Lub raum-tonifying tshuaj ntsuab cistanche tiv thaiv osteoporosis?
Mar 12, 2022
Hu rau: Audrey Hu Whatsapp / hp: 0086 13880143964 Email:audrey.hu@wecistanche.com
Osteoporosisyog ib qho kab mob hauv cov pob txha metabolic uas tshwm sim los ntawm kev txo cov pob txha loj thiab degradation ntawm cov pob txha microstructure; uas ua rau muaj pob txha fragility thiab nquag mus fractures. Tus kab mob no tuaj yeem pom nyob rau hauv cov poj niam txiv neej thiab hnub nyoog sib txawv, tab sis nws muaj ntau dua hauv cov poj niam postmenopausal thiab cov txiv neej laus. Tam sim no, tsis muaj kev kho mob zoo tagnrho rau kev kho mob ntawmosteoporosis. Cov tshuaj Western feem ntau siv cov vitamin D, calcium, estrogen, calcitonin, thiab fluoride npaj. Txawm hais tias lawv muaj qee yam teebmeem, lawv muaj ntau yam kev mob tshwm sim thiab kim heev. Cov tshuaj suav tshuaj tiv thaiv thiab kho pob txha. Kev tshawb fawb tau txais kev mloog ntau dua thiab tag nrho ntawm kev cia siab. Cov tshuaj suav tshuaj ntseeg tau tiasraumdeficiency yog lub ntsiab ua rauosteoporosis. raum-tonifyingkev kho mob ib txwm tau siv los ua qhov kev kho tseem ceeb rauosteoporosis. Ntau tsoosraum tonifyingtshuaj ntsuab muaj qhov pom tseeb los tiv thaiv thiab khoosteoporosis. Cov kev tshawb fawb pharmacological niaj hnub tau pom tiasraum tonifyingcov tshuaj yuav tiv thaiv tauosteoporosislos ntawm kev tswj ntau lub hom phiaj caj pas ntawm lub caj pas hypothalamus-pituitary, txhawb kev loj hlob thiab kev sib txawv ntawm osteoblasts, inhibiting kev loj hlob thiab kev sib txawv ntawm osteoclasts, txhawb kev ua haujlwm ntawm alkaline phosphatase, thiab cuam tshuam rau kev tso tawm ntawm cytokines.
Osteoporosis
Cistancheyog ib tsob nroj uas belongs rau genus Cisanche ntawm Oroharwhaceae, tseem hu ua suab puam ginseng thiab dayun. Nws yog tsim nyob rau hauv Xinjiang, Inner Mongolia, Gansu, thiab Ningxia. Chen Yaqiong et al. pom tias cov tshuaj pharmacological ntawmCistanchemuaj cov teebmeem ntawm nourishingraumthiab ntxiv dag zog rau cov pob txha thiab cov leeg, uas yog ze ze rau cov pob txha metabolism, thiab tau qhia txog qee yam kev ua haujlwm hauv kev tswj hwm ntawm lub paj hlwb thiab endocrine system, uas zoo ib yam li kev txhim kho ntawm osteogenesis los ntawm zes cov tshuaj hormones; Wei et al. pom tias Total phenylethanoid glycoside, echinacoside, thiab betaine hauvCistanchetxhua tus muaj androgen-zoo li protein synthesis, txhawb cov pob txha matrix nce thiab calcium thiab phosphorus deposition; Zeng Jianchun et al. pom tiasCistancheCov tshuaj noj tshuaj tuaj yeem txhawb nqa kev loj hlob ntawm BMSCs thiab ua rau BMSCs Lub luag haujlwm ntawm kev sib txawv osteogenic. Tam sim no, cov tsiaj uas nquag siv hauv kev kawm ntawmosteoporosisyog nas, tshis, thiab lwm yam. Feem ntau siv txoj kev ntawm kev ua qauv yog txiav tawm ob sab zes qe menyuam qauv ntawm nas (4). Osteoprotegerin (OPG), tseem hu ua osteoclastogenesis inhibitory factor (OCIF), muaj cov kev tswj hwm tseem ceeb ntawm osteoclastogenesis. M-KOOPG osteoporotic nas yog tshwm sim los ntawm homologous recombination ntawm nas embryonic qia hlwb ua rau ib nrab tshem tawm ntawm endogenous OPG gene sequence, thiab tom qab ntawd los ntawm blastocyst kab noj hniav txhaj tshuaj ntawm embryonic qia hlwb thiab nas yug me nyuam ua hauj lwm kom tau OPG noob knockout nas, OPG knockout nas muaj typicalosteoporosisvim muaj ntau ntau osteoclast; piv rau lwm yam tsiaj qauv ntawm theem nrabosteoporosistshwm sim los ntawm ntau yam inducing yam, lawv muaj ib tug ruaj khov qhov teeb meem ntawm systemicosteoporosis. Tus tsiaj nws tus kheej tsis raug kev cuam tshuam sab nraud. Nws yog ib tug zoo tsiaj qauv ntawm thawjosteoporosisthiab tus qauv tsiaj zoo tagnrho rau kev kawm osteoporosis ntawm tag nrho cov tsiaj. Nyob rau hauv txoj kev tshawb no, M-KOOPG osteoporosis nas qauv tau ua tiav los ntawm Xinjiang Medical Animal Model Research Key Laboratory tau siv los soj ntsuam cov txiaj ntsig ntawm cov koob tshuaj sib txawv.Cistancheextract ntawm interleukin 1 (Ⅱ4) thiab qog necrosis nyob rau hauv cov pob txha cov ntaub so ntswg ntawm M-KOOPG nas. Qhov chaw thiab kev nthuav qhia ntawm factor- (TNF-a), los tshawb txog qhovanti-osteoporosismechanism ntawmCistanche.
