Endogenous Stem Cells in Homeostasis Thiab Aging Part 3
Jul 11, 2023
7.1 Stem cell lag luam rau cov ntaub so ntswg kho
Ntau yam kev loj hlob thiab peptides, xws li stromal cell-derived factor 1 alpha (SDF-1a), VEGF, G-CSF, thiab Khoom-P, yog paub los npaj cov pob txha pob txha stem/progenitors hlwb xws li HSCs, EPCs, thiab BMSCs thiab pab kho cov ntaub so ntswg hauv cov qauv tsiaj zoo. Cov xwm txheej tshwm sim ntawm cov txheej txheem kho tsis tau raug qhia meej, tab sis ntau qhov kev tshawb fawb txhawb nqa kev koom tes ntawm kev sib koom tes ntawm EPCs thiab BMSCs, ncaj qha lossis tsis ncaj, hauv cov ntaub so ntswg rov ua dua tshiab hauv situ [149–153]. Cov molecules me me lossis biologics tuaj yeem ua tau zoo thiab siv tam sim ntawd los kho cov neeg mob thaum muaj xwm txheej ceev, xws li tom qab mob stroke lossis mob myocardial infarction (AMI), los ntawm kev siv cov neeg mob cov qia hlwb hauv cov qia cell mobilization thiab homing zoo.
Glycoside ntawm cistanche tuaj yeem ua rau muaj kev ua haujlwm ntawm SOD hauv plawv thiab daim siab cov ntaub so ntswg, thiab txo cov ntsiab lus ntawm lipofuscin thiab MDA hauv txhua cov ntaub so ntswg, tshem tawm ntau yam reactive oxygen radicals (OH-, H₂O₂, thiab lwm yam) thiab tiv thaiv DNA puas. los ntawm OH-radicals. Cistanche phenylethanoid glycosides muaj peev xwm tshem tawm cov dawb radicals, muaj peev xwm txo tau ntau dua li cov vitamin C, txhim kho cov haujlwm ntawm SOD hauv cov phev ncua, txo cov ntsiab lus ntawm MDA, thiab muaj qee yam kev tiv thaiv ntawm cov phev ua haujlwm. Cistanche polysaccharides tuaj yeem txhim kho kev ua haujlwm ntawm SOD thiab GSH-Px hauv erythrocytes thiab ntsws cov ntaub so ntswg ntawm cov nas senescent sim los ntawm D-galactose, nrog rau txo cov ntsiab lus ntawm MDA thiab collagen hauv lub ntsws thiab ntshav, thiab nce cov ntsiab lus ntawm elastin, muaj Cov nyhuv scavenging zoo ntawm DPPH, ncua lub sijhawm ntawm hypoxia hauv cov nas senescent, txhim kho cov haujlwm ntawm SOD hauv cov ntshav, thiab ncua lub physiological degeneration ntawm lub ntsws hauv kev sim cov nas nrog cellular morphological degeneration, kev sim tau pom tias Cistanche muaj peev xwm antioxidant zoo. thiab muaj peev xwm los ua ib qho tshuaj tiv thaiv thiab kho cov kab mob ntawm daim tawv nqaij laus. Nyob rau tib lub sijhawm, echinacoside hauv Cistanche muaj lub peev xwm tseem ceeb los tshem tawm DPPH dawb radicals thiab tuaj yeem tshem tawm cov pa oxygen reactive, tiv thaiv dawb radical-induced collagen degradation, thiab kuj muaj kev kho zoo ntawm thymine dawb radical anion puas.
Nyem rau ntawm cistanche amazon
【Yog xav paub ntxiv:george.deng@wecistanche.com / WhatApp:86 13632399501 】
Ntawm cov kev loj hlob ntxiv uas tam sim no tau tsim nyob rau hauv qib kho mob, G-CSF, GM-CSF, VEGF, erythropoietin (EPO), thiab SDF-1a thiab lawv cov kev sib txuas ua ke tau kawm los ntawm lawv cov EPC thiab HSC txhawb nqa lub peev xwm. txhawm rau nrhiav kev kho mob rau cov kab mob ischemic vascular, xws li AMI, ischemic limb disease, mob ntshav qab zib rwj, thiab mob stroke. Lwm cov neeg sib tw tshiab molecules, xws li Khoom-P (SP), uas khaws cia BMSC kev muaj peev xwm, kuj tseem raug tshawb fawb txog kev raug mob thiab kab mob ntawm cov tsiaj, xws li AMI, mob stroke, mob ntshav qab zib rwj, kab mob ischemic limb disease, rheumatoid mob caj dab, qaum. Kev raug mob qaum (SCI), hluav taws xob ua rau lub plab puas tsuaj, thiab pob txha raug mob [153–161].
