Gamma zaus muaj txiaj ntsig zoo rau Alzheimer's Disease

Hu rau Tinatina.xiang@wecistanche.comyog xav paub ntxiv.

Nyob rau hauv lub xyoo pua 20th, German neuropathologist Alois Alzheimer thawj zaug pom ib rooj plaub ntawm kev mob dementia, uas yog tom qab lub npe.Alzheimer tus kab mob(AD).

Raws li cov ntaub ntawv pej xeem, "Alzheimer tus kab mobNws yog ib qho kab mob neurodegenerative nrog qhov pib qeeb thiab kev loj hlob zuj zus nyob rau lub sijhawm." Nws etiology tseem tsis tau paub, thiab nws tau dhau los ua ib qho teeb meem loj hauv kev kho mob.

Yav dhau los, Cognito Therapeutics tau nthuav tawm nws thawj cov khoom kho digital rauAlzheimer tus kab mob. Cov khoom lag luam, cov khoom siv tsis yog qhov cuam tshuam neurostimulation sivGamma zausthev naus laus zis, tau lees paub los ntawm US Food and Drug Administration (FDA) raws li "cov cuab yeej tawg" rau kev kho digital ntawm Alzheimer's disease.

Cognito Therapeutics yog US-based chaw kho mob-theem tuam txhab tsim kho digital rau cov kab mob neurodegenerative xws li Alzheimer's.

Nws tau tshaj tawm tias lub tuam txhab tus tswv lag luam neuromodulation platform thev naus laus zis tau tsim los ntawm cov xibfwb Li-Huei Tsai thiab Edward Boyden hauv Lub Tsev Haujlwm Saib Xyuas Lub hlwb thiab kev paub txog kev paub ntawm MIT. Nws yog ib qho kev kho mob uas tsis muaj kev cuam tshuam rau cov kab mob neurodegenerative uas kho cov neeg mob nrog kev pom thiab hnov ​​​​qhov hnov ​​​​mob.

Tsis ntev los no, ntawm 2021 2021 AD/PD Conference, Cognito Therapeutics tshaj tawm Phase 2 cov ntaub ntawv tshwm sim rau nws qhov tseebGamma zaus neuromodulationkev kho mob.

Gamma zausneuromodulation yog ib txoj kev kho tshiab digital uas siv electroencephalogram (EEG)-calibrated auditory thiab pom stimuli rau evoke neural kev ua haujlwm hauv cov neeg mob.

Zach Malchano, Thawj Tswj Hwm ntawm Cognito Therapeutics, tau hais tias: "Gamma zaus neuromodulation yog qhov zoo hauvAlzheimer tus kab mobpiv rau cov tshuaj pharmacological li qub, uas tej zaum yuav pab tau los ntawm txoj kev sib txawv. Peb txaus siab tuaj yeem txhim kho kev kho mob ntawm gamma zaus neuromodulation therapy, xws li kev kho ib leeg lossis ua ke nrog lwm cov kev kho mob tau tsim rau Alzheimer's disease. "

Theem 2 txoj kev tshawb fawb ntawm gamma-frequency neuromodulation therapy kav ntev li 6 lub hlis, siv ib qho kev sib tw multicenter randomized controlled trial (RCT) los soj ntsuam cov kev kho mob thaum lub sij hawm kho mob rau cov neeg mob me me mus rau nruab nrab.Alzheimer tus kab mobkev nyab xeeb thiab kev ua tau zoo.

Txoj kev tshawb no qhia tau tiasgamma zaus neuromodulationkev kho mob tsis yog tsuas yog muaj kev nyab xeeb thiab siv tau tab sis kuj zam tau zoo.

Nws tau nkag siab tias txoj kev tshawb fawb tau nrhiav 76 tus neeg mob 50 xyoo thiab laus dua nrog mob me mus rau nruab nrab Alzheimer's kab mob, thiab cia lawv randomly txais 40Hz uas tsis yog-invasive audiovisual lossis sham stimulation rau ib teev thaum kho txhua hnub.

Thaum lub sijhawm 6-lub hlis kho mob, cov neeg tshawb xyuas tau siv ntau yam kev ntsuas uas siv tau los ntsuas cov kev hloov pauv hauv cov ntsiab lus kev paub, kev ua haujlwm, thiab biomarkers.