Suav tshuaj ntsuab cistanche-Anti-osteoporosis
Kev tshwm sim
Kev cuam tshuam ntawm Femur Histopathology Raws li cov pa calcium pathological slices, cov pob txha cortex ntawm pawg qauv yog nyias, tus naj npawb ntawm trabeculae yog sparse, tus naj npawb ntawm cov pob txha pob txha nyob rau hauv cov pob txha pob txha kab noj hniav kuj tsawg, qhov dawb paug cheeb tsam yog loj dua, thiab cov pob txha pob txha ntawm cov pob txha pob txha kab noj hniav kuj tsawg dua, qhov chaw dawb paug loj dua, pob txha kab noj hniav yog li ntawd kuj qhib.Cistancheextract high-dose thiab low-dose pawg, Fushan
Piv nrog rau pawg qauv, cov pob txha trabecular dav, tus lej thiab cov pob txha cortical ntawm US pab pawg tau nce me ntsis, tab sis kev txhim kho tsis tseem ceeb; Tom qab 60 hnub ntawm kev tswj hwm, cov pob txha trabecular dav thiab tus naj npawb ntawm covCistancheextract cov pab pawg siab thiab qis thiab cov pab pawg Fushanmei nce. Piv nrog rau cov qauv pab pawg neeg, cov pob txha trabecula tau dav dav dav hauv cov koob tshuaj ntauCistancheextract pab pawg, thiab cov pob txha microenvironment yog ho txhim kho piv nrog rau cov qauv pawg; Kev faib tawm, tus naj npawb, qhov dav ntawm cov pob txha trabecula thiab cov pob txha pob txha hauv cov pob txha pob txha kab noj hniav hauv cov pab pawg ua kua qis tsis zoo li cov hauv pawg neeg siab.
Qhov cuam tshuam rau kev qhia ntawm IL-1 thiab TNF- hauv cov ntaub so ntswg femoral IL-1 thiab TNF- zoo sib xws nyob rau hauv cov pob txha trabecular pob txha thiab pob txha pob txha kab noj hniav ntawm M-KOOPG nas, feem ntau nyob rau hauv osteoblasts nyob ib ncig ntawm cov pob txha trabecular, Nyob rau hauv lub cytoplasm ntawm osteoclasts thiab pob txha stromal hlwb, qhov zoo qhia cheeb tsam yog xim av daj, thiab cov qauv pab pawg neeg pom muaj zog zoo qhia. Peb caug hnub tom qab kev tswj hwm, IL-1 thiab TNF- tau muaj nyob rau hauv cytoplasm ntawm osteoblasts, osteoclasts, thiab cov pob txha pob txha stromal hlwb nyob rau saum npoo ntawm pob txha trabecula hauv cov pab pawg siab thiab qis ntawmCistancheextract, pawg Fushanmei, thiab pawg qauv. Nws yog qhov pom tseeb tau hais tawm zoo, thiab IL-1 thiab TNF- kuj tau hais tawm hauv cytoplasm thiab nucleus ntawm cov pob txha mos ntawm pob txha mos nrog chondrocytes hauv pawg no. Tom qab 60 hnub ntawm kev tswj hwm, tus naj npawb ntawm IL-1 thiab TNF- cov teeb liab zoo hauv cov pob txha trabecular periphery thiab cov pob txha pob txha hauv cov kab mob siab thiab qis ntawmCistancheextract thiab pab pawg Fushanmei tau txo qis, thiab cov staining yog sib zog dua li hauv pawg qauv. . Saib daim duab 2 thiab 3. Tom qab 30 hnub ntawm kev tswj hwm, qhov kev qhia zoo ntawm IL-1 thiab TNF- nyob rau hauv cov koob tshuaj siab, cov tshuaj qis qis, thiab Fosamax pawg ntawmCistancheextract tau txo qis, thiab tsis muaj qhov sib txawv ntawm qhov sib piv nrog cov qauv pawg; tom qab 60 hnub ntawm kev tswj hwm,Cistanchetau muab rho tawm Piv nrog rau pawg qauv, tus naj npawb ntawm IL-1 thiab TNF- qhia tau zoo ntawm cov hlwb hauv cov kua dej siab thiab qis qis, pawg Fushanmei thiab pawg qauv tau txo qis, qhov sib txawv yog qhov tseem ceeb ( P<0.05), and="" the="">Cistancheextract yog siab, Low-dose pawg thiab Fushanmei pab pawg, qhov zoo qhia ntawm IL-1 , TNF- tsis txawv statistically
