Kev Tshawb Fawb Txog Kev Ua Phem Txhaum Cai ntawm Bifidobacteria Ua Ke Nrog Suav Tshuaj Kho Mob Cistanche Ntawm Depreslonand Dementia hauv Cov Neeg Mob Parkinson's Disease Raws Li Lub hlwb-Gut Axis Theory

2 Kev tshwm sim

2.1 Cov tsos mob ntawm lub cev muaj zog

Ua ntej kev kho mob, tsis muaj qhov sib txawv ntawm cov qhab-nees thiab cov qhab-nees ntawm UPDRS ntawm ob pawg neeg mob (P > 0.05), qhia tias cov tsos mob ntawm ob pawg neeg mob sib npaug. Tom qab kev kho mob, cov tsos mob ntawm ob pawg ntawm cov neeg mob tau txhim kho mus rau qhov sib txawv, tab sis kev txhim kho ntawm pab pawg sim tau ntau dua, uas yog, tag nrho cov qhab nia thiab cov qhab nia ntawm UPDRS tau qis dua cov pawg tswj hwm (P <0.05), qhia tias Bifidobacterium ua ke nrog Suav tshuaj Cistanche deserticola kev kho mob muaj kev txhim kho zoo dua ntawm cov tsos mob ntawm cov neeg mob Parkinson's disease. Saib Table 2.

Table 2 Kev hloov pauv hauv UPDRRS cov qhab nia ntawm ob pawg neeg mob (x ± s, cov ntsiab lus)

2.2 Kev nyuaj siab degree

Ua ntej kev kho mob, tsis muaj qhov sib txawv ntawm cov qhab nia ntawm HAM ntawm ob pawg neeg mob (P ＞ {{0}}.05), qhia tias qhov kev nyuaj siab ntawm ob pawg neeg mob sib piv. Tom qab kev kho mob, qhov kev nyuaj siab ntawm ob pawg neeg mob tau txhim kho mus rau qhov sib txawv, tab sis kev txhim kho ntawm pab pawg sim tau ntau dua, uas yog, nws cov qhab nia HAM qis dua li ntawm pawg tswj hwm (P ＜ 0.05), qhia tias Bifidobacterium. ua ke nrog Suav tshuaj Cistanche deserticola kev kho mob muaj txiaj ntsig zoo rau kev txhim kho kev nyuaj siab ntawm cov neeg mob Parkinson tus kab mob. Saib Table 3.

Table 4 Kev hloov pauv hauv MoCA cov qhab nia nruab nrab ntawm ob pawg neeg mob (x ± s, cov ntsiab lus)

2.4 Serum

BDNF theem Ua ntej kev kho mob, tsis muaj qhov sib txawv hauv cov ntshav BDNF qib ntawm ob pawg (P ＞ {{0}}}.05), qhia tias cov txiaj ntsig neuroprotective ntawm ob pawg sib npaug. Tom qab kev kho mob, cov ntshav BDNF qib ntawm ob pawg tau nce mus rau qhov sib txawv, tab sis qhov nce hauv pawg sim tau ntau dua, uas yog, nws qib BDNF qib siab dua li ntawm pawg tswj hwm (P ＜ 0.05), qhia tias Bifidobacterium. ua ke nrog cov tshuaj suav suav tshuaj Cistanche deserticola kev kho mob muaj txiaj ntsig zoo dua ntawm cov txiaj ntsig neuroprotective ntawm cov neeg mob Parkinson. Saib Table 5.

Table 5 Kev hloov ntshav BDNF qib hauv ob pawg neeg mob (x ± s, ng / mL)

2.5 Cov kab mob plab hnyuv loj

Ua ntej kev kho mob, tsis muaj qhov sib txawv ntawm cov kab mob hauv plab hnyuv ntawm ob pawg neeg mob (P ＞ {{0}}}.05), qhia tias cov kab mob plab hnyuv ntawm ob pawg neeg mob sib npaug. Tom qab kev kho mob, cov kab mob plab hnyuv ntawm ob pawg ntawm cov neeg mob tau hloov pauv, tab sis cov kev hloov pauv hauv pawg sim tau zoo dua rau qhov sib npaug ntawm cov hnyuv, uas yog, piv nrog cov pab pawg tswj, qhov feem pua ​​​​ntawm cov kab mob muaj txiaj ntsig hauv cov hnyuv, xws li Raws li bifidobacteria thiab lactobacilli, nce, thaum qhov feem pua ​​​​ntawm cov kab mob tsis zoo, xws li cov kab mob anaerobic thiab cov kab mob hydrogen-sulfur-produced, txo qis (P ＜ 0.05), qhia tias bifidobacteria ua ke nrog cov tshuaj suav tshuaj suav tshuaj Cistanche deserticola kev kho mob muaj kev tswj xyuas zoo dua. cov kab mob plab hnyuv ntawm cov neeg mob Parkinson's disease. Saib Table 6.

