Cov teebmeem ntawm Dingjifumai Decoction Ntawm Electrocardiogram Thiab Sodium Potassium Pump Ntawm Cov nas Nrog Ventricular Arrhythmia
Mar 12, 2022
Hu rau: Audrey Hu Whatsapp / hp: 0086 13880143964 Email:audrey.hu@wecistanche.com
Ling Fu, Hui-Ling Liao, Yan Zhou, Fei Hu Zou, Ling Luo
1 Chongqing Traditional Chinese Medicine Hospital, Chongqing, Suav.
2 Southwest Medical University, Luzhou, Sichuan, Suav. 3Traditional Chinese Medicine Hospital, TongLiang, Chongqing, Suav.
Qhov tseem ceeb
Hauv txoj kev tshawb no, cov teebmeem ntawm Dingjifumai Decoction thiabcistanche(DJFM) ntawm Electrocardiogram thiab sodium-potassium twj tso kua mis ntawm nas nrog ventricular arrhythmia tau pom, thiab cov teebmeem thiab cov txheej txheem ntawm DJFM ntawm ventricular arrhythmia tau tham. Peb pom tias DJFM tuaj yeem ncua lub sijhawm tshwm sim ntawm lub plawv arrhythmias tshwm sim los ntawm aconitine hauv nas, xws li VP, VT, VF, thiab al. Cov txheej txheem yuav cuam tshuam rau Na plus channel ceev, thiab nws tuaj yeem tiv thaiv thiab tswj cov arrhythmias los ntawm inhibiting Na plus influx thiab txo cov lus teb ceev ceev ntawm cellular tus kheej-kev qhuab qhia. DJFM tuaj yeem tiv thaiv cov ntaub so ntswg myocardial sodium-potassium twj tso kua mis, uas tuaj yeem tiv thaiv cov hlwb myocardial thiab txhim kho cov metabolism hauv myocardial.
Abstract
Lub Hom Phiaj: Tshawb xyuas cov txiaj ntsig ntawm Dingjifumai Decoctionthiabcistanche(DJFM) ntawm Electrocardiogram (ECG) thiab sodium-potassium twj tso kua mis hauv nas nrog ventricular arrhythmia. Txoj kev: Plaub caug txiv neej noj qab nyob zoo SD nas (200 20g) tau muab faib ua pawg dawb huv, pawg qauv, pawg Metoprolol, thiab DJFM pawg. Kaum nas nyob rau hauv txhua pab pawg tau noj nrog ib txwm noj thiab haus dej dawb. Txhua pab pawg tau muab gavage, thiab tus nqi ntawm gavage nyob rau hauv txhua pab pawg raug xam raws li lub cev hnyav. Hauv pawg qauv, 0.001 feem pua Aconitine tau txhaj rau hauv cov leeg ntawm tus Tsov tus tw ntawm 30ug / kg. Hauv pawg Metoprolol, Metoprolol raug ncua raws li tus qauv ntawm 5.2mg / kg ib hnub. Hauv pawg DJFM, DJFM tau muab 17.6g / kg ib hnub. Tom qab 2 lub lis piam ntawm kev tswj hwm, kev sim biologic BL-420F tau siv los saib xyuas II lead ECG nkhaus, thiab ECG hloov pauv tau pom thiab sau tseg. Tom qab ntawd, lub ventricle ntawm tus nas raug coj mus, thiab kuaj pom ib feem ntawm lub plawv cov ntaub so ntswg sodium-potassium twj tso kua mis. Cov txiaj ntsig: (1) Cov nyhuv ntawm DJFM(Dingjifumai Decoction thiabcistanche) ntawm ECG ntawm nas nrog ventricular arrhythmia: Tom qab txhaj tshuaj aconitine, qhov tshwm sim ntawm Ventricular Premature beat (VP), Ventricular Tachycardia (VT), Ventricular Fibrillation (VF) hauv pawg qauv yog 10{{4 }} feem pua , qhia tias cov qauv tsim ntawm nas nrog ventricular arrhythmia tau ua tiav. (2) VP, VT, thiab VF lub sijhawm: Piv nrog rau pawg qauv, pawg DJFM, thiab Metoprolol pab pawg tuaj yeem ncua sijhawm rau VP, VT, thiab VF, qhov sib txawv yog qhov tseem ceeb (P < 0.="" {12}}5).="" cov="" txiaj="" ntsig="" ntawm="" pawg="" djfm="" thiab="" pawg="" metoprolol="" ncua="" sij="" hawm="" qhov="" tsos="" ntawm="" vp,="" vt="" thiab="" vf="" yog="" tib="" yam,="" tsis="" muaj="" qhov="" sib="" txawv="" tseem="" ceeb="" (p=""> 0.05). (3) Cov nyhuv ntawm DJFM ntawm sodium-potassium twj tso kua mis nyob rau hauv nas ventricular arrhythmia lub plawv cov ntaub so ntswg: Piv nrog rau cov dawb paug pab pawg neeg, tus nqi ntawm sodium-potassium twj tso kua mis nyob rau hauv cov qauv pab pawg neeg tau txo qis, thiab qhov sib txawv tseem ceeb (P <0.05). ).