Tshawb nrhiav Cov Cai Siv Tshuaj Ntawm Cov Tshuaj Suav Ntawm Xib Fwb Huang Wenzheng Rau Kev Kho Mob Raum Kab Mob Raws Li Cov Ntaub Ntawv Mining

Hu rau: Audrey Hu Whatsapp / hp: 0086 13880143964 Email:audrey.hu@wecistanche.com

Shao-Ning Dong, Yao-Guang Wang, Bing Xu, Liang Jin, Cui-Han Wang

Abstract:

Nyob rau hauv xyoo tas los no, kab mob raum mob ntev (CKD) tau txais kev saib xyuas ntau ntxiv vim nws qhov kev pheej hmoo siab thiab qhov tsis zoo. Cov kev xaiv kho mob tam sim no rau CKD raug txwv. Ntau tus neeg mob nrhiav lwm txoj kev kho mob, xws li tshuaj suav tshuaj (TCM). TCM tau siv dav hauv kev kho CKD tau ntau xyoo. Lub hom phiaj ntawm txoj kev tshawb no yog txhawm rau tshawb nrhiav cov cai tswj kev noj tshuaj ntawm xibfwb Huang Wenzheng txoj kev kho CKD nrog Suav tshuaj raws li cov ntaub ntawv mining. Cov ntaub ntawv txheej txheem tsim tau tsim rau 131 tus neeg mob CKD kho los ntawm Prof. Huang. Txoj kev sib tham hauv network tau siv los txheeb xyuas cov cai ntawm cov tshuaj suav tshuaj. Txoj kev tshawb no pom cov pob txha caj qaum thiab peb-theem network ntawm Suav tshuaj rau kev kho mob ntawm CKD los ntawm homogeneous network tsom xam. 5 sab saum toj siv tshuaj ntsuab yog Dan Shen (Radix Sahiae Miltiorrhizae), Fu Ling (Poria). Huang Qin (Radix Scutellariae), Sheng Di Huang (Radix Rehmgnmige Tsis ntev los no), thiab Sha Ren (Fructus Amomi Villosi), feem.

Keywords: Mob raum mob, Huang Wenzheng, Clinical xyaum, complex network

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1. Keeb kwm

Mob raum mob (CKD) yog ib hom kab mob raum uas qhov glomerular filtration rate (GFR) tau qis dua RSV 60ml (min 1.73 m) tsawg kawg yog 3 lub hlis. Lub raum puas yog kuaj los ntawm cov kab mob pathological txawv txav, lossis kev puas tsuaj rau lub raum kev ntsuas ntsuas (xws li ntshav, zis, lossis cov duab hauv plab)[1]. CKD hais txog ntau yam kab mob xws li mob glomerulonephritis, IgA nephropathy, thiab ntshav qab zib nephropathy. Kev tshawb fawb hauv teb chaws tsis ntev los no tau pom tias qhov kev nthuav dav ntawm CKD mus txog 10.8 feem pua hauv Suav teb [2]. CKD tau txais kev saib xyuas ntau ntxiv vim nws qhov muaj feem ntau, cov teebmeem tsis zoo, thiab cov nqi kho mob loj heev [3]. Cov kev xaiv kho mob tam sim no rau cov kab mob raum tsis zoo. Ntau tus neeg mob nrhiav lwm txoj kev kho mob xws li tshuaj suav tshuaj (TCM). TCM tau dav siv los kho ntau yam kab mob hauv Suav teb rau ntau txhiab xyoo. TCM hauv kev kho mob ntawm CKD tuaj yeem txhim kho cov tsos mob, txo hematuria thiab proteinuria, txo cov tshuaj sab hnub poob tsis zoo, ua rau muaj kev tiv thaiv lub raum, thiab txhim kho lub neej zoo ntawm cov neeg mob, txhawm rau txhim kho kev kho mob ntawm CKD. Kev tshawb fawb tau qhia TCM tuaj yeem txhim kho lub raum ua haujlwm los ntawm kev cuam tshuam glomerular filtration rate 4.5] rov qab saib xyuas cov ntaub ntawv kho mob thiab cov ntaub ntawv mining method.