CISTANCHE DESERTICOLA Kev Kho Mob

nyem qhov no kom paub meej ntxiv

3 Kev sib tham

Cov txiaj ntsig ntawm txoj kev tshawb no qhia tau hais tias Bifidobacterium ua ke nrog cov tshuaj suav tshuaj Cistanche deserticola tuaj yeem txhim kho cov tsos mob ntawm lub cev muaj zog, kev nyuaj siab, kev paub txog kev ua haujlwm, qib ntshav BDNF thiab cov kab mob plab hnyuv hauv cov neeg mob Parkinson's disease. Cov txheej txheem ua tau rau cov kev txhim kho no yuav raug txheeb xyuas ib qho los ntawm ib qho ua ke nrog cov ntaub ntawv hauv cov txiaj ntsig seem.

3. 1. Mechanism ntawm kev txhim kho cov tsos mob ntawm lub cev muaj zog

Raws li cov ntaub ntawv nyob rau hauv cov txiaj ntsig seem, UPDRS tag nrho cov qhab nia thiab txhua qhov qhab nia ntawm pawg sim tom qab kev kho mob tau qis dua li ntawm pawg tswj hwm, uas qhia tau hais tias bifidobacteria ua ke nrog cov tshuaj suav tshuaj Cistanche deserticola kev kho mob tuaj yeem txhim kho tau zoo. cov tsos mob ntawm lub cev muaj zog ntawm cov neeg mob Parkinson's disease. Cov nyhuv no yuav cuam tshuam nrog cov txheej txheem hauv qab no: (1) Kev tswj hwm qhov sib npaug ntawm lub hlwb-lub plab axis: Bifidobacterium, ua ib qho probiotic, tuaj yeem txo cov endotoxins los ntawm kev txhim kho cov qauv ntawm cov hnyuv, txo qhov feem pua ​​​​ntawm cov kab mob phem thiab nce qhov kev faib ua feem. ntawm cov kab mob muaj txiaj ntsig. thiab zus tau tej cov inflammatory yam kom txo tau kev puas tsuaj rau lub hauv paus paj hlwb [11].

(2) Ua kom cov ntshav BDNF nce qib: BDNF yog qhov tseem ceeb ntawm cov neurotrophic uas ua lub luag haujlwm tseem ceeb hauv kev loj hlob, sib txawv, ciaj sia taus thiab plasticity ntawm neurons. Bifidobacterium tuaj yeem txhawb kev tsim cov BDNF los ntawm nws cov metabolites, yog li txhim kho neuroprotection thiab txhim kho lub cev muaj zog.

3. 2 Mechanisms los txhim kho qib kev nyuaj siab

Qhov qhab nia HAMD ntawm pawg sim tom qab kev kho mob tau qis dua li ntawm pawg tswj hwm, uas qhia tau hais tias kev sib xyaw ntawm bifidobacteria.

Kev kho mob nrog cov tshuaj suav tshuaj Cistanche deserticola tuaj yeem txhim kho kev nyuaj siab hauv cov neeg mob Parkinson tus kab mob. Cov txheej txheem ua tau muaj xws li: (1) Neurotransmitter system tswj: metabolites tsim los ntawm bifidobacteria, xws li indoleacetic acid, tuaj yeem cuam tshuam rau 5-hydroxytryptaminergic system ntawm lub hauv paus paj hlwb thiab ua kom cov synthesis ntawm 5-hydroxytryptamine.

Tsim thiab tso tawm, yog li txhim kho kev nyuaj siab mus ob peb vas. (2) Cov teebmeem ntawm Cistanche deserticola: Cov khoom xyaw nquag ntawm Cistanche deserticola tuaj yeem ua rau muaj txiaj ntsig zoo ntawm 5-hydroxytryptamine los ntawm kev ua kom 5-hydroxytryptamine receptors thiab inhibiting kev qhia ntawm 5-hydroxytryptamine transporters, yog li txhim kho kev nyuaj siab. thiab kev txawj ntse muaj nuj nqi.