="" piv="" nrog="" rau="" pawg="" qauv,="" cov="" nqi="" ntawm="" sodium-potassium="" twj="" tso="" kua="" mis="" ntawm="" cov="" ntaub="" so="" ntswg="" hauv="" metoprolol="" pawg="" thiab="" djfm="" pawg="" tau="" nce,="" thiab="" qhov="" sib="" txawv="" yog="" qhov="" tseem="" ceeb="" (p=""><0.05). tsis="" muaj="" qhov="" sib="" txawv="" tseem="" ceeb="" hauv="" sodium-potassium="" twj="" nruab="" nrab="" ntawm="" pawg="" metoprolol="" thiab="" djfm="" pawg="" (p=""> 0.05). Xaus: 1. Cov qauv nas ntawm ventricular arrhythmia tuaj yeem ua tiav los ntawm kev txhaj tshuaj ntawm Aconitine hauv cov hlab ntsha. 2. DJFM(Dingjifumai Decoction thiabcistanche)tuaj yeem ncua sij hawm tshwm sim ntawm lub plawv arrhythmias tshwm sim los ntawm aconitine hauv nas, xws li VP, VT, VF, thiab al. Cov txheej txheem yuav cuam tshuam rau Na plus channel ceev, thiab nws tuaj yeem tiv thaiv thiab tswj cov arrhythmias los ntawm inhibiting Na plus influx thiab txo cov lus teb ceev ceev ntawm cellular tus kheej-kev qhuab qhia. 3. DJFM(Dingjifumai Decoction thiab cistanche)tuaj yeem tiv thaiv cov ntaub so ntswg myocardial sodium-potassium twj tso kua mis, uas tuaj yeem tiv thaiv cov hlwb myocardial thiab txhim kho cov metabolism hauv myocardial.
Keywords: Dingjifumai Decoction, Ventricular Arrhythmia, nas, Electrocardiogram, sodium-potassium twj tso kua mis
cov txiaj ntsig cistanche
Keeb kwm
Ventricular Arrhythmia (VA) yog ib hom kev kho mob plawv mob xwm txheej ceev, Ventricular Premature beat (VP), Ventricular Tachycardia (VT), Ventricular Fibrillation (VF) thiab lwm yam tag nrho rau VA [1] qeb, Feem ntau ua rau muaj ntau yam. organic plawv kab mob, kab mob uas tsis yog mob plawv, electrolyte acid-base balance disorders, thiab lwm yam. [2]. Qhov kev tsis txaus ntseeg thiab muaj feem cuam tshuam txog kev puas tsuaj ntawm VA yog yuam cov kws kho mob nrhiav kev kho mob los tiv thaiv thiab kho VA. Tam sim no, plaub hom tshuaj tiv thaiv arrhythmic uas feem ntau siv hauv kev kho mob muaj cov kev mob tshwm sim tseem ceeb ua rau mob arrhythmias tshiab, thaum cov tshuaj suav tshuaj muaj tsawg dua cov kev mob tshwm sim thiab kev ua haujlwm ruaj khov, thiab tuaj yeem txo cov kev mob tshwm sim ntawm cov tshuaj western anti-arrhythmias [3 ]. Yog li ntawd, nws yog ib qho tseem ceeb heev los txhim kho Suav tshuaj ntsuab zoo rau kev tiv thaiv thiab kev kho mob ntawm ventricular arrhythmia. Hauv kev kuaj mob thiab kev kho mob, nws tau pom tias(Dingjifumai Decoction thiab cistanche)(DJFM) muaj txiaj ntsig zoo hauv kev tiv thaiv ventricular arrhythmia, yog li qhov kev sim no tau tsim los rau kev tshawb fawb.
Cov ntaub ntawv thiab cov txheej txheem
Cov ntaub ntawv sim thiab cov cuab yeej siv
Kev sim tsiaj plaub caug tus txiv neej noj qab haus huv SD nas ntawm qib huv, qhov hnyav (200 20) g (muab los ntawm Animal Experiment Center ntawm Southwest Medical University, daim ntawv tso cai naj npawb: SCXK (Chuan) 2013-17). Kev ua pab pawg thiab kev ua cov nas tau hnyav thiab muab kev yoo mov rau 3 hnub, thiab tom qab ntawd muab faib ua 4 pawg thiab suav nrog, 10 nas nyob rau hauv txhua pab pawg, raws li pawg neeg dawb huv (ib txwm saline 2ml / 200g), pawg qauv (ib txwm saline 2ml / 200g), Metoprolol pawg thiab (Dingjifumai Decoctionand cistanche). Cov pab pawg Metoprolol tau muab tshuaj rau Metoprolol ncua kev noj tshuaj txhua hnub ntawm 5.2mg / kg. DJFM yog tsim los ntawm Suanzaoren (Ziziphus jujuba Mill.var.Spinosa), Fusion (Poria cocos Schw.), Long gu (OsDraconis), Muli (Oyster), Guizhi (CassiaTwig), Yuanzhi (Polygala tenuifolia Willd.), Dazao (Ziziphus. zizyphus), Hehuanpi (Silk ntoo Albizia Bark), Zhigancao (Glycyrrhizae.), thiab al. Nws yog yuav los ntawm Sichuan Tshiab Green Pharmaceutical Technology Development Co. LTD. Txhua tus nas tau muab tshuaj ib zaug ib hnub nrog koob tshuaj 17.6 g / kg ib hnub rau tag nrho 14 hnub.
