Cov teebmeem ntawm Cistanche Tubulosa Wight Extract Ntawm Locomotive Syndrome

Hu rau:jaslyn.ji@wecistanche.com

Abstract:Hauv cov neeg laus laus, kev tiv thaiv kev ua haujlwm tsis zoo thiab rov ua haujlwm ntawm cov kabmob hauv nruab nrog cev yog qhov tsim nyog rau lub neej ntev. Ob peb txoj kev tshawb fawb tau tshawb fawb ntxiv rau locomotive syndrome. Tsis tas li ntawd, tsawg heev kev tshawb fawb soj ntsuam ntawm locomotive syndrome tau ua raws li cov placebo-tswj, randomized, ob-dig muag kev tshawb fawb. Peb yav tas los pom tias kev tswj hwm ntawm 30 feem pua ​​​​ethanolic extract ntawm Cistanche tubulosa txhim kho txoj kev taug kev hauv cov cam khwb cia-immobilized skeletal leeg nqaij atrophy nas qauv. Yog li ntawd, peb tau ua ib qho kev tshawb fawb soj ntsuam los soj ntsuam cov teebmeem ntawm C. tubulosa (CT) extract ntawm locomotive syndrome. Nees nkaum-rau qhov kev kawm uas muaj cov tsos mob ua ntej lossis mob me me locomotive ua tiav tag nrho cov kev xeem thiab raug tshuaj xyuas hauv txoj kev tshawb no. Kev soj ntsuam ntawm cov leeg nqaij thiab lub cev ua si tau ua raws li kev soj ntsuam tag nrho. Kev noj CT extract rau 12 lub lis piam nce qib dav (ob-kauj ruam xeem) thiab kev nrawm nrawm (5 m taug kev sim) hauv cov neeg mob hnub nyoog 60 xyoo piv nrog cov placebo tswj (p=0.046). Nyob rau hauv sib piv, cov pob txha pob txha loj ntawm lub cev pob tw thiab ceg ceg tsis hloov tom qab kev tswj hwm ntawm CT extract. Cov teebmeem tsis zoo raug soj ntsuam los ntawm kev kuaj ntshav; Tsis muaj qhov tshwm sim tsis zoo tshwm sim tom qab tau txais CT extract. Hauv kev xaus, cov placebo-tswj, randomized, ob-dig muag txoj kev tshawb fawb pom tau hais tias kev kho mob nrog CT extract cuam tshuam qhov kev poob qis hauv kev taug kev yam tsis muaj qhov cuam tshuam tsis zoo rau cov neeg mob uas muaj kab mob locomotive.

Ntsiab lus: locomotive syndrome; Tubulosa; muaj peev xwm taug kev; xeem ob-kauj ruam; 5-m taug kev

tshiab cistanche

1. Taw qhia

Hauv cov neeg laus laus, kev tiv thaiv kev ua haujlwm tsis zoo thiab rov ua haujlwm ntawm cov kabmob hauv nruab nrog cev yog qhov tsim nyog rau lub neej ntev. Locomotive syndrome tau piav qhia thawj zaug los ntawm Nyiv Orthopedic Association (JOA) hauv xyoo 2007, thiab nws suav nrog ntau yam kev tsis taus ntau dua li cov tsos mob ntawm cov leeg musculoskeletal ambulation disability [1]. Lub hauv paus system muaj xws li cov leeg, pob qij txha, pob txha mos, thiab cov pob txha uas maj mam tsis muaj zog nrog lub hnub nyoog lossis vim muaj lwm yam kab mob. Cov xwm txheej, xws li tsis muaj kev tawm dag zog, kev ua neej nyob tsis muaj zog, thiab kev noj zaub mov tsis txaus, kuj ua rau muaj kev loj hlob ntawm locomotive syndrome. Kev tiv thaiv thiab kho kom zoo ntawm cov kab mob locomotive yuav tsum tau txo qis cov pej xeem xav tau kev saib xyuas. Cov kev tshawb fawb feem ntau ntawm cov kab mob locomotive tau ua los ntsuas cov txiaj ntsig zoo ntawm kev tawm dag zog. Piv txwv li, kev tawm dag zog rau 3 lub hlis raws li kev cob qhia locomotive tau txhim kho kev ua haujlwm ntawm lub cev [2]. Cov kauj ruam ntev, stride length, thiab taug kev ceev tau txhim kho nyob rau hauv cov neeg mob uas locomotive syndrome tom qab 6-lub lim piam ntawm hipflexor nqaij cob qhia [3]. Txawm li cas los xij, feem ntau cov kev tshawb fawb txog kev cuam tshuam ntawm kev tawm dag zog tau muab piv rau cov lus teb ua ntej thiab tom qab kev tawm dag zog hauv tib cov neeg mob, tsis muaj kev suav nrog pawg tswj hwm. Tsis tas li ntawd, ob peb txoj kev tshawb fawb tau tshawb fawb ntxiv rau locomotive syndrome; vitamin D supplementation rau 24 lub lis piam ho txhim kho lub zog ntawm lub hauv caug extension thiab lub duav flexion pivnrog qib kev kho ua ntej [4]. Txawm li cas los xij, txoj kev tshawb no tsis suav nrog pawg placebo [4]. Rau hnub tim, a kev cuam tshuam tsawg kho mob kev sim ntawm lub tsheb ciav hlau syndrome muaj ua ua raws li tshuaj placebo, randomized, ob-dig muag kev kawm [5].