Cistanche extract anti-osteoporosis
Sib tham
Lub pathogenesis ntawm bis feem ntau yog tshwm sim los ntawm qhov tsis txaus ntawm cov pob txha resorption thiab cov pob txha tsim nyob rau hauv cov txheej txheem ntawm cov pob txha remodeling los ntawm ntau yam xws li ib puag ncig thiab noob caj noob ces. Kev puas tsuaj ntawm pob txha resorption thiab tsim muaj cov teeb liab molecules. Ntau yam cytokines nyob rau hauv cov pob txha microenvironment kuj koom nrog, tshwj xeeb tshaj yog IIL4 thiab TNF- muaj zog rau nws. Cytokines xws li IILA, IIL-6, TNFe ncaj qha lossis tsis ncaj qha rau OC precursors; induce lawv kom sib txawv rau hauv cov laus OC, txhawb cov pob txha resorption, thiab ua rauosteoporosis. ⅡLA yog inflammatory cytokine uas txhawb cov pob txha resorption. Nws muaj feem xyuam rau kev puas tsuaj ntawm pob txha hauv b, rheumatoid mob caj dab, thiab periodontitis; Nws tuaj yeem cuam tshuam ncaj qha OC monocyte precursor cell fusion, thiab nws tuaj yeem cuam tshuam los ntawm nuclear factor-B. Lub cev activating factor ligand (RANKL) txhawb kev sib txawv osteoclast; txhawb cov pob txha resorption. Cov kev tshawb fawb tau pom tias TNF- tuaj yeem cuam tshuam ncaj qha rau kev sib txawv ntawm osteoclast thiab txhawb nws txoj haujlwm los ua lub luag haujlwm tseem ceeb hauv cov pob txha metabolism. Nws tseem tuaj yeem tswj hwm kev ua haujlwm ntawm osteoclasts hauv daim ntawv paracrine thiab txhawb cov pob txha los ntawm kev cuam tshuam rau OPCG / RANKL / RANK signaling system. Kev nqus tau lees paub tias TNF-ib koom nrog cov txheej txheem ntawm cov pob txha metabolism hauv ntau txoj hauv kev; nws kuj yog ib tug haib cytokine uas txhawb cov pob txha resorption.
Tsoos suav tshuaj ntseeg hais tias covraumtswj cov pob txha thiab tsim cov pob txha, thiab lees paub tias "lub raum" thiab cov pob txha muaj kev sib raug zoo nrog sab hauv, uas yog, lub npe hu ua "lub raum khaws cov ntsiab lus, cov ntsiab lus tsim cov pob txha; cov pob txha tau muab zais rau hauv cov pob txha; ua luam dej txhawb cov pob txha." Cov kev tshawb fawb pom tau hais tias Suav tshuaj rau invigorating lub raum yuav ua rau kom cov kev qhia ntawm VDR mRNA los ntawm activating cov kev qhia ntawm Smad3 mRNA, yog li txhawb cov pob txha tsim: Suav tshuaj rau invigorating lubraumtuaj yeem tswj hwm qhov kev qhia ntawm Smad gene hauv cov pob txha pob txha microenvironment, uas tej zaum yuav yog ib qho ntawm cov txheej txheem molecular ntawm nws cov txiaj ntsig ntawm kev txhawb cov pob txha tsim thiab kho cov pob txha puas. Ib 04. Bian Qin et al. Pom qhov cuam tshuam ntawm cov khoom xyaw zoo ntawm peb tus neeg sawv cev ntawm cov tshuaj suav tshuaj epimedium, psoralen, thiab Ligustrum lucidum ntawm icariin, psoralen, thiab oleanolic acid hauv 3 lub hlis ntawm ovariectomized nas pob txha pob txha mesenchymal qia hlwb (BMSCs). Nws ntseeg tau hais tias lub raum-tonifying Suav tshuaj tuaj yeem txhawb kev sib txawv ntawm osteogenic ntawm BMSCs nyob rau hauv cov nqe lus ntawm kev nce lub extracellular matrix ntawm BMSCs, txhawb txoj kev loj hlob ntawm cov teeb liab txoj kev, thiab nce protein synthesis, thiab thaum kawg ua tiav cov nyhuv ntawm kev kho mob.osteoporosis. Lub