Kev tsim qauv
Cov nas tau hnyav ua ntej qhov kawg gavage ntawm 14 hnub. Kaum nas nyob rau hauv txhua pab pawg tau txhaj nrog 1 feem pua pentobarbital sodium ntawm 30mg / kg thiab tshuaj loog. Cov nas tsuag tshuaj loog tau muab tso rau hauv ib qho chaw nyob rau ntawm lub rooj ntoo. Ntxig lub koob acupuncture rau hauv nas, txuas cov electrode thiab electrocardiogram (ECG) [12]. Kev taug qab II coj ECG, sau cov ECG ib txwm, zeroing LUB hauv paus, tos tus nas ECG kom ruaj khov, pawg qauv tam sim txhaj tshuaj 0.001 feem pua Aconitine 30 ug / kg daws los ntawm tus Tsov tus tw leeg, thiab qhov khoob. pab pawg txhaj koob tshuaj 0.9 feem pua saline. Lub bolus ua tiav hauv 5 vib nas this, thiab pib sau ECG rau 20 feeb, kaw VP, VT, thiab VF hauv lub sijhawm. Tom qab kev soj ntsuam, txiav lub hauv siab ntawm daim tawv nqaij thiab thav duab nrog txiab, tam sim ntawd qhib lub hauv siab, txiav tag nrho cov hlab ntsha uas txuas nrog lub plawv cov ntaub so ntswg noj qab haus huv lub plawv thiab tshem tawm tag nrho lub plawv, nyem tawm cov ntshav nyob rau hauv lub plawv kab noj hniav, thiab qhuav cov ntshav seem nyob rau saum npoo ntawm lub plawv gauze. Tom qab ntawd, sab laug ventricle txiav yog excised, thiab ib feem ntawm qhov txiav yog muab tso rau hauv ib tug cryotube, khaws cia nyob rau hauv ib tug - 80 C tub yees, thiab lub plawv cov ntaub so ntswg sodium-potassium twj tso kua mis nrhiav tau ua raws li cov khoom qhia. .
cistanche extract
Cov txiaj ntsig
Kev tsim qauv
Nyob rau hauv txoj kev tshawb no, aconitine tsis tau siv los ua kom muaj arrhythmias nyob rau hauv pab pawg neeg dawb paug, yog li VP, VT, VF, thiab lwm yam VA tsis tshwm sim nyob rau hauv pab pawg neeg dawb paug, yog li cov khub-raws li kev sib piv ntawm cov kev sim tau tsis koom nrog pawg dawb huv. Tom qab txhaj tshuaj Aconitine, qhov tshwm sim ntawm VP, VT, thiab VF hauv pawg qauv yog 100 feem pua, qhia tias VA nas qauv tau ua tiav. (Daim duab 1)
Cov teebmeem ntawm DJFM(Dingjifumai Decoction thiab cistanche)ntawm ECG ntawm nas nrog VA
① Qhov tshwm sim ntawm VP: Piv nrog rau pawg qauv, lub sijhawm ntawm VP tau qeeb qeeb hauv DJFM(Dingjifumai Decoction thiabcistanche)pab pawg thiab pawg metoprolol, thiab qhov sib txawv yog qhov tseem ceeb (P < {{0}}}="" 05),="" thaum="" qhov="" sib="" txawv="" ntawm="" pawg="" metoprolol="" thiab="" djfm="" pawg="" tsis="" tseem="" ceeb="" (p=""> 0 {8}}5). ② Lub sijhawm pib ntawm VT: Piv nrog rau pawg qauv, lub sijhawm pib ntawm VT tau qeeb qeeb hauv pawg DJFM thiab pawg Metoprolol, thiab qhov sib txawv yog qhov tseem ceeb (P < 0.05),="" thaum="" qhov="" sib="" txawv="" nruab="" nrab="" ntawm="" pawg="" metoprolol="" thiab="" djfm="" pawg="" tsis="" tseem="" ceeb="" (p=""> 0.05). ③ Lub sijhawm tshwm sim ntawm VF: Piv nrog rau pawg qauv, lub sijhawm tshwm sim ntawm VF tau qeeb qeeb hauv pawg DJFM thiab pawg Metoprolol, thiab qhov sib txawv yog qhov tseem ceeb (P <0.05), thaum="" qhov="" sib="" txawv="" ntawm="" pawg="" metoprolol="" thiab="" djfm="" pawg="" tsis="" yog="" qhov="" tseem="" ceeb="" (p=""> 0.05). (Table 1)
Cov nyhuv ntawm DJFM(Dingjifumai Decoction thiab cistanche)ntawm sodium-potassium twj tso kua mis hauv VA lub plawv cov ntaub so ntswg ntawm nas
Piv nrog rau cov pab pawg neeg dawb paug, cov nqi ntawm sodium-potassium twj tso kua mis nyob rau hauv cov qauv pawg tau txo qis, thiab qhov sib txawv yog qhov tseem ceeb (P < 0.05).="" piv="" nrog="" rau="" cov="" qauv="" pab="" pawg,="" sodium-potassium="" twj="" tso="" kua="" mis="" nqi="" ntawm="" cov="" ntaub="" so="" ntswg="" hauv="" metoprolol="" pawg="" thiab="">(Dingjifumai Decoction thiabcistanche) group increased, and the difference was statistically significant (P < 0.05). There was no significant difference in the sodium-potassium pump between the metoprolol group and the dDJFM group (P>0.05). (Table 2, Daim duab 2).