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2. Cov ntaub ntawv thiab cov txheej txheem

2.1 Cov ntaub ntawv Source

Sau thiab sau cov ntaub ntawv kho mob rau CKD yog los ntawm xibfwb. Huang Wenzheng nyob rau hauv TCM Nephropathy Clinic of First Affiliated Hospital of Tianjin University of TCM los ntawm Lub Kaum Hli 20.2003 txog Lub Ib Hlis 13, 2015. Cov ntaub ntawv no tau koom nrog 131 tus neeg mob thiab 1909 mus ntsib hauv tsev kho mob, suav nrog CG yam tsis muaj lub raum biopsy; IgA nephropathy thiab ntshav qab zib nephropathy nrog rau lub raum biopsy, nrog rau lub raum tsis ua haujlwm ntev tau nce los ntawm tus kab mob saum toj no nrog tsis-dialysis-yuav tsum tau lub raum tsis ua haujlwm.

2.2 Cov txheej txheem kuaj mob

2.2.1 Western tshuaj ntsuam xyuas cov qauv

①Ua raws li cov txheej txheem kuaj mob rau CKD hauv raum Kab Mob Qhov Ua Tau Zoo Tshaj Plaws (K / DOQl) tawm los ntawm National Kidney Foundation (NKF) hauv xyoo 2002. CKD yog hais txog kab mob raum puas lossis GFR tsawg dua 60ml / (min·1.73m²) kav ntev li ntawm 3 lub hlis. Lub raum puas yog hais txog lub raum pathological abnormalities, los yog lub raum puas tsuaj indexes (xws li ntshav, zis, los yog imaging abnormalities) [1,2].

② Raws li cov txheej txheem kuaj mob rau cov kab mob nephritis nyob rau hauv tus qauv tsim los ntawm Lub Raum Kab Mob Pab Pawg ntawm Suav Phau Ntawv Xov Xwm ntawm Internal Medicine editorial committee hauv Taiping, Anhui lub rooj sib tham thaum Lub Rau Hli 1922 [6].

③Ua raws li cov txheej txheem kuaj mob rau IgA nephropathy nyob rau hauv Phau Ntawv Qhia Txog Kev Kho Mob thiab Kev Kho Mob: Cov Lus Qhia Txog Kev Kho Mob · Nephrology Volume [7] thiab Nephrology [8] tawm los ntawm Pab Pawg Kab Mob Raum ntawm Tuam Tsev Kho Mob hauv xyoo 2012.

④ Raws li cov txheej txheem kuaj mob ntshav qab zib nephropathy hauv Phau Ntawv Qhia Txog Kev Kho Mob thiab Kev Kho Mob: Cov Lus Qhia Txog Kev Kho Mob, Cov Ntshav Qab Zib Volume [7] muab los ntawm Pab Pawg Kab Mob Raum ntawm Tuam Tsev Kho Mob hauv xyoo 2012 thiab cov txheej txheem kuaj mob rau ntshav qab zib nephropathy hauv WHO [9] .

⑤Ua raws li cov txheej txheem kuaj mob rau lub raum tsis ua haujlwm nyob rau hauv tus qauv tsim los ntawm Pawg Kab Mob Raum ntawm Suav Phau Ntawv Xov Xwm ntawm Internal Medicine editorial committee hauv Taiping, Anhui lub rooj sib tham thaum Lub Rau Hli 1992 [8].

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2.2.2 TCM Syndrome Diagnostic Criteria

Yog tias cov ntaub ntawv kho mob thawj zaug muaj xibfwb Huang Wenzheng cov ntawv sau tseg, cov ntaub ntawv kho mob thawj zaug yuav tsum yeej.

2.3 Kev soj ntsuam cov ntaub ntawv kho mob

2.3.1 Cov Txheej Txheem suav nrog

Tus kab mob ua tau raws li cov txheej txheem kuaj mob ntawm 4 kab mob tau teev tseg saum toj no. Cov ntaub ntawv kho mob ua tiav thiab txhim khu kev qha. Cov neeg mob tau kho nrog TCM decoction nkaus xwb, tsis noj lwm yam tshuaj suav. Tus neeg mob tsis tau txais kev lim ntshav.

2.3.2 Exclusion Criteria

Cov neeg mob uas muaj mob hnyav; Myocardial infarction lossis lub plawv tsis ua haujlwm; Hepatic insufficiency; Malignant hypertension thiab mob hnyav cerebrovascular; Mob ntshav qab zib ketoacidosis; Cov neeg mob uas mob malignancy thiab lwm yam mob tshwm sim los yog mob hnyav; Cov neeg mob uas tau txais kev hloov lub raum; Tsis muaj cov ntaub ntawv kho mob.

