Cov nyhuv ntawm Lycium Barbarum L. Extract On IR Drosophila Induced Los Ntawm Cov Glucose Diet Ⅱ

2 kev tshwm sim

2. 1 Kev soj ntsuam ntawm tus qauv nas ntawm menopausal hypertension thiab dryness syndrome

Covmenopausal hypertensiveqhuav syndrome qauv nas pom pom cov yam ntxwv xws liaggressiveness,chim siab, thiabua siab ntev. Tus tsiaj txoj kev noj haus tsawg zuj zus thiab nws cov plaub hau qhuav. Cov tsos mob no zoo ib yam nrog cov yam ntxwv kho mob.

Nws yuav siv sij hawm ntev npaum li cas rau CISTANCHE ua haujlwm?

2. 2 Kev hloov ntshav siab ntawm cov nas hauv txhua pab pawg ua ntej thiab tom qab siv tshuaj

Nws tuaj yeem pom los ntawm Table 1: Piv nrog rau pawg SHR, cov ntshav siab ntawm pawg sham lag luam tsis hloov pauv loj, thiab qhov sib txawv tsis tseem ceeb (P > 0. 05) ; cov ntshav siab ntawm cov nas nyob rau hauv cov qauv pab pawg neeg tau nce siab dua li ntawm pawg SHR, thiab piv nrog rau pawg neeg ua haujlwm sham. Qhov sib txawv yog qhov tseem ceeb (P <0. 05).

2. 3 Kev hloov pauv hauv cov ntshav endocrine qib ntawm cov nas hauv txhua pab pawg ua ntej thiab tom qab kev cuam tshuam tshuaj

Nws tuaj yeem pom los ntawm Table 2: Piv nrog rau cov nas hauv pawg neeg ua haujlwm sham thiab SHR pawg, cov tshuaj endocrine qib ntawm cov nas hauv pawg qauv tau siab dua, thiab qhov sib txawv ntawm cov pab pawg tau pom tseeb (P<0. 05), which was reflected in the significant decrease in E2 levels and FSH. , LH expression levels increased significantly, indicating that the endocrine indicators of rats in the model group were disordered, which was consistent with the clinical characteristics of menopausal kub siab. Tom qab kev cuam tshuam tshuaj, cov qib endocrine ntawm cov nas nyob rau hauv pab pawg zoo thiab CDPS cov pab pawg siab thiab cov koob tshuaj qis tau txhim kho mus rau qhov sib txawv. Cov pab pawg zoo tau muaj txiaj ntsig kev txhim kho kom pom tseeb, thaum CDPS cov pab pawg siab- thiab cov koob tshuaj tsawg tau muaj kev txhim kho me ntsis hauv E2 qib. Piv nrog rau pawg qauv, qhov sib txawv tsis yog qhov tseem ceeb (P＞0.05), tab sis qhov ntsuas FSH thiab LH tau zoo dua, thiab qhov sib txawv tseem ceeb (P＜0.05) .

2. 4. Kev hloov pauv hauv cov ntshav cov tshuaj neurotransmitter cov ntsiab lus ntawm cov nas hauv txhua pawg ua ntej thiab tom qab kev cuam tshuam tshuaj

Nws tuaj yeem pom los ntawm Table 3: Piv nrog rau pawg neeg ua haujlwm sham, cov lus qhia theem ntawm txhua tus neurotransmitter sib txawv hauv cov nas hauv pawg qauv (P ＜ 0}. 05), qhia tiaskev qhia theem ntawm neurotransmittersnyob rau hauv cov nas nyob rau hauv cov qauv pab pawg neeg yog txawv txav thiab cov tsos mob Nws yog raws li nyob rau hauv cov kev kho mob yam ntxwv ntawm menopausal hypertension thiab dryness syndrome. Tom qab kev cuam tshuam tshuaj, cov txiaj ntsig tau zoo ib yam li cov qauv ntawm pawg.

Piv nrog rau CDPSpab pawg tsawg, tshwj tsis yog tias pawg CDPS cov koob tshuaj qis me ntsis muaj qhov cuam tshuam me ntsis ntawm DA (P > 0. 05), pawg neeg zoo thiab CDPS ntau pab pawg tuaj yeem kho cov lus qhia theem ntawm txhua tus neurotransmitter rau qib sib txawv, thiab qhov sib txawv yog qhov tseem ceeb (P<0.05), among which the effect intensity of the positive group was stronger than that of the CDPS high-dose group.