Yav dhau los, peb tau pom tias kev tswj hwm ntawm 30 feem pua ​​​​ethanolic extract ntawm Cistanche tubulosa txhim kho kev taug kev muaj peev xwm nyob rau hauv cast-immobilized skeletal leeg nqaij atrophy nas qauv [6]. Txawm hais tias qhov ncauj kev tswj hwm ntawm cov extract tsis tau nce cov leeg pob txha lossis myofiber txoj kab uas hla, kev taug kev thiab kev nrawm nrawm dua [6]. Cistanche tshuaj ntsuab yog txhais nyob rau hauv Japanese Pharmacopoeia raws li cev nqaij daim tawv ntawm Cistanche salsa G.Beck, C. deserticola YCMa, los yog C. tubulosa Wight. Acteoside (lub ntsiab lus: verbascoside), thiab echinacoside tau lees paub tias yog cov khoom tseem ceeb ntawm cov nroj tsuag no. Acteoside- andechinacoside-nplua nuj C. deserticola extract tau ua kom pom kev ua kom qaug zog hauv nas [7]. Kev kho mob ua ntej Acteoside tau nce cov leeg nqaij contractility hauv Bufo gastrocnemius, qhia txog kev tiv thaiv cov leeg nqaij qaug zog ntawm cov tshuaj no [8]. Hauv peb txoj kev tshawb fawb yav dhau los, kev kho mob acteoside tau txhim kho lub cev muaj zog hauv cov nas nrog kev raug mob qaum qaum [9]. Cistanche tshuaj ntsuab yog cais raws li tus neeg sawv cev tsis yog tshuaj los ntawm Pharmaceutical thiab Food Safety Bureau, Ministry of Health, Labour, thiab Welfare hauv Nyiv. Kev nyab xeeb ntawm C. tubulosa (CT) extract hauv tib neeg tau tsim nyob rau theem II thiab theem III kev tshawb fawb soj ntsuam tau ua hauv Suav teb. Cov kev tshawb fawb no tau tshaj tawm tsis muaj qhov cuam tshuam tsis zoo ntawm koob tshuaj 1800 mg extract ib hnub rau 3 lub hlis [10]. Yog li ntawd, peb tau ua txoj kev tshawb fawb soj ntsuam los soj ntsuam cov txiaj ntsig zoo ntawm CT extract ntawm locomotive syndrome hauv tib neeg cov neeg laus. Peb xav tias CT extract yuav tiv thaiv kev poob ntawm lub cev muaj zog.

cistanche extract

2. Cov ntaub ntawv thiab cov txheej txheem

2.1. Kev Tsim Kho

Qhov no yog cov placebo-tswj, randomized, ob-dig muag kev kawm hauv cov neeg laus noj qab haus huv. Cov kev kawm tau thov rau txoj kev kawm los ntawm kev ua lawv tus kheej locomotive checkup tom qab pom ib daim ntawv caw lawv tuaj koom rau hauv txoj kev tshawb no muab tso rau ntawm qhov chaw nyob ze. Tom qab pom zoo los koom rau hauv txoj kev tshawb fawb ntawm University of Toyama, cov kev kawm tau raug kuaj xyuas hauv lub hauv paus. Cov ntsiab lus ntawm kev kuaj mob locomotive yuav piav qhia tom qab. Tom qab ntawd, nyob rau theem kev cuam tshuam, cov neeg kawm tau muab cov tshuaj randomized (CT extract lossis placebo), thiab cov neeg kawm ib lo lus txhua hnub rau 12-lub lim tiam tom tsev. Tom qab 12-kev cuam tshuam lub limtiam, cov neeg kawm tau rov qab kuaj lub tshuab ua haujlwm dua.