3. 3. Mechanism rau kev txhim kho kev txawj ntse

Mo⁃CA cov qhab nia ntawm pawg sim tom qab kev kho mob tau nce siab dua li ntawm pawg tswj hwm, uas qhia tau hais tias muaj kev cuam tshuam zoo ntawm bifidobacteria ua ke nrog cov tshuaj suav tshuaj Cistanche deserticola ntawm kev paub txog kev ua haujlwm ntawm cov neeg mob Parkinson tus kab mob. Cov txheej txheem yuav muaj xws li: (1) Txhim kho neuroprotection: nce BD-NF qib pab tiv thaiv cov neurons los ntawm kev puas tsuaj, txhawb nqa neuronal plasticity thiab tsim cov synapses tshiab, yog li txhim kho kev txawj ntse.

(2) Kev tswj cov kab mob neurotransmitter: Cistanche deserticola tuaj yeem pab txhim kho kev txawj ntse los ntawm kev cuam tshuam rau dopaminergic system thiab 5-hydroxytryptamine system, xws li kev txhim kho kev txawj ntse los ntawm kev ua kom muaj cov tshuaj dopamine [12].

3. 4 serum

Mechanism ntawm kev txhim kho BDNF qib thiab cov kab mob plab hnyuv. Ntshav qab zib BDNF qib ntawm pawg sim tom qab kev kho mob tau nce siab dua li ntawm pawg tswj hwm, thiab cov kab mob plab hnyuv kuj tau hloov pauv hauv kev sib npaug. Cov kev txhim kho no yuav cuam tshuam nrog cov txheej txheem hauv qab no:

(1) Metabolites ntawm probiotics: Metabolites uas tsim los ntawm Bifidobacterium tuaj yeem cuam tshuam ncaj qha rau kev qhia thiab tso tawm ntawm BDNF, yog li ua kom cov ntshav BDNF nce. (Saib ntxiv ntawm nplooj 3076)

(2) Kev tswj cov kab mob hauv plab: Los ntawm kev ua kom cov kab mob muaj txiaj ntsig zoo thiab txo qhov feem pua ​​​​ntawm cov kab mob tsis zoo, nws tuaj yeem pab txo cov plab hnyuv thiab permeability, txo kev puas tsuaj rau lub hauv nruab nrab paj hlwb, thiab yog li pab txhawb cov ntshav BDNF. thiab txhim kho txoj hnyuv flora qauv.

Hauv cov ntsiab lus, Bifidobacterium ua ke nrog cov tshuaj suav tshuaj Cistanche deserticola tuaj yeem txhim kho cov tsos mob ntawm lub cev, kev nyuaj siab thiab kev paub txog kev ua haujlwm ntawm cov neeg mob Parkinson's disease los ntawm ntau lub tswv yim ntawm kev ua. Nws tseem tuaj yeem ua rau cov ntshav BDNF nce qib thiab tswj cov plab hnyuv. Tus qauv muab cov tswv yim tshiab thiab cov hau kev rau kev kho mob ntawm Parkinson tus kab mob.

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[2] Raket LL, Oudin Åström D, Norlin JM, et al. Kev cuam tshuam ntawm lub hnub nyoog thaum pib

ntawm cov txheej txheem cov tsos mob, cov neeg kho mob

t yam ntxwv thiab kev noj qab haus huv

Qhov zoo ntawm lub neej hauv Parkinson tus kab mob ［J］ Kev tshawb fawb

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[4] Fang Jiarui, Li Zhe, Ren Yikun, et al. Lub luag hauj lwm ntawm plab hnyuv flora-gut-brain axis nyob rau hauv qhov tshwm sim thiab kev tiv thaiv ntawm neurodegenerative kab mob [J]. Phau ntawv Journal of Zhengzhou University (Medical Edition), 2021, 56

(3): ３２７⁃３３１．

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2022, 30(3): 262-265.

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[10] Jia Yangjuan, Han Ning, Guo Hui, et al. . Tus nqi ntawm MMSE thiab MoCA rau kev tshuaj xyuas ntxov ntawm cov hlab ntsha me me ntawm kev paub tsis meej tom qab mob stroke [J]. Clinical Metabolism, 2023, 38(3): 221.

[11] Sun Baihua, Li Nianying, Wang Tao, et al. Parkinson Cov Kev Hloov hauv plab hnyuv ntawm cov neeg mob leukemia thiab lawv cov kev sib raug zoo nrog cov yam ntxwv kho mob [J]. Phau ntawv Journal ntawm Shanxi Medical University, 2021, 52(2): 214-221.

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kev cai dab qhuas. Neuroscience Letters, 2023, 8 (12): 137380