawm xyoo 2008 los ntawm Lub Koom Haum ntawm Sarcopenia, Cachexia thiab Wasting Disorders. 15 Cachexia tau txhais tias yog ib qho nyuaj metabolic syndrome uas cuam tshuam nrog kev mob hauv lub hauv paus thiab tus cwj pwm los ntawm kev poob ntawm cov leeg, nrog lossis tsis muaj rog. Nyob rau tib lub sijhawm, International Society of Renal Nutrition thiab Metabolism tau npaj ib qho kev faib tawm tshwj xeeb ntawm uremia-induced wasting disorders nyob rau hauv uas cachexia yog qhov mob hnyav tshaj plaws ntawm PEW.16 Qhov kev faib tawm no tau ua tiav thiab cov lus tau txais txiaj ntsig zoo mus txog hauv zej zog nephrology. Kaum xyoo tom qab, PubMed cov ntaub ntawv tshawb fawb (los ntawm kev pib mus rau 12 Cuaj hlis 2018) tau txheeb xyuas 327 CKD cov ntawv tshaj tawm uas siv PEW hauv lawv lub npe (Daim duab 1). Txawm li cas los xij, tib lub sijhawm, tseem, hauv CKD, 180 cov ntawv tshaj tawm siv 'cachexia' taw qhia tias qee qhov tsis meej pem tseem muaj.
Dab tsi yog qhov txawv ntawm cachexia thiab protein-zog nkim hauv cov kab mob raum ntev?
Raws li pom nyob rau hauv Table 1, cov txheej txheem kuaj mob rau cachexia (thov los ntawm Lub Koom Haum ntawm Sarcopenia, Cachexia thiab Wasting Disorders) 15 thiab rau PEW (thov los ntawm ISRNM) 16 yog qhov zoo sib xws, tab sis tsis zoo ib yam. Txawm li cas los xij, tsis muaj qhov txawv txav ntawm PEW thiab cachexia los ntawm qhov pom ntawm pathophysiologic, thiab txwv lub sij hawm.cachexiamus rau cov ntaub ntawv loj ntawm PEW yog kab tias nruj dhau lawm. Nrog rau peb txoj kev nkag siab txog cov txheej txheem koom nrog hauv PEW / cachexia, cov ntsiab lus no puas yuav hloov zuj zus thiab sib haum xeeb?
Lub cev hnyav thiab lub cev muaj pes tsawg leeg
Lub ntsiab ntsuas raucachexia(Table 1) is either a weight loss>5 feem pua hauv 12 lub hlis dhau los lossis qhov ntsuas lub cev (BMI)<20 kg/m2="" and="" does="" not="" seem="" satisfactory="" in="" the="" ckd="" context="" because="" low="" bmi="" is="" not="" always="" present="" at="" the="" early="" stages="" of="" nutritional="" disorders.="" indeed,="" due="" to="" a="" tendency="" for="" elevated="" body="" weight="" in="" ckd,="" given="" that="" the="" average="" bmi="" of="" us="" dialysis="" patients="" is="">25 kg / m2, 17 tos kom qis BMI los txiav txim siabcachexiayeej yuav ua rau kev kuaj mob lig. Hauv qhov no, kev siv BMI hauv PEW lub ntsiab lus thiab cachexia tau sib tw.18 Nws yog cov kws sau ntawv xav tias qhov tshwj xeeb BMI raug txiav tawm yuav tsum tsis txhob raug txiav txim siab ntxiv lawm hauv cov kev faib tawm no tau muab kev ntxub ntxaug lwm haiv neeg thiab vim cov ntaub ntawv. muab los ntawm BMI tsis kov yeej uas coj los ntawm lub cev hnyav. Los ntawm qhov sib txawv, qhov poob phaus yog ib qho yooj yim thiab rhiab heev rau kev soj ntsuam raws li thawj qhov kev kho mob tshwm sim ntawm cachexia. Tseeb, lub cev muaj pes tsawg leeg
