Tsis txhob cia li paub txog lub raum Biopsy, Koj tuaj yeem ua qhov no rau kev kuaj mob ntxov ntawm Lupus Nephritis

Systemic lupus erythematosus yog ib tug mob inflammatory autoimmune connective cov ntaub so ntswg uas muaj ntau dua nyob rau hauv cov me nyuam thiab cov hluas thiab cov poj niam hnub nyoog nruab nrab. Nws feem ntau cuam tshuam rau ntau lub cev thiab lub cev, nrog rau lub raum kev puas tsuaj yog qhov tshwm sim ntau tshaj plaws thiab kev tuag siab. Kev tshawb fawb qhia tau hais tias li ntawm 90% ntawm cov neeg mob uas muaj kab mob lupus erythematosus muaj qhov sib txawv ntawm lub raum kev puas tsuaj thiab tuaj yeem ua rau mob lupus nephritis, thiab li ntawm 25% ntawm cov neeg mob lupus nephritis thaum kawg yuav tsim kab mob raum kawg [1].

Nyem rau Cistanche rau mob raum

Thaum lub raum koom nrog, qhov xwm txheej ntawm cov kab mob lupus erythematosus ua ntau nyuaj, kev kho mob nyuaj dua, thiab kev pheej hmoo ntawm kev tsis zoo kuj nce ntxiv. Yog tias nws tsis tuaj yeem kuaj pom lub sijhawm thiab kho kom raug, nws yuav maj mam txhim kho mus rau hauv lub raum tsis zoo, thaum kawg ua rau tus neeg mob lub neej txaus ntshai. Yog tias qhov mob raum thaum ntxov tuaj yeem kho tau sai thiab tsim nyog, qhov kev cia siab tuaj yeem txhim kho. Yog li, kev kuaj mob ntxov ntawm lupus nephritis yog qhov tseem ceeb tshwj xeeb.

Tam sim no, txoj kev kuaj mob feem ntau yog ua rau lub raum biopsy rau cov neeg mob, tab sis lub raum biopsy yog qhov cuam tshuam thiab tsis tuaj yeem lees txais los ntawm ntau tus neeg mob, thiab qee chav kho mob tseem tsis muaj cov xwm txheej los ua rau lub raum biopsy. Tsis tas li ntawd, lub raum cov ntaub so ntswg puncture sampling kuj muaj qee tus nqi ntawm kev kuaj tsis tau ntawm focal thiab me me theem ntawm lub raum thaum ntxov. Cov kev txwv no coj ntau yam teeb meem rau kev kuaj mob ntxov thiab kev soj ntsuam kab mob ntawm lupus nephritis. Yog li ntawd, nws yog ib qho tseem ceeb heev uas yuav tsum tau siv cov tshuaj uas tsis yog lub raum biopsy soj ntsuam los ceeb toom thiab paub txog kev puas tsuaj rau lub raum thaum ntxov hauv lupus erythematosus. Cov khoom kuaj xws li 24- teev cov zis protein ntau npaum li cas thiab cov ntshav creatinine feem ntau yog siv hauv kev kho mob, tab sis lawv qhov rhiab heev thiab qhov tshwj xeeb raug txwv, ua rau lawv nyuaj rau siv rau kev kuaj mob ntxov ntawm lub raum raug mob. Ntau tus kws tshawb fawb tau tshawb fawb ntau dua thiab tshwj xeeb biomarkers los ntawm kev kuaj tsis muaj kab mob, suav nrog cov ntshav thiab zis biomarkers [2], txhawm rau txhawm rau kuaj xyuas ntxov thiab saib xyuas kev mob ntawm lupus nephritis.

01 ntshav biomarkers

(1) Anti-ob-stranded DNA antibodies: ncaj qha los yog tsis ncaj qha khi rau cell nto antigens los yog raug chromatin ntawm glomerular qab daus daim nyias nyias, inducing ib tug inflammatory cascade cov tshuaj tiv thaiv; Lawv kuj tuaj yeem nkag mus rau cov hlwb, cuam tshuam cov noob qhia, thiab ua rau cov cell apoptosis. , yog ib qho tseem ceeb ntawm kev kuaj mob rau lupus nephritis.

(2) Anti-C1q antibody: C1q ua ke los tsim ib qho kev tiv thaiv kab mob, ua rau lub raum puas thiab muaj feem cuam tshuam rau cov kab mob ntawm lupus nephritis.

(3) Anti-ribosomal P protein antibodies: Anti-ribosomal P protein antibodies kho qhov tshwm sim ntawm lupus nephritis los ntawm Th1 thiab tej zaum yuav koom nrog qhov tshwm sim ntawm hom V lupus nephritis. Lawv muaj qhov rhiab heev thiab tshwj xeeb thiab tuaj yeem kwv yees qhov kev loj hlob ntawm lupus nephritis. .

(4) Anti-Sm antibody: Nws yog ib qho tshuaj tiv thaiv kab mob rau cov kab mob lupus erythematosus. Nws muaj feem xyuam rau cov proteinuria thiab tuaj yeem qhia txog nephritis. High titers ntawm anti-Sm cov tshuaj tiv thaiv tau raug txheeb xyuas raws li tus kws tshaj lij ntawm asymptomatic lupus nephritis thiab kwv yees qhov kev mob tshwm sim ntxov ntxov hauv lupus nephritis.

