Hu rau: jerry.he@wecistanche.com

Cistanche zoo heev rau Alzheimer's kab mob

Cov kws tshawb fawb tau ua tiav cov noob caj noob ces tiv thaivAlzheimer tus kab mobkab mobrau hauv tib neeg lub hlwb.

Cov kws tshawb fawb los ntawm Canada's Université Laval School of Medicine thiab Université Québec-Laval Research Center tau ua tiav cov genomes ntawm tib neeg cov hlwb loj hlob hauv vitro, qhia txog kev hloov pauv uas tuaj yeem muab cov neeg mob Alzheimer's disease. tiv thaiv kab mob. Cov ntsiab lus ntawm qhov kev tawg tau tsis ntev los no tau tshaj tawm hauv CRISPR Journal.

Kev tshawb fawb luam tawm nyob rau hauv "The CRISPR Journal" (qhov cuam tshuam tshiab kawg: 6.071) thaum Lub Ob Hlis 7, 2022

“Qee qhov kev hloov pauv caj ces ua rau muaj kev pheej hmooAlzheimer tus kab mobkab mob, tab sis muaj ib qho kev hloov pauv uas txo qhov kev pheej hmoo no," tus thawj coj xibfwb Jacques-P Tremblay tau hais tias, "ib qho kev hloov pauv tsis tshua pom muaj nyob hauv cov neeg Icelandic xyoo 2012. Qhov kev hloov pauv tsis paub txog qhov tsis zoo rau cov neeg nqa khoom thiab txo qhov kev pheej hmoo ntawmAlzheimer tus kab mobkab mob. Siv ib qho kev txhim kho ntawm CRISPR gene-editing cuab tam, peb tau hloov kho cov genome ntawm tib neeg lub hlwb los ntxig qhov kev hloov pauv no. "

Lub hlwb ntawmAlzheimer tus kab mobCov neeg mob muaj amyloid plaques uas ua rau cov neurons tuag vim lawv cov tshuaj lom. Cov plaques tsim tom qab amyloid precursor protein yog cleaved los ntawm ib tug enzyme hu ua beta-secretase. "Icelandic kev hloov pauv ua rau nws nyuaj rau cov enzyme kom tshem tawm cov amyloid precursor protein. Yog li ntawd, muaj tsawg tsim ntawm amyloid plaques," Tremblay piav qhia.

Dr. Jacqua-P Tremblay

Hauv txoj kev xav, qhia txog Icelandic gene mutation rau hauv cov genomes ntawm tib neeg muaj kev pheej hmoo ntawm kev tsim.Alzheimer tus kab mobkab mobtuaj yeem tiv thaiv lossis qeeb qhov kev loj hlob ntawm tus kab mob. "Hmoov tsis zoo, peb tsis tuaj yeem rov qab thiab kho qhov kev puas tsuaj uas ua rau cov neurons tuag," yog li kev kho mob tshwj xeeb yog tsim nyog rau cov tib neeg los ntawm cov tsev neeg cuam tshuam los ntawm cov kab mob caj ces, tsev neeg.Alzheimer tus kab mobkab mob. Tus kab mob manifests nws tus kheej li teeb meem nco nyob nruab nrab ntawm lub hnub nyoog ntawm 35 thiab 40. Yog hais tias ua tau zoo, nws kuj yuav siv tau los kho cov feem ntau tshwm sim ntawm sporadic.Alzheimer tus kab mobkab mob, uas feem ntau tshwm sim thaum ntxov ntawm tus kab mob tom qab hnub nyoog 65 xyoo. "

Raws li cov kws tshawb fawb, qhov kev sib tw tam sim no yog nrhiav txoj hauv kev los kho cov genomes ntawm ntau lab lub hlwb hlwb. "Peb tab tom tshawb nrhiav qhov muaj peev xwm sib txawv, suav nrog kev siv cov kab mob tsis kis kab mob los xa cov kev hloov kho hauv cov neurons. Tam sim no tias cov ntaub ntawv pov thawj ntawm cov tswv yim tau tsim nyob rau hauv tib neeg lub hlwb hauv vitro, peb yuav tuaj yeem ua qhov no hauv cov neuron uas nthuav tawm.Alzheimer tus kab mobkab mob. Ntsuam xyuas txoj kev no hauv nas. Yog tias qhov kev tshawb pom no ua tiav, peb vam tias yuav ua ib qho kev tshawb fawb me me rau cov neeg muaj hnub nyoog 35 thiab 40 xyoo uas muaj kev hloov caj ces uas ua rauAlzheimer tus kab mobkab mob, "Tremblay hais.

Source: University Laval

Lwm kauj ruam ntawm kev kho noob rauAlzheimer tus kab mob

Siv:

Tremblay G, Rousseau J, Mbakam CH, Tremblay JP. Ntxig ntawm Icelandic Mutation (A673T) los ntawm Prime Editing: Muaj peev xwm tiv thaiv kev kho mob rau tsev neeg thiab SporadicAlzheimer tus kab mobKab mob. CRISPR J. 2022 Feb 7. doi: 10.1089/crispr.2021.0085. Epub ua ntej luam tawm. PIB: 35133877.