cistanche ntxiv: txhim kho kev tiv thaiv
Kev sib tham
Cov qauv tsiaj ntawm VA yog tsim los ntawm luav, guinea npua, nas, nas, miv, dev lossis tshis, thiab lwm yam. Cov nas yog ib qho yooj yim kom tau txais thiab siv dav, nrog cov qauv ntawm lub cev thiab lub cev zoo ib yam li tib neeg, yog li lawv tau siv dav hauv VA qauv [4]. Kev tsim kho ntawm VA qauv muaj ntau txoj hauv kev xws li tshuaj tua kab mob, hluav taws xob stimulation-induced, coronary artery ligation, thiab kev ntxhov siab vim VA. Txoj kev siv yeeb tshuaj yog kev ua haujlwm yooj yim dua, tswj tau qhov xwm txheej, ruaj khov, lub sijhawm luv luv, thiab kev ua tiav siab. Yog li no txoj kev sim no yog induced los ntawm cov tshuaj.
Aconitine yog lub npe hu ua alkaloid ua rau arrhythmia. Nws cov txheej txheem ntawm kev ua kom induce ventricular arrhythmia yog muaj peev xwm ua rau myocardial cell membrane ntawm high voltage-gated sodium channels ua rau ua kom. Tom qab ua kom cov Na ntxiv channel, nws yog nyob rau hauv ib qho qhib lub xeev, thiab influx ntawm Na ntxiv nyob rau hauv myocardial cell nce, uas accelerates lub depolarization ntawm cell membrane, yog li ua rau nws tus kheej-kev qhuab qhia ntawm ib tug pacemaker, uas induces ectopic atherosclerosis point. [4-6]. Aconitine tuaj yeem nce Ca2 ntxiv rau hauv cov hlwb myocardial los ntawm kev nthuav tawm ntawm ICA-L, induced intracellular Ca2 ntxiv rau kev nce siab ua haujlwm, qeeb depolarization [8]. Nws tuaj yeem txhim kho kev tswj tus kheej ntawm cov hlwb nrawm, yog li tsim ib qho los yog ntau qhov chaw ntawm heterotopic atherosclerosis, shortening lub sij hawm refractory ntawm myocardium thiab ua rau arrhythmia.
Cov hlwb myocardial yuav luag txhua qhov tso siab rau aerobic metabolism. Sodium potassium twj tso kua mis yog biofilm enzyme system ubiquitous ntawm lub cell membrane ntawm lub cev [8-10]. Nws lub luag haujlwm tseem ceeb yog thauj Na plus thiab K ntxiv hla cov membrane. Nws tuaj yeem tiv thaiv electrochemical gradient ntawm ob sab ntawm lub cell membrane thaum hydrolyzing ATP thiab ua kom cov ion concentration sib txawv sab hauv thiab sab nraum daim nyias nyias ruaj khov, ua kom qhov sib npaug ntawm electrolyte thiab kua dej, tswj kev ua haujlwm ntawm sodium-potassium twj tso kua mis muaj txiaj ntsig zoo. normal physiological kev ua haujlwm ntawm cov hlwb. Myocardial membrane Sodium potassium twj tso kua mis kuj yog lub plawv glycoside receptor, uas ua lub luag haujlwm tswj hwm hauv cov metabolism thiab ua haujlwm ntawm lub plawv, thiab txhim kho lub peev xwm ntawm kev tiv thaiv arrhythmia los ntawm ntau qhov kev xav. Sodium potassium twj tso kua mis tuaj yeem hydrolyze ATP kom tso tawm lub zog thiab paub txog kev ua haujlwm tas mus li ntawm sodium-potassium twj tso kua mis los ntawm kev rov qab electrochemical gradient. Tsuas yog tswj xyuas cov dej num ntawm sodium-potassium twj tso kua mis tuaj yeem tswj qhov sib txawv ntawm ion concentration thiab xyuas kom muaj hluav taws xob ua haujlwm ntawm cov ntaub so ntswg. Thaum myocardial cell sodium-potassium twj tso kua mis yog inhibited, ib tug series ntawm kev hloov nyob rau hauv ion ndlwg yuav tshwm sim, ua extracellular Na ntxiv ntws mus rau hauv lub cell, thiab intracellular Na ntxiv nce indirectly activates Na plus -Ca2 ntxiv pauv protein, ua intracellular Ca2 ntxiv thiab ntau. ua rau Ca2 ntxiv rau overload ua rau puas myocardial contractility [11], yog li ua rau ventricular arrhythmia. Yog li ntawd, cov ntsiab lus ntawm sodium-potassium twj tso kua mis nyob rau hauv lub plawv myocytes yog ib qho tseem ceeb qhia rau saib xyuas qhov tshwm sim ntawm ventricular arrhythmias.