(5) Anti-nucleosome antibodies: Anti-nucleosome antibodies tuaj yeem tsis tsuas yog tsim cov tshuaj tiv thaiv kab mob hauv tsev nrog cov glomerular hauv qab daus daim nyias nyias tab sis kuj koom nrog hauv kev tso tawm ntawm cov kab mob hauv lub cev kom kho qhov mob. Lub xub ntiag ntawm cov tshuaj tiv thaiv antinucleosome yog txuam nrog glomerulonephritis thiab kab mob kev ua haujlwm hauv cov neeg mob uas muaj kab mob lupus erythematosus.

(6) Antiphospholipid cov tshuaj tiv thaiv: Antiphospholipid cov tshuaj tiv thaiv tuaj yeem cuam tshuam nrog plasmin, thrombin, thiab lwm yam, cuam tshuam rau lub cev anticoagulant thiab fibrinolytic systems, thiab muaj feem xyuam rau lub raum ua haujlwm luv luv rau cov neeg mob lupus nephritis.

(7) Monomeric C-reactive protein antibodies: khi rau endogenous antigens thiab koom rau hauv kev tsim ntawm lub cev tsis muaj zog, yog li inducing / exacerbating inflammatory teb. Nws yog siv los saib xyuas kev ua haujlwm ntawm lupus nephritis, ntsuas cov txiaj ntsig ntawm kev kho mob, thiab tuaj yeem siv los ua qhov ntsuas pom ntawm lupus nephritis.

(8) Dickkopf-1: Dysregulation of Dickkopf-1 tej zaum yuav muaj feem xyuam rau lub pathogenesis ntawm lupus nephritis thiab raum fibrosis, thiab tuaj yeem siv los ua ib qho kev qhia ywj pheej los txheeb xyuas cov kab mob lupus nephritis.

02 Cov zis biomarkers

(1) B cell activating factor thiab proliferation-inducing ligands: tuaj yeem txhawb B cell activation thiab proliferation, thiab lawv cov zis ntau tuaj yeem cuam tshuam lub raum ua haujlwm thiab tuaj yeem siv los ua cov cim rau kev loj hlob lupus nephritis.

(2) Lipocalin-2: Nws tuaj yeem tsim cov cell apoptosis, txhim kho B hlwb, thiab tiv thaiv lub raum. Nws cov theem qhia nyob rau hauv cov neeg mob nrog lupus nephritis muaj feem xyuam rau qhov mob hnyav ntawm tus kab mob, thiab nws tuaj yeem siv los ua kev kuaj mob ntxov thiab rov ua dua tshiab ntawm lupus nephritis.

(3) Monocyte chemoattractant protein-1: Koom nrog cov lus teb inflammatory. Nws cov lus qhia muaj feem xyuam rau kev nkag mus ntawm cov kab mob inflammatory hauv lub raum tubules thiab fibrosis ntawm lub raum interstitium. Nws muaj qhov tshwj xeeb thiab rhiab heev thiab tuaj yeem saib xyuas qhov tshwm sim thiab kev loj hlob ntawm lupus nephritis.

(4) qog necrosis yam zoo li qaug zog inducer ntawm apoptosis: Txhawb glomerular mesangial hlwb kom tso cov inflammatory chemokines, ua rau inflammatory cell infiltration. Nws tau nce ntxiv hauv cov zis ntawm cov neeg mob nrog lupus nephritis thiab ua haujlwm raws li qhov qhia txog kev ua ntawm lupus nephritis. qhov ntsuas.

(5) Neutrophil gelatinase-related lipocalin: tswj kev loj hlob, kev sib txawv, thiab apoptosis ntawm lub raum epithelial hlwb thiab tuaj yeem tiv thaiv lub raum. Nws tuaj yeem kwv yees qhov kev ua haujlwm ntawm lupus nephritis thiab tuaj yeem siv los ua ib qho kev qhia lom neeg los saib xyuas lub raum thaum ntxov thiab kho mob raum tsis ua haujlwm.

(6) Vascular endothelial adhesion molecules thiab intercellular adhesion molecules: Lawv cov qib hauv cov zis muaj feem xyuam nrog kev ua haujlwm ntawm lupus nephritis, thiab lawv cov qib tuaj yeem cuam tshuam kev loj hlob ntawm nephritis hauv cov neeg mob lupus nephritis.

(7) miRNA: tuaj yeem tswj kev tso tawm ntawm cov neeg kho mob inflammatory, innate lub cev tiv thaiv kab mob, cuam tshuam rau tus xov tooj zoo li receptors, thiab lwm yam, yog li tswj qhov tshwm sim thiab kev loj hlob ntawm cov kab mob. Nws tuaj yeem siv los ua tus kwv yees ntawm lub raum fibrosis thaum ntxov hauv cov neeg mob lupus nephritis.

Cistanche kho mob raum li cas?

