Mob ntshav qab zib nephropathy: Kev kuaj pom ntxov thiab kho thaum ntxov

Mob ntshav qab zib, ntshav siab thiab hyperlipidemia yog suav tias yog "peb tus neeg tua neeg loj" hauv lub neej niaj hnub no. Nws yog ib qho kev puas tsuaj ntau yam los ntawm lub sijhawm ntev carbohydrate, rog thiab protein metabolism tsis zoo, feem ntau ua rau mob hnyav ntawm cov ntaub so ntswg thiab cov kabmob xws li qhov muag, ob lub raum, paj hlwb, lub plawv, thiab cov hlab ntsha. Cov neeg mob feem ntau mus pw hauv tsev kho mob vim qhov ncauj qhuav, polydipsia, polyuria, lossis loog ntawm tes thiab taw, lossis lwm yam kab mob. Kev kuaj lub cev qhia pom cov ntshav qab zib siab. Cov neeg mob feem ntau tsuas yog tsom mus rau qib ntshav qab zib thiab tsis quav ntsej txog kev puas tsuaj ntawm lub cev, tshwj xeeb tshaj yog rau lub raum puas. Qee cov neeg mob txawm tsim cov kab mob raum kawg hauv lub sijhawm luv luv tom qab pom kev puas tsuaj rau lub raum, uas yog hu ua uremia los ntawm tib neeg. Qhov no yog vim kev nkag siab tsis txaus ntawm ntshav qab zib nephropathy thiab kev cuam tshuam lig.

Nyem rau Cistanche rau mob raum

1 Mob ntshav qab zib nephropathy yog dab tsi?

Mob ntshav qab zib nephropathy yog hais txog kab mob raum ntev los ntawm ntshav qab zib. Mob ntshav qab zib nephropathy tshwm sim los ntawm hom 2 mob ntshav qab zib yog ib qho ntawm cov teeb meem tseem ceeb tshaj plaws hauv cov neeg mob ntshav qab zib. Ntawm cov neeg mob ntshav qab zib hauv kuv lub tebchaws, qhov tshwm sim ntawm cov ntshav qab zib nephropathy tuaj yeem ncav cuag 30% ~ 40%; Ntawm cov neeg mob ntshav qab zib hom 2, qhov tshwm sim ntawm cov ntshav qab zib nephropathy tuaj yeem ncav cuag 20% ​​~ 38%, uas tau dhau los ua qhov tseem ceeb ntawm cov kab mob raum ntev thiab kab mob raum kawg. Yog li, rau cov neeg mob ntshav qab zib, yuav ua li cas txhawm rau kuaj ntshav qab zib nephropathy ntxov yog qhov tseem ceeb tshwj xeeb.

2 Lub cev qhia li cas thaum mob ntshav qab zib nephropathy tshwm sim?

Teeb liab 1: Proteinuria

Proteinuria yog qhov tseem ceeb tshaj plaws kev kho mob tshwm sim ntawm ntshav qab zib nephropathy. Tsis muaj qhov chaw kho mob proteinuria nyob rau hauv cov ntshav qab zib nephropathy thaum ntxov, thiab tsuas yog radioimmunoassay tuaj yeem kuaj pom microalbuminuria tsis tu ncua, uas yog ib qho cim ntawm lub raum puas thaum ntxov. Kev puas tsuaj rau lub raum ua rau cov protein tawm nrog cov zis. Raws li kev koom tes ntawm lub ntiajteb txawj nqus thiab lwm yam, cov zis ua npuas ncauj uas tsis dissipate tau ntev (ie foamy zis). Cov neeg mob feem ntau nrhiav kev kho mob vim li no, thiab kev kuaj xyuas yuav pom cov zis muaj protein ntau.

Teeb liab 2: Edema

Edema yog ib qho tsos mob ntawm tus mob ntshav qab zib nephropathy. Feem ntau tsis muaj edema nyob rau theem pib ntawm ntshav qab zib nephropathy. Qee tus neeg mob yuav muaj mob me me ua ntej cov plasma protein txo. Nyob rau theem tom ntej, lub raum kev puas tsuaj zuj zus ntxiv, thiab cov protein ntau tau tawm hauv cov zis, ua rau hypoproteinemia. Qhov tshwm sim thawj zaug yog qis qis edema, thiab theem tom qab tuaj yeem ua rau tag nrho lub cev edema, thiab tus kab mob feem ntau nthuav tawm refractory edema thaum nws nce mus rau theem kawg.