2.2. Cov neeg koom nrog

Kev txheeb xyuas lub zog ua ntej tau ua tiav. Xam siv Wilcoxon matched- khub kos npe rau qib xeem nrog qhov loj me ntawm 0.5, qhov tseem ceeb ntawm 0.05, thiab lub zog ntawm 0.8, thiab tom qab ntawd tus qauv xav tau yog 28. Peb caug-ob qhov kev kawm tau raug xaiv los ntawm 1 Kaum Ob Hlis 2018 thiab 31 Lub Kaum Hli 2019. Cov kev kawm muaj peev xwm tau muab faib ua ob pawg; 28 tau ua raws li cov txheej txheem suav nrog thiab tau tso npe. Ob qhov kev yeem thim tawm, yog li 26 tus neeg koom nrog hauv txoj kev tshawb no. Txhua yam kev kawm tau mus xyuas University of Toyama ob zaug rau kev ntsuam xyuas. Daim duab qhia txog Kev Tshaj Tawm Txog Kev Tshaj Tawm (Consolidated Standards of Reporting Trials) (CONSORT) daim duab qhia rau txoj kev tshawb fawb no muaj nyob rau hauv daim duab 1. Cov txheej txheem suav nrog yog raws li nram no: cov ntsiab lus (a) hnub nyoog siab tshaj los yog sib npaug rau 40 thiab Tsawg dua los yog sib npaug rau 80 xyoo; (b) muaj peev xwm ua kom tiav qhov kev tshawb fawb soj ntsuam no; thiab (c) tshawb xyuas yam tsawg kawg ib yam ntawm daim ntawv nug "Loco-check". Cov txheej txheem cais tawm muaj raws li hauv qab no: cov ntsiab lus (a) hnub nyoog<39 years;="" (b)="" pregnant="" or="" lactating="" females;="" (c)="" on="" medication,="" such="" as="" muscle="" relaxants,="" osteoporosis,="" or="" rheumatoid="" arthritis="" drugs;="" (d)="" diagnosed="" with="" mental="" illnesses;="" or="" (e)="" judged="" ineligible="" for="" other="" reasons.="" subjects="" were="" followed="" up="" from="" 11="" may="" 2019="" to="" 29="" february="" 2020.="" this="" study="" was="" conducted="" with="" the="" approval="" of="" the="" ethics="" committee="" of="" the="" university="" of="" toyama="" (r2018090).="" each="" subject="" signed="" an="" informed="" consent="" form="" prior="" to="" study="">

2.3. Kev cuam tshuam

Cov placebo lossis CT tau muab rau txhua qhov kev kawm ntawm qhov chaw kawm nyob rau thawj hnub sim. Lub CT extract tau npaj los ntawm Alps Pharmaceutical Ind. Co., Ltd. (Hida, Nyiv) raws li hauv qab no: C. tubulosa fleshy stems tau sau los ntawm Shinjang Uyghur Aptonom Rayoni, Tib neeg koom pheej ntawm Tuam Tshoj. Cov hmoov sib xyaw (20 kg) ntawm C. tubulosa tau muab tso rau hauv 30 feem pua ​​​​ethanol. Qhov sib tov tau refluxed rau 2 teev ntawm 55-64 ◦C. Lub extract yield yog 21.5 feem pua ​​thiab muaj 5.41 feem pua ​​acteoside thiab 17.48 feem pua ​​echinacoside.