DJFM(Dingjifumai Decoction thiabcistanche)muaj kaum hom tshuaj suav tshuaj xws li Suanzaoren, Fushen, Chuanxiong, Longgu, Muli, Guizhi, Yuanzhi, Dazao, Hehuanpi, Zhigancao. Cov tshuaj no tsuas yog siv txoj hauv kev los txhawb cov ntshav, txhawb cov ntshav, ua kom muaj zog, thiab txhawb nqa Yin. Nyob rau hauv cov tshuaj no, Suanzaoren plays lub luag hauj lwm ntawm huab tais nyob rau hauv tsoos suav tshuaj formulation thiab muaj flavors ntawm qab zib thiab qaub. Nws ua rau lub plawv meridian thiab lub siab meridian, thiab muaj lub luag haujlwm ntawm kev txhawb nqa lub plawv yin, ntxiv rau cov ntshav siab, thiab ua kom lub siab. Fushen plays lub luag haujlwm ntawm tus thawj tswj hwm hauv kev tsim tshuaj suav tshuaj suav tshuaj thiab muaj qhov xwm txheej ntawm kev thaj yeeb nyab xeeb thiab qab ntxiag thiab qab ntxiag. Nws ua rau lub plawv meridian thiab spleen meridian thiab muaj kev ua haujlwm ntxiv rau lub plawv thiab tus po thiab tranquilizing lub siab. Chuang Xiong plays lub luag hauj lwm ntawm tus pab nyob rau hauv cov tsoos suav tshuaj formulation thiab muaj nuj nqi ntawm tonifying Qi thiab activating ntshav. Guizhi plays lub luag hauj lwm ntawm tus pab nyob rau hauv cov tsoos suav tshuaj formulation thiab muaj zog ua kom sov lub plawv-Yang, txhawb lub plawv-ntshav kev, warming tus po thiab plab, thiab txhim kho cov tsos mob xws li palpitation. Cov dej num ntawm kev sib raug zoo ntawm cov tshuaj ntawm Chuangxiong, Guizhi, thiab Suanzaoren yog nourishing ntshav, activating ntshav, thiab txhim kho lub peev xwm ntawm kev koom ua ke ntawm enriching ntshav thiab txhawb cov ntshav ncig los ntawm kev sib txuas ntawm acrid saj rau dispersing, pungent-sov thiab qaub rau astringbg. Zhiyuan plays lub luag hauj lwm ntawm tus pab nyob rau hauv cov tsoos suav tshuaj formulation thiab muaj nuj nqi ntawm tranquilizing lub siab thiab tshem tawm phlegm. Hehuanpi ua lub luag haujlwm ntawm tus pabcuam hauv cov tshuaj suav tshuaj suav tshuaj thiab muaj lub luag haujlwm ntawm kev ua kom lub siab thiab sib haum xeeb qi thiab ntshav. Longgu thiab Muli ua lub luag haujlwm ntawm tus pab cuam hauv cov tshuaj suav tshuaj suav tshuaj thiab muaj lub luag haujlwm ntawm kev ua kom muaj zog, ua kom muaj zog Yin, thiab kev sib tham dissipation ntawm lub plawv Qi. Cais, Longgu muaj cov nyhuv tranquilizing ntawm daim siab meridian thiab Muli muaj cov nyhuv ntawm anchoring lub siab ntawm lub ntsws meridian. Zhigancao thiab Suanzaoren ua lub luag haujlwm ntawm cov lus qhia hauv cov tshuaj suav tshuaj suav tshuaj. Ci Licorice muaj cov nyhuv ntawm Yin-enriching, Qi-boosting, dredging Yang, thiab rov qab cov mem tes. Fructus Ziziphi Jujubae muaj cov nyhuv invigorating tus po kom ntxiv Qi, nourishing ntshav, thiab tranquilizing lub hlwb.
