Cov teebmeem ntawm Cawv Extract Los ntawm Cistanche Deserticola Ntawm Lub raum Tsis Txaus Thiab Glucose Metabolism hauv nas

GONG Xia et al.

Department of Food, Shanghai Business School, Shanghai 200235, Suav teb

Hu rau:joanna.jia@wecistanche.com/ WhatsApp: 008618081934791

Abstract

Cov kev tshawb fawb pharmacological niaj hnub qhia tiasCistanchedeserticolamuaj lub luag haujlwm ntawm kev tiv thaiv qaug zog, tiv thaiv ag⁃ ing, thiab tswj kev zais cia thiab cov metabolism. Cov teebmeem ntawm cawv extract ntawmCistanchedeserticolantawm cov nas uas muaj menyuam tsis muaj peev xwm feem ntau tau kawm txog qib tshuaj hormones, thiab yuav luag tsis muaj kev kawm txog cov piam thaj metabolism hauv cov nas. Txhawm rau tshawb xyuas qhov cuam tshuam ntawm cawv extract los ntawm Cistanches Pistola rauraumtsis muaj peev xwmthiab qabzib metabolism hauv nas, covraumtsis muaj peev xwmnas, thiab cov qauv nas ntshav qab zib tau tsim. Tom qab 21 hnub ntawm qhov chaw nres tsheb tas mus li, cov tshuaj hormones hauv cov ntshav thiab enzyme kev ua haujlwm ntawmraumkuaj nas tsis muaj peev xwm. Testis cov ntaub so ntswg raug coj mus rau paraffin-embedded seem thiab nws staining los soj ntsuam cov xwm txheej pathological. Kev hloov pauv hauv lub cev hnyav, ceev ceev cov ntshav qabzib, thiab tag nrho cov protein hauv cov nas ntshav qab zib tau kuaj pom. Cov txiaj ntsig tau pom tias cov cawv cawv tuaj yeem ua rau lub cev hnyav ntawm cov nas uas muaj lub raum tsis txaus. Cov kev ua ntawm superoxide dismutase (SOD) txo qis hauv pawg gavage, qhia tias cov cawv cawv tuaj yeem tswj cov dawb radical scavenging nyhuv (p＜0.01). Tus naj npawb ntawm cov phev nyob rau hauv lub spermatogenic tubule ntawmCistanchedeserticolapawg tau nce, qhia tias muaj peev xwm spermatogenic ntawm nas nrograumtsis muaj peev xwmtau txhim kho los ntawm cawv extract. Kev haus cawv tsawg tsawg tuaj yeem txo cov ntshav qabzib ntawm cov poj niam mob ntshav qab zib nas, thiab cawv extract tuaj yeem tswj cov qib protein ntau txawv txav los ntawm ntshav qab zib (p＜0.05). Cistanche deserticola cawv-dej extract muaj kev txhim kho kev loj hlob ntawm tus txiv neej lub raum tsis muaj peev xwm nas qauv thiab muaj qee yam cuam tshuam rau cov ntshav qabzib qib ntawm tus qauv nas ntshav qab zib.

Ntsiab lus:Cistanchedeserticola; Hydrocortisone; Deficiency ntawmraum; Ntshav qab zib

cistanchekho tauraumkab mobtxhim kholub raum ua haujlwm

Cistanche yog tsim nyob rau hauv thaj chaw suab puam ntawm sab hnub poob Tuam Tshoj. Nws yog cov kab mob tshwj xeeb uas muaj ntau yam khoom xyaw, xws li phenethyl cawv glycosides, iridoids, lignans, polysaccharides, amino acids, alkaloids, thiab kab kawm [1-2], thiab lwm yam. Cov kev tshawb fawb muaj feem xyuam tau pom tias ntxiv rau. kom tswj hwm endocrine [3], tiv thaiv qaug zog [4], moisturizing cov hnyuv thiab laxative [5], neuroprotection [6], Cistanche tuaj yeem ua lub luag haujlwm ntawm txiv neej cov tshuaj hormones [7]. Tam sim no, kev tshawb fawb txog cov txiaj ntsig ntawm Cistanche cistanche cawv extract ntawm cov nas uas muaj lub raum tsis muaj zog yog tsom rau cov qib tshuaj hormones, thiab tsis muaj kev tshawb fawb txog cov nyhuv ntawm cawv extract ntawm cov ntshav qab zib hauv cov nas hauv tsev thiab txawv teb chaws. Tsuas yog qee qhov kev tshawb fawb tau tshaj tawm tias cov tshuaj sib xyaw uas muaj Cistanche muaj cov nyhuv hypoglycemic [8-9]. Thaum lub Plaub Hlis 2018, National Health thiab Family Planning Commission tau teev tseg Cistanche ( suab puam) ua tshuaj thiab khoom noj khoom haus-homologous khoom, uas ua rau nws ua tau zoo heev rau kev ua lag luam thiab kev siv tshuaj kho mob. Txawm li cas los xij, cov khoom ua haujlwm ntawm Cistanche ntawm kev ua lag luam tsis paub zoo. Tsis muaj kev paub ntau txog Cistanche, thiab cov khoom tseem ceeb tseem yog Cistanche wine [10] thiab tshuaj yej hnab. Raws li cov tshuaj suav txuas ntxiv muaj nuj nqis los ntawm cov neeg Suav, kev tshawb fawb txog kev siv tshuaj hauv Suav kuj tseem ceeb heev. Cistanche, raws li cov tshuaj suav tshuaj hauv Suav teb, muaj txiaj ntsig kev tshawb fawb ntau thiab muaj peev xwm rau kev txhim kho thiab siv.