Kev soj ntsuam kev nyab xeeb ntawm lwm qhov ntau ntawm CT extract (acteoside < 9.0="" feem="" pua="" ​​;="" echinacoside="">< 25.0="" feem="" pua="" ​​)="" tau="" ua="" los="" ntawm="" oryza="" oil="" &="" fat="" chemical="" co.,="" ltd.="" cov="" ct="" extract="" qhia="" tsis="" muaj="" mob="" toxicity="" hauv="" nas="" (ld50=""> 26,400mg / kg), tsis muaj toxicity nyob rau hauv nas (ntawm 1650 mg / kg tom qab 180 hnub ntawm kev tswj hwm), thiab tsis muaj pov thawj ntawm genemutagenesis. Kev ntsuam xyuas kev nyab xeeb hauv chaw kho mob tau qhia tias tsis muaj qhov cuam tshuam tsis zoo thaum lub sijhawm 180-hnub kev tswj hwm ntawm 1800mg/subject/hnub [10].

Ib tug stick muaj 1800 mg ntawm CT extract, 72 mg zoo silicon dioxide, thiab 1782 mg dextrin. Ib tug pas, ib zaug ib hnub, tau noj nrog kev pab nqos tau jelly (Ryukakusan Co., Ltd., Tokyo, Nyiv). Placebo hmoov muaj 48 mg caramel xim, 72 mg zoo silicon dioxide, thiab 3480 mg dextrin. Ib tug pas tau noj ib zaug ib hnub nrog nqos pab jelly. Kev sib xyaw hmoov thiab ntim tau npaj los ntawm cov chaw tsim khoom (Sankyo Co., Ltd., Fuji, Nyiv) ua raws li Kev Tswj Xyuas Kev Tswj Xyuas Zoo thiab ISO 22, 000 ntawv pov thawj. Qhov koob tshuaj ntawm CT extracttaken txhua hnub yog 1800 mg.

2.4. Cov txiaj ntsig thiab kev soj ntsuam

Txhua tus neeg koom ua tiav cov lus nug txog keeb kwm kev noj qab haus huv thiab keeb kwm kho mob thiab tau tshaj tawm cov tshuaj uas siv los ntawm qhov pib. Cov ncauj lus uas tau kuaj xyuas yam tsawg kawg ib yam ntawm Loco-check daim ntawv nug [11], muab hauv qab no, raug xaiv thiab suav tias yog qhov pheej hmoo ntawm locomotive syndrome:

• Koj tsis tuaj yeem hnav ib nkawm thom khwm thaum sawv ntawm ib ceg.

• Koj ntog lossis plam hauv koj lub tsev.

• Koj yuav tsum siv lub tes tuav thaum nce mus rau saum.

• Koj tsis tuaj yeem hla txoj kev hla ua ntej lub teeb tsheb hloov.

• Koj muaj teeb meem taug kev tsis tu ncua li 15 feeb.

• Koj pom tias nws nyuaj rau taug kev mus tsev nqa lub hnab yuav khoom hnyav li 2 kg.

• Koj pom tias nws nyuaj rau kev ua haujlwm hauv tsev uas xav tau lub cev muaj zog.

Kev ntsuam xyuas tau ua nyob rau hauv pab pawg ntawm ib txog kaum tus neeg tuaj koom hauv ib hnub, nyob ntawm seb muaj cov neeg tuaj koom. Txhua yam khoom raug tswj hwm hauv ib hnub, thiab kev koom tes yog kwv yees li 30 feeb. Qhov kev txiav txim ntawm kev ntsuas tau pib nrog kev sau ntshav, ntsuas qhov siab, thiab ntsuas lub zog tuav, thaum lwm yam khoom tau nqa tawm ib tus zuj zus thiab random. Thaum koom nrog, cov neeg kawm raug tso cai so thaum twg lawv xav tau.

2.4.1. Kev ntsuas cov leeg nqaij

Cov leeg nqaij sab sauv thiab sab qis thiab lub cev lub cev nqaij daim tawv tau txiav txim siab los ntawm bioelectricalimpedance tsom xam nrog lub cev muaj pes tsawg leeg saib (MC-780A, Tanita, Tokyo, Nyiv).

2.4.2. Tes tuav lub zog

Lub zog tuav tes tau ntsuas los ntawm txhais tes dynamometer (TKK5001, Takei, Niigata, Nyiv).

2.4.3. Tsib-Meter Taug Kev Ceev

"Tsib-meter taug kev ceev" ntsuas lub sij hawm uas hla thaum lub sij hawm 5 m taug kev seem los ntawm teem acceleration seem ntawm 1.0 m ntawm qhov pib ntawm tag nrho 6 m ntawm taug kev ntev. Pib taw tes, 1.0 m thiab cov ntsiab lus tiav tau cim los ntawm kab. Tus neeg sau hnub tau txiav txim thiab ntsuas lub sijhawm siv lub sijhawm nres. Kev ntsuas tau ua ob zaug, thiab kev taug kev ceev tshaj plaws, tsis tau khiav, raug kaw.