Cov tshuaj no ua ke nrog Suanzaoren nrog Longgu, Muli, thiab al. rau lub hom phiaj ntawm kev ua kom muaj kev sib koom ua ke thiab kho cov nyhuv, zam qhov tsis zoo ntawm kev ua haujlwm tsis zoo thiab tsis ruaj khov ntawm cov khoom siv tshuaj ib leeg. Cov tshuaj no ua ke nrog cov tshuaj no muaj cov txiaj ntsig zoo ntawm cov ntshav, txhawb cov ntshav, ua kom lub siab, thiab txhawb nqa Yin. Cov kev tshawb fawb soj ntsuam pom tau hais tias Suanzaoren qhov xwm txheej yog nyob ntsiag to, tsw yog qaub thiab qab zib, thiab cov khoom tseem ceeb ntawm Cov Tsiaj qus jujube yog saponins, flavonoids, alkaloids, thiab lwm yam. Cov kev tshawb fawb cuam tshuam tau pom tias Suanzaoren muaj sedative, anticonvulsant, anti-arrhythmia, tiv thaiv atherosclerosis, txhim kho microcirculation, anti-ischemia, thiab kev tiv thaiv kab mob, thiab muaj cov txiaj ntsig zoo hauv plawv plawv [12]. Huang Yisheng et al. tau lees paub tias jujube saponin A tuaj yeem cuam tshuam qhov txo qis ntawm Bcl2 thiab Bax qhia hauv nas myocardial cov ntaub so ntswg tom qab kev raug mob reperfusion, thiab tuaj yeem tiv thaiv arrhythmia los ntawm txo cov ntshav LDH thiab myocardial MDA cov ntsiab lus [13-14], nce myocardial SOD kev ua thiab muaj peev xwm. los tiv thaiv oxygen-dawb radicals. Longgu thiab Muli muaj cov tshuaj sedative zoo, hypnotic thiab anticonvulsant cuam tshuam [15].
Oxygen-dawb radicals tuaj yeem ua lub luag haujlwm tseem ceeb hauv kev ua kom muaj peev xwm tuag taus arrhythmias, thiab Muli aqueous extracts tuaj yeem txhim kho kev ua haujlwm ntawm SOD thiab txo cov ntsiab lus ntawm MDA [16], yog li ua lub luag haujlwm hauv kev tiv thaiv thiab kho ventricular arrhythmias. Fushen muaj ntau yam khoom xyaw lom neeg xws li Lycium polysaccharides, tetracyclic triterpenoids, thiab al. Nws muaj lub luag haujlwm ntawm kev ua kom hypnosis, txhawb lub plawv, ua kom cov hlab ntsha, tiv thaiv qog, txhim kho kev tiv thaiv, thiab txo cov ntshav qabzib. Lin Xiaoming et al. paub tseeb tias Fuling tuaj yeem txhim kho SOD kev ua haujlwm [17], inhibit MDA ntau lawm, thiab muaj txiaj ntsig ntawm kev tshem tawm cov pa dawb radicals. Cov tshuaj tseem ceeb ntawm Guizhi yog cov roj tsis hloov pauv, phenols, organic acids, thiab al. Guizhi muaj lub luag haujlwm ntawm dilating cov hlab ntsha, tiv thaiv oxidation, txo cov ntshav lipid, txo cov ntshav siab, txhawb cov ntshav ncig, thiab tiv thaiv platelet aggregation, tiv thaiv inflammatory thiab tiv thaiv kev ua xua [18]. Piv txwv li, cinnamaldehyde tuaj yeem nthuav cov hlab ntsha, yog li ua kom cov ntshav ncig [19-20], ua kom cov ntshav ntws hauv coronary, txhim kho myocardial contractility, thiab qeeb lub plawv dhia tsis zoo, yog li tswj cov kev ua haujlwm ntawm lub plawv; xws li Guizhi kua muab rho tawm los ntawm hydro cawv txoj kev tuaj yeem txo cov ntshav lipids [21], txhim kho myocardial ischemia thiab txo qhov tshwm sim ntawm arrhythmia hauv nas nrog kab mob plawv.
Licorice feem ntau muaj triterpenoids, flavonoids, alkaloids, organic acids, licorice polysaccharides, thiab lwm yam tshuaj. Cov khoom tseem ceeb tshaj plaws yog triterpenoid saponins thiab flavonoids. Licorice muaj ntau yam teebmeem xws li kev tiv thaiv oxidation, txo cov ntshav lipids thiab tiv thaiv atherosclerosis, tiv thaiv arrhythmia, tiv thaiv myocardial ischemia, thiab kev tiv thaiv kab mob [22-23]. Ntau qhov kev tshawb fawb tau lees paub tias Zhigancao tuaj yeem siv los tiv thaiv arrhythmia hauv ntau txoj hauv kev. Xie Shirong et al. pom tias glycyrrhetinic acid tuaj yeem inhibit aconitine thiab coronary artery ligation-induced reperfusion ventricular arrhythmia [23]. Tag nrho cov flavonoids los ntawm licorice tuaj yeem ncua qhov tshwm sim ntawm arrhythmia hauv aconitine qauv nas thiab txo qhov tshwm sim ntawm ventricular fibrillation hauv chloroform qauv nas, qhia tias nws muaj cov nyhuv anti-ventricular arrhythmia [25].