Teebmeem 3: Lub raum puas

Nyob rau theem pib ntawm ntshav qab zib nephropathy, lub raum ua haujlwm feem ntau yog qhov qub. Txawm li cas los xij, ntau yam tseem ceeb txuas ntxiv ua rau lub raum, ua rau glomerular sclerosis thiab nce zuj zus ntawm glomerular pom tus nqi, uas yuav ua rau mob raum kawg (uremia) yuav tsum tau kho lub raum hloov. Cov kev tshawb fawb tau pom tias lub raum puas hauv hom 1 mob ntshav qab zib hom 1 nce mus txog ib theem txhua 5 xyoos. Qhov no yog vim hais tias tom kawg feem ntau tshwm sim nyob rau hauv lub hauv paus ntawm degenerative ob lub raum nyob rau hauv nruab nrab-hnub nyoog thiab cov neeg laus, thiab nyob rau hauv tas li ntawd mus rau cov ntshav qab zib, ntshav siab, ntshav siab lipids thiab siab uric acid feem ntau ua rau lub raum ua ke, yog li tus kab mob no mus. sai dua.

Cov kev cai thiab kev cai rau kev kuaj mob "mob ntshav qab zib raum" yog dab tsi?

Cov neeg mob ntshav qab zib yuav tsum kuaj xyuas lawv lub raum ua haujlwm tsawg kawg ib xyoos ib zaug

Txhua tus neeg mob ntshav qab zib hom 2 yuav tsum tau kuaj mob raum tsawg kawg ib xyoos ib zaug, suav nrog cov zis niaj hnub, cov zis albumin / creatinine piv thiab ntshav creatinine.

Xyoo 2021 version ntawm Suav Cov Lus Qhia txhais tau hais tias "mob ntshav qab zib raum" (mob ntshav qab zib raum kab mob, DKD) raws li cov txheej txheem kuaj mob ntshav qab zib tau tsim los ntawm American Diabetes Association xyoo 2020, nrog rau keeb kwm meej ntawm ntshav qab zib, thiab kev sib raug zoo nrog cov zis protein thiab lub raum. kev ua haujlwm hloov, thiab tsis suav nrog lwm yam kab mob thawj, theem nrab glomerular thiab kab mob hauv lub cev. DKD tuaj yeem kuaj tau yog tias muaj ib qho ntawm cov xwm txheej hauv qab no.

1. Random zis albumin/creatinine ratio (UACR) Ntau dua lossis sib npaug li 30 mg/g lossis cov zis albumin excretion rate (UAER) Ntau dua lossis sib npaug li 30 mg/24 teev, thiab rov kuaj dua UACR lossis UAER hauv 3 txog 6. lub hlis, 2 tawm ntawm 3 lub sij hawm mus txog los yog tshaj tus nqi tseem ceeb; Lwm yam cuam tshuam xws li kev kis kab mob tsis suav nrog.

2. Kwv yees glomerular filtration rate (eGFR) < 60 ml·min-1·(1.73 m2)-1 rau ntau tshaj 3 lub hlis.

3. Lub raum biopsy zoo ib yam nrog DKD pathological hloov.

Lub caij ntuj sov

Cov lus qhia sov

Mob ntshav qab zib nephropathy tsis muaj tsos mob tshwm sim thaum ntxov. Thaum cov neeg mob pom nws, nws feem ntau tau txhim kho mus rau qhov hnyav dua, yog li kev kuaj pom ntxov yog qhov tseem ceeb heev. Ua ntej theem 3, nws tuaj yeem rov qab mus rau theem 1 los ntawm kev kho mob; ib zaug nws nkag mus rau theem 4, nws nyuaj rau rov qab los.

Dab tsi yog qhov phom sij ntawm ntshav qab zib nephropathy?

Mob ntshav qab zib nephropathy maj mam zuj zus thiab nws thiaj li loj hlob mus rau hauv lub raum tsis ua haujlwm thiab uremia, thiab tsuas yog tso siab rau kev lim ntshav thiab hloov lub raum kom tswj tau txoj sia. Tsis tas li ntawd, ob qho tib si ntshav qab zib thiab kab mob raum ntev ua rau muaj kev pheej hmoo ntawm cov kab mob plawv. Piv nrog rau cov neeg mob ntshav qab zib tsis muaj teeb meem, cov nqi kho mob ntawm cov ntshav qab zib nephropathy nce 13 zaug.