2.4.4. Ob-kauj ruam xeem

Kev sim ob-kauj ruam ntsuas kev muaj peev xwm taug kev [12]. Cov ntsiab lus pib los ntawm ib qho kev sawv cev thiab raug hais kom ua cov kauj ruam mus rau pem hauv ntej nrog qhov siab tshaj plaws stride yam tsis muaj kev tshuav nyiaj li cas. Ib daim lev tshwj xeeb nrog ntsuas rau qhov kev xeem ob-kauj ruam (JOA) tau siv. Qhov ntev ntawm ob kauj ruam tau ntsuas los ntawm ntiv taw mus rau ntiv taw. Ua ntej ua qhov kev xeem, tus kws qhia qhia tau hais tias kev nce qib. Cov qhab nia suav nrog qhov ntev ntawm ob kauj ruam (cm) faib los ntawm qhov siab (cm).

2.4.5 ib. Stand-Up Test

Qhov kev ntsuam xyuas sawv ntsug yog siv los ntsuas cov leeg nqaij qis zog. Nws ntsuas tus neeg muaj peev xwm sawv ntsug siv ob txhais ceg, pib, thiab tom qab ntawd ntawm ib ceg, los ntawm qhov chaw zaum ntawm cov quav ntawm qhov siab ntawm 40, 30, 20, thiab 10 cm [13]. Cov txiaj ntsig tau qhia raws li cov qhab nia summed, siv qhov hloov dua siab tshiab Table 1.

2.4.6. GLFS -25

Lub {{0}} lo lus nug Geriatric Locomotive Function Scale (GLFS-25) yog ib lo lus nug uas tus kheej tau siv los ntsuas qhov kev ua haujlwm ntawm locomotor hauv cov neeg laus [14]. Nws suav nrog 25 yam khoom uas tau qhab nia ntawm 0–4 rau txhua yam: plaub nqe lus nug txog kev mob, 16 nqe lus nug txog kev ua ub no txhua hnub, peb lo lus nug txog kev ua haujlwm hauv zej zog, thiab ob nqe lus nug txog kev mob hlwb. Cov qhab nia txawv ntawm 0 mus rau 100, nrog cov qhab nia siab dua qhia tias muaj mob tsis zoo.

2.5. Kev soj ntsuam kev nyab xeeb

Kev ntsuas kev nyab xeeb suav nrog kev kaw cov xwm txheej tsis zoo thiab kuaj ntshav biochemical los ntsuas lub siab thiab lub raum kev ua haujlwm, thiab ntshav qab zib, thiab qib lipid ntawm txhua qhov kev mus ntsib.

2.6. Randomization

Cov neeg koom nrog raug muab tso rau ib qho ntawm ob pawg: pawg CT extract lossis pab pawg placebo.Randomization tau ua los ntawm txoj kev yooj yim randomization los ntawm tus neeg thib peb uas tau txais daim ntawv teev npe koom nrog thiab ua qhov qhib qhov tseem ceeb.

2.7. Kev txheeb cais

Cov txiaj ntsig tau qhia raws li qhov nruab nrab tus qauv sib txawv (SD). Ib qho 95 feem pua ​​​​kev ntseeg siab lub sijhawm (CI) qhia txog lub sijhawm uas yog 95 feem pua ​​​​ntawm cov neeg muaj txiaj ntsig tiag tiag, raws li nws yuav kwv yees los ntawm kev kawm loj dua. 95 feem pua ​​​​CI txwv tau pom los ntawm qhov qis thiab sab sauv. Kev sib piv kev txheeb cais tau ua tiav siv GraphPad Prism 6 (GraphPad Software, La Jolla, CA, USA) thiab SPSS (IBM, Chicago, IL, USA). Raws li cov txiaj ntsig ntawm ob qhov kev ntsuam xyuas ntawm ib txwm muaj (Kolmogorov-Smirnov test thiab Shapiro-Wilk test) thiab cov txiaj ntsig ntawm skewness thiab kurtosis, nws tau txiav txim siab siv cov kev ntsuam xyuas tsis zoo rau txhua qhov kev ntsuas ntsuas. Cov ntaub ntawv raug tshuaj xyuas siv Mann Whitney xeem (rau kev sib piv ntawm pab pawg), Wilcoxon matched-pairssigned rank test (rau intragroup sib piv), lossis Fisher qhov tseeb xeem (rau cov neeg sib piv). p tus nqi < 0.05="" tau="" suav="" tias="" yog="" qhov="" tseem="">