Cov txiaj ntsig ntawm qhov kev tshawb fawb no qhia tias piv nrog rau pawg qauv, DJFM(Dingjifumai Decoction thiabcistanche)pab pawg, thiab pab pawg metoprolol tuaj yeem ncua qhov tshwm sim ntawm VP, VT, thiab VF, qhov sib txawv yog qhov tseem ceeb (P < {{0}}}.05).="" cov="" pab="" pawg="" djfm="" thiab="" pawg="" metoprolol="" tau="" zoo="" tib="" yam="" hauv="" kev="" ncua="" sijhawm="" ntawm="" vp,="" vt,="" thiab="" vf,="" thiab="" tsis="" muaj="" qhov="" sib="" txawv="" tseem="" ceeb="" (p=""> 0.05). Nws tau qhia tias DJFM tuaj yeem ncua qhov tshwm sim ntawm ventricular arrhythmias xws li VP, VT, thiab VF hauv aconitine qauv nas. Cov txheej txheem yuav cuam tshuam rau sab hauv rectifier poov tshuaj channel (IK ntxiv), uas tuaj yeem tiv thaiv arrhythmia los ntawm kev txhawb nqa K ntxiv efflux kom txo tau qhov muaj peev xwm ntawm lub cev thiab txo tus kheej kev qhuab qhia. Ntawm qhov tod tes, nws kuj tseem yuav cuam tshuam rau Na plus channels sai, uas tuaj yeem txo qhov kev qhuab qhia ntawm tus kheej ntawm cov hlwb nrawm los ntawm inhibiting Na plus influx, yog li ua tiav cov txiaj ntsig ntawm kev tiv thaiv thiab kho arrhythmia. Nws tau qhia tias DJFM yuav muaj kev ua haujlwm ntawm kev tiv thaiv thiab kho ventricular arrhythmia qauv ntawm cov ion sib txawv.
Qhov kev sim kuj pom tau tias lub twj tso kua mis sodium-potassium nyob rau hauv cov ntaub so ntswg ntawm cov qauv pab pawg neeg tsawg dua li cov pab pawg neeg dawb paug, thiab qhov sib txawv yog qhov tseem ceeb (P < 0.05).="" cov="" pab="" pawg="" metoprolol="" thiab="">(Dingjifumai Decoction thiabcistanche)pab pawg tuaj yeem ua kom cov sodium-potassium twj tso kua mis nyob rau hauv cov ntaub so ntswg ntawm nas nrog ventricular arrhythmia (P < 0.05).="" tsis="" muaj="" qhov="" sib="" txawv="" tseem="" ceeb="" hauv="" sodium-potassium="" twj="" nruab="" nrab="" ntawm="" pawg="" djfm="" thiab="" pawg="" metoprolol="" (p=""> 0.05). Nws tau xaus lus tias DJFM tuaj yeem tiv thaiv cov twj sodium-potassium. Cov txheej txheem tuaj yeem txo qis intracellular Ca2 ntxiv rau qhov siab ncaj qha los ntawm kev txo qis intracellular Na ntxiv concentration, yog li tiv thaiv myocardial contractility kev puas tsuaj los ntawm Ca2 ntxiv rau concentration ntau dhau, thiab yog li tiv thaiv ventricular arrhythmia.
Hauv cov ntsiab lus, kev txhaj tshuaj ntawm aconitine tuaj yeem ua tiav cov qauv nas ntawm ventricular arrhythmia. DJFM(Dingjifumai Decoction thiabcistanche)zoo ib yam li metoprolol hauv kev tiv thaiv thiab kho arrhythmia. Cov txheej txheem yuav muaj feem xyuam rau kev tiv thaiv ntawm myocardial cov ntaub so ntswg sodium-potassium twj tso kua mis, thiab inhibition ntawm Na plus influx txo tus kheej-kev qhuab qhia ntawm ceev-reacting hlwb, yog li tiv thaiv cov cardiomyocytes thiab txhim kho myocardial metabolism. Txawm li cas los xij, muaj qee qhov kev mob tshwm sim ntawm cov tshuaj suav tshuaj. Yog hais tias tus syndrome yog zoo ib yam, tsis muaj teeb meem contraindications. Yog li ntawd, peb yuav tsum txhawb nqa kev siv tshuaj suav tshuaj hauv kev kho mob thiab muab kev kho mob rau ntau tus neeg mob arrhythmia.
cistanche ntxiv: txhim kho kev sib deev muaj nuj nqi
Cov ntaub ntawv
1 Cao KJ, Chen ML, Jiang HJ, et al. Suav cov kws tshaj lij pom zoo rau ventricular arrhythmias. Chin J Card Pacing Electrophysiol, 2016. 30: 283-325.
2. Chen X. Huang wan chaw kho mob electrocardiogram. 6th ed.Beijing: Tib Neeg Kev Kho Mob Publishing House, 2016: 185-186.
3. Xu HM, Ren FY, Jiang XG. Kev sib tham txog kev kho mob ntawm arrhythmia nrog tshuaj suav tshuaj. Cov txheej txheem ntawm lub rooj sib tham 12th txhua xyoo ntawm cov kab mob plawv ntawm Tuam Tshoj haiv neeg ntawm cov tshuaj suav tshuaj, 2010: 268-272.
4. Zhou GX, Gao C, Xu P. Replication Methodology of Tsiaj Models for Human Disease. Shanghai: Shanghai Scientific thiab Technological Literature Press, 2008: 13-15.