Active kev kho mob kom ncua kev loj hlob ntawm ntshav qab zib nephropathy

Kev kho mob ntshav qab zib nephropathy muaj ntau yam, suav nrog:

A. Hloov cov kev ua neej tsis zoo: xws li kev tswj qhov hnyav, kev noj zaub mov zoo, kev haus luam yeeb thiab kev tawm dag zog, thiab lwm yam.

B. Noj cov protein tsawg. Cov neeg mob uas lub raum tsis ua haujlwm yuav tsum noj 0.8g protein ib kilogram ntawm lub cev hnyav ib hnub.

C. Tswj ntshav qab zib. Kev tswj ntshav qab zib tsis zoo tuaj yeem ua rau muaj qhov tshwm sim thiab txhim kho ntshav qab zib nephropathy, thiab kev tswj ntshav qab zib kom zoo tuaj yeem ncua nws txoj kev loj hlob.

D. Tswj ntshav siab. Ntshav siab yog ib qho tseem ceeb ua rau muaj kev mob ntshav qab zib nephropathy. Ntshav siab yuav tsum tau tswj kom nquag plias. Cov ntshav siab ntawm cov neeg tsis cev xeeb tub uas muaj hnub nyoog 18 xyoo yuav tsum tswj qis dua 130/80mmHg.

E. Kev kho tshuaj, suav nrog ACEI, ARB, diuretics thiab lwm yam tshuaj tuaj yeem ua rau qeeb ntawm kev mob ntshav qab zib nephropathy, tab sis lawv yuav tsum tau siv raws li kev qhia ntawm tus kws kho mob.

F. Dialysis thiab hloov lub raum. Dialysis thiab hloov lub raum tuaj yeem txiav txim siab rau cov neeg mob uas muaj kab mob raum kawg. Hauv ntej, kev tshawb nrhiav ntxov thiab kev kho mob ntshav qab zib nephropathy yog qhov tseem ceeb heev, uas tuaj yeem ua rau qeeb ntawm kev mob ntshav qab zib nephropathy thiab txo cov neeg mob qhov mob thiab cov nqi kho mob.

Nyob rau hauv luv luv, thiaj li yuav ncua qhov tshwm sim thiab kev loj hlob ntawm lub raum kab mob mus rau qhov loj tshaj plaws, peb yuav tsum tau siv tag nrho cov kev ntsuas los tiv thaiv thiab kho cov ntshav qab zib nephropathy nyob rau hauv thaum ntxov theem, xws li: txhim kho txoj kev ua neej, tswj ntshav qab zib, tswj ntshav siab thiab ntshav lipids. , txo cov zis protein thiab lub raum raum hloov kho. Rau cov xwm txheej tshwj xeeb, koj yuav tsum mus rau lub tsev kho mob tsis tu ncua kom sab laj nrog kws kho mob.

Cistanche kho mob raum li cas?

Cistancheyog ib hom tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho ntau yam mob, suav nrograumkab mob. Nws yog muab los ntawm qhuav stems ntawmCistanchedeserticola, ib tsob nroj nyob rau hauv cov suab puam ntawm Tuam Tshoj thiab Mongolia. Lub ntsiab active Cheebtsam ntawm cistanche yogphenylethanoidglycosides, echinacoside cov tshuaj, thiabacteoside, uas tau pom tias muaj txiaj ntsig zoo rau lub raum kev noj qab haus huv.

Kab mob raum, tseem hu ua kab mob raum, hais txog ib yam mob uas lub raum ua haujlwm tsis zoo. Qhov no tuaj yeem ua rau muaj cov khoom pov tseg thiab cov co toxins hauv lub cev, ua rau muaj ntau yam tsos mob thiab teeb meem. Cistanche tuaj yeem pab kho mob raum ase los ntawm ntau lub tswv yim.