is difficult to measure with precision in a clinical setting. Bodyweight loss remains a valid criterion; in a recent study including almost 5000 patients, a significant weight loss began relatively early during the course of CKD and was associated with a substantially higher risk for death after dialysis therapy initiation.19 Overall, both classifications have identified a nonvoluntary weight loss as a phenotypical criterion based on a robust literature: greater than 5% within the past 6 months or >10% beyond 6 months as recently proposed by the Global Leadership Initiative on Malnutrition.20 The presence of a critical weight loss (>5 feem pua hauv 6 lub hlis) yuav tsum tau suav tias yog ib qho tseem ceeb rau kev txhais cachexia/PEW. Los ntawm qhov sib piv, qhov hnyav dua qis dua (<5%) should="" be="" considered="" as="" one="" criterion="" among="">
Muscle nkim (los yog sarcopenia) yog pom tseeb tias yog ib qho tseem ceeb hauv cov kab mob pathophysiology.cachexiaphenotypes thiab predisposes kom muaj kev pheej hmoo ntawm cov teeb meem co-morbid.15,21,22Hauv ob lub ntsiab lus, kev ntsuas ntawm cov leeg nqaij los ntawm nruab nrab ntawm caj npab cov leeg ncig thaj tsam. Hauv kev sib piv rau PEW, cov txheej txheem kuaj mob rau cachexia hais txog cov leeg nqaij ua haujlwm (xws li cov leeg nqaij lossis qaug zog). Qhov tseeb, cov leeg nqaij muaj zog yog ib qho kev kwv yees ntawm lub raum tshwm sim hauv cov neeg mob CKD thiab tuaj yeem pab tau rau kev kuaj mob cachexia / PEW hauv cov neeg no.23,24Hauv PEW lub ntsiab lus, creatinine zoo li tau npaj los kwv yees cov leeg nqaij tab sis nws qhov tseeb thiab kev tsim tawm tsis muaj zog, thiab hauv peb lub tswv yim, qhov kev ntsuas no yuav tsis siv ntau tam sim no.25Mechanically, kev nce hauv cov leeg nqaij proteolysis los ntawm ib qho kev hloov pauv ib txwm muaj txawm hais tias muaj ntau hom cachexia, feem ntau los ntawm ubiquitin-proteasome system thiab kev sib koom ua ke ntawm cov noob caj noob ces (atrogenes) los ntawm FOXO transcription yam.21,26,27
Muaj lus nug txog lub luag haujlwm ntawm cov rog hauv cachexia thiab txog rau tam sim no, kev rog rog tsis suav tias yog ib qho tseem ceeb ntawm cachexia tshwj tsis yog hauv PEW kev faib tawm. Hauv kev tshawb fawb txog kev kis kab mob, cov ntaub so ntswg adipose tau cuam tshuam nrog kev pheej hmoo ntawm kev tuag ntau duacachexiakab mob.28– 30Qhov kev tshawb pom txog lub peev xwm ntawm cov ntaub so ntswg adipose dawb tig mus rau xim av adipose phenotype nrog thermogenesis muaj peev xwm, ua rau kom muaj zog siv zog thiab lipid mobilization, underlines qhov tseem ceeb ntawm cov ntaub so ntswg hauv cachexia. Cov ntaub ntawv sim kuj qhia tias qhov tshwm sim no tshwm sim ua ntej cov leeg pob txha atrophy.31–33 Cov browning inductors tuaj yeem zoo sib xws hauv cov cachexia sib txawv xws li cov uas raug ntxias los ntawm parathyroid hormone (PTH) hauv CKD thiab PTH-txog peptide (PTHrP) hauv kev mob qog noj ntshav.33Hauv qhov xwm txheej no, PTH / PTHrP-induced fat-derived molecules, uas yog, adipokines, dawb fatty acids, los yog lwm yam metabolites, kho qhov crosstalk ntawm cov leeg nqaij thiab cov rog uas ua rau txoj hauv kev loj rau cov ntaub so ntswg catabolism. Txawm li cas los xij, tam sim no tsis muaj kev pom zoo txog qhov zoo tshaj plaws ntawm cov rog lossis cov rog poob uas qhia tias muaj PEW, thiab cov rog tsis tau khaws cia hauv cov lus pom zoo noj zaub mov zaum kawg.20 Cov txheej txheem lom neeg los ntsuas kev noj haus tsis zoo, cov txheej txheem lom neeg yuav tsum muaj peev xwm txheeb xyuas thiab pheej hmoo-stratify cov neeg mob nrog PEW / cachexia, paub qhov txawv ntawm qhov ua rau thiab qhov tshwm sim ntawm PEW / cachexia thiab cov kab mob hauv qab uas ua rau PEW / cachexia. Txawm li cas los xij, qee cov cim kev noj haus uas siv hauv cachexia, xws li ntshav qab zib, raug cuam tshuam los ntawm CKD thiab siv tsis tau. Kuj tsis muaj kev pom zoo rau lub luag haujlwm thiab qhov cuam tshuam ntawm qhov mob hauv cov txheej txheem ntawm PEW thiab cachexia. Hauv thawj lub ntsiab lus ntawm PEW, nws tau hais tias qhov mob tuaj yeem yog qhov tsis meej pem los ntawm kev xav tias PEW tsuas yog vim qhov mob.16Lub luag haujlwm tseem ceeb ntawm cytokines lossis o hauv pathophysiology ntawm cachexia tseem yog cov lus nug zoo. Ntau qhov kev sim thiab cov ntaub ntawv kho mob tau hais qhia tias qhov mob ua haujlwm ncaj qha rau ntawm lub hom phiaj cov ntaub so ntswg nrog rau kev hloov pauv ntawm lub hauv nruab nrab lub paj hlwb (dysregulation ntawm qab los noj mov), neuroendocrine lub hom phiaj (xws li tso tawm adrenal steroids), tus cwj pwm mob (xws li anorexia thiab qaug zog. ), thiab cov leeg catabolism.34Hauv kev mob qog noj ntshav cachexia, lub luag haujlwm tseem ceeb ntawm kev mob yog tam sim no tsis lees paub. Ntau tus pro-inflammatory cytokines yog tsim los ntawm qog crosstalk nrog cov kab mob stromal, thiab lub cev tiv thaiv kab mob thiab o yog lub hauv paus ntawm mob qog noj ntshav cachexia.35Nyob rau hauv CKD, nce ntshav inflammatory cytokines predispose rau lub pathogenesis ntawm PEW.36–38Cov ntaub ntawv khaws cia tseem qhia tau tias thaum lub sij hawm CKD, qhov tshwj xeeb acretion ntawm uremic co toxins yuav muaj kev cuam tshuam ncaj qha rau o stimulation thiab cytokines ntau lawm.39 Yog li ntawd, o ua rau PEW / cachexia nyob rau hauv ntau txoj kev, ob qho tib si los ntawm ncaj qha thiab tsis ncaj mechanisms ntawm cov leeg proteolysis thiab impinging. raws li thiab nthuav tawm lwm yam ua rau PEW hauv lub voj voog tsis zoo. Yog li, qhov laj thawj tsis suav nrog cov txheej txheem ua mob rau hauv PEW cov txheej txheem yuav raug txiav txim siab dua. Kev noj cov protein thiab lub zog Kev txo qis hauv kev noj zaub mov kom tsis muaj zog yog qhov ntsuas ntawm cachexia thiab PEW cov ntsiab lus. Hauv PEW-CKD Fifield, kev noj tsawg dua25kcal ib kg lub cev hnyav yog npaj, thiab rau cachexia, nws yog 20 kcal ib kg lub cev qhov hnyav. Nws raug lees paub tias muaj qhov tsis txaus ntseeg hauv kev txheeb xyuas qhov txo qis ntawm lub zog kom tsawg. Txhawm rau pab tswj kev siv hluav taws xob, qhov sib txawv ntawm kev siv hluav taws xob thiab kev siv hluav taws xob tuaj yeem kwv yees los ntawm kev ntsuas ncaj qha ntawm kev siv hluav taws xob so (indirect calorimetry) thiab kev ntsuas tsis ncaj los ntawm cov ntaub ntawv ntawm kev noj haus.40Txawm li cas los xij, qhov no tsis yog niaj hnub ua thiab txog rau tam sim no, tsis muaj qhov kev pom zoo ntawm qhov 'qis' lub zog noj. Lwm qhov sib txawv tseem ceeb yog kev noj cov protein, uas tsuas yog tau txiav txim siab hauv PEW txhais. Txawm hais tias nws feem ntau lees paub tias qhov kev xav tau ntawm cov neeg mob cachectic tau nce ntxiv, cov txheej txheem thoob ntiaj teb uas twb muaj lawm ntawm kev pom zoo ntawm cov protein thiab cov amino acid kom tsawg yog vague.41Qhov no qhia tau hais tias kev noj cov protein tuaj yeem sib xyaw ua kecachexiacov txheej txheem thiab tsis yog tshwj xeeb rau tus mob uremic. Piv txwv li, kev noj zaub mov muaj protein tsawg yog pom zoo rau kev tswj hwm ntawm CKD nrog cov khoom noj muaj txiaj ntsig zoo.42