2.4. Txoj kev tshawb fawb

Tsim kom muaj cov ntaub ntawv kho mob hauv hluav taws xob nrog kev pab ntawm "Cov ntaub ntawv sib qhia ntawm Kev Kho Mob thiab Kev Tshawb Fawb Kev Kho Mob hauv TCM" (Cov txheej txheem sib qhia luv luv). Nkag mus rau hauv cov ntaub ntawv los ntawm kev siv PL / SQL Development software, siv SQL nqe lus rau query lub database, thiab txuag cov lus nug tshwm sim. Siv Liquorice software los ua homogeneous thiab heterogeneous network soj ntsuam los ntawm kev siv cov txheej txheem network nyuaj, thiab rho tawm 3 qib ntawm cov ntawv sau tshuaj los ntawm cov ntaub ntawv.

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3. Qhov tshwm sim

3.1 Kev tshuaj xyuas cov tshuaj

3.1.1 Tshuaj rau CG

Qib 1 sub-network ntawm cov tshuaj rau CG sawv cev rau thawj feem ntawm xibfwb Huang cov tshuaj hauv kev kho mob (Daim duab 1A), uas Huang Qi (Radix Astragali seu Hedsari) thiab Mai Dong (Radix Ophiopogomis) tuaj yeem noj yin thiab tau txais txiaj ntsig qi. , Shan Yao (Rhizoma Dioscoreae), Fu Ling (Poria), thiab Sha Ren (Fructus Amomi Villosi) tuaj yeem ua kom cov poov xab kom tshem tawm dampness, Bai Mao Gen (Rhizoma Imperatae) tuaj yeem txias ntshav kom tsis txhob los ntshav. Hauv qib 2 sub-network ntawm daim ntawv sau tshuaj, Bian Dou Yi (Pej Txiv Hmab Txiv Ntoo Dolichoris Album), Nws Ye (Folium Nelumbinis), Si Gua Luo (Retinervus Luffae Fructus), thiab Liu Yi San muaj cov tshuaj tshuaj ntsuab uas nquag siv rau lub caij ntuj sov- cua txias. Cov pab pawg ntawm Dan Dou Chi (Semen Sojae Preparatum), Sang Ye (Folium Mori), She Gan (Rhizoma Belamcandae), thiab Ku Xing Ren (Pemen Armeniacae Amarum) zoo li muaj cov tshuaj ntsuab siv dav dav rau kev hnoos cua sov. (Daim duab 1B). Ntxiv mus, lub sub-network nyob rau theem thib peb qhia txog cov khub tshuaj ntsuab uas xibfwb Huang siv ntau zaus rau CG (Daim duab 1C). Ua ke nrog Wu Wei Zi (Fructus Schisandrae Chinensis), Wu Mei (Fructus Mume) tuaj yeem txhawb kev tsim cov kua dej hauv lub cev kom quench nqhis dej thiab noj vin los txhawb lub plawv. Kev sib xyaw ua ke ntawm Di Long (Lumbricus) thiab Hong Hua (Flos Carthami) tuaj yeem qhib cov ntshav thiab dredge collaterals. Dong Kui Zi (Fructus Mahal) nrog Wang Bu Liu Xing (Semen Vaccariae) tuaj yeem txo qis stranguria los ntawm diuresis. Tsis tas li ntawd, Bai Wei (Radix Cwanchi Atrati), Yu Zhu (Rhizoma Polvgonati Odorat), thiab Cong Bai (Bulbus Alii Fistulosi) tuaj yeem kho cua sov cua txias uas cuam tshuam nrog yin deficiency. Jiao Bin Lang (Semen Areca), Ji Nei Jin (Endothelium Corneum Gigeriae Galli), Yu Jin (Radix Curcumae), Fo Shou (Fructus Citri Sarcadactylis), thiab Mai Ya (Fructus Hordei Germinatus) tuaj yeem kho gastrectasia thiab anorexia los ntawm cov khoom noj khoom haus. thiab stagnation. Gua Lou (Fructus Trichosanthis), Xie Bai (Bulbus Alli Macrostemonis), Jiang Xiang (Lignum Dalbergiae Odoriferae), Yan Hu Suo (Rhizoma Corydalis), San Qi (Radix Notoginseng), Hu Bo (Succimum), thiab Gui Ban (Carapax Testudinis ) tuaj yeem kho mob hauv siab, angina, thiab palpitations.