ntsiab mechanism tseem yuav kawm nyob rau hauv qhov tob. Cov kev tshawb fawb pharmacological niaj hnub tau lees paub tias cov tshuaj pharmacological ntawmCistanchemuaj cov teebmeem ntawm invigorating lublub raumthiab ntxiv dag zog rau cov pob txha thiab cov leeg; Nws muaj kev tswj hwm cov txiaj ntsig ntawm lub paj hlwb thiab endocrine system thiab muaj feem cuam tshuam nrog cov pob txha metabolism. Fushanmei belongs rau bisphosphonates, uas feem ntau ua tiav covanti-osteoporosiscuam tshuam los ntawm inhibiting pob txha resorption kho los ntawm osteoclasts. Nws yog thawj kab tshuaj rau kev tiv thaiv thiab kev kho mob ntawmosteoporosisnyob rau hauv xyoo tas los no, thiab nws txoj kev kho mob zoo tau raug lees paub hauv tsev thiab txawv teb chaws. Txoj kev tshawb no qhia tau hais tias tom qab 60 hnub ntawm kev tswj hwm tas li, HE staining ntawm nas nyob rau hauv cov pab pawg siab thiab qis ntawmCistancheextract, thiab Fuchsia pab pawg pom tau hais tias qhov dav ntawm cov pob txha trabecula nce, tus naj npawb nce, thiab cov pob txha tawg; cov pob txha cortex thickened, uas yog qhov tseem ceeb piv nrog cov qauv pawg. Qhov txawv; Immunohistochemical Index L48. Tus naj npawb ntawm TNF- zoo qhia cov hlwb yog qhov sib txawv ntawm pawg qauv; Ⅱ4A; TNFa qhia cov cytoplasmic qhia ntawm osteoblasts, osteoclasts, thiab cov pob txha pob txha stromal hlwb nyob rau saum npoo ntawm cov pob txha trabecular Nws raug txo kom ntau qib, uas qhia tias Ⅱ.-, TNEFa ua rau cov pob txha tsim thiab pob txha resorption los ntawm autocrine thiab paracrine forms; qhov no yog ua raws li domestic Fan Hongbin li al. (4). Tsis muaj qhov sib txawv tseem ceeb ntawm pawg, qhia tias Cistanche extract thiab Fushanmei muaj qhov zoo sib xwsanti-osteoporosisteebmeem.
Txoj kev tshawb no kuj pom tias covanti-osteoporosisnyhuv ntawmCistanchedeserticolaextract muaj nyob rau lub sijhawm; Tom qab cov nas tau noj cov tshuaj rau 30 hnub, tus naj npawb ntawm cov pob txha trabecula thiab tus naj npawb ntawm IL- thiab TNF-zoo hlwb tsis sib txawv ntawm plaub pawg. Qhov tseem ceeb: Tom qab 60 hnub ntawm kev tswj hwm, muaj qhov sib txawv tseem ceeb ntawm cov pob txha trabecular thiab IIL-18; TNF-cov lus qhia zoo hauv pab pawg sim, pawg tswj hwm, thiab pab pawg qauv. Kev soj ntsuam pathological kuj tau pom tias tom qab 60 hnub ntawm kev tswj hwm,Cistancheextract tuaj yeem txhim kho cov pob txha trabecular qauv, thiab cov pab pawg neeg siv tshuaj ntau tau zoo tuaj. Yog li ntawd, Rou Ai Rong tuaj yeem txhim kho cov kev hloov pauv ntawm cov nas osteoporotic. Nws qhia tau hais tias lub sij hawm kho ntawmCistancheextract yuav tsum yog tsawg kawg yog ib lub hlis, thiab qhov kev kho mob mus sij hawm ntev txuas ntxiv no kuj zoo ib yam nrog Fushanmei. Xinjiang Rouhuan Rong muaj ntau cov peev txheej hauv Xinjiang. Hauv daim ntawv thov kev kho mob mus sij hawm ntev, tsis muaj qhov tsis zoo tshwm sim ntawm Xinjiang Rouhuanrong. Nws muaj lub zeem muag dav rau kev siv tshuaj. Qhov kev sim no muab cov kev xav rau yav tom ntej kev kho mob daim ntawv thov ntawm Xinjiang Cistanche extract Basis thiab kev sim hauv paus.
Cistanche tonify raum thiaj li boost zus tau tej cov pob txha
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