Ua ntej, cistanche tau pom tias muaj cov nyhuv diuretic, txhais tau tias nws tuaj yeem ua rau cov zis ntau ntxiv thiab pab tshem tawm cov khoom pov tseg ntawm lub cev. Qhov no tuaj yeem pab txo lub nra ntawm lub raum thiab tiv thaiv kev tsim cov co toxins. Los ntawm kev txhawb nqa diuresis, cistanche kuj tseem tuaj yeem pab txo qis ntshav siab, ib qho teeb meem ntawm cov kab mob raum.

Ntxiv mus, cistanche tau pom tias muaj cov teebmeem antioxidant. Kev ntxhov siab oxidative, tshwm sim los ntawm qhov tsis sib xws ntawm kev tsim cov dawb radicals thiab lub cev tiv thaiv antioxidant, ua lub luag haujlwm tseem ceeb hauv kev mob raum. ies pab neutralize dawb radicals thiab txo Oxidative kev nyuaj siab, yog li tiv thaiv lub raum los ntawm kev puas tsuaj. Cov phenylethanoid glycosides pom hauv cistanche tau tshwj xeeb hauv kev tshem tawm cov dawb radicals thiab inhibiting lipid peroxidation.

Tsis tas li ntawd, cistanche tau pom tias muaj cov nyhuv anti-inflammatory. Kev mob yog lwm yam tseem ceeb hauv kev loj hlob thiab kev loj hlob ntawm cov kab mob raum. Cistanche's anti-inflammatory zog pab txo cov zus tau tej cov pro-inflammatory cytokines thiab inhibit qhov ua kom o yuav tsum tau txoj kev, yog li alleviating o nyob rau hauv lub raum.

Tsis tas li ntawd, cistanche tau pom tias muaj cov teebmeem immunomodulatory. Hauv kab mob raum, lub cev tiv thaiv kab mob tuaj yeem ua rau tsis zoo, ua rau muaj kev mob ntau dhau thiab cov ntaub so ntswg puas. Cistanche pab tswj lub cev tiv thaiv kab mob los ntawm kev hloov kho kev tsim khoom thiab kev ua haujlwm ntawm lub cev tiv thaiv kab mob, xws li T hlwb thiab macrophages. Txoj cai tiv thaiv kab mob no pab txo qhov mob thiab tiv thaiv kev puas tsuaj ntxiv rau lub raum.

Ntxiv mus, cistanche tau pom los txhim kho lub raum kev ua haujlwm los ntawm kev txhawb nqa kev tsim kho ntawm lub raum hlab nrog cov hlwb. Lub raum tubular epithelial hlwb ua lub luag haujlwm tseem ceeb hauv kev pom thiab rov nqus cov khoom pov tseg thiab electrolytes. Hauv kab mob raum, cov hlwb no tuaj yeem raug puas tsuaj, ua rau lub raum ua haujlwm puas. Cistanche lub peev xwm los txhawb kev tsim kho ntawm cov hlwb no pab kho lub raum kom zoo thiab txhim kho lub raum tag nrho.

Ntxiv nrog rau cov kev cuam tshuam ncaj qha rau lub raum, cistanche tau pom tias muaj txiaj ntsig zoo rau lwm yam kabmob thiab lub cev hauv lub cev. Txoj hauv kev zoo rau kev noj qab haus huv no tseem ceeb tshwj xeeb hauv cov kab mob raum, vim tias tus mob feem ntau cuam tshuam rau ntau lub cev thiab lub cev. che tau pom tias muaj kev tiv thaiv rau lub siab, lub plawv, thiab cov hlab ntsha, uas feem ntau cuam tshuam los ntawm kab mob raum. Los ntawm kev txhawb nqa kev noj qab haus huv ntawm cov kabmob no, cistanche pab txhim kho lub raum tag nrho thiab tiv thaiv kev mob ntxiv.

Hauv kev xaus, cistanche yog cov tshuaj suav tshuaj ntsuab siv rau ntau pua xyoo los kho mob raum. Nws cov active Cheebtsam muaj diuretic, antioxidant, anti-inflammatory, immunomodulatory, thiab regenerative teebmeem, uas pab txhim kho lub raum ua haujlwm thiab tiv thaiv ob lub raum los ntawm kev puas tsuaj ntxiv. , cistanche muaj txiaj ntsig zoo rau lwm lub cev thiab lub cev, ua rau nws txoj hauv kev zoo rau kev kho mob raum.