Cistancheyog ib hom tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho ntau yam mob, suav nrograumkab mob. Nws yog muab los ntawm qhuav stems ntawmCistanchedeserticola, ib tsob nroj nyob rau hauv cov suab puam ntawm Tuam Tshoj thiab Mongolia. Lub ntsiab active Cheebtsam ntawm cistanche yogphenylethanoidglycosides, echinacoside cov tshuaj, thiabacteoside, uas tau pom tias muaj txiaj ntsig zoo rauraumnoj qab haus huv.

Kab mob raum, tseem hu ua kab mob raum, hais txog ib yam mob uas lub raum ua haujlwm tsis zoo. Qhov no tuaj yeem ua rau muaj cov khoom pov tseg thiab cov co toxins hauv lub cev, ua rau muaj ntau yam tsos mob thiab teeb meem. Cistanche tuaj yeem pab kho mob raum ase los ntawm ntau lub tshuab.

Ua ntej, cistanche tau pom tias muaj cov nyhuv diuretic, txhais tau tias nws tuaj yeem ua rau cov zis ntau ntxiv thiab pab tshem tawm cov khoom pov tseg ntawm lub cev. Qhov no tuaj yeem pab txo lub nra ntawm lub raum thiab tiv thaiv kev tsim cov co toxins. Los ntawm kev txhawb nqa diuresis, cistanche kuj tseem tuaj yeem pab txo qis ntshav siab, ib qho teeb meem ntawm cov kab mob raum.

Ntxiv mus, cistanche tau pom tias muaj cov teebmeem antioxidant. Kev ntxhov siab oxidative, tshwm sim los ntawm qhov tsis sib xws ntawm kev tsim cov dawb radicals thiab lub cev tiv thaiv antioxidant, ua lub luag haujlwm tseem ceeb hauv kev mob raum. ies pab neutralize dawb radicals thiab txo Oxidative kev nyuaj siab, yog li tiv thaiv lub raum los ntawm kev puas tsuaj. Cov phenylethanoid glycosides pom hauv cistanche tau tshwj xeeb hauv kev tshem tawm cov dawb radicals thiab inhibiting lipid peroxidation.

Tsis tas li ntawd, cistanche tau pom tias muaj cov nyhuv anti-inflammatory. Kev mob yog lwm yam tseem ceeb hauv kev loj hlob thiab kev loj hlob ntawm cov kab mob raum. Cistanche's anti-inflammatory zog pab txo cov zus tau tej cov pro-inflammatory cytokines thiab inhibit qhov ua kom o yuav tsum tau txoj kev, yog li alleviating o nyob rau hauv lub raum.

Tsis tas li ntawd, cistanche tau pom tias muaj cov teebmeem immunomodulatory. Hauv kab mob raum, lub cev tiv thaiv kab mob tuaj yeem ua rau tsis zoo, ua rau muaj kev mob ntau dhau thiab cov ntaub so ntswg puas. Cistanche pab tswj lub cev tiv thaiv kab mob los ntawm kev hloov kho kev tsim khoom thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob, xws li T hlwb thiab macrophages. Txoj cai tiv thaiv kab mob no pab txo qhov mob thiab tiv thaiv kev puas tsuaj ntxiv rau lub raum.

Ntxiv mus, cistanche tau pom los txhim kho lub raum kev ua haujlwm los ntawm kev txhawb nqa kev tsim kho ntawm lub raum hlab nrog cov hlwb. Lub raum tubular epithelial hlwb ua lub luag haujlwm tseem ceeb hauv kev pom thiab rov nqus cov khoom pov tseg thiab electrolytes. Hauv kab mob raum, cov hlwb no tuaj yeem raug puas tsuaj, ua rau lub raum ua haujlwm puas. Cistanche lub peev xwm los txhawb kev tsim kho ntawm cov hlwb no pab kho lub raum kom zoo thiab txhim kho lub raum tag nrho.

Ntxiv nrog rau cov kev cuam tshuam ncaj qha rau lub raum, cistanche tau pom tias muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev hauv lub cev. Txoj hauv kev zoo rau kev noj qab haus huv no tseem ceeb tshwj xeeb hauv cov kab mob raum, vim tias tus mob feem ntau cuam tshuam rau ntau lub cev thiab lub cev. che tau pom tias muaj kev tiv thaiv rau lub siab, lub plawv, thiab cov hlab ntsha, uas feem ntau cuam tshuam los ntawm kab mob raum. Los ntawm kev txhawb nqa kev noj qab haus huv ntawm cov kabmob no, cistanche pab txhim kho lub raum tag nrho thiab tiv thaiv kev mob ntxiv.

Hauv kev xaus, cistanche yog cov tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho mob raum. Nws cov active Cheebtsam muaj diuretic, antioxidant, anti-inflammatory, immunomodulatory, thiab regenerative teebmeem, uas pab txhim kho lub raum ua haujlwm thiab tiv thaiv ob lub raum los ntawm kev puas tsuaj ntxiv. , cistanche muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev, ua rau nws txoj hauv kev zoo rau kev kho mob raum.