3. Cov txiaj ntsig

3.1. Cov yam ntxwv tseem ceeb ntawm Pawg Kawm

Kev tshawb fawb pej xeem suav nrog 32 txiv neej thiab poj niam. Daim duab 1 nthuav qhia CON- SORT flow diagram, kev faib khoom, thiab cov txheej txheem kev kawm ntawm tus kheej. Peb caug-ob qhov kev kawm tau muab faib ua ob pawg. Plaub qhov kev kawm raug cais vim lawv tsis ua raws li cov txheej txheem suav nrog. Ib pawg tau muab faib rau txais placebo rau 12 lub lis piam, thiab lwm pab pawg tau faib kom tau txais CT extract rau 12 lub lis piam. Nees nkaum rau qhov kev kawm tiav tag nrho cov kev xeem thiab tau suav nrog hauv cov kev tshuaj ntsuam tom ntej; Cov yam ntxwv hauv qab tau qhia hauv Table 2. Cov kev cuam tshuam tau raug soj ntsuam hauv cov kev kawm uas muaj cov tsos mob ua ntej lossis mob me me locomotive syndrome. Kev soj ntsuam ntawm cov leeg nqaij thiab lub cev ua si tau ua nyob rau ntawm tag nrho cov kev tsom xam. Lub hnub nyoog ntawm cov kev kawm hauv pawg CT extract tau nce siab dua li cov neeg kawm hauv pawg placebo. Qhov siab, lub cev hnyav, thawj lub cev qhov hnyav (BMI), thiab thawj Locomo 7 cov qhab nia tsis txawv ntawm cov placebo thiab CT extract pawg (Table 2).

3.2. Cov leeg nqaij thiab lub cev ua si

Tsis muaj qhov sib txawv tseem ceeb hauv cov leeg nqaij ntawm lub cev pob tw, caj npab, thiab ceg, lossis lub cev hnyav ntawm cov placebo thiab CT extract pawg (Table 3). Intragroup kev sib piv ua ntej thiab tom qab kev kho mob nrog cov placebo lossis CT extract qhia tsis muaj kev hloov pauv tseem ceeb hauv ib qho ntawm cov kev hloov pauv saum toj no (Table 3). Kev tuav tes, 5 m taug kev ceev, ob-kauj ruam, thiab cov qhab nia xeem sawv ntsug, thiab GLFS-25 cov qhab nia raug ntsuas los ntsuas kev ua haujlwm ntawm lub cev. Inter- thiab intragroup kev sib piv (Table 4, Daim duab 2A) qhia tsis muaj qhov sib txawv tseem ceeb hauv cov txiaj ntsig ntawm ib qho kev xeem.

Next, physical activities were analyzed by stratifying by age (>60 or >65 years). The improvement in the two-step test score in the CT extract group was significantly larger than that in the placebo group in subjects aged >60 years (Table 5, Figure 2B). A more evident positive effect of CT extract on the two-step test score was observed in subjects aged >65 xyoo (Table 6, Daim duab 2C). Intragroup kev sib piv tau qhia tias qhov kev xeem ob-kauj ruam ua rau muaj kev cuam tshuam tom qab kev kho mob hauv pab pawg placebo whereas hauv pawg CT extract tau khaws cia thaum lub sijhawm xeem (Table 6). Tsis muaj qhov sib txawv tseem ceeb hauv cov leeg nqaij thiab lub cev hnyav tau pom, txawm tias thaum muaj hnub nyoog stratified.

The number of subjects aged >60 xyoo uas nws cov qhab nia tau txhim kho nyob rau hauv ob qho tib si 5 m taug kev thiab ob-kauj ruam kev xeem tau muab piv rau cov pab pawg. Kev noj cov CT extract tau txhim kho qhov muaj feem ntawm cov lus teb zoo hauv cov ntsiab lus (Daim duab 3).