cistanche tuaj yeem khomob raumcachexia thiab txhim kho lub raum ua haujlwm
Xaus
Kev soj ntsuam ntawm cov protein thiab lub zog raws li txoj cai yog ib lub ntsiab lus dav thiab nyuaj, tshwj xeeb hauv CKD. Tsis muaj kev pom zoo muaj nyob rau hauv cov ntsiab lus ntawm cov ntsiab lus thiab cov txheej txheem rau kev ntsuas cov leeg pob txha, txo cov zaub mov noj, thiab cov cim qhia txog kev hloov pauv ntawm cov metabolism. Lub hom phiaj ntawm PEW nomenclature yog los sib sau ua ke cov ntsiab lus los piav qhia txog kev mob cachectic uas tshwm sim hauv ntau tus neeg mob nrog CKD. Qhov kev siv ntawm qhov kev faib tawm no yog qhov ua tau zoo, thiab tsis sib xws rau cov ntsiab lus cachexia uas tau hais los ntawm Evans thiab cov neeg ua haujlwm sib koom ua ke, 15 PEW tau raug lees paub los kwv yees kev tuag hauv ntau pawg ntawm cov neeg mob CKD.5,43 Ntxiv rau, siv cov generic vs. . ib lub ntsiab txhais hauvraumcov kab mob cov pej xeem tsis tau ua kom deb li deb. Peb tsis paub tias qhov no puas tuaj yeem txhim kho kev kuaj mob thiab kev tswj xyuas cov txiaj ntsig tsis zoo hauv cov neeg mob no. Txawm li cas los xij, qhov sib txawv ntawm PEW16 thiab cachexia15 muaj tsawg heev (Table 1) thiab tsis muaj kev ncaj ncees. Thawj qhov tshwm sim ntawm cachexia yuav txawv ntawm cov kab mob ntev, tab sis txoj hauv kev catabolic thiab physiopathology zoo sib xws thiab ua rau muaj qhov sib piv phenotype. Peb xav hais tias PEW yog cachexia thiab yuav tsum tau hu ua 'raumkab mob cachexia' raws li kev txuas ntxiv nrog PEW thawj zaug tom qab cachexia. Hloov PEW los ntawm kab mob raumcachexiaTej zaum yuav tsis meej pem los piav txog qhov tshwm sim zoo sib xws uas tau pom hauv lwm cov kab mob cachectic raws li pom hauv qog noj ntshav.22 Thaum kawg, cachexia lub ntsiab lus yuav tsum hloov zuj zus los piav qhia qhov tseeb thiab coj mus rau hauv tus account rog poob thiab tsis txaus cov protein. Kev tshawb fawb yav tom ntej yuav ua rau pom tseeb thiab paub meej tias cov txheej txheem ntawm cachexia zoo sib xws thiab pab tau rau kev saib xyuas kev noj haus tsis zoo hauv CKD.
Kev lees paub
Txoj kev tshawb no tau txhawb nqa los ntawm Université de Lyon thiab Hospices Civils de Lyon, Fabkis. LK thiab DF tsis muaj teeb meem ntawm kev txaus siab los nthuav tawm. KKZ tau txais kev qhuas los ntawm Abbott Nutrition thiab Fresenius Kabi. Txhua tus kws sau ntawv tshaj tawm tias cov ntawv xa tawm tsis tau luam tawm ua ntej (tsis hais lus Askiv lossis lwm yam lus) thiab tias txoj haujlwm tsis raug txiav txim siab rau kev tshaj tawm lwm qhov. Cov kws sau ntawv lees paub tias lawv ua raws li cov lus qhia kev coj ncaj ncees rau kev tshaj tawm hauv Phau Tsom Faj ntawmCachexia, Sarcopenia, thiab Muscle: hloov tshiab 2017. 44
Kev coj ncaj ncees
Cov ntawv sau tsis muaj cov kev tshawb fawb soj ntsuam lossis cov ntaub ntawv tus neeg mob.
Los ntawm lub raum cachexia los yog protein-zog nkim nyob rau hauv mob raum kab mob: qhov tseeb thiab cov lej los ntawmLaetitia Koob1*ua al
---Phau ntawv Journal of Cachexia, Sarcopenia thiab Muscle 2019; 10: 479–484 DOI: 10.1002/jcsm.12421
Cov ntaub ntawv
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