3 Kev sib tham

Menopausal Syndrome (MPS) yog hais txog cov poj niam cev xeeb tub uas nws lub zes qe menyuam ua haujlwm poob qis, ua rau txo qis E2 tso tawm thiab tsis muaj zog tawm tswv yim kev tswj hwm ntawm hypothalamic-pituitary system, inducing pulse-type secretion of gonadotropes in the arcuate nucleus of the hypothalamus and the paraventricular nucleus. hormonal tso zis

(GnRH) mus rau lub portal circulation system, stimulating lub pituitary caj pas kom secrete FSH thiab LH kom nce, ua rau hypothalamic-pituitary-ovarian axis (HPOA) dysfunction [7], yog li cuam tshuam rau hypothalamic monoamine neurotransmission zoo tshuav nyiaj li cas. Neurotransmitters ua lub luag haujlwm tseem ceeb hauv kev xa cov ntaub ntawv ntawm cov paj hlwb thiab nruab nrab ntawm cov paj hlwb thiab endocrine thiab lub cev tiv thaiv kab mob. Neurotransmitters feem ntau yog monoamine neurotransmitters, suav nrog catecholamines (xws li DA), thiab indole (xws li 5-HT), thiab 5-HT yog cov khoom tseem ceeb tshaj plaws uas tswj tib neeg lub siab xav thiab cuam tshuam ncaj qha rau lub cev lub cev. thiab kev ua haujlwm puas siab puas ntsws. Cov kev hloov pauv hauv cov neurotransmitters hauv cov poj niam laus yuav

Nws ua rau kev ua haujlwm tsis zoo ntawm lub cev tsis zoo ntawm lub cev, uas ua rau muaj kev cuam tshuam rau tus kheej thiab kev ua haujlwm ntawm lub cev, ua rau cov tsos mob xws li insomnia, dreaminess, irritability, thiab lwm yam tsos mob [8]; Qee qhov kev tshawb fawb tau lees paub [9] tias qhov txo qis hauv cov ntshav E2 qhia qib yog txuam nrog kev nce hauv FSH thiab LH. Cov qib siab muaj feem cuam tshuam nrog qhov pib ntawm menopause hauv cov poj niam. Nyob rau hauv cov tshuaj suav tshuaj, menopause muaj lub npe meej sib xws rau nws. Raws li tus neeg mob cov tsos mob, tus kab mob tuaj yeem cuam tshuam nrog cov kab mob xws li "dryness", "tawm hmo ntuj" thiab "kiv taub hau". Cov tshuaj suav tshuaj suav hais tias cov poj niam siv lub siab ua lub hauv paus thiab siv cov ntshav ua haujlwm. Hauv cov poj niam cev xeeb tub, Tiangui tab tom yuav tua tab sis tseem tsis tau tua. Cov yin thiab ntshav tsis txaus, lub siab poob nws cov khoom noj, thiab daim siab qi tsis zoo vim qhov tsis ua haujlwm. Yog li ntawd, "lub siab stagnation" tshwm sim thaum lub sij hawm cev xeeb tub. cim; Yog tias lub siab poob nws txoj haujlwm, lub zog qi yuav qeeb thiab cov ntshav ncig yuav tsis zoo, uas tuaj yeem ua rau cov ntshav stasis, yog li "ntshav stasis" yog qhov tshwm sim tseem ceeb ntawm pathological; Yog tias daim siab poob nws cov khoom noj, lub raum yuav nkees dhau sijhawm, thiab lub raum qi yuav tsis muaj zog thiab cov ntsiab lus yuav poob. Cov ntshav tsis txaus thiab qhov tsis txaus ntawm yin thiab yang, yog li "lub raum tsis muaj peev xwm"yog lub hauv paus ua rau; raws li kev sib txawv ntawm cov kab mob, cov txheej txheem ntawm kev tshem tawm phlegm, relieving stagnation, thiab purging hluav taws kuj siv; "menopause" tiag tiag yog ib tug syndrome ntawm thawj deficiency thiab tshaj, thiab kev kho mob yuav tsum yog "nourishing lub siab thiab ob lub raum" [10]. Raws li qhov no, thaum sim sim cov qauv tsiaj, cov qauv dryness syndrome tau rov ua dua raws li tus qauv ntawm cov poj niam cev xeeb tub, uas zoo sib xws nrog cov yam ntxwv ntawm lub cev tsis muaj zog.