3.3. Kev nyab xeeb

Peb caug-ib qhov ntsuas hauv cov ntshav, nrog rau cov xwm txheej tsis zoo tau raug soj ntsuam tom qab tau txais CTextract thiab placebo. Cov txiaj ntsig ntawm kev soj ntsuam kev nyab xeeb tau teev tseg hauv Table 7. Qhov zoo siab, qib sodium ion leucine aminopeptidase tau hloov pauv ntawm cov placebo thiab CT extract pawg. Tsis muaj lwm qhov tsis sib txawv ntawm cov pab pawg. Cov ntaub ntawv nyoos sodium hauv cov placebo pab pawg ua ntej thiab tom qab kev kho mob yog 140.8 thiab 142.0 mEq/L, raws li. Hauv qhov sib piv, cov ntaub ntawv nyoos sodium hauv CT extract pawg ua ntej thiab tom qab kho yog 141.7 thiab 141.7 mEq / L, raws li. Cov kev tshawb pom no qhia tias qib sodium ion tsis cuam tshuam los ntawm kev noj cov CT extract, thiab lawv nyob hauv qhov ib txwm muaj nyob hauv ob pawg (ntau dua 136 mEq / L). Rawdata rau leucine aminopeptidase nyob rau hauv pab pawg placebo ua ntej thiab tom qab kev kho mob yog 56.7 thiab 62.0 U / L, feem. , raws. Cov txiaj ntsig no qhia tau tias tsis muaj kev hloov pauv hauv qib leucine aminopeptidase tom qab CT extract tau txais, thiab leucine aminopeptidase qib hauv ob pawg nyob hauv qhov qub (37-81 U / L). Zuag qhia tag nrho, tsis muaj qhov tsis zoo tshwm sim tom qab tau txais CT extract.

4. Kev sib tham

Txoj kev tshawb no yog thawj zaug tshaj tawm tias 12-lub lim tiam kev noj CT extract tuaj yeem nce qib dav (ob-kauj ruam xeem) thiab nrawm nrawm (5 m taug kev) hauv cov neeg mob hnub nyoog tshaj 60 xyoo piv nrog cov placebo tswj. Txawm hais tias muaj hnub nyoog ntawm CT pab pawg laus dua li ntawm pawg placebo (Table 2), CT tau txais txiaj ntsig tau zoo dua cov kev ua ub no ntawm lub cev.Qhov txiaj ntsig no qhia tau hais tias cov txiaj ntsig ntawm CT extract yog qhov ntseeg tau. Hauv qhov sib piv, cov leeg pob txha pob txha ntawm lub cev pob txha thiab ceg ceg tsis hloov pauv los ntawm CT extract kom tsawg. Peb siv tib CT extract hauv kev tshawb fawb tsiaj yav dhau los. Kev tswj hwm ntawm qhov ncauj ntawm CT extract rau 13 hnub txhim kho kev taug kev hauv cov nas-immobilized leeg atrophy nas, tab sis tsis ua rau cov nqaij pob txha loj [6]. Ntau qhov kev tshawb fawb tib neeg tau tshaj tawm tias cov leeg nqaij thiab cov leeg nqaij zoo, xws li lub zog, tsis tas yuav tsum ua kom zoo sib xws. Ib txoj kev tshawb fawb loj, suav nrog 1880 cov neeg laus, tau pom tias cov leeg nqaij muaj zog poob qis thaum 36-hloov rov qab tsis muaj qhov poob ntawm cov leeg nqaij [15]. Lwm txoj kev tshawb nrhiav kev tswj xyuas tau pom tias kev kawm tiv thaiv rau 6 lub hlis ua rau cov leeg nqaij muaj zog ntawm cov leeg qis; Txawm li cas los xij, cov leeg nqaij pob txha tsis hloov los ntawm kev cuam tshuam [16].