5. Wang GB, Fu Q, Lin XM, et al. Kev Tshawb Fawb Txog Kev Tshawb Fawb Txog Kev Tawm Tsam ntawm Xinlu Tai Capsule. Tradi Chin Drug Res Clin Pharmacol, 2003. 5: 105-107.
6. Li HW. Kev sim kawm txog cov txheej txheem ntawm yiqi hom kev sib xyaw ua ke hauv kev kho mob ntxov ntxov ventricular contraction. Beijing University of tsoos suav tshuaj, 2013.
7. Zhou YH, Piao XM, Liu X, et al. Arrhythmogenesis toxicity ntawm aconitine muaj feem xyuam rau intracellular Ca2 ntxiv rau cov cim. Int J Med Sci.2013. 10: 1242-1249.
8. Hu X, Wang DS. Cov nyhuv ntawm Dingxin decoction ntawm arrhythmia hauv tus qauv nas. Chin J Mod Med, 2016. 26: 18-21.
9. Schemer Bobis G. Lub twj tso kua mis sodium. Nws cov khoom molecular thiab mechanics ntawm ion thauj. Eu r J Biochem, 2002. 269: 2424 2433. .
10. Zang YJ. Na plus , K plus -ATPase, Health, and Sports. J Shenyang Sport Univ, 2006. 6: 59-62.
11. Noble D, Noble PJ. Sodium lig tam sim no nyob rau hauv pathophysiology ntawm kab mob plawv: qhov tshwm sim ntawm sodium-calcium overload. Lub plawv. 2006. 4: iv1-iv5.
12. Geng X, Li TL. Kev nce qib ntawm Tshuaj Chemical Composition thiab Pharmacological Activities ntawm Semen Zizyphi Spinosa. Acta Chin Med Pharmacol, 2016. 44: {3}}.
13. Huang YS, Mi XY, Xiong YH. Qhov cuam tshuam ntawm Mechanism ntawm Zizyphi Spinosaeand ntawm arrhythmia ntawm myocardial ischemia-reperfusion raug mob hauv nas. Nei Mongol J Tradi Chin Med, 2013. 29: 45-46.
14. Huang YS, Jia YH, Sun XG, et al. Cov teebmeem ntawm jujube saponins A ntawm arrhythmia thiab BCL-2 thiab BAX qhia hauv ischemia-reperfusion raug mob nas. Tradi Chin Drug Res Clin Pharmacol, 2011. 13: {5}}.
15. Zhang H, Zhang L, Liu Y. Kev tshawb fawb txog tshuaj lom neeg thiab kev ua haujlwm tshuaj ntawm Os Draconis (Longgu) thiab Ostreae Concha. Chin J Chin Mater Med, 2011. 36: 1839-1840}.
16. Feng L, Zhao WJ, Chang WJ. Tshawb nrhiav kev nce qib ntawm kev ua tshuaj pharmacological thiab kev siv tshuaj kho mob ntawm oysters. Inf Tradi Chin Med, 2011. 28: 114-116.
17. Lin XM, Feng JY, Long Z, et al. Cov nyhuv ntawm tremella, Poria thiab gynostemma ntawm murine immunological thiab scavenging dawb radicals muaj nuj nqi. J Beijing Med Univ, 1995. 37: 455-457 ntxiv 473.
18. Hou JY. Pharmacology ntawm tsoos suav tshuaj. Beijing: Tuam Tshoj Xovxwm ntawm Tsob Ntoo Suav Tshuaj, 2002: 30-31.
19. Liu P., Zhang LP. Kev tshawb fawb txog tshuaj Chemical Constituents hauv Dried Tender Stem of Cinnamomi Cassia. Liaoning J Tradi Chin Med, 2012. 39: 1926-1927.
20. Chen JY, Ya QK, Lu WJ. Txheej txheem cej luam ntawm kev tshawb fawb ntawm cinnamon. Guangxi Med J, 2009. 31: 872-874.
21. Jiang B, Jiang HY, Ren LL, et al. Kev tswj cov nyhuv ntawm Guizhi ntawm cov ntshav lipo qib ntawm nas qauv ntawm kab mob plawv. Shenzhen J Integr Tradi Chin Western Med, 2003. 3: 234-235.
22. Zhang YL, Wang MY, Yang JY, et al. Kev tshawb nrhiav kev nce qib ntawm cov tshuaj lom neeg thiab cov tshuaj pharmacological ntawm cov licorice txhawb nqa. Acad J Shanghai Univ Tradi Chin Med, 2015. 29: 99-102.
23. Wang B, Wang YX, Zhao HY, et al. Kev tshawb fawb kev nce qib ntawm cov khoom tseem ceeb thiab cov tshuaj pharmacological ntawm Glycyrrhiza uralensis Fisch. J Jilin Med Coll, 2013. 34: 215-218.
24. Xie SR, Huang CY, Huang SY, et al. Antiarrhythmic nyhuv ntawm glycyrrhetinic acid. Herald Med, 2004. 19: 140-142.
25. Hu XY, Peng GP, Chen RY. Cov teebmeem ntawm glycyrrhiza flavonoids ntawm arrhythmia. Chin Tradi Tshuaj ntsuab, 1996. 27: 733-735.