Cistanche deserticolabelongs rau "qib saum toj kawg nkaus" tshuaj suav tshuaj hauv "Shen Nong's Materia Medica". Nws yog lub qia qhuav nrog scaly nplooj ntawm Cistanche deserticola YC Ma. Nws muaj lub luag haujlwm ntawm kev txhawb nqa lub raum thiab ntxiv dag zog rau yang, ntxiv cov ntsiab lus thiab cov pob txha, nourishing ntshav thiab moisturizing, cov nyhuv ntxim nyiam thiab ua rau lub neej ntev, vim tsis muaj peev txheej, nws tau raug teev tseg raws li lub teb chaws thib ob tiv thaiv nroj tsuag. Kev tshawb fawb tshuaj niaj hnub tau lees paub tiasCistanche deserticolamuaj ntau yam kev ua si lom neeg. Lub ntsiab active cov khoom xyaw uas exert no biological kev ua si yogpolysaccharides, zoo litxhawb lub cev tsim cov interleukin -2, txhawb kev tiv thaiv kab mob cell proliferation, txhawb phagocytosisntawmreticuloendothelial system, thiab txhawb nqa Immunomodulatory teebmeem xws li tso tawm ntawm cov hlwb thymic paub tab mus rau sab nraud [11-13]. Kuntai Capsule (yav tas los hu ua Gengnian Ningxin Capsule) yog siv rau menopausal syndrome, tshwj xeeb tshaj yog rau cov neeg mob menopausal nyob rau hauv lub sij hawm hloov pauv ntawm menopause. Nws tau pom zoo tias qhov kev npaj no tuaj yeem ua ncaj qha rau ntawm zes qe menyuam cov ntaub so ntswg, txhawb nqa intraovarian microcirculation, thiab txhim khu kev ua haujlwm ntawm zes qe menyuam. Txhim khu kev ua haujlwm ntawm zes qe menyuam; Nyob rau tib lub sijhawm, cov tshuaj suav tshuaj xws li rehmannia glutinosa thiab nees luav-ntxhais gelatin nyob rau hauv daim ntawv tshuaj tuaj yeem ua rau cov follicles atretic, rov ua haujlwm ntawm zes qe menyuam zais zis, thiab tswj qhov sib npaug ntawm cov tshuaj hormone secretion; ncua qhov tseem ceeb ntawm zes qe menyuam thiab ncua cov poj niam cev xeeb tub [14 - 15], yog li tsab xov xwm no Kuntai capsule tau siv los ua cov tshuaj zoo los koom nrog kev tswj hwm.

Kev txiav txim los ntawm cov txiaj ntsig kev tshawb fawb: tsis muaj qhov hloov pauv tseem ceeb hauv cov ntshav siab systolic ntawm cov hlab ntsha hauv cov qauv ntawm cov nas ua ntej thiab tom qab ovariectomy (P ＞ {{0}}}. 05) , qhia tias qhov kev ntxhov siab ntawm ovariectomy ntawm SHR nas tsis cuam tshuam qhov kev hloov pauv ntawm cov ntshav siab; Muaj qhov txawv txav ntawm qhov ntsuas endocrine hauv nas. Tom qab cov nas raug ovariectomized, cov lus qhia theem ntawm cov tshuaj estrogen E2 hauv cov ntshav poob qis (P < 0.05), qhia tias qhov kev tawm tswv yim tsis zoo ntawm lub caj pas hypothalamus-pituitary tsis muaj zog nyob rau lub sijhawm no, thiab FSH tau them rov qab. , LH cov ntsiab lus nce (P < 0. 05), ua rau muaj kev ua haujlwm tsis zoo ntawm endocrine. Qhov kev hloov pauv no yog ua raws li cov yam ntxwv ntawm kev ua tsis taus, thiab cov kab mob endocrine yuav cuam tshuamkom sib npaug ntawm monoamine neurotransmitters hauv hypothalamus; kev tshawb fawb qhia tau hais tias CDPS cov pab pawg siab- thiab cov koob tshuaj qis qis txo qis-tswj cov lus qhia theem ntawm FSH thiab LH (P < 0. 05), tab sis qhov kev hloov pauv ntawm kev qhia theem ntawm E2 yog tsis pom tseeb, uas yog me ntsis qis dua li ntawm pawg qauv. Siab, qhov sib piv ntawm cov pab pawg tau pom tias qhov sib txawv tsis tseem ceeb (P> 0. 05). Los ntawm qhov kev xav ntawm neurotransmitters: cov ntshav 5-HT thiab 5-HIAA cov ntsiab lus ntawm cov nas hauv pawg qauv tau nce ntau, thiab NPY, NE, thiab DA cov ntsiab lus poob qis heev. Qhov kev hloov pauv no zoo ib yam nrog cov kev hloov pauv hauv cov tshuaj neurotransmitters hauv cov poj niam laus laus; Qhov laj thawj tseem ceeb tuaj yeem yog Lub anabolism ntawm catecholamine transmitters yog inhibited thiab cov catabolism yog txhim kho. Qhov no yuav ua rau muaj kev nce ntxiv hauv cov metabolism thiab kev ua haujlwm neural ntawm 5-HT hauv lub hlwb, rhuav tshem qhov sib npaug ntawm 5-HT / NE, thiab 5-HT nyob hauv lub cev. Cov txiaj ntsig tseem ceeb yog txhawm rau txo qis kev zoo siab, thiab kev nce siab ntawm nws cov ntsuas tuaj yeem ua rau lub siab tsis zoo, kev nyuaj siab, thiab kev tsis zoo siab. Qhov no kuj yog ib qho ntawm cov kab mob pathophysiological ntawm 5-HT uas tuaj yeem ua rau lub paj hlwb qis thiab ua rau muaj kev nyuaj siab.