Txawm hais tias cov kauj ruam dav hauv pawg placebo txo ​​qis 12 lub lis piam tom qab hauv daim duab 2B, C, cov kauj ruam dav hauv pawg CT extract tau khaws cia. Ib qho kev poob qis hauv cov kauj ruam dav tshaj li ob peb lub hlis tau pom nyob rau hauv lwm txoj kev tshawb fawb. Kev tshawb fawb ntawm cov neeg laus noj qab nyob zoo (hnub nyoog nruab nrab: 57 xyoo) tau qhia tias qhov qhab nia xeem ob-kauj ruam poob qis hauv 8, 12, thiab 16 lub lis piam txawm nyob hauv pab pawg placebo-kho [17]. Ua ke, cov ntaub ntawv qhia tias CT extract tuaj yeem tiv thaiv qhov txo qis ntawm cov leeg nqaij. Ntau qhov kev cuam tshuam tau raug tshawb xyuas hauv tib neeg los txhim kho kev taug kev, suav nrog cov tshuaj vitamin D [4] thiab cov kua mis nyuj, xws li ricotta [18], whey [19], thiab amino acids [19–21]. Ib qho kev txhim kho tseem ceeb hauv kev nrawm tau pom nyob rau hauv ib txoj kev tshawb fawb [22], tab sis tsis nyob hauv lwm tus [4,18–21]. Tsis tas li ntawd nyob rau hauv nas, branched-chain amino acid supplementation txhim kho lub cev ua si [23]. Txawm hais tias muaj txiaj ntsig zoo ntawm kev tawm dag zog ntawm kev taug kev kev ua haujlwm tau raug tshaj tawm, kev txhim kho ntxiv nrog cov amino acid supplementation tau raug ntsuas tsis zoo [24]. Yog li ntawd, tus naj npawb ntawm cov muaj peev xwm ntxiv cov neeg sib tw uas tiv thaiv locomotive syndrome yog txwv. Cov txiaj ntsig ntawm txoj kev tshawb fawb tam sim no tau qhia tias CT extract tuaj yeem tiv thaiv kev poob qis hauv kev taug kev, qhia tias CT extract tej zaum yuav yog tus neeg sawv cev tshiab rau locomotive syndrome.

Hais txog lub hauv paus ntsiab lus ntawm cov nyhuv ntawm CT extract ntawm cov leeg lub zog, peb xav tias qhov no suav nrog kev txhim kho axonal innervation los ntawm cov neurons mus rau cov leeg pob txha los ntawm acteoside, ib qho tseem ceeb hauv CT extract. Peb yav dhau los tau txheeb xyuas cov acteoside ua cov ntsiab lus tseem ceeb hauv CT extract (cov ntaub ntawv tsis qhia) thiab pom tias nws tuaj yeem ua kom muaj zog axonal elongation, uas ua rau muaj kev tswj hwm ntawm lub cev muaj zog [9]. Txawm li cas los xij, qhov tseeb molecular mechanism hauv qab cov txiaj ntsig ntawm CT extract lossis acteoside ntawm cov leeg nqaij yuav tsum tau txiav txim siab siv cov qauv tsiaj tsim nyog yav tom ntej.

Ntau qhov kev txwv ntawm qhov kev tshawb nrhiav no yuav tsum tau sau tseg. Peb tso npe rau ib qho piv txwv ntawm cov neeg laus Asian hnub nyoog 40-80 xyoo; yog li ntawd, peb cov txiaj ntsig tsis tuaj yeem txuas mus rau lwm tus neeg. Tsis tas li ntawd, peb tsis tau ntsuas kev noj zaub mov txhua hnub lossis qib kev ua haujlwm ntawm lub cev; Nws yog, yog li ntawd, tsis paub meej tias cov no puas cuam tshuam rau txoj kev tshawb fawb. Cov neeg koom tau raug qhia kom tsis txhob hloov lawv tus cwj pwm noj mov lossis cov qauv kev ua si thaum muaj kev cuam tshuam. Thaum kawg, qhov kev tshawb fawb tau txwv los ntawm cov qauv me me.

5. Cov lus xaus

Hauv kev xaus, qhov placebo-tswj, randomized, ob-dig muag txoj kev tshawb fawb tau qhia tias kev kho mob nrog CT extract cuam tshuam qhov kev poob qis hauv kev taug kev tsis muaj kev cuam tshuam. Raws li cov ntaub ntawv pov thawj hauv txoj kev tshawb no, peb yuav txhawb nqa kev txhim kho ntawm CT extract raws li Cov Khoom Noj Nrog Cov Khoom Siv Ua Haujlwm thiab Cov Tshuaj Tshaj Tawm hauv Nyij Pooj.

Cistanche extract tiv thaiv qhov poob ntawm kev muaj peev xwm taug kev.

Yog xav paub ntxiv, thov nias daim duab.