ToojNws yog ib qho khoom noj khoom haus uas tsim nyog rau lub cev kom tau txais, thiab cov kab no feem ntau tau txais los ntawm cov khoom noj xws li cov plhaub ntses, cov nqaij nruab deg, cov khoom lag luam, cov noob, thiab txiv ntoo, tab sis cov kev tshawb fawb tsis ntev los no tau pom tias cov khoom siv tooj liab kuj tseem muaj. txiav txim siab rau qee qhov ntawm cov noob. Kev hloov pauv hauv cov kab sib txuas hauv ntau lub cev hauv lub cev, suav nrog lub hlwb, lub plawv, lub raum, thiab daim siab, tau txuas nrog kev raug mob ntsig txog kev tuag. Kev noj zaub mov ntau dhau ntawm tooj liab yuav ua rau tooj liab tso rau hauv lub raum thiab nephrotoxicity los ntawm oxidative stress, cellular puas ua rau cov tubular necrosis, thiab txo lub raum ua haujlwm.

Txawm li cas los xij, kev sib cuam tshuam ntawm tooj liab thiab lub raum kab mob yog bidirectional, raws li homeostatic imbalances nyob rau hauv circulating tooj liab theem kuj yuav tshwm sim nyob rau hauv cov neeg mob.mob raum mob (CKD)vim lub raum tsis ua haujlwm thiab hloov pauv cov metabolism hauv cov protein. Tseeb tiag, kev tswj hwm qib tooj liab hauv cov neeg mob uas muaj kab mob raum ntev yog qhov tseem ceeb rau kev tiv thaiv cov teeb meem. Hauv kev soj ntsuam yav dhau los, kev nce qib ntawm cov tooj liab tau cuam tshuam nrog cov kab mob raum ntev. Txawm hais tias ntau dua ntawm tooj liab hauv cov ntshav ua rau lub raum raug mob, kev poob qis hauv lub raum ua haujlwm sai thiab muaj kev pheej hmoo ntawm cov kab mob raum ntev tseem yuav tsum tau lees paub, raws li cov kev tshawb fawb soj ntsuam kab mob kis tau zoo yuav ua rau tsis meej pem thiab thim rov qab.

Nyem no kom tau tNws cuam tshuam ntawm Cistanche rau lub raumthiabCistanche tubulosa yog dab tsi

nug ntxiv

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Mendelian randomization yog ib txoj hauv kev los ua kom muaj kev sib raug zoo ntawm txoj kev ua neej thiab cov kab mob tshwm sim. Mendelian randomization yog ib lub hauv paus rau kev soj ntsuam kev sib raug zoo ntawm kev hloov pauv tau cuam tshuam nrog cov phenotypes sib txawv, qhov twg cov noob caj noob ces cuam tshuam nrog kev raug siv los ua cov cuab yeej sib txawv. Muab qhov sib txawv ntawm kev sib txawv ntawm cov noob caj noob ces thaum lub sij hawm xeeb tub, genetic variants feem ntau tsis cuam tshuam nrog cov muaj peev xwm confounders nyob rau hauv kev sib raug zoo-cov txiaj ntsig koom haum. Tsis muaj cov kev tshawb fawb yav dhau los tau tshawb fawb txog kev sib raug zoo ntawm cov qib tooj liab thiab CKD.

Peb xav tias kev nce qib ntawm cov tooj liab yuav ua rau muaj kev pheej hmoo ntawm CKD. Txhawm rau kom paub meej qhov kev xav no, peb tau ua ib qho kev soj ntsuam ua ntej ntawm kev sib koom ua ke ntawm cov caj ces kwv yees cov qib tooj liab thiab CKD. Hauv kev soj ntsuam thib ob, peb tau tshawb xyuas seb puas muaj cov caj ces kwv yees siab ntawm cov tooj liab uas muaj feem cuam tshuam nrog qis duakwv yees glomerular filtration rate(eGFR), nce raum sai sai, thiab mob raum.

Cistanche extract

Txoj kev tshawb no tau tsim raws liMR. MR mus kom ze tau ua raws li peb qhov kev xav. Ua ntej, cov kev hloov pauv caj ces yuav tsum muaj feem cuam tshuam nrog kev kis. Qhov thib ob, cov kev hloov pauv caj ces yuav tsum muaj feem cuam tshuam nrog cov neeg muaj peev xwm confounders. Thaum kawg, cov kev hloov pauv caj ces yuav tsum cuam tshuam cov txiaj ntsig tau hloov pauv los ntawm kev raug. Qhov kev xav tau raug sim los ntawm ob-tus qauv MR mus kom ze siv cov noob caj noob ces cuam tshuam nrog tooj liab ua qhov ntsuas qhov sib txawv. Tsis tas li ntawd, vim kev hloov pauv caj ces tsis tuaj yeem hloov pauv los ntawm lub xeev kab mob, MR kev tshawb fawb tsis yooj yim thim rov qab.