Hauv cov ntsiab lus, Cistanche deserticola polysaccharide tuaj yeem tswj hwm epinephrine thiab corticosteroids los ntawm kev txhim kho HPOA muaj nuj nqi. Kev txo qis ntawm FSH thiab LH ntsuas thiab rov qab los ntawm E2 cov ntsiab lus qhia tias Cistanche deserticola polysaccharide tuaj yeem txhim kho lub cev cov txheej txheem endocrine thiab kho hypothalamic neurotransmitters. Cov kab mob tsis zoo, txhim kho kev ua haujlwm ntawm lub paj hlwb, ua kom lub cev ruaj khov nyob hauv ib puag ncig, txhawb kev txhim kho endocrine muaj nuj nqi, ua kom cov metabolism hauv lub cev, thiab ua lub luag haujlwm hauv kev txhim kho cov tsos mob menopausal.

Cov ntaub ntawv:

[1] Zulihumar Yusufu, Guo Wei, Xu Yan, thiab lwm yam Suav thiab Western Tshuaj Tiv Thaiv thiab Kho Cov Poj Niam Menopausal Hypertension

Kev tshawb fawb txog kev mob ntshav siab ］J Tuam Tshoj Medical Herald, 2015, 33(12): 46-50.

[2] Marnocha SK, Bergstrom M, Dempsey LF. Kev ua neej nyob ntawm perimenopause thiab menopause ［J］． Contemp Nurse, 2011, 37(2): 229-240.

[3] Duan Xianchun, Wang Yongzhong, Fang Zhaohui, thiab lwm yam. Kev kho cov nyhuv ntawm Yuangui Yishen Granules ntawm ntshav qab zib nephropathy qauv nas ［J］ Suav Patent Tshuaj, 2015, 37(3): 473-477.

[4] Liu Xin. Kawm txog qhov cuam tshuam ntawm Cistanche deserticola ntawm kev ua me nyuam endocrine ua haujlwm ntawm poj niam nas nrog raum tsis muaj zog ［D］］］. Guangzhou: Sun Yat-sen University, 2010.

[5] Ge Li, Lin Xue, Li Hongxia, thiab lwm yam. Suav General Medicine, 2015, 18(30): 3692-3696.

[6] Lin Xu, Zhou Bin, Gan Qinglei. Kawm txog cov txiaj ntsig ntawm Xuzao Gengping Powder ntawm cov ntshav siab hloov pauv ntawm sphygmomanometer hauv cov neeg laus mob ntshav siab ［J］. Suav General Medicine, 2013, 16(5): 567-571.

[7] Yang Songwei, Guo Jiansheng, Wang Xiaoqian, thiab lwm yam. Cov nyhuv ntawm Bushenzhugeng extract ntawm neuroendocrine dysfunction nyob rau hauv ovariectomized menopausal qauv nas［J］］. Suav Patent Tshuaj, 2016, 38(3): 651-654.

[8] Otrmann O, Doren M, Windler E, et al. Hormone therapy in perimenopause and postmenopause (HT) interdisciplinary S3 guideline, Association of the scientific medical scientists in Germany AWMF 015/062- short version［J］ Arch Gynecol Obstet, 2011, 284(2): 343-355.

[9] Xu Fengquan, Zheng Yu, Xu Linjie, thiab lwm yam. Phau ntawv Journal of Psychiatry, 2016, 29(1): 69-72.

[10] Xu Fengquan, Xu Linjie, Zhang Ying. Kev tshawb fawb soj ntsuam ntawm cov qauv kev faib tawm ntawm TCM cov tsos mob hauv 98 tus poj niam cov neeg mob uas muaj kev nyuaj siab rau kev laus ［J］. World Journal of Integrated Traditional Chinese and Western Medicine, 2014, 9(10): 1056-1058