Qee qhov kev tshawb fawb soj ntsuam tau pom cov txiaj ntsig sib txawv thiab muaj kev cuam tshuam ntau dua li qhov xav tau. Lawv cov txiaj ntsig sib txawv tuaj yeem taw qhia txog qhov teeb meem tseem ceeb ntawm cov ntaub so ntswg rov tsim dua tshiab hauv cov neeg laus: cov ntaub so ntswg rov ua dua tshiab hauv qhov chaw yuav tsum tau rov ua dua ntawm kev loj hlob organogenesis. Yog li, cov tswv yim yuav tsum tau tsim los ua kom zoo-tu thiab tswj cov txheej txheem nyuaj thiab cov hlwb, spatial nrog rau lub sijhawm, raws li cov txheej txheem organogenesis thiab cov yam ntxwv ntawm cov ntaub so ntswg tshwj xeeb raug mob thiab cov neeg mob. Tshwj xeeb tshaj yog, qhov tseem ceeb ntawm qhov tseem ceeb ntawm cov ntsiab lus xav tau, hauv zos thiab hauv lub cev, txhawm rau pib kev lag luam ntawm progenitor thiab qia hlwb mus rau lub hom phiaj ntawm lub cev tsis paub ntau. Tsis tas li ntawd, cov khoom siv ntawm tes, xws li cov cell myeloid thiab lymphocytes, tuaj yeem tso cov khoom siv los tswj cov kab mob inflammatory, tshem tawm cov cell tuag los npaj cov ntaub so ntswg ib puag ncig rau cov kab mob rov qab los, thiab pab txhawb kev nrhiav neeg ua haujlwm hauv zos thiab muab tso rau ntawm cov hlwb mus rau. reconstruct ib tug zoo txhais cov ntaub so ntswg architecture. Cov luag haujlwm no tsis tau txiav txim siab tob rau cov ntaub so ntswg rov ua dua tshiab hauv qhov chaw.
Vim tias muaj ntau yam kab mob uas muaj hnub nyoog muaj feem cuam tshuam tuaj yeem raug txiav txim siab los ntawm kev kho cov ntaub so ntswg tsis zoo thiab rov qab los ntawm cov ntaub so ntswg qis txhua hnub uas tshwm sim los ntawm ntau yam kev thuam thiab kab mob thoob plaws hauv lub neej, ntau yam endogenous, yav tas los txheeb xyuas hauv qia cell nws tus kheej. -Kev rov ua dua tshiab thiab kev lag luam thiab kev yooj yim ntawm kev kho cov ntaub so ntswg, tuaj yeem yog cov neeg sib tw rau kev tiv thaiv kev laus. Qee tus ntawm lawv muaj kev sib raug zoo nrog cov tsos mob ntawm cov kab mob ntev thiab kev laus phenotype, tab sis pov thawj ntawm lawv lub luag haujlwm hauv kev laus yog lub ntsiab lus yav tom ntej rau daim teb no.
7.2 SP raws li BMSC mobilizer thiab anti-inflammatory modulator: kev cia siab rau kev tiv thaiv kev laus
SP yog ib qho 11-amino acid neuropeptide secreted los ntawm peripheral terminals ntawm lub paj hlwb sensory, qhov twg nws ua raws li ib tug neurotransmitter los yog hormone. Subsets ntawm neurons nyob rau hauv nruab nrab thiab peripheral paj hlwb [162], non-neuronal hlwb nrog rau cov macrophages thiab T lymphocytes, lub cev tsis muaj zog, thiab pob txha pob txha stroma [163, 164] qhia SP thiab lwm yam peptides structurally ntsig txog [165], tag nrho cov uas. yog encoded los ntawm tib lub noob, preprotachykinin-1 (PPT-1). Ntxiv mus, SP receptor neurokinin 1 receptor yog qhia rau ntau yam ntawm cov hlwb uas tsis yog neuronal, xws li BMSCs, chondrocytes, osteocytes, osteoblasts, osteoclasts, thiab mast cells [166–168]. SP mediates qhov mob xaav, neuro-immune modulation, cell proliferation, thiab txhim khu kev loj hlob thiab kev sib txawv ntawm endothelial hlwb, tag nrho cov uas yuav tsum tau los ntawm nws lub zos ua: ncaj paj hlwb innervation thiab ncaj qha cellular hu [169, 170]. Ntxiv rau nws qhov kev ua haujlwm hauv zos, cov tshuaj txhaj tshuaj SP ua haujlwm ua haujlwm los txhawb CD29. stromal-zoo li cov hlwb (xws li BMSCs) los ntawm cov pob txha pob txha mus rau qhov chaw ntawm cov ntshav, ua rau kom ceev qhov txhab kho [153–161]. Qhov kev ua haujlwm tshiab no ntawm SP tau pib pom tias yog tus xa xov raug mob-inducible los ua kom lub qhov txhab kho qhov txhab endogenous, uas rov qab BMSCs mobilizing thiab homeing rau cov ntaub so ntswg raug mob.