Kev kwv yees kwv yees kwv yees rau kev sib kis tooj liab tau muab los ntawm genome-wide koom haum meta-kev soj ntsuam ntawm peb pawg neeg raws li cov pej xeem (xws li 6937 tus neeg ntawm cov neeg nyob sab Europe). Hauv qhov kev tshawb fawb meta-analysis, peb ntsuas cov qib tooj liab hauv ob qho tib si hauv ntshav thiab ntshav. Txoj kev tshawb no tau txheeb xyuas ob lub genome-dav qhov tseem ceeb ntawm cov noob caj noob ces muaj txiaj ntsig zoo nrog cov qib tooj liab (rs17564336 rau SELENBP1 thiab rs34951015 rau CP). Ob qho kev hloov pauv tau siv los ua cov cuab yeej caj ces rau kev tshawb fawb MR

Cistanche ntxiv

Txhawm rau ntsuas qhov muaj peev xwm ua rau muaj kev sib raug zoo ntawm cov qib tooj liab thiab CKD kev pheej hmoo, peb tau txais kev kwv yees kwv yees kwv yees rau CKD los ntawm kev tshawb fawb genome-wide Association (GWAS) meta-analysis uas muaj 12,385 CKD mob thiab 104,780 tsis yog-European [8] mob. cKD tau txhais tias yog cov ntshav creatinine raws li 60 mL-min - 1 / 1.73 m2 eGFR. eGFR genetic Association kwv yees (raws li qhov sib txawv tsis tu ncua) tau txais los ntawm GWAS uas muaj 312,468 ntau tus neeg xeeb leej xeeb ntxwv (discovery dataset) [9], thiab CKDGEN consortium thiab UK Biosample Repository cohort (n=1},004,040) (replication dataset) ).

Txhawm rau txheeb xyuas qhov muaj peev xwm ua rau muaj kev sib raug zoo ntawm cov qib tooj liab thiab creatinine kev pheej hmoo raws li qhov ceev glomerular pom tus nqi poob qis (eGFRcrea), peb tau txais kev kwv yees kwv yees kwv yees rau eGFRcrea los ntawm Gorski li al. eGFRcrea tau soj ntsuam raws li cov qauv los ntawm CKDGEN koom nrog thiab UK Biosample Repository cohort. Cov mob eGFRcrea nrawm (tseem hu ua CKDi25, suav nrog n mob=19},901 thiab n tswj=175,244) tau txhais tias muaj cov kab hauv qab eGFR Ntau dua lossis sib npaug li 60 mL / min / 1.73 m2 thiab 25% txo qis hauv eGFR los ntawm lub hauv paus. 60 mL / min / 1.73 m2, CKDi25 pab pawg yog cov uas muaj lub hauv paus hauv paus eGFR thiab gt; 60 mL / (min{16}}.73 m2) thiab tsis ua raws li cov kev txwv no ntawm lub raum ua haujlwm poob qis (tsis muaj 25 feem pua ​​​​txo qis hauv eGFR ). Lub sijhawm ua raws li qhov nruab nrab eGFR poob qis sib txawv ntawm cov pab pawg koom nrog hauv txoj kev tshawb no (1 ~ 15 xyoo). Serum creatinine tau ntsuas hauv txhua qhov kev kawm uas siv cov enzymatic thiab Jaffe cov tshuaj tiv thaiv raws li cov tshuaj creatinine. Lub raum mob raum kab mob sib kis txoj kev tshawb fawb sib koom tes (CKD-EPI) cov qauv siv los kwv yees eGFR.

Txhawm rau tshawb xyuas qhov muaj peev xwm ua rau muaj kev sib raug zoo ntawm cov qib tooj liab thiab lub raum puas tsuaj, Teumer li al [12] tau txais kev kwv yees kwv yees kwv yees rau cov cim ntawm lub raum puas tsuaj hauv GWAS meta-analysis. Lub raum puas tau tshwm sim los ntawm cov zis albumin / creatinine piv (n=48,589) thiab normoalbuminuria vs. micro/loj albuminuria (n=48,255) [12]. Tag nrho cov kev tshawb fawb suav nrog yog cov neeg European qhovntsej thiaj tsis mob, hnub nyoog> 18 xyoo, thiab suav nrog txiv neej thiab poj niam. Tag nrho cov kev tshawb fawb suav nrog ua raws li Kev Tshaj Tawm ntawm Helsinki cov txheej txheem.

Cov txiaj ntsig ntawm Cistanche Tubulosa

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