Tsis tas li ntawd, txoj kev tshawb fawb tau soj ntsuam kev hloov pauv ntawm lub hlwb ntim hauv Alzheimer cov neeg mob uas muaj kev puas hlwb me me mus rau nruab nrab.

Cov kev tshawb pom pom tias Alzheimer cov neeg mob kho nrog gamma zaus neuromodulation tau ntsib kev txhim kho hauv kev nco, kev paub, lub hlwb atrophy, thiab ntim poob.

Nws tau nkag siab tias piv nrog cov neeg mob hauv pawg placebo, cov neeg mob hauv pab pawg kho mob hauv txoj kev tshawb fawb tau txo qis hauv Alzheimer's tus kab mob ntsig txog tag nrho lub hlwb atrophy thiab ntim poob los ntawm 61 feem pua.

Placebo hais txog cov tshuaj uas tsis muaj kev kho mob los ntawm nws tus kheej. Hauv kev tshawb nrhiav tshuaj kho mob, txhawm rau soj ntsuam qhov ua tau zoo ntawm qee yam tshuaj, nws yog siv hauv pawg tswj hwm kom tswj tau tus neeg mob lub siab.

Tsis tas li ntawd, tom qab 6 lub hlis ntawm gamma zaus neuromodulation, pab pawg kho mob tau ntsib 84 feem pua ​​​​kev poob qis hauv Kev Ua Haujlwm Txhua Hnub (ADCS-ADL) thiab qeeb qeeb hauv Mini-Mental State Examination (MMSE) hauv 6 lub hlis 83 feem pua.

Brent Vaughan, CEO ntawm Cognito Therapeutics hais tias "Peb tos ntsoov kom nrawm rau kev kho mob ntawm gamma zaus neuromodulation, uas cog lus tias yuav yog thawj tus kab mob-hloov kho digital kho rau Alzheimer's kab mob," said Brent Vaughan, CEO ntawm Cognito Therapeutics.

Tsis ntev los no, ntawm 2021 Alzheimer's Association International Conference (AAIC 2021), Cognito Therapeutics ib zaug ntxiv tau nthuav tawm cov ntaub ntawv tshawb fawb tshiab ntawm gamma zaus neuromodulation.

Lub paj hlwb atrophy hauv cov neeg mob Alzheimer's muaj feem cuam tshuam nrog kev paub txog kev poob qis thiab kev ua haujlwm tsis zoo thiab yog qhov tseem ceeb hauv kev mob thiab kev tuag ntawm Alzheimer's disease.

Cov kev tshawb fawb tau pom tias gamma zaus neuromodulation tuaj yeem txo cov hlwb atrophy hauv cov neeg uas muaj Alzheimer's disease. Thaum lub sijhawm 6-hli lub sijhawm kho mob, cov neeg mob hauv pab pawg kho mob tau ntsib 65 feem pua ​​​​ntawm tag nrho cov hlwb poob qis piv rau pawg tswj hwm.

Tsis tas li ntawd, kev pw tsaug zog txawv txav yog txuam nrog kev loj hlob thiab kev loj hlob ntawm Alzheimer's disease, thiab kev txhim kho kev pw tsaug zog yog ib qho tseem ceeb hauv kev kho mob ntawm Alzheimer's disease. Cov kev tshawb fawb tau pom tias cov neeg mob me me mus rau nruab nrab Alzheimer's disease tau txo lub sijhawm ua haujlwm thaum hmo ntuj pw tsaug zog thaum kho nrog gamma zaus neuromodulation.

"Neurophysiological txoj kev kho mob tuaj yeem cuam tshuam txog kev kis kab mob los ntawm kev txhim kho kev nco, kev paub thiab cov tsos mob ua haujlwm, thiab txo cov hlwb atrophy, thiab kev pw tsaug zog zoo dua hmo ntuj hauv Alzheimer's cov neeg mob tau pom lub sijhawm no muab qhov kev xav tshiab rau peb," Vaughn tau hais. Hloov cov txheej txheem ntawm tus kab mob hauv cov neeg mob muab kev txhawb nqa ntxiv. Qhov no yog lub sijhawm tseem ceeb thiab peb cia siab tias yuav nthuav dav kev soj ntsuam kev siv tau ntawm Cognito Therapeutics hauv kev tshawb fawb tseem ceeb Alzheimer. "