Txoj kev tshawb no npaj los tsim kom muaj hydrocortisone-induced txiv neej lub raum-yang-deficiency nas, sau cov kev hloov pauv ntawm cov nas tom qab gavage ntawm Cistanche, ntsuas ntshav cov tshuaj hormones thiab cov ntaub so ntswg enzyme kev ua ub no, thiab ua cov kev tshawb fawb pathological ntawm nas testis los tshawb txog cov teebmeem ntawm Cistanche. cuam ​​tshuam rau lub raum tsis txaus nyob rau hauv nas. Tsim kom muaj tus qauv streptozotocin-induced mob ntshav qab zib nas tus qauv txhawm rau txheeb xyuas qhov kev hloov pauv hauv lub cev qhov hnyav, ceev cov ntshav qabzib, thiab plasma tag nrho cov ntsiab lus protein ntawm Cistanche cistanche tom qab nws tus kheej gavage ntawm Cistanche, txhawm rau tshawb nrhiav cov txiaj ntsig ntawm Cistanche ntawm cov piam thaj metabolism hauv cov nas. Kev tshawb nrhiav thiab kev tsim cov peev txheej cog rau tshuaj thiab zaub mov muab kev sim hauv paus.

acteosidehauv cistanche muaj cov teebmeem zoo rauraum

Kev sib tham

Tshawb nrhiav cov txiaj ntsig ntawm Cistanche cistanche cawv extract ntawm lub raum tsis muaj zog nas. Txoj kev tshawb no qhia tau hais tias los ntawm qhov pom ntawm qhov hnyav ntawm cov nas hloov, qhov hnyav nce ntawm cov qauv pab pawg nas tau qeeb dua li ntawm pawg neeg dawb paug. Tom qab 21 hnub ntawm kev tswj hwm intragastric ntawm ethanol extract ntawm Cistanche, qhov hnyav nce ntawm cov nas hauv pawg tswj hwm tau ntau dua li ntawm pawg neeg dawb huv thiab cov qauv, qhia tias Cistanche muaj qee yam kev kho mob rau cov nas uas muaj lub raum tsis txaus. Los ntawm kev pom ntawm cov tshuaj hormones hauv cov ntshav, Cistanche deserticola extract tuaj yeem txhim kho lub peev xwm spermatogenic ntawm cov noob qes. Qhov sib txawv tseem ceeb hauv superoxide dismutase (SOD) ntawm cov pab pawg yog p<0.01, indicating="" that="" cistanche="" deserticola="" extract="" can="" regulate="" the="" metabolism="" of="" free="" radicals="" in="" mice.="" from="" the="" perspective="" of="" histopathology,="" observe="" the="" testicular="" pathological="" tissue="" slices.="" the="" interstitial="" space="" in="" the="" testicular="" seminiferous="" tubules="" of="" the="" mice="" in="" the="" cistanche="" administration="" group="" m1="" and="" m2="" has="" a="" certain="" degree="" compared="" with="" that="" of="" the="" model="" group.="" the="" degree="" of="" decrease="" indicates="" that="" the="" cistanche="" deserticola="" extract="" has="" a="" certain="" therapeutic="" effect="" on="" kidney-deficiency="" mice.="" however,="" the="" levels="" of="" malondialdehyde,="" testosterone,="" and="" gonadotropin-releasing="" hormones="" did="" not="" change="" significantly,="" indicating="" that="" the="" crude="" extract="" of="" cistanche="" is="" not="" specific="" enough="" in="" regulating="" these="" hormones,="" and="" its="" comprehensive="" regulation="" in="" vivo="" conceals="" its="" remarkable="" curative="">

acteosidehauvcistanchetuaj yeem kho mob raum

Tshawb nrhiav cov txiaj ntsig ntawm ethanol extract ntawm Cistanche ntawm cov piam thaj metabolism hauv cov nas pom tau tias piv nrog pawg M0, qhov hnyav ntawm pawg M1 tau nce ntau (p<0.05), and="" the="" weight="" of="" the="" m2="" group="" increased="" significantly=""><0.01). it="" shows="" that="" the="" alcohol="" extract="" of="" cistanche="" can="" increase="" the="" weight="" of="" diabetic="" mice.="" in="" terms="" of="" changes="" in="" fasting="" blood="" glucose="" levels,="" for="" male="" diabetic="" mice,="" the="" low-dose="" group="" showed="" a="" hypoglycemic="" effect="" on="" male="" diabetic="" mice="" during="" gavage=""><0.05). however,="" the="" fasting="" blood="" glucose="" level="" of="" the="" mice="" in="" the="" m2="" group="" was="" significantly="" increased="" after="" two="" weeks="" of="" intragastric="" administration,="" which="" may="" be="" caused="" by="" the="" high="" concentration="" of="" cistanche,="" which="" needs="" to="" be="" further="" studied="" in="" the="" follow-up.="" for="" female="" diabetic="" mice,="" both="" the="" m1="" and="" m2="" groups="" showed="" hypoglycemic="" effect="" after="" two="" weeks="" of="" intragastric="" administration=""><0.05), but="" the="" blood="" sugar="" rose="" to="" the="" level="" before="" intragastric="" administration="" for="" 21="" days,="" which="" is="" presumably="" due="" to="" cistanche="" cistanche="" alcohol="" extract="" has="" a="" significant="" hypoglycemic="" effect="" on="" blood="" sugar="" within="" a="" certain="" period="" of="" time,="" but="" the="" effect="" is="" unstable.="" next,="" it="" is="" necessary="" to="" carry="" out="" further="" studies="" on="" different="" concentrations="" and="" longer="" time="" gavage="" experiments="" to="" clarify="" the="" mechanism="" of="" cistanche="" deserticola="" extract="" for="" lowering="" blood="" sugar="" and="" improving="">raumtsis muaj peev xwm.

Cistanchetuaj yeem kho taumob raum

Kev sib tham

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