Ntxiv rau nws txoj haujlwm BMSC mobilizer, SP txhim kho BMSC-mediated immune modulation ntawm BMSC lig dhau los ntawm kev zais TGF-b1. SP-induced BMSCs inhibit qhov ua kom CD4? Jurkat T hlwb thiab txo qhov tso tawm ntawm IL-2 thiab IFN-c los ntawm T hlwb txawm tias muaj qhov ua kom muaj zog xws li LPS lossis CD3 / CD28 cov tshuaj tiv thaiv [171]. Tsis ntev los no, SP txoj haujlwm tshiab raws li cytokine tau txheeb xyuas; SP tuaj yeem ncaj qha polarize monocyte thiab macrophage phenotypes [172]. SP txhawb nqa cov pob txha pob txha-derived monocytes thiab macrophages los ua cov ntaub so ntswg kho M2 macrophages los ntawm NK-1R signaling uas qhia txog arginase-1 thiab secretes anti-inflammatory cytokine IL-10 [172]. Tsis tas li ntawd, SP txhawb kev tsiv teb tsaws ntawm monocytes los ntawm cov pob txha pob txha thiab lawv cov infiltration mus rau cov ntaub so ntswg raug mob ntawm nas nrog SCI. Yog li ntawd, tau txais kev hloov pauv SP-induced M2 macrophages mus txog SCI qhov chaw mob thiab txhim kho SCI kev ua haujlwm rov qab. Sib sau ua ke, SP tuaj yeem muaj lub luag haujlwm tseem ceeb hauv kev kho cov ntaub so ntswg los ntawm kev nrhiav cov qia hlwb los ntawm cov pob txha pob txha, nrog rau kev tiv thaiv kab mob hauv lub cev, hauv zos, thiab hauv cov pob txha pob txha qia cell niche. Nws yog ib qho tseem ceeb ntawm kev tswj hwm kev loj hlob, kev saib xyuas, thiab kev ua haujlwm ntawm HSCs, BMSCs, thiab EPCs. Vim tias qib SP hauv cov ntshav qis qis hauv cov neeg mob ntshav qab zib thiab cov neeg mob uas muaj kab mob plawv, nws lub luag haujlwm hauv kev nrhiav kev kho cov ntaub so ntswg zoo, tshwj xeeb tshaj yog nyob rau hauv cov ntaub so ntswg raug mob, tej zaum yuav tsis raug tua zoo rau cov laus thiab cov neeg muaj cov kab mob. . Yog li, SP lossis nws cov tshuaj sib npaug tuaj yeem tsim kho kom rov zoo li homeostatic basal theem ntawm SP thiab nws cov kev raug mob-kho cov txheej txheem induction.
8 Kev xaus thiab kev pom
Txoj kev tshawb no tau muab cov ntsiab lus nthuav dav ntawm lub cev lub cev homeostatic lub luag haujlwm ntawm cov kab mob endogenous / precursor hlwb hauv cov pob txha pob txha (HSCs, BMSCs, thiab EPCs), nrog rau lawv cov kev ua haujlwm tsis zoo hauv ntau yam kab mob ntev thiab kev laus. Cov neeg sib tw cov txheej txheem los yog cov khoom me me uas txhawb kev laus lossis rov ua kom rov zoo dua, o, qia cell lag luam, thiab kho cov ntaub so ntswg raug tshuaj xyuas los ntawm qhov kev xav ntawm lub hnub nyoog- lossis kab mob-kev hloov pauv, thiab cov hom phiaj pharmacological tau elucidated rau kev tiv thaiv kev laus, retardation ntawm senescence. nyob rau hauv ex vivo cell kab lis kev cai, thiab kab mob kho cov neeg ua haujlwm. Cov kev tshawb fawb soj ntsuam ntawm cov qia cell kho tau qhia ntau yam kev txwv ntawm lub xeev tam sim no ntawm ex vivo kab lis kev cai qia cell kho. Txawm li cas los xij, cov xwm txheej uas txhawb nqa qia cell rov ua dua nws tus kheej thiab rov ua kom tsis muaj zog uas tau hais hauv qhov kev tshuaj xyuas no tuaj yeem muab txoj hauv kev tshiab rau kev kho qia cell. Cov kev tshawb fawb yav tom ntej uas siv cov kev laus thiab cov hnub nyoog muaj feem cuam tshuam txog cov kab mob degenerative tuaj yeem lees paub cov kev cia siab zoo.
Kev lees paubTxoj haujlwm no tau txais kev txhawb nqa los ntawm Grants NRF2016M3A9B4917320 los ntawm Kauslim Ministry of Science, ICT thiab Future Planning, thiab HI13C1479 los ntawm Korean Ministry of Health thiab Welfare rau Dr. Y Son.
Ua raws li cov qauv kev coj ncaj ncees
Kev tsis sib haum xeebCov neeg sau ntawv tsis muaj teeb meem nyiaj txiag ntawm kev txaus siab.
Hais lus ncaj nceesTsis muaj kev sim tsiaj ua tiav rau tsab xov xwm.
Cov ntaub ntawv
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